{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:49:37Z","timestamp":1792212577055,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100015789","name":"Dalian High-Level Talent Innovation Program","doi-asserted-by":"publisher","award":["2022RG14"],"award-info":[{"award-number":["2022RG14"]}],"id":[{"id":"10.13039\/100015789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32222086"],"award-info":[{"award-number":["32222086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230110"],"award-info":[{"award-number":["32230110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015300","name":"Fund for Outstanding Talents and Innovative Team of Agricultural Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2203087"],"award-info":[{"award-number":["XLYC2203087"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.dci.2025.105366","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:02:14Z","timestamp":1743735734000},"page":"105366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The molecular mechanism of ferroptosis in the Pacific oyster Crassostrea gigas under Erastin treatment or high temperature stress"],"prefix":"10.1016","volume":"166","author":[{"given":"Jinyuan","family":"Leng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2025.105366_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2018.03.113","article-title":"ENPP2 protects cardiomyocytes from erastin-induced ferroptosis","volume":"499","author":"Bai","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dci.2025.105366_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.dci.2025.105366_bib3","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2025.105366_bib4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dci.2025.105366_bib5","article-title":"Ferroptosis-like death in plant cells","volume":"4","author":"Conlon","year":"2017","journal-title":"Mol. Cell. Oncol."},{"key":"10.1016\/j.dci.2025.105366_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aquaculture.2006.10.025","article-title":"Summer mortality of hatchery-produced Pacific oyster spat (Crassostrea gigas). I. Estimation of genetic parameters for survival and growth","volume":"262","author":"D\u00e9gremont","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2025.105366_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1083\/jcb.201605110","article-title":"Heat stress induces ferroptosis-like cell death in plants","volume":"216","author":"Distefano","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.dci.2025.105366_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.dci.2025.105366_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.dci.2025.105366_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153551","article-title":"Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells","volume":"85","author":"Du","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.dci.2025.105366_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dci.2025.105366_bib12","first-page":"3227","volume":"vol. 278","author":"Gourley","year":"2003"},{"key":"10.1016\/j.dci.2025.105366_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108556","article-title":"The ferroptosis in haemocytes of Pacific oyster Crassostrea gigas upon erastin treatment","volume":"133","author":"Guo","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105366_bib15","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/cdd.2015.93","article-title":"Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation","volume":"23","author":"Hayano","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.dci.2025.105366_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179271","article-title":"Overview of ferroptosis and synthetic lethality strategies","volume":"22","author":"Kinowaki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2025.105366_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-9861(78)90479-4","article-title":"Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase","volume":"186","author":"Kono","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.dci.2025.105366_bib18","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.dci.2025.105366_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/humrep\/deaa363","article-title":"Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis","volume":"36","author":"Li","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.dci.2025.105366_bib20","article-title":"Ferroptosis: mechanism and connections with cutaneous diseases","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.dci.2025.105366_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.dci.2025.105366_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3354\/dao02944","article-title":"Summer mortalities and detection of ostreid herpesvirus microvariant in Pacific oyster Crassostrea gigas in Sweden and Norway","volume":"117","author":"Mortensen","year":"2016","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.dci.2025.105366_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104919","article-title":"The application of ferroptosis in diseases","volume":"159","author":"Qiu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.dci.2025.105366_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ani10040628","article-title":"Comparative transcriptome analysis of gill tissue in response to hypoxia in silver Sillago (Sillago sihama)","volume":"10","author":"Saetan","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.dci.2025.105366_bib25","article-title":"Dissecting the mechanism of regulation of a ferroptosis-like form of cell death in Drosophila melanogaster","volume":"2","author":"Saini","year":"2023"},{"key":"10.1016\/j.dci.2025.105366_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225931","article-title":"Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo","volume":"14","author":"Shibata","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2025.105366_bib27","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.dci.2025.105366_bib28","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.4049\/jimmunol.1900238","article-title":"CgCLec-HTM-mediated signaling pathway regulates lipopolysaccharide-induced CgIL-17 and CgTNF production in oyster","volume":"203","author":"Sun","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2025.105366_bib29","doi-asserted-by":"crossref","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","volume":"30","author":"Tang","year":"2020","journal-title":"Ferroptosis. Current biology : CB"},{"key":"10.1016\/j.dci.2025.105366_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fsi.2022.05.010","article-title":"Cortisol modulates glucose metabolism and oxidative response after acute high temperature stress in Pacific oyster Crassostrea gigas","volume":"126","author":"Wang","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105366_bib31","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1021\/acsnano.1c00380","article-title":"Metabolic control by heat stress determining cell fate to ferroptosis for effective cancer therapy","volume":"15","author":"Xie","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.dci.2025.105366_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2020.11.024","article-title":"Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1","volume":"81","author":"Yan","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dci.2025.105366_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41467-020-14324-x","article-title":"Nedd4 ubiquitylates VDAC2\/3 to suppress erastin-induced ferroptosis in melanoma","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dci.2025.105366_bib34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","article-title":"Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.dci.2025.105366_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature11413","article-title":"The oyster genome reveals stress adaptation and complexity of shell formation","volume":"490","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.dci.2025.105366_bib36","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.2147\/OTT.S254995","article-title":"The role of erastin in ferroptosis and its prospects in cancer therapy","volume":"13","author":"Zhao","year":"2020","journal-title":"OncoTargets Ther."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25000552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25000552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:35:38Z","timestamp":1762245338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X25000552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":35,"alternative-id":["S0145305X25000552"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2025.105366","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The molecular mechanism of ferroptosis in the Pacific oyster Crassostrea gigas under Erastin treatment or high temperature stress","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2025.105366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105366"}}