{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:23:41Z","timestamp":1778628221848,"version":"3.51.4"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"am","delay-in-days":283,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"USDA-ARS","doi-asserted-by":"publisher","award":["5090-31320-004-00D"],"award-info":[{"award-number":["5090-31320-004-00D"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"USDA-ARS","doi-asserted-by":"publisher","award":["5090-31320-005-00D"],"award-info":[{"award-number":["5090-31320-005-00D"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"USDA-ARS","doi-asserted-by":"publisher","award":["8082-32000-007-00D"],"award-info":[{"award-number":["8082-32000-007-00D"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"USDA-ARS","doi-asserted-by":"publisher","award":["8082-31000-012"],"award-info":[{"award-number":["8082-31000-012"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.dci.2020.103961","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T02:01:42Z","timestamp":1607306502000},"page":"103961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Structure and regulation of the NK-lysin (1\u20134) and NK-lysin like (a and b) antimicrobial genes in rainbow trout (Oncorhynchus mykiss)"],"prefix":"10.1016","volume":"116","author":[{"given":"Hao","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Chiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-8878","authenticated-orcid":false,"given":"Yniv","family":"Palti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangtu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-6541","authenticated-orcid":false,"given":"Sixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra E.","family":"Palmquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Wiens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-6920","authenticated-orcid":false,"given":"Brian S.","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.dci.2020.103961_bib2","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/j.1460-2075.1995.tb07150.x","article-title":"NK\u2010lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity","volume":"14","author":"Andersson","year":"1995","journal-title":"EMBO J."},{"issue":"1\u20134","key":"10.1016\/j.dci.2020.103961_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-2427(96)05677-2","article-title":"NK-lysin, structure and function of a novel effector molecule of porcine T and NK cells","volume":"54","author":"Andersson","year":"1996","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2020.103961_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/1874401X01104010040","article-title":"A review of Flavobacterium psychrophilum biology, clinical signs, and bacterial cold water disease prevention and treatment","volume":"4","author":"Barnes","year":"2011","journal-title":"Open Fish Sci. J."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.iy.13.040195.000425","article-title":"Peptide antibiotics and their role in innate immunity","volume":"13","author":"Boman","year":"1995","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1128\/iai.10.1.136-145.1974","article-title":"Insect immunity I. Characteristics of an inducible cell-free antibacterial reaction in hemolymph of Samia cynthia pupae","volume":"10","author":"Boman","year":"1974","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/BJ20050051","article-title":"A short guided tour through functional and structural features of saposin-like proteins","volume":"389","author":"Bruhn","year":"2005","journal-title":"Biochem. J."},{"issue":"8","key":"10.1016\/j.dci.2020.103961_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/biology9080233","article-title":"Antimicrobial peptides of salmonid fish: from form to function","volume":"9","author":"Brunner","year":"2020","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1472-6750-5-31","article-title":"Standardisation of data from real-time quantitative PCR methods\u2013evaluation of outliers and comparison of calibration curves","volume":"5","author":"Burns","year":"2005","journal-title":"BMC Biotechnol."},{"issue":"9","key":"10.1016\/j.dci.2020.103961_bib10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/app6090240","article-title":"Expression, purification and antibacterial activity of NK-lysin mature peptides from the channel catfish (Ictalurus punctatus)","volume":"6","author":"Cai","year":"2016","journal-title":"Appl. Sci."},{"key":"10.1016\/j.dci.2020.103961_bib11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/gbe\/evp038","article-title":"A universal nonmonotonic relationship between gene compactness and expression levels in multicellular eukaryotes","volume":"1","author":"Carmel","year":"2009","journal-title":"Genome Biol. Evol."},{"issue":"4","key":"10.1016\/j.dci.2020.103961_bib12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng940","article-title":"Selection for short introns in highly expressed genes","volume":"31","author":"Castillo-Davis","year":"2002","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/raq.12306","article-title":"Antimicrobial peptides of fish: innocuous alternatives to antibiotics","volume":"12","author":"Chaturvedi","year":"2020","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.dci.2020.103961_bib14","first-page":"53","article-title":"New insights on early evolution of spiny-rayed fishes (Teleostei: acanthomorpha)","volume":"1","author":"Chen","year":"2014","journal-title":"Fron. Mar. Sci."