{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:00:09Z","timestamp":1777777209449,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J01487"],"award-info":[{"award-number":["2021J01487"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015303","name":"Seed Industry Innovation and Industrialization Engineering Project of Fujian Province","doi-asserted-by":"publisher","award":["2021FJSCZY01"],"award-info":[{"award-number":["2021FJSCZY01"]}],"id":[{"id":"10.13039\/501100015303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32473143"],"award-info":[{"award-number":["32473143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20264"],"award-info":[{"award-number":["U21A20264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.dci.2025.105540","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T17:04:58Z","timestamp":1766163898000},"page":"105540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Molecular characterization of laao in large yellow croaker and its functional response to Cryptocaryon irritans infection"],"prefix":"10.1016","volume":"174","author":[{"given":"Zhou","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuimu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongshu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2025.105540_bib2","first-page":"11","article-title":"Anatomy of teleost fish immune structures and organs","volume":"3","author":"Bj\u00f8rgen","year":"2022","journal-title":"Prin. Fish Immunol.: Cells Mol. Host Protect."},{"key":"10.1016\/j.dci.2025.105540_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/srep42673","article-title":"CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer","volume":"7","author":"Costa","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dci.2025.105540_bib4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.fsi.2020.08.026","article-title":"Phylogeny of Slc15 family and response to Aeromonas hydrophila infection following Lactococcus lactis dietary supplementation in Cyprinus carpio","volume":"106","author":"Dong","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1469-185X.2009.00091.x","article-title":"Genus\u2010level supertree of cyprinidae (Actinopterygii: cypriniformes), partitioned qualitative clade support and test of macro\u2010evolutionary scenarios","volume":"84","author":"Gaubert","year":"2009","journal-title":"Biol. Rev."},{"key":"10.1016\/j.dci.2025.105540_bib6","series-title":"Strategy for RNA-Seq Experimental Design and Data Analysis, Oral Biology: Molecular Techniques and Applications","first-page":"249","author":"Gimenez","year":"2022"},{"key":"10.1016\/j.dci.2025.105540_bib7","article-title":"The effects of cryptococcosis infection on the physiological, biochemical and immune indicators of large yellow croaker","volume":"48","author":"Hu","year":"2024","journal-title":"J. Fish. China"},{"key":"10.1016\/j.dci.2025.105540_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104040","article-title":"Expression profile of the fish immune enzyme l-amino acid oxidase (LAAO) after Streptococcus agalactiae infection in zebrafish (Danio rerio)","volume":"119","author":"Huang","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib9","series-title":"Study on the Disease Resistance Characteristics of Siganus canaliculatus Against Cryptocaryon irritans Infection","author":"Jiang","year":"2019"},{"key":"10.1016\/j.dci.2025.105540_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fsi.2017.08.009","article-title":"L-amino acid oxidase expression profile and biochemical responses of rabbitfish (Siganus oramin) after exposure to a high dose of Cryptocaryon irritans","volume":"69","author":"Jiang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib11","article-title":"Immune regulation differences in large yellow croaker with varied resistance to Cryptocaryon irritans infection","volume":"5","author":"Jiang","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.dci.2015.02.007","article-title":"Identification of the Atlantic cod l-amino acid oxidase and its alterations following bacterial exposure","volume":"50","author":"Kitani","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cbpb.2010.08.006","article-title":"Discovery of serum L-amino acid oxidase in the rockfish sebastes schlegeli: isolation and biochemical characterization","volume":"157","author":"Kitani","year":"2010","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2025.105540_bib17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.fsi.2020.08.028","article-title":"L-Amino acid oxidase as a fish host-defense molecule","volume":"106","author":"Kitani","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.fsi.2020.08.028","article-title":"L-Amino acid oxidase as a fish host-defense molecule","volume":"106","author":"Kitani","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2020.08.028","article-title":"l-Amino acid oxidase as a fish host-defense molecule","volume":"106","author":"Kitani","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104058","article-title":"Identification and characterization of L-amino acid oxidase 2 gene in orange-spotted grouper (Epinephelus coioides)","volume":"120","author":"Leu","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.24272\/j.issn.2095-8137.2022.388","article-title":"Intercross population study reveals that co-mutation of mitfa genes in two subgenomes induces red skin color in common carp (Cyprinus carpio wuyuanensis)","volume":"44","author":"Li","year":"2023","journal-title":"Zool. Res."