{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:31:27Z","timestamp":1779258687899,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":282,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["420,553\/2017\\u20137"],"award-info":[{"award-number":["420,553\/2017\\u20137"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["442055\/2019-6"],"award-info":[{"award-number":["442055\/2019-6"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["309862\/2015-9"],"award-info":[{"award-number":["309862\/2015-9"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.dci.2021.104061","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T22:10:41Z","timestamp":1614723041000},"page":"104061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A comparative approach on the activation of the three complement system pathways in different hosts of Visceral Leishmaniasis after stimulation with Leishmania infantum"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-7509","authenticated-orcid":false,"given":"Thais Cristina","family":"Tirado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-2284","authenticated-orcid":false,"given":"Lorena","family":"Bavia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-5856","authenticated-orcid":false,"given":"Altair Rogerio","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique Paiva","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"de Almeida Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iara Jose","family":"Messias-Reason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiano Borges","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2021.104061_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004349","article-title":"A historical overview of the classification, evolution, and dispersion of Leishmania parasites and sandflies","volume":"10","author":"Akhoundi","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.dci.2021.104061_bib2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/0972-9062.249481","article-title":"Low susceptibility of domestic cats to experimental Leishmania infantum infection","volume":"55","author":"Akhtardanesh","year":"2018","journal-title":"J. Vector Borne Dis."},{"key":"10.1016\/j.dci.2021.104061_bib3","doi-asserted-by":"crossref","first-page":"13236","DOI":"10.1073\/pnas.1106746108","article-title":"Unique structure of iC3b resolved at a resolution of 24 \u00c5 by 3D-electron microscopy","volume":"108","author":"Alcorlo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.dci.2021.104061_bib4","doi-asserted-by":"crossref","first-page":"105673","DOI":"10.1016\/j.actatropica.2020.105673","article-title":"Novel findings on the role of ficolins and colectins in the innate response against Leishmania braziliensis","volume":"212","author":"Ambrosio","year":"2020","journal-title":"Acta Trop."},{"key":"10.1016\/j.dci.2021.104061_bib5","first-page":"1","article-title":"Is the cat an important reservoir host for visceral leishmaniasis? A systematic review with meta-analysis","author":"Asfaram","year":"2019","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.dci.2021.104061_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900401","article-title":"Inhibitory effect of supercritical extracts from Arctium lappa L. On the lectin pathway of the complement system","volume":"16","author":"Bavia","year":"2019","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.dci.2021.104061_bib7","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.ijpara.2007.03.008","article-title":"Protein turnover and differentiation in Leishmania","volume":"37","author":"Besteiro","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.dci.2021.104061_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetpar.2016.10.004","article-title":"Parasite load in the blood and skin of dogs naturally infected by Leishmania infantum is correlated with their capacity to infect sand fly vectors","volume":"229","author":"Borja","year":"2016","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.dci.2021.104061_bib9","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1590\/0037-8682-0041-2014","article-title":"Coinfection by Toxoplasma gondii and Leishmania spp. in domestic cats (Felis catus) in state of mato grosso do sul","volume":"47","author":"Braga","year":"2014","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.dci.2021.104061_bib10","article-title":"Role of the Leishmania surface protease GP63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis","volume":"4758","author":"Brittingham","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2021.104061_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2019.00330","article-title":"Leishmania spp-host interaction: there is always an onset, but is there an end?","volume":"9","author":"Concei\u00e7\u00e3o-Silva","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.dci.2021.104061_bib12","first-page":"1","article-title":"Cats are not small dogs: is there an immunological explanation for why cats are less affected by arthropod-borne disease than dogs?","author":"Day","year":"2016","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.dci.2021.104061_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01851","article-title":"Be on target: strategies of targeting alternative and lectin pathway components in complement-mediated diseases","volume":"9","author":"Dob\u00f3","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2021.104061_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2012.00110","article-title":"The immune response to sand fly salivary proteins and its influence on Leishmania immunity","volume":"3","author":"Gomes","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2021.104061_bib15","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ni.3858","article-title":"Novel mechanisms and functions of complement","volume":"18","author":"Hajishengallis","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2021.104061_bib16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.54987\/jebat.v2i2.218","article-title":"Evaluation of several mathematical models for fitting the growth and kinetics of the catechol-degrading Candida parapsilopsis: Part 1","volume":"2","author":"Halmi","year":"2014","journal-title":"J. Environ. Bioremed. Toxicol."