{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:39:29Z","timestamp":1790393969853,"version":"4.1.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.dci.2022.104339","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T11:11:52Z","timestamp":1641381112000},"page":"104339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Perkinsus marinus suppresses in vitro eastern oyster apoptosis via IAP-dependent and caspase-independent pathways involving TNFR, NF-kB, and oxidative pathway crosstalk"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-7334","authenticated-orcid":false,"given":"Erin M.","family":"Witkop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary H.","family":"Wikfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-0078","authenticated-orcid":false,"given":"Dina A.","family":"Proestou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn Markey","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gomez-Chiarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2022.104339_bib1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1645\/GE-1864.1","article-title":"Development of an in vitro assay to examine intracellular survival of Perkinsus marinus trophozoites upon phagocytosis by oyster (Crassostrea virginica and Crassostrea ariakensis) hemocytes","volume":"95","author":"Alavi","year":"2009","journal-title":"J. Parasitol."},{"key":"10.1016\/j.dci.2022.104339_bib2","series-title":"topGO: Enrichment Analysis for Gene Ontology","author":"Alexa","year":"2019"},{"key":"10.1016\/j.dci.2022.104339_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jip.2012.12.011","article-title":"Early host-pathogen interactions in marine bivalves: evidence that the alveolate parasite Perkinsus marinus infects through the oyster mantle during rejection of pseudofeces","volume":"113","author":"Allam","year":"2013","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.dci.2022.104339_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/fsim.1998.0174","article-title":"Perkinsus marinus secretory products modulate superoxide anion production by oyster (Crassostrea virginica) haemocytes","volume":"9","author":"Anderson","year":"1999","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib5","article-title":"Increased reactive oxygen intermediate production by hemocytes withdrawn from Crassostrea virginica infected with Perkinsus marinus","volume":"183","author":"Anderson","year":"1992","journal-title":"Ref. Biol. Bull"},{"key":"10.1016\/j.dci.2022.104339_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13567-018-0567-1","article-title":"Endonuclease G takes part in AIF-mediated caspase-independent apoptosis in Mycobacterium bovis-infected bovine macrophages","volume":"49","author":"Ben\u00edtez-Guzm\u00e1n","year":"2018","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2022.104339_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.dci.2022.104339_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3354\/meps139127","article-title":"Host-parasite interactions among broadly distributed populations of the eastern oyster Crassostrea virginica and the protozoan Perkinsus marinus","volume":"139","author":"Bushek","year":"1996","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.dci.2022.104339_bib9","unstructured":"Bushnell, B., 2014. BBMap: A Fast, Accurate, Splice-Aware Aligner. Accessed through https:\/\/sourceforge.net\/projects\/bbmap\/."},{"key":"10.1016\/j.dci.2022.104339_bib98","series-title":"Oxidative stress in microbial diseases, oxidative stress in microbial diseases","author":"Chakraborti","year":"2019"},{"key":"10.1016\/j.dci.2022.104339_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aquatox.2012.02.023","article-title":"Immunomodulation in eastern oysters, Crassostrea virginica, exposed to a PAH-contaminated, microphytobenthic diatom","volume":"118\u2013119","author":"Croxton","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.dci.2022.104339_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2014.00153","article-title":"Transport proteins of parasitic protists and their role in nutrient salvage","volume":"5","author":"Dean","year":"2014","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.dci.2022.104339_bib13","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1158\/1078-0432.CCR-16-2172","article-title":"Therapeutic small molecules target inhibitor of apoptosis proteins in cancers with deregulation of extrinsic and intrinsic cell death pathways","volume":"23","author":"Derakhshan","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.dci.2022.104339_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2016.00256","article-title":"Infection strategies of intestinal parasite pathogens and host cell responses","volume":"7","author":"Di Genova","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.dci.2022.104339_bib15","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.cdd.4400594","article-title":"Caspase inhibitors","volume":"6","author":"Ekert","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.dci.2022.104339_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/toxsci\/kfs265","article-title":"Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-\u03b1 pharmacology","volume":"131","author":"Erickson","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dci.2022.104339_bib17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.semcdb.2014.03.035","article-title":"IAPs, regulators of innate immunity and inflammation","volume":"39","author":"Estornes","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.dci.2022.104339_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0305-0491(99)00088-7","article-title":"Isolation and characterization of Perkinsus marinus proteases using bacitracin-sepharose affinity chromatography","volume":"123","author":"Faisal","year":"1999","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2022.104339_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2008.07.162","article-title":"Perkinsus marinus superoxide dismutase 2 (PmSOD2) localizes to single-membrane subcellular compartments","volume":"375","author":"Fern\u00e1ndez-Robledo","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dci.2022.104339_bib20","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1021\/jm300060k","article-title":"Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)","volume":"55","author":"Flygare","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.dci.2022.104339_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3354\/dao051187","article-title":"Comparison of in vitro-cultured