{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:14:02Z","timestamp":1792095242704,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672614"],"award-info":[{"award-number":["31672614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802253"],"award-info":[{"award-number":["31802253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M632398"],"award-info":[{"award-number":["2018M632398"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["17KJB230007"],"award-info":[{"award-number":["17KJB230007"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160062"],"award-info":[{"award-number":["BK20160062"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007062","name":"Outstanding Young Backbone Teacher Foundation of Yangzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201908320077"],"award-info":[{"award-number":["201908320077"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Topnotch Academic Programs Project of Jiangsu Higher Education Institutions"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.dci.2019.103568","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T01:53:57Z","timestamp":1575683637000},"page":"103568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Progesterone inhibits inflammatory response in E.coli- or LPS-Stimulated bovine endometrial epithelial cells by NF-\u03baB and MAPK pathways"],"prefix":"10.1016","volume":"105","author":[{"given":"Luying","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2019.103568_bib1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.4103\/0253-7613.144922","article-title":"The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis","volume":"46","author":"Aksoy","year":"2014","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.dci.2019.103568_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.anireprosci.2008.01.010","article-title":"Postpartum uterine infection in cattle","volume":"105","author":"Azawi","year":"2008","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.dci.2019.103568_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1600-0897.2012.01106.x","article-title":"Explants of intact endometrium to model bovine innate immunity and inflammation ex vivo","volume":"67","author":"Borges","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.dci.2019.103568_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1095\/biolreprod.111.092718","article-title":"Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium","volume":"86","author":"Cronin","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.dci.2019.103568_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0012-1606(92)90234-8","article-title":"Interleukin-1, interleukin-6, and tumor necrosis factor \u03b1 are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone","volume":"151","author":"De","year":"1992","journal-title":"Dev. Biol."},{"key":"10.1016\/j.dci.2019.103568_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12917-018-1360-0","article-title":"Cortisol modulates inflammatory responses in LPS-stimulated RAW264.7 cells via the NF-\u03baB and MAPK pathways","volume":"14","author":"Dong","year":"2018","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.dci.2019.103568_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.intimp.2018.01.021","article-title":"Cortisol inhibits NF-\u03baB and MAPK pathways in LPS activated bovine endometrial epithelial cells","volume":"56","author":"Dong","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.dci.2019.103568_bib8","series-title":"Dukes' Physiology of Domestic Animals","author":"Erickson","year":"2015"},{"key":"10.1016\/j.dci.2019.103568_bib9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0093-691X(91)90414-9","article-title":"Progesterone profiles in postpartum Holstein dairy cows as an aid in the study of retained fetal membranes, pyometra and anestrus","volume":"35","author":"Etherington","year":"1991","journal-title":"Theriogenology"},{"key":"10.1016\/j.dci.2019.103568_bib10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.molimm.2017.02.006","article-title":"Inhalation of progesterone inhibits chronic airway inflammation of mice exposed to ozone","volume":"85","author":"Fei","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2019.103568_bib11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1071\/RD09120","article-title":"Selected pro-inflammatory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis","volume":"22","author":"Fischer","year":"2010","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.dci.2019.103568_bib12","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.theriogenology.2012.06.022","article-title":"Proinflammatory cytokine gene expression in endometrial cytobrush samples harvested from cows with and without subclinical endometritis","volume":"78","author":"Ghasemi","year":"2012","journal-title":"Theriogenology"},{"key":"10.1016\/j.dci.2019.103568_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vph.2013.06.001","article-title":"Selective suppression of endothelial cytokine production by progesterone receptor","volume":"59","author":"Goddard","year":"2013","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.dci.2019.103568_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0165-0378(98)00035-7","article-title":"Regulation of uterine immune function by progesterone\u2014lessons from the sheep","volume":"40","author":"Hansen","year":"1998","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.dci.2019.103568_bib15","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1210\/endo-90-5-1336","article-title":"Plasma estrogen and progesterone levels after mating, and during late pregnancy and postpartum in cows","volume":"90","author":"Henricks","year":"1972","journal-title":"Endocrinology"},{"key":"10.1016\/j.dci.2019.103568_bib16","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1210\/en.2005-1113","article-title":"Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus","volume":"147","author":"Herath","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.dci.2019.103568_bib17","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1210\/en.2008-1379","article-title":"Bacterial lipopolysaccharide induces an endocrine switch from prostaglandin F2\u03b1 to prostaglandin E2 in bovine endometrium","volume":"150","author":"Herath","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.dci.2019.103568_bib18","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.fertnstert.2004.11.042","article-title":"Progesterone and progestational compounds attenuate tumor necrosis factor alpha-induced interleukin-8 production via nuclear factor kappa B inactivation in endometriotic stromal cells","volume":"83","author":"Horie","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.dci.2019.103568_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3168\/jds.S0022-0302(80)82901-8","article-title":"Accuracy of predicting stages of bovine estrous cycle by gross appearance of the corpus luteum","volume":"63","author":"Ireland","year":"1980","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.dci.2019.103568_bib20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-kappa B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.dci.2019.103568_bib21","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/oxfordjournals.humrep.a019379","article-title":"The production of tumour necrosis factor alpha (TNF-alpha) by human endometrial cells in culture","volume":"11","author":"Laird","year":"1996","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.dci.2019.103568_bib22","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/jcb.25383","article-title":"Anti-inflammatory effect of ascochlorin in LPS-stimulated RAW 264.7 macrophage cells is accompanied with the down-regulation of iNOS, COX-2 and proinflammatory cytokines through NF-\u03baB, ERK1\/2 and p38 signaling