{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:28:31Z","timestamp":1759048111047,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.dci.2021.104071","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T01:40:37Z","timestamp":1616463637000},"page":"104071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Differential capability of Bacillus thuringiensis Cry1Ac protoxin and toxin to induce in vivo activation of dendritic cells and B lymphocytes"],"prefix":"10.1016","volume":"121","author":[{"given":"Cynthia Daniela","family":"Ibarra-Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damaris","family":"Ilhuicatzi-Alvarado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Moreno-Fierros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2021.104071_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.immuni.2008.08.013","article-title":"Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells","volume":"29","author":"Allenspach","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2021.104071_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.00741","article-title":"Langerin+CD8+ dendritic cells in the splenic marginal zone: not so marginal after all","volume":"10","author":"Backer","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.biopha.2018.06.026","article-title":"Efficacy and safety of immunological adjuvants. Where is the cut-off?","volume":"105","author":"Batista-Duharte","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.dci.2021.104071_bib4","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1006\/jmbi.1999.2649","article-title":"N-acetylgalactosamine on the putative insect receptor aminopeptidase N is recognised by a site on the domain III lectin-like fold of a Bacillus thuringiensis insecticidal toxin","volume":"287","author":"Burton","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dci.2021.104071_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0143391","article-title":"Dengue virus directly stimulates Polyclonal B cell activation","volume":"10","author":"Correa","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.dci.2021.104071_bib6","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1084\/jem.20170335","article-title":"Dendritic cell and antigen dispersal landscapes regulate T cell immunity","volume":"214","author":"Gerner","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2021.104071_bib7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.vetmic.2014.11.021","article-title":"The protoxin Cry1Ac of Bacillus thuringiensis improves the protection conferred by intranasal immunization with Brucella abortus RB51 in a mouse model","volume":"175","author":"Gonz\u00e1lez-Gonz\u00e1lez","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2021.104071_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1084\/jem.192.10.1425","article-title":"Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex","volume":"192","author":"Gretz","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2021.104071_bib9","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.molimm.2004.06.026","article-title":"Structural implication of the induced immune response by Bacillus thuringiensis Cry proteins: role of the N-terminal region","volume":"41","author":"Guerrero","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1084\/jem.20091964","article-title":"CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells","volume":"207","author":"Henri","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2021.104071_bib11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/pim.12103","article-title":"Coadministration of protoxin Cry1Ac from Bacillus thuringiensis with metacestode extract confers protective immunity to murine cysticercosis","volume":"36","author":"Ibarra-Moreno","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib12","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ni957","article-title":"Antigen presentation to naive CD4 T cells in the lymph node","volume":"4","author":"Itano","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1074-7613(03)00175-4","article-title":"Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity","volume":"19","author":"Itano","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2021.104071_bib14","first-page":"108","article-title":"The effects of purified mitogenic proteins (Pa 1 and Pa 2) from pokeweed on human T and B lymphocytes in vitro","volume":"26","author":"Janossy","year":"1976","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib15","doi-asserted-by":"crossref","first-page":"10644","DOI":"10.1073\/pnas.0914347107","article-title":"B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase","volume":"107","author":"Johnson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.dci.2021.104071_bib16","first-page":"391","article-title":"Lymphocyte activation. I. Expression of theta, H-2 and immunoglobulin determinants on lymphocytes stimulated by phytohaemagglutinin, pokeweed mitogen, concanavalin A or histocompatibility antigen","volume":"12","author":"Jones","year":"1972","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib17","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1111\/j.1432-1033.2004.04238.x","article-title":"Characterization of a Cry1Ac-receptor alkaline phosphatase in susceptible and resistant Heliothis virescens larvae","volume":"271","author":"Jurat-Fuentes","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.dci.2021.104071_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-018-0084-5","article-title":"The immunological anatomy of the skin","volume":"19","author":"Kabashima","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib19","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1016\/j.febslet.2010.08.022","article-title":"Receptors and signaling mechanisms for B-lymphocyte activation, proliferation