{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:56:51Z","timestamp":1782345411936,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.dci.2024.105261","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:38:44Z","timestamp":1725521924000},"page":"105261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["First report of a chemokine from camelids: Dromedary CXCL8 is induced by poxvirus and heavy metal toxicity"],"prefix":"10.1016","volume":"161","author":[{"given":"Avinash","family":"Premraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abi George","family":"Aleyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita","family":"Nautiyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-2549","authenticated-orcid":false,"given":"Thaha Jamal","family":"Rasool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2024.105261_bib1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/life13030732","article-title":"Heavy metals levels in Soil, water and feed and relation to slaughtered camels\u2019 tissues (Camelus dromedarius) from five districts in Saudi Arabia during spring","volume":"13","author":"Abdelrahman","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.dci.2024.105261_bib2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1473-3099(22)00662-4","article-title":"Immunological signature in human cases of monkeypox infection in 2022 outbreak: an observational study","volume":"23","author":"Agrati","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.dci.2024.105261_bib3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3390\/ani12060707","article-title":"Heavy metal accumulation, tissue injury, oxidative stress, and inflammation in dromedary camels living near petroleum industry sites in Saudi Arabia","volume":"12","author":"Ajarem","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.dci.2024.105261_bib4","series-title":"Proceedings of 4th Conference of ISOCARD \u201cSilk Road Camel: the Camelids, Main Stakes for Sustainable Development.\u201d Special Issue of Scientific and Practical Jourmal Veterinariya #2 (42) 2015","first-page":"95","article-title":"Development of camel renal cell line using different immortalizing agents","author":"Aleyas","year":"2015"},{"key":"10.1016\/j.dci.2024.105261_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154895","article-title":"MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines\/chemokines and elevated inflammatory innate immune response in the lower respiratory tract","volume":"126","author":"Alosaimi","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.dci.2024.105261_bib6","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1182\/blood.V82.8.2371.2371","article-title":"Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells","volume":"82","author":"Aman","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.dci.2024.105261_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008077","article-title":"Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation","volume":"15","author":"Ang","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.dci.2024.105261_bib8","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051280","article-title":"Toll\u2010like receptor 4 is activated by platinum and contributes to cisplatin\u2010induced ototoxicity","volume":"22","author":"Babolmorad","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.dci.2024.105261_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s13337-013-0145-0","article-title":"Camelpox, an emerging orthopox viral disease","volume":"24","author":"Balamurugan","year":"2013","journal-title":"Indian J. Virol."},{"key":"10.1016\/j.dci.2024.105261_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.vetmic.2011.04.010","article-title":"Zoonotic cases of camelpox infection in India","volume":"152","author":"Bera","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2024.105261_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.virusres.2012.11.013","article-title":"Cowpox virus but not Vaccinia virus induces secretion of CXCL1, IL-8 and IL-6 and chemotaxis of monocytes in vitro","volume":"171","author":"Bourquain","year":"2013","journal-title":"Virus Res."},{"key":"10.1016\/j.dci.2024.105261_bib12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41423-023-00974-6","article-title":"The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention","volume":"20","author":"Cambier","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib13","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/toxsci\/kfr310","article-title":"An NF-\u03baB\u2013independent and Erk1\/2-dependent mechanism controls CXCL8\/IL-8 responses of airway epithelial cells to Cadmium","volume":"125","author":"Cormet-Boyaka","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dci.2024.105261_bib14","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3109\/17453674.2010.537806","article-title":"Cobalt ions induce chemokine secretion in a variety of systemic cell lines","volume":"81","author":"Devitt","year":"2010","journal-title":"Acta Orthop."},{"key":"10.1016\/j.dci.2024.105261_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/taap.1998.8481","article-title":"Toxic metals stimulate inflammatory cytokines in hepatocytes through oxidative stress mechanisms","volume":"151","author":"Dong","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.dci.2024.105261_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3390\/pathogens12030363","article-title":"Orthopoxvirus Zoonoses\u2014do we still remember and are ready to fight?","volume":"13","author":"Giery\u0144ska","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.dci.2024.105261_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.imlet.2008.07.002","article-title":"LPS induces inflammatory responses in human aortic vascular smooth muscle cells via Toll-like receptor 4 expression and nitric oxide production","volume":"120","author":"Heo","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.dci.2024.105261_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.614150","article-title":"Recent advances in camel immunology","volume":"11","author":"Hussen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.smallrumres.2020.106050","article-title":"Evaluation of global expression of selected genes as potential candidates for internal normalizing control during transcriptome analysis in dromedary camel (Camelus dromedarius)","volume":"184","author":"Ibrahim","year":"2020","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.dci.2024.105261_bib20","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s00705-020-04730-3","article-title":"Gene expression pattern differences in primary human pulmonary epithelial cells infected with MERS-CoV or SARS-CoV-2","volume":"165","author":"Jang","year":"2020","journal-title":"Arch. Virol."