{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:39:17Z","timestamp":1793421557003,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.dci.2021.104125","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T11:42:41Z","timestamp":1622547761000},"page":"104125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection"],"prefix":"10.1016","volume":"123","author":[{"given":"Yorick A.","family":"van der Wal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiferaw","family":"Jenberie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"Nordli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Greiner-Tollersrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-2461","authenticated-orcid":false,"given":"Jaap","family":"Kool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvill","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-6777","authenticated-orcid":false,"given":"Jorunn B.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.dci.2021.104125_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082737","article-title":"Transcriptional heterogeneity of IgM+ cells in rainbow trout (Oncorhynchus mykiss) tissues","volume":"8","author":"Ab\u00f3s","year":"2013","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3354\/dao029137","article-title":"Salmonid rickettsial septicemia caused by Piscirickettsia salmonis:a review","volume":"29","author":"Almendras","year":"1997","journal-title":"Dis. Aquat. Org."},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib3","first-page":"337","article-title":"Effects of infection with transmissible gastroenteritis virus on concomitant immune responses to dietary and injected antigens","volume":"11","author":"Bailey","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib4","first-page":"57","article-title":"Innate-like B cells and their rules of engagement","volume":"vol. 785","author":"Baumgarth","year":"2013"},{"issue":"1","key":"10.1016\/j.dci.2021.104125_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00251-020-01195-1","article-title":"Immunoglobulins in teleosts","volume":"73","author":"Bilal","year":"2021","journal-title":"Immunogenetics"},{"key":"10.1016\/j.dci.2021.104125_bib6","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.4049\/jimmunol.173.12.7317","article-title":"Plasmablast and plasma cell production and distribution in trout immune tissues","volume":"173","author":"Bromage","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.dci.2017.01.012","article-title":"Expansion and differentiation of IgM+ B cells in the rainbow trout peritoneal cavity in response to different antigens","volume":"70","author":"Castro","year":"2017","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0044-8486(86)90027-X","article-title":"Secondary response of rainbow trout (Salmo gairdneri Richardson) to DNP-haemocyanin and Yersinia ruckeri","volume":"52","author":"Cossarini-Dunier","year":"1986","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2021.104125_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fsi.2018.11.039","article-title":"Role of teleost B cells in viral immunity","volume":"86","author":"D\u00edaz-Rosales","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3389\/fimmu.2016.00482","article-title":"Immunization strategies against Piscirickettsia salmonis infections: review of vaccination approaches and modalities and their associated immune response profiles","volume":"7","author":"Evensen","year":"2016","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2021.104125_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1099\/00207713-42-1-120","article-title":"Piscirickettsia salmonis gen. Nov., sp. nov., the causative agent of an epizootic disease in salmonid fishes","volume":"42","author":"Fryer","year":"1992","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.dci.2021.104125_bib13","doi-asserted-by":"crossref","first-page":"15066","DOI":"10.1038\/srep15066","article-title":"Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation","volume":"5","author":"Gunti","year":"2015","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.dci.2021.104125_bib14","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.fsi.2012.09.009","article-title":"Antibodies recognizing both IgM isotypes in Atlantic salmon","volume":"33","author":"Hedfors","year":"2012","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.dci.2021.104125_bib51","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/jfd.12427","article-title":"Comprehensive antibiotic susceptibility profiling of Chilean Piscirickettsia salmonis field isolates","volume":"39","author":"Henr\u00edquez","year":"2016","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.dci.2021.104125_bib18","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3389\/fimmu.2020.01682","article-title":"Salmonid alphavirus subtype 3 induces prolonged local B cell responses in atlantic salmon (Salmo salar) after intraperitoneal infection","volume":"11","author":"Jenberie","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2021.104125_bib17","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1038\/s41598-018-21895-9","article-title":"Profiling Atlantic salmon B cell populations: CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression","volume":"8","author":"Jenberie","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.dci.2021.104125_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.dci.2009.07.009","article-title":"CpG-induced secretion of MHCIIbeta and exosomes from salmon (Salmo salar) APCs","volume":"34","author":"Iliev","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fimmu.2013.00137","article-title":"Homing of antigen-presenting cells in head kidney and spleen - salmon head kidney hosts diverse APC types","volume":"4","author":"Iliev","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib11","series-title":"Evaluaci\u00f3n de la duraci\u00f3n de la EFICACIA de vacunnas para el control de PISCIRRICKETTSIOSIS en trucha arco\u00edris Y salm\u00f3n del atl\u00e1ntico MEDIANTE desaf\u00edo por cohabitaaci\u00f3n","author":"Intesal","year":"2014"},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0145-305X(01)00064-7","article-title":"Affinity maturation in trout: clonal dominance of high affinity antibodies late in the immune response","volume":"26","author":"Kaattari","year":"2002","journal-title":"Dev. Comp. Immunol."},{"issue":"10","key":"10.1016\/j.dci.2021.104125_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1365-2761.2008.00948.x","article-title":"Real time PCR detection of Piscirickettsia salmonis from formalin-fixed paraffin-embedded tissues","volume":"31","author":"Karatas","year":"2008","journal-title":"J. Fish. Dis."},{"issue":"4","key":"10.1016\/j.dci.2021.104125_bib21","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.fsi.2013.07.032","article-title":"Novel insights into the peritoneal inflammation of rainbow trout (Oncorhynchus mykiss)","volume":"35","author":"Koryt\u00e1\u0159","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.dci.2021.104125_bib22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.dci.2012.07.011","article-title":"CD40L\u2013a costimulatory molecule involved in the maturation of antigen presenting cells in Atlantic salmon (Salmo salar)","volume":"38","author":"Lagos","year":"2012","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0145-305X(01)00059-3","article-title":"Immunity induced shortly after DNA vaccination of rainbow trout against rhabdoviruses protects against heterologous virus but not against bacterial pathogens","volume":"26","author":"Lorenzen","year":"2002","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molimm.2018.12.018","article-title":"A time-course study of gene expression and antibody repertoire at early time post vaccination of Atlantic salmon","volume":"106","author":"Lund","year":"2019","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","article-title":"Innate immunity of fish (overview)","volume":"20","author":"Magnad\u00f3ttir","year":"2006","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.dci.2021.104125_bib26","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/biology4030512","article-title":"Antibody affinity maturation in fishes-our current understanding","volume":"4","author":"Magor","year":"2015","journal-title":"Biology"},{"issue":"3","key":"10.1016\/j.dci.2021.104125_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/14760584.2017.1244483","article-title":"Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective","volume":"16","author":"Maisey","year":"2017","journal-title":"Expet Rev. Vaccine"},{"key":"10.1016\/j.dci.2021.104125_bib28","doi-asserted-by":"crossref","first-page":"104021","DOI":"10.1016\/j.dci.2021.104021","article-title":"Do ectothermic vertebrates have a home in which to affinity mature their antibody responses?","volume":"119","author":"Muthupandian","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fimmu.2019.00037","article-title":"Profiling the atlantic salmon IgM+ B cell surface proteome: novel information on teleost fish B cell protein repertoire and identification of potential B cell markers","volume":"10","author":"Pe\u00f1aranda","year":"2019","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.dci.2021.104125_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110920","article-title":"Immunological characterization of the teleost adipose tissue and its modulation in response to viral infection and fat-content in the diet","volume":"9","author":"Pignatelli","year":"2014","journal-title":"PloS One"},{"issue":"12","key":"10.1016\/j.dci.2021.104125_bib31","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.dci.2011.03.007","article-title":"Advances in fish vaccine delivery","volume":"35","author":"Plant","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"3","key":"10.1016\/j.dci.2021.104125_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/jfd.12211","article-title":"Piscirickettsiosis and Piscirickettsia salmonis in fish: a review","volume":"37","author":"Rozas","year":"2014","journal-title":"J. Fish. Dis."},{"issue":"6","key":"10.1016\/j.dci.2021.104125_bib33","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.dci.2021.104125_bib35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3354\/dao037165","article-title":"Routes of entry of Piscirickettsia salmonis in rainbow trout Oncorhynchus mykiss","volume":"37","author":"Smith","year":"1999","journal-title":"Dis. Aquat. Org."