{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:05:46Z","timestamp":1789088746218,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100013986","name":"Government of the United Kingdom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013986","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.dci.2018.04.026","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T02:39:55Z","timestamp":1525747195000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Differential innate immune responses induced by classical and variant infectious bronchitis viruses in specific pathogen free chicks"],"prefix":"10.1016","volume":"87","author":[{"given":"Rajesh","family":"Chhabra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Chantrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Ganapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2018.04.026_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(01)78001-7","article-title":"Toll-like receptors and innate immunity","volume":"78","author":"Akira","year":"2001","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.dci.2018.04.026_bib2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2307\/1591367","article-title":"Early pathogenesis in chicks of infection with an enterotropic strain of infectious bronchitis virus","volume":"34","author":"Ambali","year":"1990","journal-title":"Avian Dis."},{"key":"10.1016\/j.dci.2018.04.026_bib3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/vim.2006.0109","article-title":"Interleukin-6 expression after infectious bronchitis virus infection in chickens","volume":"20","author":"Asif","year":"2007","journal-title":"Viral Immunol."},{"key":"10.1016\/j.dci.2018.04.026_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.rvsc.2016.01.001","article-title":"Experimental infection of IS\/885\/00-like infectious bronchitis virus in specific pathogen free and commercial broiler chicks","volume":"105","author":"Awad","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.dci.2018.04.026_bib5","doi-asserted-by":"crossref","first-page":"916","DOI":"10.2307\/1591383","article-title":"Pathogenesis of H13 nephropathogenic infectious bronchitis virus","volume":"34","author":"Butcher","year":"1990","journal-title":"Avian Dis."},{"key":"10.1016\/j.dci.2018.04.026_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/03079459608419141","article-title":"Histopathology and immunohistochemistry of renal lesions due to infectious bronchitis virus in chicks","volume":"25","author":"Chen","year":"1996","journal-title":"Avian Pathol."},{"key":"10.1016\/j.dci.2018.04.026_bib8","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1128\/CVI.00368-15","article-title":"Mucosal, cellular, and humoral immune responses induced by different live infectious bronchitis virus vaccination regimes and protection conferred against infectious bronchitis virus Q1 strain","volume":"22","author":"Chhabra","year":"2015","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.dci.2018.04.026_bib9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.virol.2015.11.011","article-title":"Pathogenicity and tissue tropism of infectious bronchitis virus is associated with elevated apoptosis and innate immune responses","volume":"488","author":"Chhabra","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.dci.2018.04.026_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/ps\/86.1.50","article-title":"Comparative histopathology of two serotypes of infectious bronchitis virus (T and n1\/88) in laying hens and cockerels","volume":"86","author":"Chousalkar","year":"2007","journal-title":"Poult. Sci."},{"key":"10.1016\/j.dci.2018.04.026_bib11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1186\/1471-2164-14-743","article-title":"Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infection","volume":"14","author":"Cong","year":"2013","journal-title":"BMC Genom."},{"key":"10.1016\/j.dci.2018.04.026_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/03079450094108","article-title":"Detection of infectious bronchitis virus","volume":"29","author":"De Wit","year":"2000","journal-title":"Avian Pathol."},{"key":"10.1016\/j.dci.2018.04.026_bib13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/03079457.2011.599060","article-title":"Induction of cystic oviducts and protection against early challenge with infectious bronchitis virus serotype D388 (genotype QX) by maternally derived antibodies and by early vaccination","volume":"40","author":"de Wit","year":"2011","journal-title":"Avian Pathol."},{"key":"10.1016\/j.dci.2018.04.026_bib14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.vetmic.2011.11.001","article-title":"New insights on infectious bronchitis virus pathogenesis: characterization of Italy 02 serotype in chicks and adult hens","volume":"156","author":"Dolz","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2018.04.026_bib16","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1136\/vr.101005","article-title":"QX-like infectious bronchitis virus isolated from cases of proventriculitis in commercial broilers in England","volume":"171","author":"Ganapathy","year":"2012","journal-title":"Vet. Rec."},{"key":"10.1016\/j.dci.2018.04.026_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2307\/1591619","article-title":"Attenuation of avian infectious bronchitis virus by cold-adaptation","volume":"35","author":"Gelb","year":"1991","journal-title":"Avian Dis."},{"key":"10.1016\/j.dci.2018.04.026_bib18","first-page":"403","article-title":"Pathogenicity of infectious bronchitis virus isolates from Ontario chickens","volume":"72","author":"Grgic","year":"2008","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.dci.2018.04.026_bib19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.vetimm.2007.09.016","article-title":"Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system","volume":"121","author":"Guo","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2018.04.026_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0034-5288(18)32975-8","article-title":"Induction of chicken interferon by avian infectious bronchitis virus","volume":"25","author":"Holmes","year":"1978","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.dci.2018.04.026_bib21","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1637\/10227-043012-Review.1","article-title":"Review of infectious bronchitis virus around the world","volume":"56","author":"Jackwood","year":"2012","journal-title":"Avian Dis."