},{"issue":"52","key":"10.1016\/j.dci.2020.103961_bib15","doi-asserted-by":"crossref","first-page":"E7223","DOI":"10.1073\/pnas.1519374113","article-title":"Bovine NK-lysin: copy number variation and functional diversification","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.fsi.2009.02.023","article-title":"Development of an ELISA for quantification of the antimicrobial peptide piscidin 4 and its application to assess stress in fish","volume":"27","author":"Corrales","year":"2009","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212678","article-title":"Variation of gene expression in plants is influenced by gene architecture and structural properties of promoters","volume":"14","author":"Das","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.dci.2020.103961_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2761.2001.00322.x","article-title":"In vivo study of phagocytosis, intracellular survival and multiplication of Flavobacterium psychrophilum in rainbow trout, Oncorhynchus mykiss (Walbaum), spleen phagocytes","volume":"24","author":"Decostere","year":"2001","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.dci.2020.103961_bib19","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.fsi.2019.06.021","article-title":"Molecular characterization of the NK-lysin in a teleost fish, Boleophthalmus pectinirostris: antimicrobial activity and immunomodulatory activity on monocytes\/macrophages","volume":"92","author":"Ding","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.dci.2020.103961_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fgene.2018.00147","article-title":"A new single nucleotide polymorphism database for rainbow trout generated through whole genome resequencing","volume":"9","author":"Gao","year":"2018","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib22","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3390\/molecules23020422","article-title":"A comparative study of human saposins","volume":"23","author":"Garrido-Arandia","year":"2018","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0145-305X(84)90036-3","article-title":"Nonspecific cytotoxic cells in fish (Ictalurus punctatus) I. Optimum requirements for target cell lysis","volume":"8","author":"Graves","year":"1984","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/protein\/4.2.155","article-title":"Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence","volume":"4","author":"Guruprasad","year":"1990","journal-title":"Protein Eng. Des. Sel."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-2427(00)00235-X","article-title":"Modulation of the fish immune system by hormones","volume":"77","author":"Harris","year":"2000","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"29","key":"10.1016\/j.dci.2020.103961_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciimmunol.aau5265","article-title":"Cvejic, Single-cell transcriptional analysis reveals ILC-like cells in zebrafish","volume":"3","author":"Hern\u00e1ndez","year":"2018","journal-title":"Sci. Immunol."},{"issue":"12","key":"10.1016\/j.dci.2020.103961_bib27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nchembio.1393","article-title":"Immune modulation by multifaceted cationic host defense (antimicrobial) peptides","volume":"9","author":"Hilchie","year":"2013","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.dci.2020.103961_bib28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.fsi.2006.08.003","article-title":"Characterization of Japanese flounder (Paralichthys olivaceus) NK-lysin, an antimicrobial peptide","volume":"22","author":"Hirono","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103961_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.fsi.2017.11.002","article-title":"NK-lysin from Oreochromis niloticus improves antimicrobial defence against bacterial pathogens","volume":"72","author":"Huang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/bioinformatics\/8.3.275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"Jones","year":"1992","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.dci.2020.103961_bib31","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/biology4040607","article-title":"Antimicrobial peptides as mediators of innate Immunity in teleosts","volume":"4","author":"Katzenback","year":"2015","journal-title":"Biology"},{"issue":"7","key":"10.1016\/j.dci.2020.103961_bib32","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7. 0 for bigger datasets brief communication","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.dci.2020.103961_bib33","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.fsi.2016.09.053","article-title":"Proinflammatory cytokine and cytokine receptor gene expression kinetics following challenge with Flavobacterium psychrophilum in resistant and susceptible lines of rainbow trout (Oncorhynchus mykiss)","volume":"58","author":"Kutyrev","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103961_bib34","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.fsi.2018.08.004","article-title":"Turbot (Scophthalmus maximus) Nk-lysin induces protection against the pathogenic parasite Philasterides dicentrarchi via membrane disruption","volume":"82","author":"Lama","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.dci.2020.103961_bib35","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.2527\/jas.2009-2538","article-title":"Response to selection for bacterial cold water disease resistance in rainbow trout","volume":"88","author":"Leeds","year":"2010","journal-title":"J. Anim. Sci."