{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:27:24Z","timestamp":1786987644109,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFAA026502"],"award-info":[{"award-number":["2023GXNSFAA026502"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["YCSCYJ20210014"],"award-info":[{"award-number":["YCSCYJ20210014"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["CX(22)3199"],"award-info":[{"award-number":["CX(22)3199"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["CX(23)3066"],"award-info":[{"award-number":["CX(23)3066"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MC208"],"award-info":[{"award-number":["ZR2023MC208"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160873"],"award-info":[{"award-number":["32160873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.dci.2025.105529","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:32:53Z","timestamp":1763969573000},"page":"105529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Characterization of the CD28 signaling pathway related genes (CD28, Grb2 and SLP-76) of golden pompano (Trachinotus ovatus)"],"prefix":"10.1016","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-9522","authenticated-orcid":false,"given":"Zhitao","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushuai","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youchuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2025.105529_bib1","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.4049\/jimmunol.176.7.4191","article-title":"Costimulatory receptors in a teleost fish: typical CD28, elusive CTLA4","volume":"176","author":"Bernard","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-065X.2011.01011.x","article-title":"Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28\/B7 family","volume":"241","author":"Bour-Jordan","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.dci.2025.105529_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104621","article-title":"Regulatory roles of cytokines in T and B lymphocytes-mediated immunity in teleost fish","volume":"144","author":"Cao","year":"2023","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2025.199529","article-title":"Isolation, characterization and genomic analysis of bacteriophages for biocontrol of vibriosis caused by Vibrio alginolyticus","volume":"353","author":"Chaichana","year":"2025","journal-title":"Virus Res."},{"key":"10.1016\/j.dci.2025.105529_bib6","article-title":"Two non-mammalian toll-like receptors (TLR21 and TLR22) from golden pompano (Trachinotus ovatus): molecular cloning, gene characterization and expression analysis","volume":"21","author":"Gao","year":"2021","journal-title":"Aquaculture Rep."},{"key":"10.1016\/j.dci.2025.105529_bib7","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ni.3298","article-title":"The burgeoning family of unconventional T cells","volume":"16","author":"Godfrey","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.fsi.2020.12.006","article-title":"Molecular characterization of the T cell costimulatory receptors CD28 and CTLA4 in the European sea bass","volume":"109","author":"Gonz\u00e1lez-Fern\u00e1ndez","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib9","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.fsi.2012.02.021","article-title":"Molecular characterization of Cynoglossus semilaevis CD28","volume":"32","author":"Hu","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib10","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.fsi.2007.10.011","article-title":"Structure, organization and expression of common carp (Cyprinus carpio L.) SLP-76 gene","volume":"24","author":"Huang","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2017.10.008","article-title":"Conservation of structural and interactional features of CD28 and CD80\/86 molecules from Nile tilapia (Oreochromis niloticus)","volume":"72","author":"Huang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.fsi.2017.05.013","article-title":"Molecular characterization of a T cell co-stimulatory receptor, CD28 of rock bream (Oplegnathus fasciatus): transcriptional expression during bacterial and viral stimulation","volume":"66","author":"Jeswin","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.dci.2025.105529_bib13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-0684.2009.00372.x","article-title":"CD4 T cell subsets in the mucosa are CD28+Ki-67-HLA-DR-CD69+ but show differential infection based on alpha4beta7 receptor expression during acute SIV infection","author":"Kader","year":"2009","journal-title":"J. Med. Primatol."},{"key":"10.1016\/j.dci.2025.105529_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2020.107802","article-title":"Prediction of CD28-CD86 protein complex structure using different level of resolution approach","volume":"103","author":"Krupa","year":"2021","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.dci.2025.105529_bib15","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/molbev\/msy096","article-title":"MEGA X: molecular evolutionary genetics analysis across computing platforms","volume":"35","author":"Kumar","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.dci.2025.105529_bib16","first-page":"1219","volume":"vol 214","author":"Li","year":"2025"},{"key":"10.1016\/j.dci.2025.105529_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.24272\/j.issn.2095-8137.2023.053","article-title":"Full T-cell activation and function in teleosts require collaboration of first and co-stimulatory signals","volume":"45","author":"Liang","year":"2024","journal-title":"Zool. Res."