and wild-type Perkinsus marinus. I. pathogen virulence","volume":"51","author":"Ford","year":"2002","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.dci.2022.104339_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.immuni.2016.01.020","article-title":"Caspases connect cell-death signaling to organismal homeostasis","volume":"44","author":"Galluzzi","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2022.104339_bib23","series-title":"Advances in Comparative Immunology","first-page":"225","article-title":"Immunity in molluscs: recognition and effector mechanisms, with a focus on Bivalvia","author":"Gerdol","year":"2018"},{"key":"10.1016\/j.dci.2022.104339_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-29776-x","article-title":"Molecular and cellular characterization of apoptosis in flat oyster a key mechanisms at the heart of host-parasite interactions","volume":"8","author":"Gervais","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dci.2022.104339_bib25","first-page":"487","article-title":"Immunomodulation of Crassostrea gigas and Crassostrea virginica cellular defense mechanism by Perkinsus marinus","volume":"24","author":"Goedken","year":"2005","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.dci.2022.104339_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2983\/0730-8000(2005)24[177:TEOTAS]2.0.CO;2","article-title":"The effects of temperature and salinity on apoptosis of Crassostrea virginica hemocytes and Perkinsus marinus","volume":"24","author":"Goedken","year":"2005","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.dci.2022.104339_bib27","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.dci.2022.104339_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.fsi.2012.05.028","article-title":"Mutation in promoter region of a serine protease inhibitor confers Perkinsus marinus resistance in the eastern oyster (Crassostrea virginica)","volume":"33","author":"He","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-0981(03)00235-1","article-title":"Flow cytometric analysis of haemocytes from eastern oysters, Crassostrea virginica, subjected to a sudden temperature elevation II. Haemocyte functions: aggregation, viability, phagocytosis, and respiratory burst","volume":"293","author":"H\u00e9garet","year":"2003","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.dci.2022.104339_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-0981(03)00236-3","article-title":"Flow-cytometric analysis of haemocytes from eastern oysters, Crassostrea virginica, subjected to a sudden temperature elevation I. Haemocyte types and morphology","volume":"293","author":"H\u00e9garet","year":"2003","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.dci.2022.104339_bib31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/mmi.13245","article-title":"Interference with nuclear factor kappaB signaling pathway by pathogen-encoded proteases: global and selective inhibition","volume":"99","author":"Hodgson","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.dci.2022.104339_bib32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s13277-014-2648-8","article-title":"GDC-0152 induces apoptosis through down-regulation of IAPs in human leukemia cells and inhibition of PI3K\/Akt signaling pathway","volume":"36","author":"Hu","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.dci.2022.104339_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fsi.2010.03.003","article-title":"Apoptosis as a host defense mechanism in Crassostrea virginica and its modulation by Perkinsus marinus","volume":"29","author":"Hughes","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib34","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.molcel.2015.01.018","article-title":"Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death","volume":"57","author":"Ichim","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.dci.2022.104339_bib35","doi-asserted-by":"crossref","first-page":"102368","DOI":"10.1016\/j.parint.2021.102368","article-title":"Toxoplasma gondii manipulates host cell signaling pathways via its secreted effector molecules","volume":"83","author":"Ihara","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.dci.2022.104339_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-11-228","article-title":"The alveolate Perkinsus marinus: biological insights from EST gene discovery","volume":"11","author":"Joseph","year":"2010","journal-title":"BMC Genom."},{"key":"10.1016\/j.dci.2022.104339_bib37","first-page":"357","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2016","journal-title":"Daehwan"},{"key":"10.1016\/j.dci.2022.104339_bib38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10495-009-0446-3","article-title":"Apoptosis and its functional significance in molluscs","volume":"15","author":"Kiss","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.dci.2022.104339_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0145-305X(95)00017-N","article-title":"In vitro interaction of Perkinsus marinus merozoites with eastern and pacific oyster hemocytes","volume":"19","author":"La Peyre","year":"1995","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib40","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.dci.2009.08.007","article-title":"Serine protease inhibitor cvSI-1 potential role in the eastern oyster host defense against the protozoan parasite Perkinsus marinus","volume":"34","author":"La Peyre","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.dci.2022.104339_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1001057","article-title":"Is my network module preserved and reproducible?","volume":"7","author":"Langfelder","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.dci.2022.104339_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2018.04.019","article-title":"Regulation of oyster (Crassostrea virginica) hemocyte motility by the intracellular parasite Perkinsus marinus : a possible mechanism for host infection","author":"Lau","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.fsi.2018.09.006","article-title":"Regulation of apoptosis-related genes during interactions between oyster hemocytes and the alveolate parasite Perkinsus marinus","volume":"83","author":"Lau","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib45","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.dci.2022.104339_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2019.01081","article-title":"Identification of hub genes and key pathways associated with bipolar disorder based on weighted gene Co-expression network