},{"issue":"10","key":"10.1016\/j.dci.2020.103961_bib36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nsb1097-793","article-title":"Saposin fold revealed by the NMR structure of NK-lysin","volume":"4","author":"Liepinsh","year":"1997","journal-title":"Nat. Struct. Biol."},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib37","article-title":"RNA-seq analysis of early hepatic response to handling and confinement stress in rainbow trout","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/08997659.2014.920735","article-title":"Histopathologic changes in disease-resistant-line and disease-susceptible-line juvenile rainbow trout experimentally infected with Flavobacterium psychrophilum","volume":"26","author":"Marancik","year":"2014","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.dci.2020.103961_bib39","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3389\/fgene.2014.00453","article-title":"Whole-body transcriptome of selectively bred, resistant-, control-, and susceptible-line rainbow trout following experimental challenge with Flavobacterium psychrophilum","volume":"5","author":"Marancik","year":"2015","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/ph7030265","article-title":"Antimicrobial peptides from fish","volume":"7","author":"Masso-Silva","year":"2014","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1152\/physiolgenomics.00085.2013","article-title":"Bovine \u03b2-defensin gene family: opportunities to improve animal health?","volume":"46","author":"Meade","year":"2014","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.dci.2020.103961_bib42","series-title":"Design and Analysis of Experiments","first-page":"757","author":"Montgomery","year":"2013"},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.fsi.2014.08.001","article-title":"Neuroendocrine mechanisms for immune system regulation during stress in fish","volume":"40","author":"Nardocci","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib44","first-page":"44","article-title":"Application of antimicrobial polypeptide host defenses to aquaculture: exploitation of downregulation and upregulation responses","volume":"6","author":"Noga","year":"2011","journal-title":"Comp. Biochem. Physiol. (D: Genom. Proteom.)"},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ygcen.2010.07.017","article-title":"The endocrinology of stress in fish: an environmental perspective","volume":"170","author":"Pankhurst","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"issue":"147","key":"10.1016\/j.dci.2020.103961_bib46","article-title":"New edge of antibiotic development: antimicrobial peptides and corresponding resistance","volume":"5","author":"Parachin","year":"2014","journal-title":"Front. Microbiol."},{"issue":"12","key":"10.1016\/j.dci.2020.103961_bib47","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/s41559-019-1044-6","article-title":"Sex-dependent dominance maintains migration supergene in rainbow trout","volume":"3","author":"Pearse","year":"2019","journal-title":"Nat. Ecol. Evol."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.dci.2015.03.009","article-title":"Zebrafish Nk-lysins: first insights about their cellular and functional diversification","volume":"51","author":"Pereiro","year":"2015","journal-title":"Dev. Comp. Immunol."},{"issue":"1458","key":"10.1016\/j.dci.2020.103961_bib49","article-title":"Nucleated teleost erythrocytes play an Nk-lysin- and autophagy-dependent role in antiviral immunity","volume":"8","author":"Pereiro","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib50","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.biotechadv.2017.02.001","article-title":"Computational tools for exploring sequence databases as a resource for antimicrobial peptides","volume":"35","author":"Porto","year":"2017","journal-title":"Biotechnol. Adv."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib51","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2761.2011.01343.x","article-title":"Expression profiles of seven channel catfish antimicrobial peptides in response to Edwardsiella ictaluri infection","volume":"35","author":"Pridgeon","year":"2012","journal-title":"J. Fish. Dis."},{"issue":"5","key":"10.1016\/j.dci.2020.103961_bib52","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/jid.2012.503","article-title":"Antimicrobial peptides (AMPs) from fish epidermis: perspectives for investigative dermatology","volume":"133","author":"Rakers","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"10.1016\/j.dci.2020.103961_bib53","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/vr.144.10.251","article-title":"Histopathological and electron microscopical observations on rainbow trout fry syndrome","volume":"144","author":"Rangdale","year":"1999","journal-title":"Vet. Rec."