{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:00:15Z","timestamp":1777777215769,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000199","name":"US Department of Agriculture","doi-asserted-by":"publisher","award":["2019-05906"],"award-info":[{"award-number":["2019-05906"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.dci.2024.105298","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T12:36:53Z","timestamp":1733315813000},"page":"105298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Ontogeny of the organized nasopharynx-associated lymphoid tissue in rainbow trout"],"prefix":"10.1016","volume":"162","author":[{"given":"Benjamin J.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narmin","family":"Musayeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysler","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yago","family":"Serra dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-6571","authenticated-orcid":false,"given":"Irene","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2024.105298_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.dci.2017.06.013","article-title":"The interbranchial lymphoid tissue likely contributes to immune tolerance and defense in the gills of Atlantic salmon","volume":"76","author":"Aas","year":"2017","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.dci.2014.02.007","article-title":"Transcriptional response of immune genes in gills and the interbranchial lymphoid tissue of Atlantic salmon challenged with infectious salmon anaemia virus","volume":"45","author":"Austbo","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib3","series-title":"Principles of Fish Immunology : from Cells and Molecules to Host Protection","first-page":"495","article-title":"The ontogeny of the fish immune system","author":"Buchmann","year":"2022"},{"key":"10.1016\/j.dci.2024.105298_bib50","doi-asserted-by":"crossref","first-page":"109371","DOI":"10.1016\/j.fsi.2024.109371","article-title":"The early ontogenetic development of immune cells and organs in teleosts","volume":"146","author":"Buchmann","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/jmor.20403","article-title":"The interbranchial lymphoid tissue of Atlantic Salmon (Salmo salar L) extends as a diffuse mucosal lymphoid tissue throughout the trailing edge of the gill filament","volume":"276","author":"Dalum","year":"2015","journal-title":"J. Morphol."},{"key":"10.1016\/j.dci.2024.105298_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fsi.2016.09.013","article-title":"Morphological and functional development of the interbranchial lymphoid tissue (ILT) in Atlantic salmon (Salmo salar L)","volume":"58","author":"Dalum","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.769901","article-title":"High-resolution, 3D imaging of the zebrafish gill-associated lymphoid tissue (GIALT) reveals a novel lymphoid structure, the amphibranchial lymphoid tissue","volume":"12","author":"Dalum","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/intimm\/dxx064","article-title":"NALT M cells are important for immune induction for the common mucosal immune system","volume":"29","author":"Date","year":"2017","journal-title":"Int. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/eji.1830130706","article-title":"Lymphocyte heterogeneity in the trout, Salmo gairdneri, defined with monoclonal antibodies to IgM","volume":"13","author":"DeLuca","year":"1983","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fsi.2004.05.006","article-title":"The ontogeny of MHC class I expression in rainbow trout (Oncorhynchus mykiss)","volume":"18","author":"Fischer","year":"2005","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1074-7613(02)00339-4","article-title":"Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells","volume":"17","author":"Fukuyama","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2024.105298_bib12","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.4049\/jimmunol.2200396","article-title":"A novel organized nasopharynx-associated lymphoid tissue in teleosts that expresses molecular markers characteristic of mammalian germinal centers","volume":"209","author":"Garcia","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.1500322","article-title":"Identification of teleost skin CD8alpha+ dendritic-like cells, representing a potential common ancestor for mammalian cross-presenting dendritic cells","volume":"195","author":"Granja","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0145-305X(03)00028-4","article-title":"Immunoglobulin producing cells in the spotted wolffish (Anarhichas minor Olafsen): localization in adults and during juvenile development","volume":"27","author":"Grontvedt","year":"2003","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib15","doi-asserted-by":"crossref","first-page":"986","DOI":"10.4049\/jimmunol.168.3.986","article-title":"Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent","volume":"168","author":"Harmsen","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1469-7580.2008.00943.x","article-title":"Identification and characterization of a novel intraepithelial lymphoid tissue in the gills of Atlantic salmon","volume":"213","author":"Haugarvoll","year":"2008","journal-title":"J. Anat."},{"key":"10.1016\/j.dci.2024.105298_bib17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nri1439","article-title":"NALT- versus Peyer's-patch-mediated mucosal immunity","volume":"4","author":"Kiyono","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib18","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1469-7580.2010.01305.x","article-title":"Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue","volume":"217","author":"Koppang","year":"2010","journal-title":"J. Anat."},{"key":"10.1016\/j.dci.2024.105298_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fimmu.2012.00024","article-title":"Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?","volume":"3","author":"Lane","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib21","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/joa.13147","article-title":"A teleost structural analogue to the avian bursa of Fabricius","volume":"236","author":"Loken","year":"2020","journal-title":"J. Anat."