},{"key":"10.1016\/j.dci.2024.105261_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/19393210.2024.2326917","article-title":"Toxic metal levels in raw camel milk sold in the northern Algerian Sahara","volume":"17","author":"Kerdoun","year":"2024","journal-title":"Food Addit. Contam. Part B"},{"key":"10.1016\/j.dci.2024.105261_bib22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/vbz.2016.2070","article-title":"Human and dromedary camel infection with Camelpox virus in Eastern Sudan","volume":"17","author":"Khalafalla","year":"2017","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.dci.2024.105261_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/toxsci\/kfu096","article-title":"Identification of noninvasive biomarkers for nephrotoxicity using HK-2 Human kidney epithelial cells","volume":"140","author":"Kim","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dci.2024.105261_bib24","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1021\/bi972867o","article-title":"Identification of a glycosaminoglycan binding surface on Human interleukin-8","volume":"37","author":"Kuschert","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.dci.2024.105261_bib25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1039\/c3tx50042j","article-title":"An in vitro method for the prediction of renal proximal tubular toxicity in humans","volume":"2","author":"Li","year":"2013","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.dci.2024.105261_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0021-9258(17)42316-7","article-title":"Regulation of interleukin-8 expression in porcine alveolar macrophages by bacterial lipopolysaccharide","volume":"269","author":"Lin","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2024.105261_bib27","first-page":"5300","article-title":"Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-\u03baB site","volume":"14","author":"Oliveira","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.dci.2024.105261_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2023.104754","article-title":"Viperin from the dromedary camel: first report of an antiviral interferon-responsive gene from camelids","volume":"147","author":"Premraj","year":"2023","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib29","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.molimm.2022.12.003","article-title":"Novel type-I interferons from the dromedary camel: molecular identification, prokaryotic expression and functional characterization of camelid interferon-delta","volume":"153","author":"Premraj","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104443","article-title":"Beta interferons from the extant camelids: unique among eutherian mammals","volume":"133","author":"Premraj","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.molimm.2020.01.020","article-title":"Camelid type I interferons: identification and functional characterization of interferon alpha from the dromedary camel (Camelus dromedarius)","volume":"119","author":"Premraj","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.molimm.2015.06.022","article-title":"Identification of interleukin-26 in the dromedary camel (Camelus dromedarius): evidence of alternative splicing and isolation of novel splice variants","volume":"67","author":"Premraj","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/cod.12042","article-title":"Transition metal sensing by Toll\u2010like receptor\u20104: next to nickel, cobalt and palladium are potent human dendritic cell stimulators","volume":"68","author":"Rachmawati","year":"2013","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.dci.2024.105261_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/1744666X.2014.894886","article-title":"The CXCL8\/IL-8 chemokine family and its receptors in inflammatory diseases","volume":"10","author":"Russo","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.dci.2024.105261_bib35","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/biomedicines9081033","article-title":"In vitro nephrotoxicity studies of established and experimental platinum-based compounds","volume":"9","author":"Schoch","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.dci.2024.105261_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003756","article-title":"An increasing danger of Zoonotic Orthopoxvirus infections","volume":"9","author":"Shchelkunov","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.dci.2024.105261_bib37","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1046\/j.1365-2052.2002.00938_3.x","article-title":"Genomic structure of the porcine Interleukin 8 gene and development of a microsatellite marker within intron 1","volume":"33","author":"Shimanuki","year":"2002","journal-title":"Anim. Genet."},{"key":"10.1016\/j.dci.2024.105261_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2015.05.014","article-title":"Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells","volume":"237","author":"Singh","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.dci.2024.105261_bib39","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0006-291X(87)90432-3","article-title":"Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes","volume":"149","author":"Walz","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dci.2024.105261_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1515\/jvetres-2016-0036","article-title":"Parapoxvirus orf virus infection induces an increase in interleukin-8, tumour necrosis factor-\u03b1, and decorin in goat skin fibroblast cells","volume":"60","author":"Wang","year":"2016","journal-title":"J. Vet. Res."},{"key":"10.1016\/j.dci.2024.105261_bib41","doi-asserted-by":"crossref","first-page":"20861","DOI":"10.1074\/jbc.M002896200","article-title":"Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4: MD-2 is required for activation of mitogen-activated protein kinases and Elk-1","volume":"275","author":"Yang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2024.105261_bib42","doi-asserted-by":"crossref","first-page":"9233","DOI":"10.1073\/pnas.84.24.9233","article-title":"Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines","volume":"84","author":"Yoshimura","year":"1987","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dci.2024.105261_bib43","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1046\/j.1365-2567.2001.01189.x","article-title":"The 3\u2032\u2010untranslated region of human interleukin\u20108 mRNA suppresses IL\u20108 gene expression","volume":"102","author":"Yu","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2024.105261_bib44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12917-024-03882-7","article-title":"Impact of grazing around industrial areas on milk heavy metals contamination and reproductive ovarian hormones of she-camel with assessment of some technological processes on reduction of toxic residue concentrations","volume":"20","author":"Zakaria","year":"2024","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.dci.2024.105261_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X24001332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X24001332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T18:57:38Z","timestamp":1726772258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X24001332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"alternative-id":["S0145305X24001332"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2024.105261","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First report of a chemokine from camelids: Dromedary CXCL8 is induced by poxvirus and heavy metal toxicity","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2024.105261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105261"}}