{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:35:12Z","timestamp":1788410112962,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.dci.2020.103629","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T09:39:41Z","timestamp":1579858781000},"page":"103629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Molecular and functional characterization of IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) in Nile tilapia (Oreochromis niloticus)"],"prefix":"10.1016","volume":"106","author":[{"given":"Enxu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2020.103629_bib1","doi-asserted-by":"crossref","first-page":"30004","DOI":"10.1038\/srep30004","article-title":"Distinct differentiation programs triggered by IL-6 and LPS in teleost IgM+ B Cells in the absence of germinal centers","volume":"6","author":"Ab\u00f3s","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dci.2020.103629_bib2","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1038\/sj.onc.1204461","article-title":"The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway","volume":"20","author":"Abe","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.dci.2020.103629_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60532-5","article-title":"Interleukin-6 in biology and medicine","volume":"54","author":"Akira","year":"1993","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib4","doi-asserted-by":"crossref","first-page":"16968","DOI":"10.1074\/jbc.C300081200","article-title":"A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor","volume":"278","author":"Ancey","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2020.103629_bib5","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/jclinpath-2014-202493","article-title":"Gene of the month: interleukin 6 (IL-6)","volume":"67","author":"Ataie-Kachoie","year":"2014","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.dci.2020.103629_bib6","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1073\/pnas.87.18.6934","article-title":"Structural design and molecular evolution of a cytokine receptor superfamily","volume":"87","author":"Bazan","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2020.103629_bib7","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/emboj\/17.6.1665","article-title":"Crystal structure of a cytokine-binding region of gp130","volume":"17","author":"Bravo","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.dci.2020.103629_bib8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"Calandra","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib9","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1182\/blood.V85.12.3577.bloodjournal85123577","article-title":"The functional characterization of interleukin-10 receptor expression on human natural killer cells","volume":"85","author":"Carson","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.dci.2020.103629_bib10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.dci.2012.06.013","article-title":"The bioactivity of teleost IL-6: IL-6 protein in orange-spotted grouper (Epinephelus coioides) induces Th2 cell differentiation pathway and antibody production","volume":"38","author":"Chen","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aquaculture.2018.09.060","article-title":"Complement 1q-binding protein from Nile tilapia (Oreochromis niloticus): molecular characterization, expression pattern upon bacterial infection and its binding properties","volume":"500","author":"Chen","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2020.103629_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.fsi.2011.10.016","article-title":"Long-term stimulation of trout head kidney cells with the cytokines MCSF, IL-2 and IL-6: gene expression dynamics","volume":"32","author":"Corripio-Miyar","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib13","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.molimm.2011.05.027","article-title":"Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression","volume":"48","author":"Costa","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00251-011-0581-1","article-title":"Molecular characterization and expression analysis of the putative interleukin 6 receptor (IL-6R\u03b1 and glycoprotein-130) in rainbow trout (Oncorhynchus mykiss): Salmonid IL-6R\u03b1 possesses a polymorphic N-terminal Ig domain with variable numbers of two repe","volume":"64","author":"Costa","year":"2012","journal-title":"Immunogenetics"},{"key":"10.1016\/j.dci.2020.103629_bib15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.fsi.2016.12.014","article-title":"Identification and characterization of C1 inhibitor in Nile tilapia (Oreochromis niloticus) in response to pathogenic bacteria","volume":"61","author":"Ding","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib16","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1158\/0008-5472.CAN-12-0721","article-title":"IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs","volume":"72","author":"Emmerich","year":"2012","journal-title":"Canc. Res."},{"key":"10.1016\/j.dci.2020.103629_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","article-title":"Plasticity and cross-talk of Interleukin 6-type cytokines","volume":"23","author":"Garbers","year":"2012","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.dci.2020.103629_bib18","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.172.6.1625","article-title":"Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells","volume":"172","author":"Go","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2020.103629_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ni.3632","article-title":"Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells","volume":"18","author":"Heink","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib20","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0092-8674(90)90411-7","article-title":"Molecular cloning and expression of an IL-6 signal transducer, gp130","volume":"63","author":"Hibi","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.dci.2020.103629_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0014-5793(95)00053-C","article-title":"The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor","volume":"360","author":"Horsten","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.dci.2020.103629_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2017.10.008","article-title":"Conservation