},{"key":"10.1016\/j.dci.2021.104061_bib17","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.4049\/jimmunol.1302121","article-title":"Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system","volume":"191","author":"Henriksen","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2021.104061_bib18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.det.2015.03.018","article-title":"New world and old world Leishmania infections: a practical review","volume":"33","author":"Kevric","year":"2015","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.dci.2021.104061_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00281-017-0644-y","article-title":"Complement as a regulator of adaptive immunity","volume":"40","author":"Killick","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.dci.2021.104061_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0001155","article-title":"Comparative microsatellite typing of new world Leishmania infantum reveals low heterogeneity among populations and its recent old world origin","volume":"5","author":"Kuhls","year":"2011","journal-title":"PLOS Negl. Trop. Dis"},{"key":"10.1016\/j.dci.2021.104061_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pt.2011.03.008","article-title":"Can domestic cats be considered reservoir hosts of zoonotic leishmaniasis?","volume":"27","author":"Maia","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.dci.2021.104061_bib22","first-page":"1","article-title":"Different host complement systems and their interactions with saliva from Lutzomyia longipalpis (Diptera , psychodidae) and Leishmania infantum","volume":"8","author":"Mendes-Sousa","year":"2013","journal-title":"Promastigotes"},{"key":"10.1016\/j.dci.2021.104061_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00262","article-title":"Complement system part I - molecular mechanisms of activation and regulation","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2021.104061_bib24","first-page":"1","article-title":"Association of ficolin-2 serum levels and FCN2 genetic variants with Indian visceral leishmaniasis","volume":"10","author":"Mishra","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.dci.2021.104061_bib25","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.4049\/jimmunol.135.4.2785","article-title":"The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes","volume":"135","author":"Mosser","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2021.104061_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-015-0909-z","article-title":"LeishVet update and recommendations on feline leishmaniosis","volume":"8","author":"Pennisi","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.dci.2021.104061_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.vetpar.2018.01.012","article-title":"Feline leishmaniosis: is the cat a small dog?","volume":"251","author":"Pennisi","year":"2018","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.dci.2021.104061_bib28","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1189\/jlb.0212086","article-title":"The roles of complement receptor 3 and Fc\u03b3 receptors during Leishmania phagosome maturation","volume":"93","author":"Polando","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.dci.2021.104061_bib29","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.4049\/jimmunol.145.12.4311","article-title":"Serum resistance of metacyclic stage Leishmania major promastigotes is due to release of C5b-9","volume":"145","author":"Puentes","year":"1990","journal-title":"Jounal Immunol"},{"key":"10.1016\/j.dci.2021.104061_bib30","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1645\/GE-3130.1","article-title":"Differential surface deposition of complement proteins on logarithmic and stationary phase Leishmania chagasi promastigotes","volume":"98","author":"Ramer-Tait","year":"2012","journal-title":"J. Parasitol."},{"key":"10.1016\/j.dci.2021.104061_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-6148-3-11","article-title":"In vitro binding and survival assays of Leishmania parasites to peripherical blood monocytes and monocyte-derived macrophages isolated from dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi","volume":"3","author":"Sampaio","year":"2007","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.dci.2021.104061_bib32","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1128\/IAI.69.8.5212-5215.2001","article-title":"Mannan-binding lectin enhances susceptibility to visceral leishmaniasis","volume":"69","author":"Santos","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2021.104061_bib33","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.4049\/jimmunol.162.6.3481","article-title":"Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene","volume":"162","author":"Stover","year":"1999","journal-title":"J. Immunol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21000690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21000690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:37:45Z","timestamp":1778668665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X21000690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":33,"alternative-id":["S0145305X21000690"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2021.104061","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparative approach on the activation of the three complement system pathways in different hosts of Visceral Leishmaniasis after stimulation with Leishmania infantum","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2021.104061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104061"}}