{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:35:12Z","timestamp":1784122512430,"version":"3.55.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012752","name":"ELANCO","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012752","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SEPPIC"},{"DOI":"10.13039\/501100007288","name":"Mahasarakham University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015535","name":"MASTS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015535","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000360","name":"Scottish Funding Council","doi-asserted-by":"publisher","award":["HR09011"],"award-info":[{"award-number":["HR09011"]}],"id":[{"id":"10.13039\/501100000360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.dci.2017.11.001","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T04:16:28Z","timestamp":1510114588000},"page":"83-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Rainbow trout (Oncorhynchus mykiss) adipose tissue undergoes major changes in immune gene expression following bacterial infection or stimulation with pro-inflammatory molecules"],"prefix":"10.1016","volume":"81","author":[{"given":"Kimberly A.","family":"Veenstra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eakapol","family":"Wangkahart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-8959","authenticated-orcid":false,"given":"Tiehui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln","family":"Tubbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Ben Arous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Secombes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.fsi.2010.07.010","article-title":"Functional analysis of carp interferon-\u03b3: evolutionary conservation of classical phagocyte activation","volume":"29","author":"Arts","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.dci.2017.11.001_bib2","doi-asserted-by":"crossref","first-page":"e66118","DOI":"10.1371\/journal.pone.0066118","article-title":"The pyloric caeca area is a major site for IgM+ and IgT+ B cell recruitment in response to oral vaccination in rainbow trout","volume":"8","author":"Ballesteros","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2017.11.001_bib3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","article-title":"Cellular responses to interferon-gamma","volume":"15","author":"Boehm","year":"1997","journal-title":"Annu. Rev. Immunol. Palo Alto"},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib4","doi-asserted-by":"crossref","first-page":"e20446","DOI":"10.1371\/journal.pone.0020446","article-title":"The anti-inflammatory and antibacterial basis of human omental defense: selective expression of cytokines and antimicrobial peptides","volume":"6","author":"Chandra","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/AAC.50.1.185-195.2006","article-title":"Two cathelicidin genes are present in both rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar)","volume":"50","author":"Chang","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.dci.2010.12.001","article-title":"PAMP induced expression of immune relevant genes in head kidney leukocytes of rainbow trout (Oncorhynchus mykiss)","volume":"35","author":"Chettri","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"15\u201316","key":"10.1016\/j.dci.2017.11.001_bib7","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.molimm.2011.05.027","article-title":"Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression","volume":"48","author":"Costa","year":"2011","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.dci.2017.11.001_bib8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.fsi.2009.06.008","article-title":"Rainbow trout interleukin-2: cloning, expression and bioactivity analysis","volume":"27","author":"D\u00edaz-Rosales","year":"2009","journal-title":"Fish Shellfish Immunol."},{"issue":"6\u20137","key":"10.1016\/j.dci.2017.11.001_bib9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0145-305X(03)00036-3","article-title":"Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish","volume":"27","author":"Douglas","year":"2003","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2017.11.001_bib10","first-page":"117","article-title":"The vaccine formulation and its role in inflammatory processes in fish\u2013effects and adverse effects","volume":"121","author":"Evensen","year":"2005","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1095-8649.1997.tb01360.x","article-title":"Control of skeletal muscle fibres and adipose cells size in the flesh of rainbow trout","volume":"50","author":"Fauconneau","year":"1997","journal-title":"J.\u00a0Fish Biol."},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-4827(71)90230-8","article-title":"Studies on transport of macromolecules and small particles across mesothelial cells of the mouse omentum","volume":"69","author":"Fedorko","year":"1971","journal-title":"Exp. Cell Res."},{"issue":"Suppl.\u00a03","key":"10.1016\/j.dci.2017.11.001_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/dom.12154","article-title":"The immune cells in adipose tissue","volume":"15","author":"Ferrante","year":"2013","journal-title":"Diabetes & Obes. Metabolism"},{"issue":"3","key":"10.1016\/j.dci.2017.11.001_bib14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/oby.21003","article-title":"Adipose tissue as an immunological organ","volume":"23","author":"Grant","year":"2015","journal-title":"Obes. (Silver Spring, Md.)"