of structural and interactional features of CD28 and CD80\/86 molecules from Nile tilapia (Oreochromis niloticus)","volume":"72","author":"Huang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ni.3153","article-title":"IL-6 as a keystone cytokine in health and disease","volume":"16","author":"Hunter","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1046\/j.1432-1327.2001.01867.x","article-title":"Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses","volume":"268","author":"Jostock","year":"2010","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.dci.2020.103629_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.dci.2012.02.002","article-title":"Teleost IL-6 promotes antibody production through STAT3 signaling via IL-6R and gp130","volume":"38","author":"Kaneda","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.1411569","article-title":"Interleukin 6 receptor: a paradigm for cytokines","volume":"258","author":"Kishimoto","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.dci.2020.103629_bib27","doi-asserted-by":"crossref","first-page":"14847","DOI":"10.1074\/jbc.270.25.14847","article-title":"Separate signaling mechanisms are involved in the control of STAT protein activation and gene regulation via the interleukin 6 response element by the box 3 motif of gp130","volume":"270","author":"Lai","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2020.103629_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aar7388","article-title":"Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses","volume":"11","author":"Lamertz","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.dci.2020.103629_bib29","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/01.CCM.0000191278.04636.D8","article-title":"Macrophage migration inhibitory factor","volume":"33","author":"Leng","year":"2005","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.dci.2020.103629_bib30","doi-asserted-by":"crossref","first-page":"103515","DOI":"10.1016\/j.dci.2019.103515","article-title":"CD38 play roles in T cell-dependent response and B cell differentiation in nile tilapia (Oreochromis niloticus)","volume":"103","author":"Li","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aquaculture.2018.09.062","article-title":"Expression and functional analysis of polymeric immunoglobulin receptor in Nile tilapia (Oreochromis niloticus)","volume":"500","author":"Liu","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2020.103629_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2002","journal-title":"Methods"},{"key":"10.1016\/j.dci.2020.103629_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/1043-4666(92)90043-Q","article-title":"Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor","volume":"4","author":"Lust","year":"1992","journal-title":"Cytokine"},{"key":"10.1016\/j.dci.2020.103629_bib34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0014-5793(93)80507-Q","article-title":"Differential shedding of the two subunits of the interleukin-6 receptor","volume":"332","author":"M\u00fcllberg","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.dci.2020.103629_bib35","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/eji.1830230226","article-title":"The soluble interleukin-6 receptor is generated by shedding","volume":"23","author":"M\u00fcllberg","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000237353","article-title":"Soluble receptors for cytokines and growth factors","volume":"111","author":"M\u00fcller-Newen","year":"1996","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib37","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.4049\/jimmunol.149.6.2021","article-title":"Complex of soluble human IL-6-receptor\/IL-6 up-regulates expression of acute-phase proteins","volume":"149","author":"Mackiewicz","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib38","doi-asserted-by":"crossref","first-page":"11349","DOI":"10.1073\/pnas.88.24.11349","article-title":"Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family","volume":"88","author":"Murakami","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2020.103629_bib39","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1182\/blood.V82.4.1120.1120","article-title":"Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130","volume":"82","author":"Narazaki","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.dci.2020.103629_bib40","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.170.4.1409","article-title":"Soluble cytokine receptors are present in normal human urine","volume":"170","author":"Novick","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2020.103629_bib41","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/intimm\/dxh396","article-title":"Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells","volume":"18","author":"Oberg","year":"2006","journal-title":"Int. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib42","doi-asserted-by":"crossref","first-page":"31764","DOI":"10.1074\/jbc.272.50.31764","article-title":"Role of metalloproteases in the release of the IL-1 type II decoy receptor","volume":"272","author":"Orlando","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2020.103629_bib43","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.282.5392.1281","article-title":"An essential role for ectodomain shedding in mammalian development","volume":"282","author":"Peschon","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.dci.2020.103629_bib44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3000281","article-title":"Soluble receptors for cytokines and growth factors: generation and biological function","volume":"300","author":"Rose-john","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.dci.2020.103629_bib45","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1517\/14728222.11.5.613","article-title":"The IL-6\/sIL-6R complex as a novel target for therapeutic approaches","volume":"11","author":"Rose-john","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.dci.2020.103629_bib46","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"21","author":"Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.dci.2020.103629_bib47","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1016\/j.molimm.2007.02.018","article-title":"A novel type-1 cytokine receptor from fish involved in the janus kinase\/signal transducers and activators of transcription (Jak\/STAT) signal pathway","volume":"44","author":"Santos","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib48","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.dci.2020.103629_bib49","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00430-006-0019-9","article-title":"Interleukin-6 and its receptor: from bench to bedside","volume":"195","author":"Scheller","year":"2006","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib50","first-page":"14","article-title":"Fish red blood cells express immune genes and responses","volume":"3","author":"Shen","year":"2018","journal-title":"Aquacult. Fish."