},{"issue":"10","key":"10.1016\/j.dci.2021.104125_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204924","article-title":"Transcriptome analyses of Atlantic salmon muscle genes induced by a DNA vaccine against salmonid alphavirus, the causative agent of salmon pancreas disease (PD)","volume":"13","author":"Sobhkhez","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.dci.2021.104125_bib37","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2017.00827","article-title":"Melanomacrophage centers as a histological indicator of immune function in fish and other poikilotherms","volume":"8","author":"Steinel","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5114\/ceji.2019.87072","article-title":"Melanomacrophages and melanomacrophage centres in Osteichthyes","volume":"44","author":"Stosik","year":"2019","journal-title":"Cent. Eur. J. Immunol."},{"issue":"11","key":"10.1016\/j.dci.2021.104125_bib39","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.dci.2011.03.016","article-title":"Formulations combining CpG containing oliogonucleotides and poly I:C enhance the magnitude of immune responses and protection against pancreas disease in Atlantic salmon","volume":"35","author":"Strandskog","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib40","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.3389\/fimmu.2019.02425","article-title":"Microbial danger signals control transcriptional induction of distinct MHC class I L lineage genes in atlantic salmon","volume":"10","author":"Svenning","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2021.104125_bib41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/vaccines2020228","article-title":"Vaccine adjuvants in fish vaccines make a difference: comparing three adjuvants (montanide ISA763A oil, CpG\/poly I: C combo and VHSV glycoprotein) alone or in combination formulated with an inactivated whole salmonid alphavirus antigen","volume":"2","author":"Thim","year":"2014","journal-title":"Vaccines"},{"issue":"12","key":"10.1016\/j.dci.2021.104125_bib42","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/j.vaccine.2010.12.107","article-title":"Oral vaccination of Atlantic salmon (Salmo salar) against salmonid rickettsial septicaemia","volume":"29","author":"Tobar","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2021.104125_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.dci.2017.11.001","article-title":"Rainbow trout (Oncorhynchus mykiss) adipose tissue undergoes major changes in immune gene expression following bacterial infection or stimulation with pro-inflammatory molecules","volume":"81","author":"Veenstra","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2021.104125_bib44","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1038\/s41598-017-06324-7","article-title":"Alternatives to mineral oil adjuvants in vaccines against Aeromonas salmonicida subsp. salmonicida in rainbow trout offer reductions in adverse effects","volume":"7","author":"Villumsen","year":"2017","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.dci.2021.104125_bib45","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1016\/j.vaccine.2006.03.027","article-title":"A vaccine against the salmonid pathogen Piscirickettsia salmonis based on recombinant proteins","volume":"24","author":"Wilhelm","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2021.104125_bib46","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.3389\/fimmu.2019.02324","article-title":"Long-lived plasma cells secrete high-affinity antibodies responding to a T-dependent immunization in a teleost fish","volume":"10","author":"Wu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib47","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.fsi.2018.10.057","article-title":"Affinity maturation occurs in channel catfish (Ictalurus punctaus) following immunization with a T-cell dependent antigen","volume":"84","author":"Wu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2021.104125_bib48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.fsi.2018.01.035","article-title":"What could be the mechanisms of immunological memory in fish?","volume":"85","author":"Yamaguchi","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.dci.2021.104125_bib49","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.fsi.2013.10.015","article-title":"The teleost humoral immune response","volume":"35","author":"Ye","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.dci.2021.104125_bib50","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.dci.2008.06.008","article-title":"Molecular and cellular analysis of B-cell populations in the rainbow trout using Pax5 and immunoglobulin markers","volume":"32","author":"Zwollo","year":"2008","journal-title":"Dev. Comp. Immunol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21001336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21001336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:44:07Z","timestamp":1758937447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X21001336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":50,"alternative-id":["S0145305X21001336"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2021.104125","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2021.104125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104125"}}