{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:43:40Z","timestamp":1776501820199,"version":"3.51.2"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160873"],"award-info":[{"award-number":["32160873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFAA026502"],"award-info":[{"award-number":["2023GXNSFAA026502"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["YCSCYJ20210014"],"award-info":[{"award-number":["YCSCYJ20210014"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["CX(23)3066"],"award-info":[{"award-number":["CX(23)3066"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MC208"],"award-info":[{"award-number":["ZR2023MC208"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.dci.2026.105598","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:46:24Z","timestamp":1774939584000},"page":"105598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Characterization and functional analysis of the interferon regulatory factor 5 (IRF5) from the GIFT Oreochromis niloticus"],"prefix":"10.1016","volume":"178","author":[{"given":"Youchuan","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenfei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixiang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiejun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-9522","authenticated-orcid":false,"given":"Zhitao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2026.105598_bib1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s12033-019-00217-y","article-title":"Structural characterization of open reading frame-encoded functional genes from Tilapia Lake virus (TiLV)","volume":"61","author":"Acharya","year":"2019","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.dci.2026.105598_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/MRA.01368-19","article-title":"Genomic Characterization of Tilapia lake virus isolates recovered from moribund Nile Tilapia (Oreochromis niloticus) on a farm in the United States","volume":"9","author":"Ahasan","year":"2020","journal-title":"Microbiol. Resour. Announc."},{"key":"10.1016\/j.dci.2026.105598_bib3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41587-019-0036-z","article-title":"SignalP 5.0 improves signal peptide predictions using deep neural networks","volume":"37","author":"Armenteros","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.dci.2026.105598_bib4","first-page":"2141","article-title":"Co-Infections of Tilapia Lake virus, Aeromonas hydrophila and Streptococcus agalactiae in farmed red hybrid tilapia","volume":"10","author":"Basri","year":"2020","journal-title":"Animal"},{"key":"10.1016\/j.dci.2026.105598_bib5","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkab225","article-title":"Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users","volume":"49","author":"Duvaud","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dci.2026.105598_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.molcel.2007.04.022","article-title":"Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer","volume":"26","author":"Escalante","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dci.2026.105598_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fsi.2020.09.018","article-title":"Unique duplication of IFNh genes in Nile tilapia (Oreochromis niloticus) reveals lineage-specific evolution of IFNh in perciform fishes","volume":"107","author":"Gan","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.dci.2011.06.003","article-title":"Molecular cloning and characterization of interferon regulatory factor 1 (IRF-1), IRF-2 and IRF-5 in the chondrostean paddlefish Polyodon spathula and their phylogenetic importance in the Osteichthyes","volume":"36","author":"Gan","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fsi.2020.10.001","article-title":"Molecular characterization of the interferon regulatory factor (IRF) family and functional analysis of IRF11 in the large yellow croaker (Larimichthys crocea)","volume":"107","author":"Guan","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib10","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.aquaculture.2018.08.028","article-title":"Susceptibility of important warm water fish species to tilapia lake virus (TiLV) infection","volume":"497","author":"Jaemwimol","year":"2018","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2026.105598_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2024.105152","article-title":"Interferon regulatory factors inhibit TiLV replication by activating interferon-a3 in tilapia (Oreochromis niloticus)","volume":"155","author":"Ke","year":"2024","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biocel.2018.03.012","article-title":"Diverse mechanisms of IRF5 action in inflammatory responses","volume":"99","author":"Khoyratty","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.dci.2026.105598_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.coviro.2018.12.008","article-title":"Emerging viruses in aquaculture","volume":"34","author":"Kibenge","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.dci.2026.105598_bib15","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"Mega 7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.dci.2026.105598_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108463","article-title":"Effect of CRISPR\/Cas9-mediated knockout of either IRF-3 or IRF-5 gene in Epithelioma papulosum cyprini cells on type I interferon response and NF-\u03baB activity","volume":"132","author":"Kwak","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.dci.2017.11.015","article-title":"Composition and transcription of all interferon regulatory factors (IRFs), IRF1-11 in a perciform fish, the mandarin fish, Siniperca chuatsi","volume":"81","author":"Laghari","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.vetimm.2012.11.010","article-title":"Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle","volume":"151","author":"Lee","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2026.105598_bib19","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3390\/v15040900","article-title":"The modulation of immune responses in tilapinevirus tilapiae-infected fish cells through MAPK\/ERK signalling","volume":"15","author":"Lertwannakarn","year":"2023","journal-title":"Virus"},{"key":"10.1016\/j.dci.2026.105598_bib20","article-title":"SMART v10: three decades of the protein domain annotation resource","volume":"8","author":"Letunic","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dci.2026.105598_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103846","article-title":"IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi","volume":"114","author":"Li","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.147083","article-title":"The origin and loss of interferon regulatory factor 10 (IRF10) in different lineages of vertebrates","volume":"854","author":"Li","year":"2023","journal-title":"Gene"},{"key":"10.1016\/j.dci.2026.105598_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126541","article-title":"A comprehensive review on the dynamic role of toll-like receptors (TLRs) in frontier aquaculture research and as a promising avenue for fish disease management","volume":"253","author":"Mahapatra","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.dci.2026.105598_bib24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.aquaculture.2015.08.033","article-title":"Evaluation of the growth and carcass quality of diallel crosses of four strains of Nile tilapia (Oerochromis niloticus)","volume":"451","author":"Neira","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2026.105598_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dci.2026.105598_bib26","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1111\/are.15470","article-title":"Molecular characterization and expression analysis of suppressors of cytokine signalling from golden pompano (Trachinotus ovatus)","volume":"52","author":"Qiao","year":"2021","journal-title":"Aquac. Res."