},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.dci.2008.09.001","article-title":"Molecular characterization, expression and functional analysis of goldfish (Carassius aurutus L.) interferon gamma","volume":"33","author":"Grayfer","year":"2009","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.fsi.2006.05.009","article-title":"Characterization of an interleukin-15 like (IL-15L) gene from zebrafish (Danio rerio)","volume":"22","author":"Gunimaladevi","year":"2007","journal-title":"Fish Shellfish Immunol."},{"issue":"11","key":"10.1016\/j.dci.2017.11.001_bib17","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1084\/jem.20061041","article-title":"Regulation of B1 cell migration by signals through Toll-like receptors","volume":"203","author":"Ha","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.fsi.2011.04.010","article-title":"Sequencing of a second interleukin-10 gene in rainbow trout Oncorhynchus mykiss and comparative investigation of the expression and modulation of the paralogues in\u00a0vitro and in\u00a0vivo","volume":"31","author":"Harun","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"26","key":"10.1016\/j.dci.2017.11.001_bib19","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1016\/j.vaccine.2011.04.003","article-title":"Gene expression profiling in na\u00efve and vaccinated rainbow trout after Yersinia ruckeri infection: insights into the mechanisms of protection seen in vaccinated fish","volume":"29","author":"Harun","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2017.11.001_bib20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1677\/joe.0.1750261","article-title":"Recombinant interleukin-1\u03b2 activates the hypothalamic-pituitary-interrenal axis in rainbow trout, Oncorhynchus mykiss","volume":"175","author":"Holland","year":"2002","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.dci.2017.11.001_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-2427(01)00328-2","article-title":"The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant IL-1\u03b2","volume":"81","author":"Hong","year":"2001","journal-title":"Veterinary Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2017.11.001_bib22","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0145-305X(03)00056-9","article-title":"The effect of intraperitoneally administered recombinant IL-1\u03b2 on immune parameters and resistance to Aeromonas salmonicida in the rainbow trout (Oncorhynchus mykiss)","volume":"27","author":"Hong","year":"2003","journal-title":"Dev. Comp. Immunol."},{"issue":"12","key":"10.1016\/j.dci.2017.11.001_bib23","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.4049\/jimmunol.1301584","article-title":"Two types of TNF-\u03b1 exist in teleost fish: phylogeny, expression, and bioactivity analysis of type-II TNF-\u03b13 in rainbow trout Oncorhynchus mykiss","volume":"191","author":"Hong","year":"2013","journal-title":"J.\u00a0Immunol."},{"issue":"3","key":"10.1016\/j.dci.2017.11.001_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.dci.2012.07.010","article-title":"Cloning of the IL-1\u03b23 gene and IL-1\u03b24 pseudogene in salmonids uncovers a second type of IL-1\u03b2 gene in teleost fish","volume":"38","author":"Husain","year":"2012","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.fsi.2014.06.024","article-title":"Identification and characterisation of the IL-27 p28 subunits in fish: cloning and comparative expression analysis of two p28 paralogues in Atlantic salmon Salmo salar","volume":"41","author":"Husain","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"44","key":"10.1016\/j.dci.2017.11.001_bib26","doi-asserted-by":"crossref","first-page":"7678","DOI":"10.1016\/j.vaccine.2011.07.138","article-title":"Immune response of Atlantic salmon to recombinant flagellin","volume":"29","author":"Hynes","year":"2011","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.dci.2017.11.001_bib27","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.molimm.2006.07.297","article-title":"Cloning and expression analysis of an IL-6 homolog in rainbow trout (Oncorhynchus mykiss)","volume":"44","author":"Iliev","year":"2007","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.molimm.2015.03.014","article-title":"Identification and expression analysis of two interleukin-23\u03b1 (p19) isoforms, in rainbow trout Oncorhynchus mykiss and Atlantic salmon Salmo salar","volume":"66","author":"Jiang","year":"2015","journal-title":"Mol. Immunol."},{"issue":"1\u20134","key":"10.1016\/j.dci.2017.11.001_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0044-8486(01)00884-5","article-title":"Coupling body weight and its composition: a qualitative genetic analysis in rainbow trout","volume":"211","author":"Kause","year":"2002","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib30","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.fsi.2013.07.032","article-title":"Novel insights into the peritoneal inflammation of rainbow trout (Oncorhynchus mykiss)","volume":"35","author":"Koryt\u00e1\u0159","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0145-305X(01)00092-1","article-title":"Identification and analysis of an interleukin 8-like molecule in rainbow trout Oncorhynchus mykiss","volume":"26","author":"Laing","year":"2002","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.dci.2017.11.001_bib32","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J.