{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:15:55Z","timestamp":1773339355651,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010784","name":"Banco Santander","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100010784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.dci.2025.105498","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:14:26Z","timestamp":1761300866000},"page":"105498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exploring trained immunity to complement vaccination against Streptococcus suis in swine"],"prefix":"10.1016","volume":"172","author":[{"given":"Lidia","family":"S\u00e1nchez-Morales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"P\u00e9rez-Sancho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Garc\u00eda-Seco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Balseiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"P\u00e9rez-Domingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ar\u00e1nzazu","family":"Buend\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Diez-Guerrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Garc\u00eda","family":"de Garnica Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Mareque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"de los \u00c1ngeles Risalde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gort\u00e1zar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2025.105498_bib1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2460\/ajvr.79.9.941","article-title":"Assessment of pig saliva as a Streptococcus suis reservoir and potential source of infection on farms by use of a novel quantitative polymerase chain reaction assay","volume":"79","author":"Arai","year":"2018","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.dci.2025.105498_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.dci.2025.105498_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105561","article-title":"African swine fever virus: a raised global upsurge and a continuous threaten to pig husbandry","volume":"167","author":"Ata","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.dci.2025.105498_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1746-6148-9-107","article-title":"Trap-effectiveness and response to tiletamine-zolazepam and medetomidine anaesthesia in Eurasian wild boar captured with cage and corral traps","volume":"9","author":"Barasona","year":"2013","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.dci.2025.105498_bib5","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1128\/CVI.00159-10","article-title":"Immunogenicity of an autogenous Streptococcus suis bacterin in preparturient sows and their piglets in relation to protection after weaning","volume":"17","author":"Baums","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.dci.2025.105498_bib6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.atherosclerosis.2016.10.019","article-title":"Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo","volume":"254","author":"Bekkering","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.dci.2025.105498_bib7","article-title":"Streptococcus suis outbreak caused by an emerging zoonotic strain with acquired multi-drug resistance in Thailand","volume":"9","author":"Brizuela","year":"2023","journal-title":"Microb. Genom."},{"key":"10.1016\/j.dci.2025.105498_bib8","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2025.105498_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.748103","article-title":"The bacterial mucosal immunotherapy MV130 protects against SARS-CoV-2 infection and improves COVID-19 vaccines immunogenicity","volume":"12","author":"Del Fresno","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105498_bib10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1152\/physrev.00031.2021","article-title":"Trained immunity: adaptation within innate immune mechanisms","volume":"103","author":"Dominguez-Andres","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.dci.2025.105498_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2025.127076","article-title":"Immunostimulant effect of heat-inactivated Mycobacterium bovis in mice challenged with vector-borne pathogens","volume":"53","author":"Ferreras-Colino","year":"2025","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2025.105498_bib12","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1016\/S0264-410X(03)00181-6","article-title":"BCG scar and positive tuberculin reaction associated with reduced child mortality in West Africa. A non-specific beneficial effect of BCG?","volume":"21","author":"Garly","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2025.105498_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2020.08.051","article-title":"Activate: randomized clinical trial of BCG vaccination against infection in the elderly","volume":"183","author":"Giamarellos-Bourboulis","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.dci.2025.105498_bib14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cimid.2016.06.001","article-title":"Characterization of the immune response and evaluation of the protective capacity of rSsnA against Streptococcus suis infection in pigs","volume":"47","author":"Gomez-Gascon","year":"2016","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.dci.2025.105498_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-1135(00)00250-9","article-title":"The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions","volume":"76","author":"Gottschalk","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2025.105498_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2014.45","article-title":"Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing","volume":"3","author":"Goyette-Desjardins","year":"2014","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.dci.2025.105498_bib17","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1128\/IAI.00139-16","article-title":"Protection against Streptococcus suis serotype 2 infection using a capsular polysaccharide glycoconjugate vaccine","volume":"84","author":"Goyette-Desjardins","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2025.105498_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.medmal.2017.10.001","article-title":"Understanding the virulence of Streptococcus suis: a veterinary, medical, and economic challenge","volume":"48","author":"Haas","year":"2018","journal-title":"Med. Maladies Infect."},{"key":"10.1016\/j.dci.2025.105498_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.vetmic.2017.06.002","article-title":"Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014","volume":"207","author":"Hernandez-Garcia","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2025.105498_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9010040","article-title":"Analysis of porcine Pro- and anti-inflammatory cytokine induction by S. suis in vivo and in vitro","volume":"9","author":"Hohnstein","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.dci.2025.105498_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12917-016-0937-8","article-title":"Immunization with Streptococcus suis bacterin plus recombinant Sao protein in sows conveys passive immunity to their piglets","volume":"13","author":"Hsueh","year":"2017","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.dci.2025.105498_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13567-024-01313-x","article-title":"Immune response induced by a Streptococcus suis multi-serotype autogenous vaccine used in sows to protect post-weaned