pathway","volume":"117","author":"Lee","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.dci.2019.103568_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103969","article-title":"Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia","volume":"9","author":"Lei","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2019.103568_bib24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.anireprosci.2004.04.026","article-title":"Steroidal regulation of uterine immune defenses","volume":"82\u201383","author":"Lewis","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.dci.2019.103568_bib25","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.4049\/jimmunol.160.10.5098","article-title":"Regulation of TNF-\u03b1 production in activated mouse macrophages by progesterone","volume":"160","author":"Miller","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2019.103568_bib26","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.fertnstert.2011.09.040","article-title":"Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells","volume":"96","author":"Mita","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.dci.2019.103568_bib27","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.3390\/ijms15058443","article-title":"Inhibitory effects of palmultang on inflammatory mediator production related to suppression of NF-\u03baB and MAPK pathways and induction of HO-1 expression in macrophages","volume":"15","author":"Oh","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2019.103568_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2014.03.008","article-title":"The effect of progesterone on genes involved in preterm labor","volume":"104\u2013105","author":"Okabe","year":"2014","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.dci.2019.103568_bib29","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0093-691X(00)00234-X","article-title":"Risk factors for post partum ovarian dysfunction in high producing dairy cows in Belgium: a field study","volume":"53","author":"Opsomer","year":"2000","journal-title":"Theriogenology"},{"key":"10.1016\/j.dci.2019.103568_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-kappa B and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dci.2019.103568_bib31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.coi.2007.09.002","article-title":"The inflammasome: a danger sensing complex triggering innate immunity","volume":"19","author":"P\u00e9trilli","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.dci.2019.103568_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2460\/ajvr.1983.44.02.247","article-title":"Association of increased estradiol and progesterone blood values with altered bovine polymorphonuclear leukocyte function","volume":"44","author":"Roth","year":"1983","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.dci.2019.103568_bib33","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/171749a0","article-title":"Influence of ovarian hormones on uterine infection","volume":"171","author":"Rowson","year":"1953","journal-title":"Nature"},{"key":"10.1016\/j.dci.2019.103568_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1530\/REP-14-0230","article-title":"Ovarian steroids do not affect bovine endometrial cytokine or chemokine responses to Escherichia coli or LPS in vitro","volume":"148","author":"Saut","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.dci.2019.103568_bib35","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1530\/REP-14-0163","article-title":"Innate immunity and inflammation of the bovine female reproductive tract in health and disease","volume":"148","author":"Sheldon","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.dci.2019.103568_bib36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.anireprosci.2004.04.006","article-title":"Postpartum uterine health in cattle","volume":"82\u201383","author":"Sheldon","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.dci.2019.103568_bib37","doi-asserted-by":"crossref","first-page":"622","DOI":"10.21451\/1984-3143-AR1006","article-title":"Postpartum uterine infection and endometritis in dairy cattle","volume":"14","author":"Sheldon","year":"2017","journal-title":"Anim. Reprod."},{"key":"10.1016\/j.dci.2019.103568_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0531.2009.01465.x","article-title":"Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle","volume":"44","author":"Sheldon","year":"2009","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.dci.2019.103568_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009192","article-title":"Specific strains of Escherichia coli are pathogenic for the endometrium of cattle and cause pelvic inflammatory disease in cattle and mice","volume":"5","author":"Sheldon","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2019.103568_bib40","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2527\/jas1979.483570x","article-title":"Relationships among luteinizing hormone, estradiol, progesterone, glucocorticoids, milk yield, body weight and postpartum ovarian activity in Holstein cows","volume":"48","author":"Stevenson","year":"1979","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.dci.2019.103568_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.imlet.2009.07.003","article-title":"Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-\u03baB activation and enhancing SOCS1 expression","volume":"125","author":"Su","year":"2009","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.dci.2019.103568_bib42","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0093-691X(97)00038-1","article-title":"Neutrophil migration into the uterine lumen of the cow: the influence of endogenous and exogenous sex steroid hormones using two intrauterine chemoattractants","volume":"47","author":"Subandrio","year":"1997","journal-title":"Theriogenology"},{"key":"10.1016\/j.dci.2019.103568_bib43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1530\/jrf.0.0590133","article-title":"Plasma progesterone and gonadotrophin concentrations and ovarian activity in post-partum dairy cows","volume":"59","author":"Webb","year":"1980","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.dci.2019.103568_bib44","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0039-128X(03)00040-0","article-title":"Sex steroid hormones do not influence the oxidative burst activity of polymorphonuclear leukocytes from ovariectomized cows in vitro","volume":"68","author":"Winters","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.dci.2019.103568_bib45","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.2527\/2003.8151242x","article-title":"Progesterone increases susceptibility of gilts to uterine infections after intrauterine inoculation with infectious bacteria","volume":"81","author":"Wulster-Radcliffe","year":"2003","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.dci.2019.103568_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.theriogenology.2017.04.007","article-title":"Expression and regulation of interleukin 6 and its receptor at the maternal-conceptus interface during pregnancy in pigs","volume":"96","author":"Yoo","year":"2017","journal-title":"Theriogenology"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X19302332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X19302332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:38:13Z","timestamp":1758937093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X19302332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":46,"alternative-id":["S0145305X19302332"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2019.103568","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progesterone inhibits inflammatory response in E.coli- or LPS-Stimulated bovine endometrial epithelial cells by NF-\u03baB and MAPK pathways","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2019.103568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103568"}}