\u00a0Clin. Investigation"},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.fsi.2012.11.011","article-title":"Transforming growth factor-\u03b21b: a second TGF-\u03b21 paralogue in the rainbow trout (Oncorhynchus mykiss) that has a lower constitutive expression but is more responsive to immune stimulation","volume":"34","author":"Maehr","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.it.2004.02.009","article-title":"The intricate interface between immune system and metabolism","volume":"25","author":"Matarese","year":"2004","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.dci.2017.11.001_bib35","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2527\/2004.823935x","article-title":"The adipocyte as an endocrine cell","volume":"82","author":"Miner","year":"2004","journal-title":"J.\u00a0Animal Sci."},{"key":"10.1016\/j.dci.2017.11.001_bib36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.molimm.2017.10.007","article-title":"Two types of TNF\u03b1 in Meagre (Argyrosomus regius): discovery, distribution and expression modulation","volume":"92","author":"Milne","year":"2017","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cyto.2011.03.015","article-title":"Cloning, expression analysis and bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-22","volume":"55","author":"Monte","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.dci.2017.11.001_bib38","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.fsi.2012.05.023","article-title":"Cloning and expression analysis of two ROR-\u03b3 homologues (ROR-\u03b3a1 and ROR-\u03b3a2) in rainbow trout Oncorhynchus mykiss","volume":"33","author":"Monte","year":"2012","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib39","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1128\/IAI.00599-12","article-title":"Cloning and characterization of rainbow trout interleukin-17A\/F2 (IL-17A\/F2) and IL-17 receptor A: expression during infection and bioactivity of recombinant IL-17A\/F2","volume":"81","author":"Monte","year":"2013","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.fsi.2003.10.002","article-title":"Sequential study of antigen persistence and concomitant inflammatory reactions relative to side-effects and growth of Atlantic salmon (Salmo salar L.) following intraperitoneal injection with oil-adjuvanted vaccines","volume":"16","author":"Mutoloki","year":"2004","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib41","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.fsi.2014.03.020","article-title":"Inflammatory responses and side effects generated by several adjuvant-containing vaccines in turbot","volume":"38","author":"Noia","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2017.11.001_bib42","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1128\/IAI.63.10.3966-3972.1995","article-title":"A\u00a0novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock","volume":"63","author":"Okamura","year":"1995","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.dci.2017.11.001_bib44","doi-asserted-by":"crossref","first-page":"e110920","DOI":"10.1371\/journal.pone.0110920","article-title":"Immunological characterization of the teleost adipose tissue and its modulation in response to viral infection and fat-content in the diet","volume":"9","author":"Pignatelli","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2017.11.001_bib45","series-title":"R: a Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2016"},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.immuni.2009.03.014","article-title":"Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens","volume":"30","author":"Rangel-Moreno","year":"2009","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib47","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fsi.2005.01.010","article-title":"The interferon system of teleost fish","volume":"20","author":"Robertsen","year":"2006","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/CIRCRESAHA.108.177105","article-title":"Interferon-\u03b3, a Th1 cytokine, regulates fat inflammation","volume":"103","author":"Rocha","year":"2008","journal-title":"Circulation Res."},{"issue":"6","key":"10.1016\/j.dci.2017.11.001_bib49","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.it.2010.03.001","article-title":"Innate immunity and adipose tissue biology","volume":"31","author":"Sch\u00e4ffler","year":"2010","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-\u03b3: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"32","key":"10.1016\/j.dci.2017.11.001_bib52","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1016\/j.vaccine.2013.05.025","article-title":"Non-adjuvanted flagellin elicits a non-specific protective immune response in rainbow trout (Oncorhynchus mykiss, Walbaum) towards bacterial infections","volume":"31","author":"Scott","year":"2013","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib53","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0305-0491(88)90322-7","article-title":"Lipid dynamics in fish: aspects of absorption, transportation, deposition and mobilization","volume":"90","author":"Sheridan","year":"1988","journal-title":"Comp. Biochem. Physiology B"},{"issue":"1\u20134","key":"10.1016\/j.dci.2017.11.001_bib54","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0044-8486(89)90408-0","article-title":"Alterations in lipid metabolism accompanying smoltification and seawater adaptation of salmonid fish","volume":"82","author":"Sheridan","year":"1989","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib55","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0305-0491(94)90176-7","article-title":"Regulation of lipid metabolism in poikilothermic vertebrates","volume":"107","author":"Sheridan","year":"1994","journal-title":"Comp. Biochem. Physiology B"},{"issue":"7","key":"10.1016\/j.dci.2017.11.001_bib56","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/gerona\/glp046","article-title":"Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6","volume":"64A","author":"Starr","year":"2009","journal-title":"Journals Gerontology Ser. A"},{"issue":"17","key":"10.1016\/j.dci.2017.11.001_bib57","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1128\/JVI.00319-11","article-title":"Antiviral activity of salmonid gamma interferon against infectious pancreatic necrosis virus and salmonid alphavirus and its dependency on type I interferon","volume":"85","author":"Sun","year":"2011","journal-title":"J.