analysis","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.dci.2022.104339_bib96","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fcimb.2019.00103","article-title":"Mechanisms of human innate immune evasion by Toxoplasma gondii","volume":"9","author":"Lodoen","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.dci.2022.104339_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.dci.2022.104339_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6152489","article-title":"Toxoplasma gondii modulates the host cell responses: an overview of apoptosis pathways","author":"Mammari","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.dci.2022.104339_bib50","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.gene.2013.09.085","article-title":"Molecular characterisation of TNF, AIF, dermatopontin and VAMP genes of the flat oyster Ostrea edulis and analysis of their modulation by diseases","volume":"533","author":"Mart\u00edn-G\u00f3mez","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.dci.2022.104339_bib51","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/IAI.68.3.1710-1713.2000","article-title":"Intestinal epithelial cell apoptosis following Cryptosporidium parrum infection","volume":"68","author":"Mccole","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2022.104339_bib52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.dci.2022.104339_bib53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/IAI.70.1.55-61.2002","article-title":"Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection","volume":"70","author":"Perfettini","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2022.104339_bib54","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA- seq experiments with HISAT , StringTie and Transcript-level expression analysis of RNA-seq experiments with HISAT , StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.dci.2022.104339_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jgar.2019.01.023","article-title":"Drug resistance in Protozoan parasites: an incessant wrestle for survival","volume":"18","author":"Pramanik","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.dci.2022.104339_bib56","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fsi.2019.12.001","article-title":"Variation in global transcriptomic response to Perkinsus marinus infection among eastern oyster families highlights potential mechanisms of disease resistance","volume":"96","author":"Proestou","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib95","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1111\/are.14095","article-title":"Defining Dermo resistance phenotypes in an eastern oyster breeding population","volume":"50","author":"Proestou","year":"2019","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.dci.2022.104339_bib76","series-title":"RStudio: Integrated Development for R","year":"2020"},{"key":"10.1016\/j.dci.2022.104339_bib58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2020.09.026","article-title":"Both quiescent and proliferating cells circulate in the blood of the invasive apple snail Pomacea canaliculata","volume":"107","author":"Rodriguez","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib59","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.fsi.2015.03.038","article-title":"The complexity of apoptotic cell death in mollusks: an update","volume":"46","author":"Romero","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ydbio.2018.10.015","article-title":"IAP genes partake weighty roles in the astogeny and whole body regeneration in the colonial urochordate Botryllus schlosseri","volume":"448","author":"Rosner","year":"2019","journal-title":"Dev. Biol."},{"key":"10.1016\/j.dci.2022.104339_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.00808-19","article-title":"Toxoplasma GRA15 activates the NF-Kb pathway through interactions with TNF receptor-associated factors","volume":"10","author":"Sangar\u00e9","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.dci.2022.104339_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.00808-19","article-title":"Toxoplasma GRA15 activates the NF-Kb pathway through interactions with TNF receptor-associated factors","volume":"10","author":"Sangar\u00e9","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.dci.2022.104339_bib63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.molbiopara.2009.05.005","article-title":"The role of ATP-binding cassette (ABC) proteins in protozoan parasites","volume":"167","author":"Sauvage","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.dci.2022.104339_bib97","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.exppara.2003.12.012","article-title":"The protistan parasite Perkinsus marinus is resistant to selected reactive oxygen species","volume":"105","author":"Schott","year":"2003","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.dci.2022.104339_bib65","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.dci.2022.104339_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0006512","article-title":"Cysteine proteases in protozoan parasites","volume":"12","author":"Siqueira-Neto","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.dci.2022.104339_bib67","series-title":"A review of current state of knowledge concerning Perkinsus marinus effects on Crassostrea virginica (Gmelin) (the Eastern Oyster)","first-page":"404","volume":"50","author":"Smolowitz","year":"2013"},{"key":"10.1016\/j.dci.2022.104339_bib68","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jip.2013.06.001","article-title":"Host \u2013 parasite interactions : marine bivalve molluscs and protozoan parasites , Perkinsus species","volume":"114","author":"Soudant","year":"2013","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.dci.2022.104339_bib69","doi-asserted-by":"crossref","first-page":"736831","DOI":"10.1016\/j.aquaculture.2021.736831","article-title":"Survival and transcriptomic responses to different Perkinsus marinus exposure methods in an Eastern oyster family","volume":"542","author":"Sullivan","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2022.104339_bib70","first-page":"3355","article-title":"A molecular signature for anastasis, recovery from the brink of apoptotic cell death","volume":"216","author":"Sun","year":"2017","journal-title":"bioRxiv"},{"key":"10.1016\/j.dci.2022.104339_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"Revigo summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2022.104339_bib72","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1038\/onc.2008.311","article-title":"Caspase-independent