{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:14:55Z","timestamp":1792707295187,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["301965"],"award-info":[{"award-number":["301965"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.dci.2025.105330","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:20:45Z","timestamp":1738275645000},"page":"105330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Sustained T cell-independent type 2 antibody response in a naturally MHC II-deficient teleost fish"],"prefix":"10.1016","volume":"164","author":[{"given":"Adri\u00e1n","family":"L\u00f3pez-Porras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-Wang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-4996","authenticated-orcid":false,"given":"Finn-Eirik","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2025.105330_bib1","first-page":"109","article-title":"TLR4 as the mammalian endotoxin sensor","volume":"270","author":"Beutler","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib2","article-title":"Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection","volume":"7","author":"Bohannon","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dci.2025.105330_bib3","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.4049\/jimmunol.2200088","article-title":"Clonotypic IgH response against systemic viral infection in pronephros and spleen of a teleost fish","volume":"208","author":"Castro","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri3803","article-title":"A brief history of T cell help to B cells","volume":"15","author":"Crotty","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2761.1991.tb00588.x","article-title":"Vaccination experiments and studies of the humoral immune-responses in cod, gadus-morhua L, to 4 strains of monoclonal-defined vibrio-anguillarum","volume":"14","author":"Espelid","year":"1991","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.dci.2025.105330_bib6","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.4049\/jimmunol.1001155","article-title":"Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics","volume":"185","author":"Good-Jacobson","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib7","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.3389\/fimmu.2019.02902","article-title":"Rainbow trout IgM+ B cells preferentially respond to thymus-independent antigens but are activated by CD40L","volume":"10","author":"Granja","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib8","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1186\/s12864-024-10571-0","article-title":"Systematic characterization of immunoglobulin loci and deep sequencing of the expressed repertoire in the Atlantic cod (Gadus morhua)","volume":"25","author":"Gyorkei","year":"2024","journal-title":"BMC Genom."},{"key":"10.1016\/j.dci.2025.105330_bib9","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2004.01775.x","article-title":"T lymphocyte dependence of the antibody response to 'T lymphocyte independent type 2' antigens","volume":"111","author":"Jeurissen","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2025.105330_bib11","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.fsi.2007.04.006","article-title":"Specificity and durability of antibody responses in Atlantic cod (Gadus morhua L.) immunised with Vibrio anguillarum O2b","volume":"23","author":"Lund","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib12","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.dci.2006.02.004","article-title":"Comparison of antibody responses in Atlantic cod (Gadus morhua L.) to Aeromonas salmonicida and Vibrio anguillarum","volume":"30","author":"Lund","year":"2006","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/eji.201242570","article-title":"Differential compartmentalization of memory B cells versus plasma cells in salmonid fish","volume":"43","author":"Ma","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"2014","key":"10.1016\/j.dci.2025.105330_bib14","first-page":"41","article-title":"The immune response of Atlantic cod. Gadus morhua L","volume":"27","author":"Magnadottir","year":"2014","journal-title":"Icel. Agr. Sci."},{"issue":"1998","key":"10.1016\/j.dci.2025.105330_bib15","first-page":"47","article-title":"Comparison of immunoglobulin (IgM) from four fish species","volume":"12","author":"Magnad\u00f3ttir","year":"1998","journal-title":"Icel. Agr. Sci"},{"key":"10.1016\/j.dci.2025.105330_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/fsim.2001.0364","article-title":"The carbohydrate moiety of serum IgM from Atlantic cod (Gadus morhua L.)","volume":"12","author":"Magnad\u00f3ttir","year":"2002","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cbpb.2009.07.005","article-title":"Natural antibodies of cod (Gadus morhua L.): specificity, activity and affinity","volume":"154","author":"Magnadottir","year":"2009","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2025.105330_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0305-0491(98)10156-6","article-title":"Humoral immune parameters in Atlantic cod (Gadus morhua L.) I. The effects of environmental temperature","volume":"122","author":"Magnadottir","year":"1999","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2025.105330_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0305-0491(98)10157-8","article-title":"Humoral immune parameters in Atlantic cod (Gadus morhua L.) II. The effects of size and gender under different environmental conditions","volume":"122","author":"Magnadottir","year":"1999","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2025.105330_bib20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/fsim.2000.0296","article-title":"Immune parameters of immunised cod (Gadus morhua L.)","volume":"11","author":"Magnadottir","year":"2001","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib21","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/ng.3645","article-title":"Evolution of the immune system influences speciation rates in teleost fishes","volume":"48","author":"Malmstrom","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.dci.2025.105330_bib22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.fsi.2010.11.007","article-title":"Vibriosis vaccines based on various sero-subgroups of Vibrio anguillarum O2 induce specific protection in Atlantic cod (Gadus morhua L.) juveniles","volume":"30","author":"Mikkelsen","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev.iy.13.040195.003255","article-title":"T cell-independent antigens type 2","volume":"13","author":"Mond","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1084\/jem.20052036","article-title":"T-independent type II immune responses generate memory B cells","volume":"203","author":"Obukhanych","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2025.105330_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0145-305X(91)90005-J","article-title":"Isolation and partial characterization of immunoglobulin from cod (Gadus morhua L.)","volume":"15","author":"Pilstrom","year":"1991","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib26","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1444-2906.2005.01052.x","article-title":"Why is the antibody response of Atlantic cod so poor? The search for a genetic explanation","volume":"71","author":"Pilstrom","year":"2005","journal-title":"Fish. Sci."},{"key":"10.1016\/j.dci.2025.105330_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1086\/589862","article-title":"Vaccines: correlates of vaccine\u2010induced immunity","volume":"47","author":"Plotkin","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.dci.2025.105330_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/srep25211","article-title":"Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions","volume":"6","author":"Solbakken","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dci.2025.105330_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature10342","article-title":"The genome sequence of Atlantic cod reveals a unique immune system","volume":"477","author":"Star","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.dci.2025.105330_bib30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1471-2148-12-256","article-title":"Diversification of the expanded teleost-specific toll-like receptor family in Atlantic cod, Gadus morhua","volume":"12","author":"Sundaram","year":"2012","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.dci.2025.105330_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.791095","article-title":"IgA plasma cells are long-lived residents of gut and bone marrow that express isotype- and tissue-specific gene expression patterns","volume":"12","author":"Wilmore","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105330_bib32","doi-asserted-by":"crossref","first-page":"E70","DOI":"10.1503\/cmaj.110506","article-title":"The role of seroepidemiology in the comprehensive surveillance of vaccine-preventable diseases","volume":"184","author":"Wilson","year":"2012","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"key":"10.1016\/j.dci.2025.105330_bib33","doi-asserted-by":"crossref","first-page":"844","DOI":"10.4049\/jimmunol.0902364","article-title":"The strength of B cell interaction with antigen determines the degree of IgM polymerization","volume":"184","author":"Ye","year":"2010","journal-title":"J. Immunol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:58:33Z","timestamp":1740441513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X25000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":33,"alternative-id":["S0145305X25000199"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2025.105330","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained T cell-independent type 2 antibody response in a naturally MHC II-deficient teleost fish","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2025.105330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105330"}}