\u00a0Virology"},{"issue":"10","key":"10.1016\/j.dci.2017.11.001_bib58","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib59","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2164-11-39","article-title":"Gene expression profiles in Atlantic salmon adipose-derived stromo-vascular fraction during differentiation into adipocytes","volume":"11","author":"Todor\u010devi\u0107","year":"2010","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.dci.2017.11.001_bib60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/jcm5010003","article-title":"The effect of marine derived n-3 fatty acids on adipose tissue metabolism and function","volume":"5","author":"Todor\u010devi\u0107","year":"2016","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.dci.2017.11.001_bib61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molimm.2017.05.026","article-title":"Analysis of adipose tissue immune gene expression after vaccination of rainbow trout with adjuvanted bacterins reveals an association with side effects","volume":"88","author":"Veenstra","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2017.11.001_bib62","series-title":"Modern Applied Statistics with S","author":"Venables","year":"2002"},{"key":"10.1016\/j.dci.2017.11.001_bib64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/bjs.18004820717","article-title":"Antibody formation by the greater omentum","volume":"48","author":"Walker","year":"1960","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.dci.2017.11.001_bib65","first-page":"222","article-title":"The greater omentum as a site of antibody synthesis","volume":"42","author":"Walker","year":"1961","journal-title":"Br. J. Exp. Pathology"},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib66","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.dci.2014.04.008","article-title":"The expanding repertoire of the IL-12 cytokine family in teleost fish: identification of three paralogues each of the p35 and p40 genes in salmonids, and comparative analysis of their expression and modulation in Atlantic salmon Salmo salar","volume":"46","author":"Wang","year":"2014","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib67","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.molimm.2007.08.016","article-title":"Rainbow trout suppressor of cytokine signalling (SOCS)-1, 2 and 3: molecular identification, expression and modulation","volume":"45","author":"Wang","year":"2008","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.dci.2017.11.001_bib68","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.fsi.2013.08.030","article-title":"The cytokine networks of adaptive immunity in fish","volume":"35","author":"Wang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib69","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1742-4658.2005.04544.x","article-title":"Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss","volume":"272","author":"Wang","year":"2005","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.dci.2017.11.001_bib70","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.4049\/jimmunol.179.3.1475","article-title":"Molecular and functional characterization of IL-15 in rainbow trout Oncorhynchus mykiss: a potent inducer of IFN-\u03b3 expression in spleen leukocytes","volume":"179","author":"Wang","year":"2007","journal-title":"J.\u00a0Immunol."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib71","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.dci.2009.11.011","article-title":"Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated","volume":"34","author":"Wang","year":"2010","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib72","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.dci.2009.09.003","article-title":"Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family","volume":"34","author":"Wang","year":"2010","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib73","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.fsi.2010.06.016","article-title":"Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus mykiss and analysis of their expression during bacterial and parasitic infection","volume":"29","author":"Wang","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2017.11.001_bib74","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.molimm.2010.06.015","article-title":"Identification of two FoxP3 genes in rainbow trout (Oncorhynchus mykiss) with differential induction patterns","volume":"47","author":"Wang","year":"2010","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib75","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00251-010-0508-2","article-title":"Two copies of the genes encoding the subunits of putative interleukin (IL)-4\/IL-13 receptors, IL-4R\u03b1, IL-13R\u03b11 and IL-13R\u03b12, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation","volume":"63","author":"Wang","year":"2011","journal-title":"Immunogenetics"},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib76","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4049\/jimmunol.1001203","article-title":"Functional characterization of a non-mammalian IL-21: rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-gamma, IL-10, and IL-22","volume":"186","author":"Wang","year":"2011","journal-title":"J.