},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib54","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3923\/rji.2010.146.156","article-title":"Antimicrobial peptides from the marine fishes","volume":"3","author":"Ravichandran","year":"2010","journal-title":"Res. J. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3354\/dao044097","article-title":"Histone-like protein: a novel method for measuring stress in fish","volume":"44","author":"Robinette","year":"2001","journal-title":"Dis. Aquat. Org."},{"issue":"4","key":"10.1016\/j.dci.2020.103961_bib56","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat. Protcols"},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121778","article-title":"Transcriptome assembly, gene annotation and tissue gene expression atlas of the rainbow trout","volume":"10","author":"Salem","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib58","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1186\/1471-2164-12-626","article-title":"Generation of a reference transcriptome for evaluating rainbow trout responses to various stressors","volume":"12","author":"S\u00e1nchez","year":"2011","journal-title":"BMC Genom."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pathogens4010001","article-title":"Alternatives to antibiotics in animal agriculture: an ecoimmunological view","volume":"4","author":"Sang","year":"2015","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib60","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13059-017-1339-3","article-title":"Intron retention enhances gene regulatory complexity in vertebrates","volume":"18","author":"Schmitz","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.dci.2020.103961_bib61","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.fsi.2018.01.003","article-title":"Effects of cortisol and lipopolysaccharide on expression of select growth-, stress- and immune-related genes in rainbow trout liver","volume":"74","author":"Shepherd","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib62","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2527\/jas.2008-1157","article-title":"Rainbow trout resistance to bacterial cold-water disease is moderately heritable and is not adversely correlated with growth","volume":"87","author":"Silverstein","year":"2009","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.dci.2020.103961_bib63","series-title":"Principles and Procedures of Statistics: A Biometrical Approach","author":"Steele","year":"1980"},{"issue":"2","key":"10.1016\/j.dci.2020.103961_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006160","article-title":"New paradigms to help solve the global aquaculture disease crisis","volume":"13","author":"Stentiford","year":"2017","journal-title":"PLoS Pathog."},{"issue":"19","key":"10.1016\/j.dci.2020.103961_bib65","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1021\/bi0504005","article-title":"Structural characterization of the antimicrobial peptide pleurocidin from winter flounder","volume":"44","author":"Syvitski","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.dci.2020.103961_bib66","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.aquaculture.2014.09.027","article-title":"Effects of transportation stress and addition of salt to transport water on the skin mucosal homeostasis of rainbow trout (Oncorhynchus mykiss)","volume":"435","author":"Tacchi","year":"2015","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2172-12-69","article-title":"Impact of acute stress on antimicrobial polypeptides mRNA copy number in several tissues of marine sea bass (Dicentrarchus labrax)","volume":"12","author":"Terova","year":"2011","journal-title":"BMC Immunol."},{"issue":"22","key":"10.1016\/j.dci.2020.103961_bib68","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.dci.2020.103961_bib69","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.dci.2011.07.002","article-title":"Stress and immune modulation in fish","volume":"35","author":"Tort","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"14","key":"10.1016\/j.dci.2020.103961_bib70","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/bioinformatics\/btr304","article-title":"Java bioinformatics analysis web services for multiple sequence alignment\u2014JABAWS:MSA","volume":"27","author":"Troshin","year":"2011","journal-title":"Bioinformatics"},{"issue":"15","key":"10.1016\/j.dci.2020.103961_bib71","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks596","article-title":"Primer3\u2014new capabilities and interfaces","volume":"40","author":"Untergasser","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dci.2020.103961_bib72","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.fsi.2019.01.034","article-title":"NK-lysin from skin-secreted mucus of Atlantic salmon and its potential role in bacteriostatic activity","volume":"87","author":"Valero","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib73","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13567-018-0558-2","article-title":"The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production","volume":"49","author":"van Dijk","year":"2018","journal-title":"Vet. Res."