{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T02:10:08Z","timestamp":1758939008201,"version":"3.44.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.dci.2021.104303","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T02:17:30Z","timestamp":1635560250000},"page":"104303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The mitochondrial activity of leukocytes from Artibeus jamaicensis bats remains unaltered after several weeks of flying restriction"],"prefix":"10.1016","volume":"127","author":[{"given":"F. Javier","family":"S\u00e1nchez-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alvaro","family":"Aguilar-Setien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Ang\u00e9lica","family":"P\u00e9rez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon E.","family":"Kolstoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-0143","authenticated-orcid":false,"given":"Alun","family":"Coker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-3907","authenticated-orcid":false,"given":"Emilio","family":"Rendon-Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Maximina Bertha","family":"Moreno-Altamirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2021.104303_bib1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3389\/fimmu.2018.01605","article-title":"Diverse roles of mitochondria in immune responses: novel insights into immuno-metabolism","volume":"9","author":"Angajala","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2021.104303_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1863-2378.2012.01528.x","article-title":"Antiviral immune responses of bats: a review","volume":"60","author":"Baker","year":"2013","journal-title":"Zoonoses and public health"},{"key":"10.1016\/j.dci.2021.104303_bib4","series-title":"Bioenergetics. A Practical Approach","first-page":"39","article-title":"Measurement of mitochondrial protonmotive force","author":"Brand","year":"1995"},{"key":"10.1016\/j.dci.2021.104303_bib5","doi-asserted-by":"crossref","first-page":"101255","DOI":"10.1016\/j.redox.2019.101255","article-title":"Mitochondria as central hub of the immune system","volume":"26","author":"Breda","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.dci.2021.104303_bib6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tim.2014.12.004","article-title":"Bats as \u201cspecial\u201d reservoirs for emerging zoonotic pathogens","volume":"23","author":"Brook","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.dci.2021.104303_bib7","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","article-title":"Calcium, ATP, and ROS: a mitochondrial love-hate triangle","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.dci.2021.104303_bib8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.mad.2009.05.002","article-title":"Examining the mechanisms responsible for lower ROS release rates in liver mitochondria from the long-lived house sparrow (Passer domesticus) and big brown bat (Eptesicus fuscus) compared to the short-lived mouse (Mus musculus)","volume":"130","author":"Brown","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.dci.2021.104303_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mad.2003.09.003","article-title":"Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammals","volume":"125","author":"Brunet-Rossinni","year":"2004","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.dci.2021.104303_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1469-7793.2000.00057.x","article-title":"Mitochondria and calcium: from cell signalling to cell death","volume":"529","author":"Duchen","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.dci.2021.104303_bib11","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nri1710","article-title":"Fuel feeds function: energy metabolism and the T-cell response","volume":"5","author":"Fox","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.dci.2021.104303_bib12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1074-7613(02)00323-0","article-title":"The CD28 signaling pathway regulates glucose metabolism","volume":"16","author":"Frauwirth","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2021.104303_bib14","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1113\/jphysiol.2012.228387","article-title":"Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria","volume":"590","author":"Gerencser","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.dci.2021.104303_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cmet.2020.06.013","article-title":"The world goes bats: living longer and tolerating viruses","volume":"32","author":"Gorbunova","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.dci.2021.104303_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","article-title":"Calcium and ROS: a mutual interplay","author":"G\u00f6rlach","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.dci.2021.104303_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41556-018-0217-x","article-title":"Metabolism as a guiding force for immunity","volume":"21","author":"Jung","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.dci.2021.104303_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0300-9629(87)90447-6","article-title":"On the relation between basal and maximum metabolic rate in mammals","volume":"87","author":"Koteja","year":"1987","journal-title":"Comp. Biochem. Physiol. Physiol."},{"key":"10.1016\/j.dci.2021.104303_bib20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.redox.2013.12.026","article-title":"A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: implications for their use as bioenergetic biomarkers","volume":"2","author":"Kramer","year":"2014","journal-title":"Redox Biol"},{"key":"10.1016\/j.dci.2021.104303_bib21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1118391","article-title":"Bats are natural reservoirs of SARS-like coronaviruses","volume":"310","author":"Li","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.dci.2021.104303_bib24","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1242\/jeb.203.20.3045","article-title":"What it takes to fly: the structural and functional respiratory refinements in birds and bats","volume":"203","author":"Maina","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.dci.2021.104303_bib25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0009-9120(99)00075-2","article-title":"Antioxidant enzymes and human diseases","volume":"32","author":"Mates","year":"1999","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.dci.2021.104303_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154371","article-title":"Impaired cellular bioenergetics causes mitochondrial calcium handling defects in MT-ND5 mutant cybrids","volume":"11","author":"McKenzie","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2021.104303_bib27","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nri.2017.66","article-title":"Mitochondrial control of immunity: beyond ATP","volume":"17","author":"Mehta","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2021.104303_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the powerhouses of immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2021.104303_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0010-406X(67)90130-2","article-title":"Temperature