cell death: leaving the set without the final cut","volume":"27","author":"Tait","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.dci.2022.104339_bib73","article-title":"Anastasis: recovery from the brink of cell death","volume":"5","author":"Tang","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"10.1016\/j.dci.2022.104339_bib74","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.4049\/jimmunol.179.5.3086","article-title":"A galectin of unique domain organization from hemocytes of the eastern oyster (Crassostrea virginica) is a receptor for the protistan parasite Perkinsus marinus","volume":"179","author":"Tasumi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddis.2016.214","article-title":"Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152","volume":"7","author":"Tchoghandjian","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.dci.2022.104339_bib78","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/icb.2016.118","article-title":"Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins","volume":"95","author":"Vasilikos","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.dci.2022.104339_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103721","article-title":"Galectin-mediated immune recognition: opsonic roles with contrasting outcomes in selected shrimp and bivalve mollusk species","author":"Vasta","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fchem.2020.00098","article-title":"Biochemical characterization of oyster and clam galectins: selective recognition of carbohydrate ligands on host hemocytes and Perkinsus parasites","volume":"8","author":"Vasta","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.dci.2022.104339_bib81","series-title":"Redox Signaling and the Onset of the Inflammatory Cascade, Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support","author":"Vazquez-Medina","year":"2017"},{"key":"10.1016\/j.dci.2022.104339_bib82","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0145-305X(94)00059-O","article-title":"Suppression of chemiluminescence of eastern oyster (Crassostrea virginica) hemocytes by the protozoan parasite Perkinsus marinus","volume":"19","author":"Volety","year":"1995","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib83","first-page":"15","article-title":"Granular hemocytes are phagocytic, but agranular hemocytes are not, in the Eastern Oyster Crassostrea virginica","volume":"1","author":"Wikfors","year":"2014","journal-title":"Invertebr. Immun."},{"key":"10.1016\/j.dci.2022.104339_bib84","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/MCB.01065-07","article-title":"Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP","volume":"28","author":"Wilkinson","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.dci.2022.104339_bib85","unstructured":"Witkop, E.M., Proestou, D.A., G\u00f3mez-Chiarri, M., n.d. The expanded Inhibitor of Apoptosis gene family in oysters possesses novel domain architectures and may play diverse roles in apoptosis following immune challenge. Press. BMC Genom.."},{"key":"10.1016\/j.dci.2022.104339_bib86","doi-asserted-by":"crossref","first-page":"107214","DOI":"10.1016\/j.jip.2019.107214","article-title":"Pathogen proteases and host protease inhibitors in molluscan infectious diseases","volume":"166","author":"Xue","year":"2019","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.dci.2022.104339_bib87","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cbpb.2006.05.010","article-title":"A novel slow-tight binding serine protease inhibitor from eastern oyster (Crassostrea virginica) plasma inhibits perkinsin, the major extracellular protease of the oyster protozoan parasite Perkinsus marinus","volume":"145","author":"Xue","year":"2006","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2022.104339_bib88","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.fsi.2009.05.006","article-title":"Evidence indicating the existence of a novel family of serine protease inhibitors that may be involved in marine invertebrate immunity","volume":"27","author":"Xue","year":"2009","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.dci.2022.104339_bib89","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.pt.2020.05.002","article-title":"Perkinsus marinus","volume":"36","author":"Yadavalli","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.dci.2022.104339_bib90","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ijpara.2010.11.012","article-title":"Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells","volume":"41","author":"Yamada","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.dci.2022.104339_bib91","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/08830185.2020.1768251","article-title":"Reactive oxygen species and immune regulation","volume":"39","author":"Yang","year":"2020","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.dci.2022.104339_bib92","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2983\/0730-8000(2005)24[1035:AOTPOP]2.0.CO;2","article-title":"Apoptosis of the protozoan oyster pathogen Perkinsus marinus in vivo and in vitro in the Chesapeake Bay and the long island sound","volume":"24","author":"Yee","year":"2005","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.dci.2022.104339_bib93","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.taap.2004.01.018","article-title":"Mechanisms that regulate production of reactive oxygen species by cytochrome P450","volume":"199","author":"Zangar","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.dci.2022.104339_bib94","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/bioinformatics\/bty895","article-title":"Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences","volume":"35","author":"Zhu","year":"2018","journal-title":"Bioinformatics"}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X22000015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X22000015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:46:10Z","timestamp":1758937570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X22000015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":93,"alternative-id":["S0145305X22000015"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2022.104339","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perkinsus marinus suppresses in vitro eastern oyster apoptosis via IAP-dependent and caspase-independent pathways involving TNFR, NF-kB, and oxidative pathway crosstalk","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2022.104339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104339"}}