},{"key":"10.1016\/j.dci.2025.105540_bib22","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.fsi.2013.09.026","article-title":"Siganus oramin recombinant L-amino acid oxidase is lethal to Cryptocaryon irritans","volume":"35","author":"Li","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/raq.12594","article-title":"Cryptocaryon irritans (Brown, 1951) is a serious threat to aquaculture of marine fish","volume":"14","author":"Li","year":"2022","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.dci.2025.105540_bib24","article-title":"Molecular characterization, expression pattern and immunologic function of CD82a in large yellow croaker (Larimichthys crocea)","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.dci.2025.105540_bib26","article-title":"Identification, characterization, and functional verification of a novel fish-egg lectin (FEL) from the golden pompano, Trachinotus ovatus","volume":"51","author":"Luo","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib27","doi-asserted-by":"crossref","first-page":"107288","DOI":"10.1016\/j.toxicon.2023.107288","article-title":"Affected inflammation-related signaling pathways in snake envenomation: a recent insight","volume":"234","author":"Luo","year":"2023","journal-title":"Toxicon"},{"key":"10.1016\/j.dci.2025.105540_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cbpb.2009.05.006","article-title":"Isolation and cDNA cloning of an antibacterial L-amino acid oxidase from the skin mucus of the great sculpin Myoxocephalus Polyacanthocephalus. Comparative biochemistry physiology part B","volume":"154","author":"Nagashima","year":"2009","journal-title":"Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2025.105540_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106154","article-title":"Bothrops moojeni venom and BmooLAAO-I downmodulate CXCL8\/IL-8 and CCL2\/MCP-1 production and oxidative burst response, and upregulate CD11b expression in human neutrophils","volume":"80","author":"Pereira Crott","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.dci.2025.105540_bib31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/fsim.1998.0181","article-title":"The morphology of the immune system in teleost fishes","volume":"9","author":"Press","year":"1999","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib32","first-page":"23","article-title":"Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms","volume":"148","author":"Rauta","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2025.105540_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2164-9-498","article-title":"Local and systemic gene expression responses of Atlantic salmon (Salmo salar L.) to infection with the salmon louse (Lepeophtheirus salmonis)","volume":"9","author":"Skugor","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.dci.2025.105540_bib34","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1128\/JB.00363-08","article-title":"SO-LAAO, a novel L-amino acid oxidase that enables Streptococcus oligofermentans to outcompete Streptococcus mutans by generating H2O2 from peptone","volume":"190","author":"Tong","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.dci.2025.105540_bib35","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/jfb.12386","article-title":"Establishment and characterization of a head kidney cell line from large yellow croaker Pseudosciaena crocea","volume":"84","author":"Wang","year":"2014","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.dci.2025.105540_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.toxicon.2009.04.017","article-title":"Purification, characterization and biological activities of the L-amino acid oxidase from Bungarus fasciatus snake venom","volume":"54","author":"Wei","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.dci.2025.105540_bib37","article-title":"Molecular and functional identification of a LC3C homolog in large yellow croaker (Larimichthys crocea)","volume":"45","author":"Wei","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2025.105540_bib40","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1002\/ece3.5374","article-title":"Evolution of the intermuscular bones in the Cyprinidae (Pisces) from a phylogenetic perspective","volume":"9","author":"Yang","year":"2019","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.dci.2025.105540_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735786","article-title":"Genomic selection for parasitic ciliate Cryptocaryon irritans resistance in large yellow croaker","volume":"531","author":"Zhao","year":"2021","journal-title":"Aquaculture"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25002290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X25002290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:49:13Z","timestamp":1777488553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X25002290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"alternative-id":["S0145305X25002290"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2025.105540","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization of laao in large yellow croaker and its functional response to Cryptocaryon irritans infection","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2025.105540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105540"}}