},{"key":"10.1016\/j.dci.2018.04.026_bib22","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.3382\/ps.2013-03116","article-title":"Altered pro-inflammatory cytokine mRNA levels in chickens infected with infectious bronchitis virus","volume":"92","author":"Jang","year":"2013","journal-title":"Poult. Sci."},{"key":"10.1016\/j.dci.2018.04.026_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.virol.2013.12.001","article-title":"Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens","volume":"450\u2013451","author":"Kameka","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.dci.2018.04.026_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.dci.2007.08.004","article-title":"Activation of the TLR3 pathway regulates IFNbeta production in chickens","volume":"32","author":"Karpala","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2018.04.026_bib25","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1128\/JVI.02671-14","article-title":"Activation of the chicken type I interferon response by infectious bronchitis coronavirus","volume":"89","author":"Kint","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.dci.2018.04.026_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1292\/jvms.62.397","article-title":"Kinetics of lymphocytic subsets in chicken tracheal lesions infected with infectious bronchitis virus","volume":"62","author":"Kotani","year":"2000","journal-title":"J.\u00a0Vet. Med. Sci."},{"key":"10.1016\/j.dci.2018.04.026_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1743-422X-9-230","article-title":"18S rRNA is a reliable normalisation gene for real time PCR basedon influenza virus infected cells","volume":"9","author":"Kuchipudi","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.dci.2018.04.026_bib44","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13567-014-0118-3","article-title":"Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses","volume":"45","author":"Kuchipudi","year":"2014","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2018.04.026_bib27","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.ppat.0020053","article-title":"Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia","volume":"2","author":"Le Goffic","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.dci.2018.04.026_bib28","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.4049\/jimmunol.178.6.3368","article-title":"Cutting Edge: influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells","volume":"178","author":"Le Goffic","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.dci.2018.04.026_bib30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/03079450701338730","article-title":"S1 gene sequence heterogeneity of a pathogenic infectious bronchitis virus strain and its embryo-passaged, attenuated derivatives","volume":"36","author":"Liu","year":"2007","journal-title":"Avian Pathol."},{"key":"10.1016\/j.dci.2018.04.026_bib31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/CMR.00005-07","article-title":"Current status of veterinary vaccines","volume":"20","author":"Meeusen","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.dci.2018.04.026_bib32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/vim.2014.0054","article-title":"Inflammatory and cell-mediated immune responses in the respiratory tract of chickens to infection with avian infectious bronchitis virus","volume":"27","author":"Okino","year":"2014","journal-title":"Viral Immunol."},{"key":"10.1016\/j.dci.2018.04.026_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172275","article-title":"Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles","volume":"12","author":"Okino","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2018.04.026_bib34","first-page":"55","article-title":"Interferon induction by several strains of avian infectious bronchitis virus, a coronavirus, in chickens","volume":"32","author":"Otsuki","year":"1988","journal-title":"Acta Virol."},{"key":"10.1016\/j.dci.2018.04.026_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-1135(87)90126-X","article-title":"Comparison of two strains of avian infectious bronchitis virus for their interferon induction, viral growth and development of virus-neutralizing antibody in experimentally-infected chickens","volume":"15","author":"Otsuki","year":"1987","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2018.04.026_bib36","first-page":"230","article-title":"A\u00a0Toll-like receptor 3 agonist (polyI: C) elicits innate host responses in the spleen and lungs of chickens","volume":"76","author":"Parvizi","year":"2012","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.dci.2018.04.026_bib38","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/03079459608419165","article-title":"Sequence of the spike protein of the Belgian B164S isolate of nephropathogenic infectious bronchitis virus","volume":"25","author":"Shaw","year":"1996","journal-title":"Avian Pathol."},{"key":"10.1016\/j.dci.2018.04.026_bib39","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.dci.2018.04.026_bib40","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1089\/vim.2006.19.768","article-title":"Transcriptome of local innate and adaptive immunity during early phase of infectious bronchitis viral infection","volume":"19","author":"Wang","year":"2006","journal-title":"Viral Immunol."},{"key":"10.1016\/j.dci.2018.04.026_bib41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/03079450801986529","article-title":"A\u00a0reverse transcriptase-polymerase chain reaction survey of infectious bronchitis virus genotypes in Western Europe from 2002 to 2006","volume":"37","author":"Worthington","year":"2008","journal-title":"Avian Pathol."},{"key":"10.1016\/j.dci.2018.04.026_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/vr.146.7.191","article-title":"Avian infectious bronchitis virus: isolation of an apparently new variant in Italy","volume":"146","author":"Zanella","year":"2000","journal-title":"Vet. Rec."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X17306948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X17306948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:35:55Z","timestamp":1758936955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X17306948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":40,"alternative-id":["S0145305X17306948"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2018.04.026","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential innate immune responses induced by classical and variant infectious bronchitis viruses in specific pathogen free chicks","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2018.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}