},{"key":"10.1016\/j.dci.2020.103629_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0952-7915(95)80024-7","article-title":"Signaling mechanisms through cytokine receptors that share signal transducing receptor components","volume":"7","author":"Taga","year":"1995","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.dci.2011.11.004","article-title":"Characterisation, expression and ontogeny of interleukin-6 and its receptors in zebrafish (Danio rerio)","volume":"37","author":"Varela","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib53","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1046\/j.1432-1327.1999.00511.x","article-title":"A role for the immunoglobulin-like domain of the human IL-6 receptor: intracellular protein transport and shedding","volume":"263","author":"Vollmer","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.dci.2020.103629_bib54","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.fsi.2018.12.031","article-title":"Molecular characterization of grass carp interleukin-6 receptor and the agonistic activity of its soluble form in head kidney leucocytes","volume":"86","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.dci.2018.08.012","article-title":"Interleukin-6 gets involved in response to bacterial infection and promotes antibody production in Nile tilapia (Oreochromis niloticus)","volume":"89","author":"Wei","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib56","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.fsi.2019.04.059","article-title":"Molecular characterization and transcriptional expression of a B cell transcription factor Pax5 in Nile tilapia (Oreochromis niloticus)","volume":"90","author":"Wu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib57","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.3389\/fimmu.2019.02225","article-title":"Effects of cell differentiation on the phagocytic activities of IgM + B cells in a teleost fish","volume":"10","author":"Wu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib58","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.dci.2019.05.002","article-title":"Blimp-1 is involved in B cell activation and maturation in Nile tilapia (Oreochromis niloticus)","volume":"98","author":"Wu","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib59","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molimm.2012.02.003","article-title":"Identification, expression and bioactivity of a chitotriosidase-like homolog in amphioxus: dependence of enzymatic and antifungal activities on the chitin-binding domain","volume":"51","author":"Xu","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib60","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.3136546","article-title":"Cloning and expression of the human interleukin-6 (BSF-2\/IFN beta 2) receptor","volume":"241","author":"Yamasaki","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.dci.2020.103629_bib61","doi-asserted-by":"crossref","first-page":"103532","DOI":"10.1016\/j.dci.2019.103532","article-title":"Complement C1q subunit molecules from Xenopus laevis possess conserved function in C1q-immunoglobulin interaction","volume":"103","author":"Yan","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib62","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/j.1460-2075.1993.tb05815.x","article-title":"Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130","volume":"12","author":"Yawata","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.dci.2020.103629_bib63","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.fsi.2013.01.012","article-title":"Regulation of nodularin-induced apoptosis by epigallocatechin-3-gallate on fish lymphocytes in vitro","volume":"34","author":"Zhang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib64","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.fsi.2017.09.015","article-title":"C1r and C1s from Nile tilapia (Oreochromis niloticus): molecular characterization, transcriptional profiling upon bacterial and IFN-\u03b3 inductions and potential role in response to bacterial infection","volume":"70","author":"Zhong","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib65","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.fsi.2019.07.049","article-title":"The interleukin-6 regulates the function of monocytes\/macrophages (MO\/M\u0424) via the interleukin-6 receptor \u03b2 in ayu (Plecoglossus altivelis)","volume":"93","author":"Zhu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103629_bib66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.fsi.2016.01.041","article-title":"Molecular and immune response characterizations of IL-6 in large yellow croaker (Larimichthys crocea)","volume":"50","author":"Zhu","year":"2016","journal-title":"Fish Shellfish Immunol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X19305592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X19305592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:39:39Z","timestamp":1758937179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X19305592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":66,"alternative-id":["S0145305X19305592"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2020.103629","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular and functional characterization of IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) in Nile tilapia (Oreochromis niloticus)","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2020.103629","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103629"}}