},{"key":"10.1016\/j.dci.2026.105598_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.fsi.2022.09.009","article-title":"Molecular characterization of the evolutionary conserved signaling intermediate in Toll pathways (ECSIT) of soiny mullet (Liza haematocheila)","volume":"130","author":"Qi","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.fsi.2018.08.033","article-title":"Molecular characterization of three toll-like receptors (TLR21, TLR22, and TLR25) from a primitive ray-finned fish Dabry's sturgeon (Acipenser dabryanus)","volume":"82","author":"Qi","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.fsi.2021.02.005","article-title":"Transcriptome analysis of liver elucidates key immune-related pathways in Nile tilapia Oreochromis niloticus following infection with tilapia lake virus","volume":"111","author":"Sood","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/MRA.00084-19","article-title":"Genome Sequence of Tilapia lake virus associated with syncytial hepatitis of Tilapia in an Ecuadorian aquaculture facility","volume":"8","author":"Subramaniam","year":"2019","journal-title":"Microbiol. Resour. Announc."},{"key":"10.1016\/j.dci.2026.105598_bib31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1349-7006.2007.00720.x","article-title":"Interferon regulatory factor family of transcription factors and regulation of oncogenesis","volume":"99","author":"Takaoka","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.dci.2026.105598_bib32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/tbed.13693","article-title":"Tilapia lake virus (TiLV): genomic epidemiology and its early origin","volume":"68","author":"Thawornwattana","year":"2021","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.dci.2026.105598_bib33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1128\/JCM.01808-16","article-title":"Detection of Tilapia lake virus in clinical samples by culturing and nested reverse transcription-PCR","volume":"55","author":"Tsofack","year":"2017","journal-title":"J. Clin. Miocrobiol."},{"key":"10.1016\/j.dci.2026.105598_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41392-024-01980-4","article-title":"The multiple roles of interferon regulatory factor family in health and disease","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.dci.2026.105598_bib35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.fsi.2014.02.002","article-title":"Genomic characterization of interferon regulatory factor 5 from rock bream (Oplegnathus fasciatus) and its role in antiviral defense","volume":"37","author":"Wickramaarachchi","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.fsi.2011.10.021","article-title":"Molecular characterization and expression analysis of interferon regulatory factor 5 (IRF-5) in turbot, Scophthalmus maximus","volume":"32","author":"Xia","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib37","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2010.07.003","article-title":"Characteristics of the interferon regulatory factor pairs zfIRF5\/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio)","volume":"34","author":"Xiang","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.vetimm.2009.10.020","article-title":"The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon Idella","volume":"134","author":"Xu","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2026.105598_bib39","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1111\/tbed.14143","article-title":"Uncovering the first occurrence of Tilapia parvovirus in Thailand in tilapia during co-infection with Tilapia tilapinevirus","volume":"68","author":"Yamkasem","year":"2021","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.dci.2026.105598_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109968","article-title":"bcIRF5 activates bcTBK1 phosphorylation to enhance PANoptosis during GCRV infection","volume":"154","author":"Yang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103426","article-title":"Black carp IRF5 interacts with TBK1 to trigger cell death following viral infection","volume":"100","author":"Yang","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib42","article-title":"Behavioral dysregulation in Nile tilapia (Oreochromis niloticus, GIFT) post-streptococcus agalactia infection: role of the microbiota-gut-brain axis","volume":"285","author":"Yi","year":"2024","journal-title":"Comp. Biochem. Phaysiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.dci.2026.105598_bib43","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.fsi.2015.02.033","article-title":"Molecular characterization and expression analysis of eleven interferon regulatory factors in half-smooth tongue sole, Cynoglossus semilaevis","volume":"44","author":"Zhang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105598_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12917-016-0750-4","article-title":"Characterization of common carp (Cyprinus carpio L.) interferon regulatory factor 5 (IRF5) and its expression in response to viral and bacterial challenges","volume":"12","author":"Zhu","year":"2016","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.dci.2026.105598_bib45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.fsi.2019.12.058","article-title":"Structural and expression analysis of golden pompano Trachinotus ovatus IRF5 and its role in regulation of type I IFN","volume":"97","author":"Zhu","year":"2020","journal-title":"Fish Shellfish Immunol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26000546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26000546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:05:56Z","timestamp":1776499556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X26000546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":45,"alternative-id":["S0145305X26000546"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2026.105598","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization and functional analysis of the interferon regulatory factor 5 (IRF5) from the GIFT Oreochromis niloticus","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2026.105598","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105598"}}