piglets","volume":"55","author":"Jeffery","year":"2024","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2025.105498_bib23","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202217084","article-title":"Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung","volume":"15","author":"Kang","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.dci.2025.105498_bib24","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2025.105498_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/trstmh\/tru168","article-title":"Trained immunity: consequences for the heterologous effects of BCG vaccination","volume":"109","author":"Kleinnijenhuis","year":"2015","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.dci.2025.105498_bib26","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/infdis\/jiv332","article-title":"BCG vaccination enhances the immunogenicity of subsequent influenza vaccination in healthy volunteers: a randomized, placebo-controlled pilot Study","volume":"212","author":"Leentjens","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.dci.2025.105498_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2023.100513","article-title":"Prevalence of Streptococcus suis in pigs in China during 2000-2021: a systematic review and meta-analysis","volume":"16","author":"Liu","year":"2023","journal-title":"One Health"},{"key":"10.1016\/j.dci.2025.105498_bib28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1473-3099(07)70001-4","article-title":"Streptococcus suis: an emerging zoonotic pathogen","volume":"7","author":"Lun","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.dci.2025.105498_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.dci.2025.105498_bib30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2025.105498_bib31","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.cell.2018.11.007","article-title":"Trained immunity and local innate immune memory in the lung","volume":"175","author":"Netea","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.dci.2025.105498_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","article-title":"Trained immunity: a memory for innate host defense","volume":"9","author":"Netea","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.dci.2025.105498_bib33","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1038\/s41598-025-88176-0","article-title":"Orally administered live BCG and heat-inactivated Mycobacterium bovis protect bison against experimental bovine tuberculosis","volume":"15","author":"Niroula","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dci.2025.105498_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41581-022-00633-5","article-title":"Trained immunity - basic concepts and contributions to immunopathology","volume":"19","author":"Ochando","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.dci.2025.105498_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0300985812450726","article-title":"Current state of knowledge on porcine circovirus type 2-associated lesions","volume":"50","author":"Opriessnig","year":"2013","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.dci.2025.105498_bib36","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1128\/AAC.00629-12","article-title":"Characterization of a Streptococcus suis tet(O\/W\/32\/O)-carrying element transferable to major streptococcal pathogens","volume":"56","author":"Palmieri","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.dci.2025.105498_bib37","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/104063879500700323","article-title":"Fibrinohemorrhagic pneumonia in pigs naturally infected with Streptococcus suis","volume":"7","author":"Reams","year":"1995","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.dci.2025.105498_bib38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13567-024-01325-7","article-title":"Neuropathological lesions in intravenous BCG-stimulated K18-hACE2 mice challenged with SARS-CoV-2","volume":"55","author":"Sanchez-Morales","year":"2024","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2025.105498_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1633977","article-title":"The impact of mycobacteria-induced trained immunity on SARS-CoV-2 vaccine responses","volume":"16","author":"S\u00e1nchez-Morales","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105498_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/165974","article-title":"Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view","volume":"2013","author":"Schulte","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.dci.2025.105498_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1079\/AHR2005106","article-title":"Porcine circovirus diseases","volume":"6","author":"Segales","year":"2005","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.dci.2025.105498_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9050374","article-title":"Update on Streptococcus suis research and prevention in the era of antimicrobial restriction: 4th international workshop on S. suis","volume":"9","author":"Segura","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.dci.2025.105498_bib43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1574-695X.2006.00067.x","article-title":"Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole-blood culture system","volume":"47","author":"Segura","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.dci.2025.105498_bib44","doi-asserted-by":"crossref","first-page":"11495","DOI":"10.1073\/pnas.1806068115","article-title":"Global trends in infectious diseases of swine","volume":"115","author":"Vanderwaal","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2025.105498_bib45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13567-022-01047-8","article-title":"Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs","volume":"53","author":"Vaz-Rodrigues","year":"2022","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2025.105498_bib46","first-page":"1","article-title":"ggplot2: elegant graphics for data analysis","author":"Wickham","year":"2009","journal-title":"Ggplot2: Elegant Graphics Data Anal."},{"key":"10.1016\/j.dci.2025.105498_bib47","article-title":"Characterization of a novel linezolid resistance gene optrA and Bacitracin resistance locus-carrying multiple antibiotic resistant integrative and conjugative element ICESsu1112S in Streptococccus Suis","volume":"10","author":"Yang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.dci.2025.105498_bib48","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/infdis\/jiad454","article-title":"Streptococcus suis Serotype 2 type IV secretion effector SspA-1 induces proinflammatory cytokine production via TLR2 endosomal and type I interferon signaling","volume":"230","author":"Yin","year":"2024","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.dci.2025.105498_bib49","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3201\/eid1206.051194","article-title":"Human Streptococcus suis outbreak, Sichuan, China","volume":"12","author":"Yu","year":"2006","journal-title":"Emerg. Infect. Dis."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25001879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25001879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:14:32Z","timestamp":1773303272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X25001879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":49,"alternative-id":["S0145305X25001879"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2025.105498","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring trained immunity to complement vaccination against Streptococcus suis in swine","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2025.105498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105498"}}