\u00a0Immunol. Baltim. Md. 1950)"},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib77","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.molimm.2012.09.008","article-title":"Identification of IL-34 in teleost fish: differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor","volume":"53","author":"Wang","year":"2013","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.dci.2017.11.001_bib78","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/eji.201344273","article-title":"Differential expression, modulation and bioactivity of distinct fish IL-12 isoforms: implication towards the evolution of Th1-like immune responses","volume":"44","author":"Wang","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.dci.2017.11.001_bib79","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00251-015-0838-1","article-title":"Identification of the salmonid IL-17A\/F1a\/b, IL-17A\/F2b, IL-17A\/F3 and IL-17N genes and analysis of their expression following in\u00a0vitro stimulation and infection","volume":"67","author":"Wang","year":"2015","journal-title":"Immunogenetics"},{"issue":"10","key":"10.1016\/j.dci.2017.11.001_bib80","doi-asserted-by":"crossref","first-page":"10917","DOI":"10.18632\/oncotarget.7295","article-title":"First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.dci.2017.11.001_bib81","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.dci.2015.12.017","article-title":"Re-examination of the rainbow trout (Oncorhynchus mykiss) immune response to flagellin: Yersinia ruckeri flagellin is a potent activator of acute phase proteins, anti-microbial peptides and pro-inflammatory cytokines in\u00a0vitro","volume":"57","author":"Wangkahart","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2017.11.001_bib82","series-title":"Gplots: Various R Programming Tools for Plotting Data. R Package Version 3.0.1","author":"Warnes","year":"2016"},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib83","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11160-012-9288-0","article-title":"Characteristics and metabolism of different adipose tissues in fish","volume":"23","author":"Weil","year":"2013","journal-title":"Rev. Fish Biol. Fish."},{"issue":"6","key":"10.1016\/j.dci.2017.11.001_bib84","doi-asserted-by":"crossref","first-page":"e287","DOI":"10.1371\/journal.pmed.0030287","article-title":"Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications","volume":"3","author":"Yang","year":"2006","journal-title":"PLOS Med."},{"key":"10.1016\/j.dci.2017.11.001_bib85","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1139\/f95-197","article-title":"Adipocytes and lipid distribution in the muscle tissue of Atlantic salmon (Salmo salar)","volume":"53","author":"Zhou","year":"1996","journal-title":"Can. J. Fish. Aquat. Sci."},{"issue":"2","key":"10.1016\/j.dci.2017.11.001_bib86","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1139\/f95-197","article-title":"Adipocytes and lipid distribution in tissue of Atlantic salmon (Salmo salar)","volume":"53","author":"Zhou","year":"2011","journal-title":"Can. J. Fish. Aquatic Sci."},{"issue":"Pt 1","key":"10.1016\/j.dci.2017.11.001_bib87","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bj3400153","article-title":"Fish macrophages express a cyclo-oxygenase-2 homologue after activation","volume":"340","author":"Zou","year":"1999","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.dci.2017.11.001_bib88","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0145-305X(03)00077-6","article-title":"Functional characterisation of the recombinant tumor necrosis factors in rainbow trout, Oncorhynchus mykiss","volume":"27","author":"Zou","year":"2003","journal-title":"Dev. Comp. Immunol."},{"issue":"10","key":"10.1016\/j.dci.2017.11.001_bib89","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1111\/j.1432-1033.2004.04101.x","article-title":"Identification and expression analysis of an IL-18 homologue and its alternatively spliced form in rainbow trout (Oncorhynchus mykiss)","volume":"271","author":"Zou","year":"2004","journal-title":"Eur. J. Biochem."},{"issue":"4","key":"10.1016\/j.dci.2017.11.001_bib90","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.4049\/jimmunol.175.4.2484","article-title":"Identification and bioactivities of IFN-\u03b3 in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fish","volume":"175","author":"Zou","year":"2005","journal-title":"J.\u00a0Immunol."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X17304275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X17304275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T08:34:47Z","timestamp":1603269287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X17304275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":88,"alternative-id":["S0145305X17304275"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2017.11.001","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rainbow trout (Oncorhynchus mykiss) adipose tissue undergoes major changes in immune gene expression following bacterial infection or stimulation with pro-inflammatory molecules","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2017.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}