{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:02:43Z","timestamp":1792018963726,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M602024"],"award-info":[{"award-number":["2016M602024"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1708085QC58"],"award-info":[{"award-number":["1708085QC58"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006462","name":"Anhui Agriculture University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701027"],"award-info":[{"award-number":["31701027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.dci.2021.104178","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T03:11:14Z","timestamp":1624072274000},"page":"104178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Cordycepin inhibits inflammatory responses through suppression of ERK activation in zebrafish"],"prefix":"10.1016","volume":"124","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-sheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-min","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-na","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Long","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2021.104178_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s11671-015-0851-1","article-title":"'Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity","volume":"10","author":"Aramwit","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.dci.2021.104178_bib2","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1128\/AAC.33.9.1428","article-title":"'Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide","volume":"33","author":"Danner","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.dci.2021.104178_bib3","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1182\/blood-2010-10-314120","article-title":"'mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish","volume":"117","author":"Ellett","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.dci.2021.104178_bib4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-213X-7-42","article-title":"'The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish","volume":"7","author":"Hall","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.dci.2021.104178_bib5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/08923973.2018.1510964","article-title":"'Cordycepin ameliorates skin inflammation in a DNFB-challenged murine model of atopic dermatitis","volume":"40","author":"Han","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.dci.2021.104178_bib6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1189\/jlb.1112594","article-title":"'Zebrafish as a model for the study of neutrophil biology","volume":"94","author":"Henry","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.dci.2021.104178_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/hep.31749","article-title":"\u2019Cordycepin ameliorates nonalcoholic steatohepatitis via activation of AMP-activated protein kinase signaling pathway","author":"Lan","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.dci.2021.104178_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s12272-011-0418-3","article-title":"'Anti-inflammatory effects of eriodictyol in lipopolysaccharide-stimulated raw 264.7 murine macrophages","volume":"34","author":"Lee","year":"2011","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.dci.2021.104178_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.2042-3306.1985.tb02056.x","article-title":"'Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse'","volume":"17","author":"Lees","year":"1985","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.dci.2021.104178_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.mib.2008.05.013","article-title":"\u2019Insights into early mycobacterial pathogenesis from the zebrafish","volume":"11","author":"Lesley","year":"2008","journal-title":"Curr Opin Microbiol."},{"key":"10.1016\/j.dci.2021.104178_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13229-018-0204-x","article-title":"'CRISPR\/Cas9-induced shank3b mutant zebrafish display autism-like behaviors","volume":"9","author":"Liu","year":"2018","journal-title":"Mol. Autism."},{"key":"10.1016\/j.dci.2021.104178_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1124\/jpet.119.263202","article-title":"'Cordycepin inhibits cancer cell proliferation and angiogenesis through a DEK interaction via ERK signaling in cholangiocarcinoma'","volume":"373","author":"Liu","year":"2020","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.dci.2021.104178_bib12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"'Origin and physiological roles of inflammation'","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.dci.2021.104178_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.biopha.2016.03.009","article-title":"'Cordycepin protects PC12 cells against 6-hydroxydopamine induced neurotoxicity via its antioxidant properties","volume":"81","author":"Olatunji","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.dci.2021.104178_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.intimp.2017.03.002","article-title":"'Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1","volume":"47","author":"Qing","year":"2017","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.dci.2021.104178_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/JOE-15-0329","article-title":"'Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation","volume":"227","author":"Ren","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.dci.2021.104178_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1189\/jlb.0811402","article-title":"'Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation'","volume":"91","author":"Sadik","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.dci.2021.104178_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/icb.2012.57","article-title":"'P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish'","volume":"91","author":"Taylor","year":"2013","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.dci.2021.104178_bib18","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.3892\/etm.2017.4855","article-title":"'Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK\/Akt signaling pathway","volume":"14","author":"Wang","year":"2017","journal-title":"Exper. Therapeut. Med."},{"key":"10.1016\/j.dci.2021.104178_bib19","article-title":"'Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dci.2021.104178_bib20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1089\/zeb.2016.1287","article-title":"'Comparative developmental toxicity and stress protein responses of dimethyl sulfoxide to rare minnow and zebrafish embryos\/larvae","volume":"14","author":"Xiong","year":"2017","journal-title":"Zebrafish"},{"key":"10.1016\/j.dci.2021.104178_bib21","first-page":"2415","article-title":"'Cordycepin induces apoptosis and G2\/M phase Arrest through the ERK pathways in esophageal cancer cells'","volume":"10","author":"Xu","year":"2019","journal-title":"J. Canc."},{"key":"10.1016\/j.dci.2021.104178_bib22","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.biopha.2017.09.103","article-title":"'Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation","volume":"95","author":"Yang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.dci.2021.104178_bib23","doi-asserted-by":"crossref","first-page":"117645","DOI":"10.1016\/j.lfs.2020.117645","article-title":"'Cordycepin protects against acute pancreatitis by modulating NF-kappaB and NLRP3 inflammasome activation via AMPK","volume":"251","author":"Yang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.dci.2021.104178_bib24","doi-asserted-by":"crossref","first-page":"14102","DOI":"10.3390\/ijms150814102","article-title":"'Melatonin suppresses hypoxia-induced migration of HUVECs via inhibition of ERK\/Rac1 activation","volume":"15","author":"Yang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2021.104178_bib25","first-page":"407","article-title":"'Natural medicinal resources and their therapeutic applications","volume":"70","author":"Ziemska","year":"2019","journal-title":"Rocz. Panstw. Zakl. Hig."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21001865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21001865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:43:24Z","timestamp":1758937404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X21001865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":26,"alternative-id":["S0145305X21001865"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2021.104178","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cordycepin inhibits inflammatory responses through suppression of ERK activation in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2021.104178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104178"}}