{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:42:23Z","timestamp":1785199343730,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.dci.2023.104915","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T11:12:32Z","timestamp":1692011552000},"page":"104915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["hnRNPM suppressed IRF7-mediated IFN signaling in the antiviral innate immunity in triploid hybrid fish"],"prefix":"10.1016","volume":"148","author":[{"given":"Huijuan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibin","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianle","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2023.104915_bib34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1099\/jgv.0.000436","article-title":"Spring viraemia of carp virus: recent advances","volume":"97","author":"Ashraf","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.dci.2023.104915_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007983","article-title":"The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors","volume":"15","author":"Cao","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.dci.2023.104915_bib2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4049\/jimmunol.2100125","article-title":"Zebrafish Uba1 degrades IRF3 through K48-linked ubiquitination to inhibit IFN production","volume":"207","author":"Chen","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11427-009-0079-3","article-title":"Biological characteristics of an improved triploid crucian carp","volume":"52","author":"Chen","year":"2009","journal-title":"Sci. China, Ser. A C"},{"key":"10.1016\/j.dci.2023.104915_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/imm.12714","article-title":"Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current 478 knowledge and future perspectives","volume":"151","author":"Chen","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2023.104915_bib4","article-title":"Grass carp (Ctenopharyngodon idella) KAT8 inhibits IFN 1 response through acetylating IRF3\/IRF7","volume":"12","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib5","doi-asserted-by":"crossref","first-page":"10728","DOI":"10.1128\/JVI.01381-16","article-title":"The P protein of spring viremia of carp virus negatively regulates the fish interferon response by inhibiting the kinase activity of TANK-binding kinase 1","volume":"90","author":"Li","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.dci.2023.104915_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/v10030127","article-title":"Cellular hnRNP A1 interacts with nucleocapsid protein of porcine epidemic diarrhea virus and impairs viral replication","volume":"10","author":"Li","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.dci.2023.104915_bib6","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.4049\/jimmunol.1101704","article-title":"Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7","volume":"187","author":"Liang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11427-010-0057-9","article-title":"Distant hybridization leads to different ploidy fishes","volume":"53","author":"Liu","year":"2010","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.dci.2023.104915_bib8","doi-asserted-by":"crossref","first-page":"aaa2630","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.dci.2023.104915_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738087","article-title":"DDX19 inhibits RLR\/IRF3 mediated type I interferon signaling of black carp Mylopharyngodon piceus by restricting IRF3 from entering nucleus","volume":"553","author":"Liu","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2023.104915_bib10","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.4049\/jimmunol.1502038","article-title":"Spring viremia of carp virus N protein suppresses fish IFN\u03c61 production by targeting the mitochondrial antiviral signaling protein","volume":"196","author":"Lu","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01272-19","article-title":"Zebrafish RPZ5 degrades phosphorylated IRF7 to repress interferon production","volume":"93","author":"Lu","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.dci.2023.104915_bib12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41423-020-00602-7","article-title":"Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors","volume":"18","author":"Onomoto","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib13","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200316R","article-title":"E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7","volume":"36","author":"Qi","year":"2022","journal-title":"Faseb. J."},{"key":"10.1016\/j.dci.2023.104915_bib14","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.4049\/jimmunol.2100086","article-title":"RACK1 T50 phosphorylation by AMPK potentiates its binding with IRF3\/7 and inhibition of type 1 IFN production","volume":"207","author":"Qin","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01555-22","article-title":"hnRNP K degrades viral nucleocapsid protein and induces type I IFN production to inhibit porcine epidemic diarrhea virus replication","volume":"96","author":"Qin","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.dci.2023.104915_bib16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s41577-020-0288-3","article-title":"RIG-I-like receptors: their regulation and roles in RNA sensing","volume":"20","author":"Rehwinkel","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/gcc.22463","article-title":"HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases: HNRNPM, CD44S, and Breast Cancer with Axillary LNM","volume":"56","author":"Sun","year":"2017","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.dci.2023.104915_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.762162","article-title":"Fish paralog proteins RNASEK-a and -b enhance type I interferon secretion and promote apoptosis","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113613","article-title":"Interaction of influenza A nucleoprotein with host hnRNP-C is implicated in viral replication","volume":"23","author":"Tang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2023.104915_bib20","article-title":"Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4049\/jimmunol.2200477","article-title":"Spring viremia of carp virus N protein negatively regulates IFN induction through autophagy-lysosome-dependent degradation of STING","volume":"210","author":"Wang","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00791-22","article-title":"Negative regulatory role of the spring viremia of carp virus matrix protein in the host interferon response by targeting the MAVS\/TRAF3 signaling Axis","volume":"96","author":"Wang","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.dci.2023.104915_bib23","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.celrep.2019.01.030","article-title":"The EF-hand protein CALML6 suppresses antiviral innate immunity by impairing IRF3 dimerization","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.dci.2023.104915_bib24","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.celrep.2019.09.078","article-title":"The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages","volume":"29","author":"West","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.dci.2023.104915_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fsi.2019.03.044","article-title":"MAVS of triploid hybrid of red crucian carp and allotetraploid possesses the improved antiviral activity compared with the counterparts of its parents","volume":"89","author":"Xiao","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.dci.2018.07.007","article-title":"Establishment of fin cell lines and their use to study the immune gene expression in cyprinid fishes with different ploidy in rhabdovirus infection","volume":"88","author":"Xiao","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104294","article-title":"Identification and comparative study of melanoma differentiation-associated gene 5 homologues of triploid hybrid fish and its parents","volume":"127","author":"Xiao","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2023.104915_bib28","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1101\/gad.241968.114","article-title":"Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing","volume":"28","author":"Xu","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.dci.2023.104915_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738872","article-title":"PRMT6 inhibits K63-linked ubiquitination and promotes the degradation of IRF3 in the antiviral innate immunity of black carp Mylopharyngodon piceus","volume":"562","author":"Yang","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2023.104915_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.999219","article-title":"PRKX down-regulates TAK1\/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus","volume":"13","author":"Yang","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X23010686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X23010686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:50:54Z","timestamp":1758937854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X23010686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":33,"alternative-id":["S0145305X23010686"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2023.104915","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"hnRNPM suppressed IRF7-mediated IFN signaling in the antiviral innate immunity in triploid hybrid fish","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2023.104915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104915"}}