},{"key":"10.1016\/j.dci.2025.105529_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109475","article-title":"Identification, expression and molecular polymorphism of T-cell receptors \u03b1 and \u03b2 from the glacial relict Hucho bleekeri","volume":"148","author":"Lin","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib19","article-title":"Molecular and functional analyses of the primordial costimulatory molecule CD80\/86 and its receptors CD28 and CD152 (CTLA-4) in a teleost fish","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/dom.16015","article-title":"The role of GRB2 in diabetes, diabetes complications and related disorders","volume":"27","author":"Ma","year":"2025","journal-title":"Diabetes Obes. Metabol."},{"issue":"2","key":"10.1016\/j.dci.2025.105529_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10456-021-09774-w","article-title":"The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk","volume":"24","author":"Mauri","year":"2021","journal-title":"Angiogenesis"},{"key":"10.1016\/j.dci.2025.105529_bib22","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1189\/jlb.0811407","article-title":"poly(I:C) costimulation induces a stronger antiviral chemokine and granzyme B release in human CD4 T cells than CD28 costimulation","volume":"92","author":"Meyer","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.dci.2025.105529_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.fsi.2018.07.040","article-title":"Molecular cloning and bioactivity of an IL-2 homologue in large yellow croaker (Larimichthys crocea)","volume":"81","author":"Mu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2022.106792","article-title":"Interdomain interactions in Grb2 revealed by the conformational stability and CD28 binding analysis","volume":"284","author":"Ochi","year":"2022","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.dci.2025.105529_bib25","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dci.2025.105529_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741615","article-title":"TLRs signaling pathway regulation, antibacterial and apoptotic activity of largemouth bass ECSIT during Edwardsiella piscicida infection","volume":"595","author":"Pi","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2025.105529_bib27","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/s41598-017-01660-0","article-title":"Molecular mechanisms underlying the evolution of the slp76 signalosome","volume":"7","author":"Qu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dci.2025.105529_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2012.08.003","article-title":"Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms","volume":"148","author":"Rauta","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.dci.2025.105529_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.2009.00784.x","article-title":"Mechanisms of costimulation","volume":"229","author":"Sharpe","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.dci.2025.105529_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/BJ20140040","article-title":"T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses","volume":"460","author":"Sk\u00e5nland","year":"2024","journal-title":"Biochem. J."},{"key":"10.1016\/j.dci.2025.105529_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.2806","article-title":"Molecular design and optimization of hepatic cancer SLP76-derived PLC\u03b31 SH3-binding peptide with the systematic N-substitution of peptide PXXP motif","volume":"32","author":"Tang","year":"2019","journal-title":"J. Mol. Recogn."},{"key":"10.1016\/j.dci.2025.105529_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.imlet.2014.10.020","article-title":"TCR and CD28 activate the transcription factor NF-\u03baB in T-cells via distinct adaptor signaling complexes","volume":"163","author":"Thaker","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.dci.2025.105529_bib33","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1084\/jem.185.12.2089","article-title":"T cell stimulation in vivo by lipopolysaccharide (LPS)","volume":"185","author":"Tough","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2025.105529_bib34","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.3390\/ijms21082674","article-title":"Modes of communication between T cells and relevance for immune responses","volume":"21","author":"Uhl","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2025.105529_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fsi.2019.07.020","article-title":"Transcriptome comparative analysis of immune tissues from asymptomatic and diseased Epinephelus moara naturally infected with nervous necrosis virus","volume":"93","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib36","article-title":"Molecular characterization and functional analysis of DIGIRR from golden pompano (Trachinotus ovatus)","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.765036","article-title":"The expression of CD28 and its synergism on the immune response of flounder (Paralichthys olivaceus) to thymus-dependent antigen","volume":"12","author":"Xing","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105529_bib38","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.3389\/fimmu.2019.01704","article-title":"Bridging the gap: modulatory roles of the Grb2-family adaptor, Gads, in cellular and allergic immune responses","volume":"10","author":"Yablonski","year":"2019","journal-title":"Front. Immunol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25002186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25002186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:39:55Z","timestamp":1773851995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X25002186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":38,"alternative-id":["S0145305X25002186"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2025.105529","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the CD28 signaling pathway related genes (CD28, Grb2 and SLP-76) of golden pompano (Trachinotus ovatus)","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2025.105529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105529"}}