},{"key":"10.1016\/j.dci.2024.105298_bib22","first-page":"23","article-title":"Phylogeny of the mucosal immune system, principles of mucosal immunology","author":"Miller","year":"2020","journal-title":"Garland Science"},{"key":"10.1016\/j.dci.2024.105298_bib25","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dci.2024.105298_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s004290050113","article-title":"Expression of lymphocyte antigenic determinants in developing gut-associated lymphoid tissue of the sea bass Dicentrarchus labrax (L.)","volume":"196","author":"Picchietti","year":"1997","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.dci.2024.105298_bib27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1146\/annurev.immunol.26.021607.090257","article-title":"Development of secondary lymphoid organs","volume":"26","author":"Randall","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1095-8649.1990.tb05592.x","article-title":"Ontogeny of IgM-producing cells in the lymphoid organs of rainbow trout, Salmo gairdneri Richardson: an immuno- and enzyme-histochemical study","volume":"36","author":"Razquin","year":"1990","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.dci.2024.105298_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj0101","article-title":"Identification of a pharyngeal mucosal lymphoid organ in zebrafish and other teleosts: tonsils in fish?","volume":"9","author":"Resseguier","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.dci.2024.105298_bib31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1006\/fsim.1997.0097","article-title":"Leucocyte subpopulations in developing carp (Cyprinus carpioL.): immunocytochemical studies","volume":"7","author":"Romano","year":"1997","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib32","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fsi.2010.09.001","article-title":"Teleost intestinal immunology","volume":"31","author":"Rombout","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.fsi.2005.03.007","article-title":"Phylogeny and ontogeny of fish leucocytes","volume":"19","author":"Rombout","year":"2005","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib34","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.dci.2010.06.012","article-title":"Common carp have two subclasses of bonyfish specific antibody IgZ showing differential expression in response to infection","volume":"34","author":"Ryo","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.dci.2015.05.015","article-title":"Nasal vaccination of young rainbow trout (Oncorhynchus mykiss) against infectious hematopoietic necrosis and enteric red mouth disease","volume":"53","author":"Salinas","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib36","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.dci.2011.11.009","article-title":"Mucosal immunoglobulins and B cells of teleost fish","volume":"35","author":"Salinas","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib37","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.4049\/jimmunol.1600678","article-title":"Tissue microenvironments in the nasal epithelium of rainbow trout (Oncorhynchus mykiss) define two distinct CD8alpha+ cell populations and establish regional immunity","volume":"197","author":"Sepahi","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib38","doi-asserted-by":"crossref","first-page":"12428","DOI":"10.1073\/pnas.1900083116","article-title":"Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner","volume":"116","author":"Sepahi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2024.105298_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.dci.2005.06.007","article-title":"Antibody repertoire development in teleosts--a review with emphasis on salmonids and Gadus morhua L","volume":"30","author":"Solem","year":"2006","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib40","first-page":"29","article-title":"Development of T lymphocytes in the nasal-associated lymphoid tissue (NALT) from growing Wistar rats","volume":"11","author":"Sosa","year":"2004","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib41","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.cub.2015.07.066","article-title":"African lungfish reveal the evolutionary origins of organized mucosal lymphoid tissue in vertebrates","volume":"25","author":"Tacchi","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.dci.2024.105298_bib42","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1038\/ncomms6205","article-title":"Nasal immunity is an ancient arm of the mucosal immune system of vertebrates","volume":"5","author":"Tacchi","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dci.2024.105298_bib43","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.dci.2011.02.008","article-title":"The expression of CD8alpha discriminates distinct T cell subsets in teleost fish","volume":"35","author":"Takizawa","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0165-2427(86)90114-5","article-title":"The ontogeny of humoral immunity in rainbow trout, Salmo gairdneri","volume":"12","author":"Tatner","year":"1986","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2024.105298_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0145-305X(83)90056-3","article-title":"The ontogeny of cellular immunity in the rainbow trout, Salmo gairdneri Richardson, in relation to the stage of development of the lymphoid organs","volume":"7","author":"Tatner","year":"1983","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib46","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF00333711","article-title":"Reticulum cells in the ontogeny of nasal-associated lymphoid tissue (NALT) in the rat","volume":"273","author":"van Poppel","year":"1993","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.dci.2024.105298_bib47","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3389\/fimmu.2018.02144","article-title":"Epithelial MHC class II expression and its role in antigen presentation in the gastrointestinal and respiratory tracts","volume":"9","author":"Wosen","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib48","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fsi.2004.09.005","article-title":"Ontogeny of the immune system of fish","volume":"20","author":"Zapata","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2024.105298_bib49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ni.1913","article-title":"IgT, a primitive immunoglobulin class specialized in mucosal immunity","volume":"11","author":"Zhang","year":"2010","journal-title":"Nat. Immunol."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X24001708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X24001708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:49:24Z","timestamp":1777488564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X24001708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S0145305X24001708"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2024.105298","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.08.04.552019","asserted-by":"object"}]},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ontogeny of the organized nasopharynx-associated lymphoid tissue in rainbow trout","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2024.105298","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105298"}}