regulation in some Brazilian phyllostomoid bats","volume":"21","author":"Morrison","year":"1967","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.dci.2021.104303_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.dci.2021.104303_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1474-9728.2003.00079.x","article-title":"Mitochondrial membrane potential and aging","volume":"3","author":"Nicholls","year":"2004","journal-title":"Aging Cell"},{"key":"10.1016\/j.dci.2021.104303_bib32","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26686","article-title":"Cyclic bouts of extreme bradycardia counteract the high metabolism of frugivorous bats","volume":"6","author":"O'Mara","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.dci.2021.104303_bib33","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3201\/eid2005.130539","article-title":"Bat flight and zoonotic viruses","volume":"20","author":"O'Shea","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.dci.2021.104303_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri.2017.139","article-title":"Immunometabolism in 2017: driving immunity: all roads lead to metabolism","volume":"18","author":"Pearce","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2021.104303_bib36","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.18632\/aging.101861","article-title":"A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats","volume":"11","author":"Pollard","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.dci.2021.104303_bib37","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological roles of mitochondrial reactive oxygen species","volume":"48","author":"Sena","year":"2012","journal-title":"Mol. Cell."},{"key":"10.1016\/j.dci.2021.104303_bib38","doi-asserted-by":"crossref","first-page":"8666","DOI":"10.1073\/pnas.0912613107","article-title":"Adaptive evolution of energy metabolism genes and the origin of flight in bats","volume":"107","author":"Shen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dci.2021.104303_bib39","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948395","article-title":"Causal roles of mitochondrial dynamics in longevity and healthy aging","author":"Sharma","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.dci.2021.104303_bib41","series-title":"Bat Ecology","first-page":"430","article-title":"Physiological ecology and energetics of bats","author":"Speakman","year":"2003"},{"key":"10.1016\/j.dci.2021.104303_bib42","doi-asserted-by":"crossref","first-page":"20150576","DOI":"10.1098\/rsbl.2015.0576","article-title":"No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat","volume":"11","author":"Stockmaier","year":"2015","journal-title":"Biol. Lett."},{"key":"10.1016\/j.dci.2021.104303_bib43","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3390\/v11020192","article-title":"Immune system modulation and viral persistence in bats: understanding viral spillover","volume":"11","author":"Subudhi","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.dci.2021.104303_bib44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12576-014-0326-7","article-title":"The destiny of Ca2+ released by mitochondria","volume":"65","author":"Takeuchi","year":"2015","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.dci.2021.104303_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.dci.2021.104303_bib47","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1890\/09-2232.1","article-title":"Refueling while flying: foraging bats combust food rapidly and directly to power flight","volume":"91","author":"Voigt","year":"2010","journal-title":"Ecology"},{"key":"10.1016\/j.dci.2021.104303_bib48","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1365-2435.2007.01321.x","article-title":"Nectar-feeding bats fuel their high metabolism directly with exogenous carbohydrates","volume":"21","author":"Voigt","year":"2007","journal-title":"Funct. Ecol."},{"key":"10.1016\/j.dci.2021.104303_bib49","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.1073\/pnas.1916414117","article-title":"Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program","volume":"117","author":"Vyssokikh","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dci.2021.104303_bib50","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.bbabio.2009.01.007","article-title":"Modulation of calcium signalling by mitochondria","volume":"1787","author":"Walsh","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.dci.2021.104303_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/nyas.12737","article-title":"Carbon stable-isotope tracking in breath forcomparative studies of fuel use","author":"Welch","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.dci.2021.104303_bib52","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2021.104303_bib53","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cbpc.2006.11.015","article-title":"Antioxidant defenses, longevity and ecophysiology of South American bats","volume":"146","author":"Wilhelm","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.dci.2021.104303_bib54","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1089\/ars.2012.4889","article-title":"Circadian rhythm connections to oxidative stress: implications for human health","volume":"19","author":"Wilking","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.dci.2021.104303_bib55","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/rmv.520","article-title":"Bats as a continuing source of emerging infections in humans","volume":"17","author":"Wong","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.dci.2021.104303_bib56","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.200406038","article-title":"Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit","volume":"167","author":"Yi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.dci.2021.104303_bib57","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1230835","article-title":"Comparative analysis of bat genomes provides insight into the evolution of flight and immunity","volume":"339","author":"Zhang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.dci.2021.104303_bib58","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.dci.2021.104303_bib59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1134\/S1990747818010129","article-title":"Functional significance of the mitochondrial membrane potential","volume":"12","author":"Zorova","year":"2018","journal-title":"Biochem. Moscow Suppl. Ser. A"}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21003116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X21003116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:49:28Z","timestamp":1758937768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X21003116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":51,"alternative-id":["S0145305X21003116"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2021.104303","relation":{},"ISSN":["0145-305X"],"issn-type":[{"type":"print","value":"0145-305X"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mitochondrial activity of leukocytes from Artibeus jamaicensis bats remains unaltered after several weeks of flying restriction","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2021.104303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104303"}}