},{"issue":"4","key":"10.1016\/j.dci.2020.103961_bib74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12064-012-0162-3","article-title":"Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples","volume":"131","author":"Wagner","year":"2012","journal-title":"Theor. Biosci."},{"issue":"10","key":"10.1016\/j.dci.2020.103961_bib75","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.molimm.2005.09.023","article-title":"NK-lysin of channel catfish: gene triplication, sequence variation, and expression analysis","volume":"43","author":"Wang","year":"2006","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2020.103961_bib76","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fsi.2017.11.030","article-title":"Identification, expression analysis, and antibacterial activity of NK-lysin from common carp Cyprinus carpio","volume":"73","author":"Wang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib77","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1152\/physrev.1997.77.3.591","article-title":"The stress response in fish","volume":"77","author":"Wendelaar Bonga","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.dci.2020.103961_bib78","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.aquaculture.2013.01.018","article-title":"On-farm performance of rainbow trout (Oncorhynchus mykiss) selectively bred for resistance to bacterial cold water disease: effect of rearing environment on survival phenotype","volume":"388","author":"Wiens","year":"2013","journal-title":"Aquaculture"},{"issue":"16","key":"10.1016\/j.dci.2020.103961_bib79","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1093\/bioinformatics\/bti534","article-title":"RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins","volume":"21","author":"Yang","year":"2005","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib80","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.dci.2020.103961_bib81","first-page":"134","article-title":"A tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012"},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib82","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1051\/vetres:2000121","article-title":"Porcine antimicrobial peptides: new prospects for ancient molecules of host defense","volume":"31","author":"Zhang","year":"2000","journal-title":"Vet. Res."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib83","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.vetimm.2004.05.005","article-title":"Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout","volume":"101","author":"Zhang","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"3","key":"10.1016\/j.dci.2020.103961_bib84","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.dci.2013.03.005","article-title":"A NK-lysin from Cynoglossus semilaevis enhances antimicrobial defense against bacterial and viral pathogens","volume":"40","author":"Zhang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"issue":"9","key":"10.1016\/j.dci.2020.103961_bib85","article-title":"NKLP27: a teleost NK-Lysin peptide that modulates immune response, induces degradation of bacterial DNA, and inhibits bacterial and viral infection","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2020.103961_bib86","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.fsi.2019.09.014","article-title":"Identification and characterization of five Nk-lysins from Pseudocrossocheilus bamaensis and their diverse expression patterns in response to bacterial infection","volume":"94","author":"Zhang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103961_bib87","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.fsi.2016.05.035","article-title":"Identification, expression and antibacterial activities of an antimicrobial peptide NK-lysin from a marine fish Larimichthys crocea","volume":"55","author":"Zhou","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2020.103961_bib88","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.aquaculture.2018.10.012","article-title":"Molecular structure, expression and antibacterial characterization of a novel antimicrobial peptide NK-lysin from the large yellow croaker Larimichthys crocea","volume":"500","author":"Zhou","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2020.103961_bib89","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.fsi.2017.04.011","article-title":"Three new piscidins from orange-spotted grouper (Epinephelus coioides): phylogeny, expression and functional characterization","volume":"66","author":"Zhuang","year":"2017","journal-title":"Fish Shellfish Immunol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X20305152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X20305152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:43:25Z","timestamp":1758937405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X20305152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":89,"alternative-id":["S0145305X20305152"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2020.103961","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure and regulation of the NK-lysin (1\u20134) and NK-lysin like (a and b) antimicrobial genes in rainbow trout (Oncorhynchus mykiss)","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2020.103961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103961"}}