and differentiation - insights from both in vivo and in vitro approaches","volume":"584","author":"Maddaly","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.dci.2021.104071_bib20","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.4049\/jimmunol.165.9.5027","article-title":"Microbial and T Cell-Derived stimuli regulate antigen presentation by dendritic cells in vivo","volume":"165","author":"Manickasingham","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib21","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1002\/eji.200535179","article-title":"Virus-induced polyclonal B cell activation improves protective CTL memory via retained CD27 expression on memory CTL","volume":"35","author":"Matter","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.intimp.2013.10.005","article-title":"Cry1Ac protoxin from Bacillus thuringiensis promotes macrophage activation by upregulating CD80 and CD86 and by inducing IL-6, MCP-1 and TNF-\u03b1 cytokines","volume":"17","author":"Moreno-Fierros","year":"2013","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.dci.2021.104071_bib23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1245\/s10434-006-9044-6","article-title":"Lymphatic drainage of the peritoneal space: a pattern dependent on bowel lymphatics","volume":"14","author":"Parungo","year":"2007","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.dci.2021.104071_bib24","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1128\/IAI.72.8.4368-4375.2004","article-title":"Intranasal coadministration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis","volume":"72","author":"Rojas-Hern\u00e1ndez","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2021.104071_bib25","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcb.26216","article-title":"The macrophage activation induced by Bacillus thuringiensis Cry1Ac protoxin involves ERK1\/2 and p38 pathways and the interaction with cell-surface-HSP70","volume":"119","author":"Rubio-Infante","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.dci.2021.104071_bib26","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/jat.3252","article-title":"An overview of the safety and biological effects of Bacillus thuringiensis Cry toxins in mammals","volume":"36","author":"Rubio-Infante","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.dci.2021.104071_bib27","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4049\/jimmunol.160.2.708","article-title":"Three populations of mouse lymph node dendritic cells with different origins and dynamics","volume":"160","author":"Salomon","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2021.104071_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.intimp.2018.05.029","article-title":"Study of the allergenic potential of Bacillus thuringiensis Cry1Ac toxin following intra-gastric administration in a murine model of food-allergy","volume":"61","author":"Santos-Vigil","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.dci.2021.104071_bib29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jconrel.2016.08.034","article-title":"The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8+ T-cell responses: the immunological consequences of the biodistribution profile","volume":"239","author":"Schmidt","year":"2016","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.dci.2021.104071_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/135675","article-title":"Mode of action and specificity of Bacillus thuringiensis toxins in the control of caterpillars and stink bugs in soybean culture","volume":"135675","author":"Sch\u00fcnemann","year":"2014","journal-title":"ISRN Microbiol"},{"key":"10.1016\/j.dci.2021.104071_bib31","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1073\/pnas.0912817107","article-title":"Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants","volume":"107","author":"Sen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.dci.2021.104071_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.0105-2896.2009.00870.x","article-title":"The CD8+ dendritic cell subset","volume":"234","author":"Shortman","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.dci.2021.104071_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2004.11.013","article-title":"The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node","volume":"22","author":"Sixt","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2021.104071_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biocel.2016.06.022","article-title":"Cry1Ac toxin induces macrophage activation via ERK1\/2, JNK and p38 mitogen-activated protein kinases","volume":"78","author":"Torres-Mart\u00ednez","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.dci.2021.104071_bib35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1046\/j.1365-3083.1999.00534.x","article-title":"Bacillus thuringiensis Cry1Ac protoxin is a potent systemic and mucosal adjuvant","volume":"49","author":"V\u00e1zquez","year":"1999","journal-title":"Scand. J. Immunol."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21000793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21000793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:42:17Z","timestamp":1758937337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X21000793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":35,"alternative-id":["S0145305X21000793"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2021.104071","relation":{},"ISSN":["0145-305X"],"issn-type":[{"type":"print","value":"0145-305X"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential capability of Bacillus thuringiensis Cry1Ac protoxin and toxin to induce in vivo activation of dendritic cells and B lymphocytes","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2021.104071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104071"}}