{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:47:05Z","timestamp":1785876425814,"version":"3.56.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42406127"],"award-info":[{"award-number":["42406127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QC107"],"award-info":[{"award-number":["ZR2023QC107"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QC233"],"award-info":[{"award-number":["ZR2022QC233"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tstp20240518"],"award-info":[{"award-number":["tstp20240518"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015335","name":"Modern Agricultural Technology Industry System of Shandong province","doi-asserted-by":"publisher","award":["SDAIT-14-01"],"award-info":[{"award-number":["SDAIT-14-01"]}],"id":[{"id":"10.13039\/501100015335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015335","name":"Modern Agricultural Technology Industry System of Shandong province","doi-asserted-by":"publisher","award":["202203"],"award-info":[{"award-number":["202203"]}],"id":[{"id":"10.13039\/501100015335","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.dci.2026.105662","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:49:44Z","timestamp":1782143384000},"page":"105662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The significant regulatory role of cytochrome P450 in the innate immune response of the Zhikong scallop (Chlamys farreri)"],"prefix":"10.1016","volume":"181","author":[{"given":"Yue","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vengatesen","family":"Thiyagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-5684","authenticated-orcid":false,"given":"Baoyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2026.105662_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.fsi.2014.01.002","article-title":"Bioinformatics analysis of hemocyte miRNAs of scallop Chlamys farreri against acute viral necrobiotic virus (AVNV)","volume":"37","author":"Chen","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105662_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.743020","article-title":"Two novel TRAF homologs are implicated in the immunological response and interact with IRAK in the Zhikong scallop (Chlamys farreri)","volume":"611","author":"Chen","year":"2026","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2026.105662_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108674","article-title":"Essential role of the Cytochrome P450 2 (CYP2) in the mud crab Scylla paramamosain antioxidant defense and immune responses","volume":"135","author":"Cheng","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105662_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2020.103490","article-title":"Diversity and evolution of the P450 family in arthropods","volume":"127","author":"Dermauw","year":"2020","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2026.105662_bib5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.tibs.2020.03.004","article-title":"Natural compounds as pharmaceuticals: the key role of cytochromes P450 reactivity","volume":"45","author":"Di Nardo","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.dci.2026.105662_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165020","article-title":"Genome-wide analysis, classification, evolution, and expression analysis of the cytochrome P450 93 family in land plants","volume":"11","author":"Du","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2026.105662_bib8","first-page":"1997","article-title":"ERK\/MAPK signalling pathway and tumorigenesis","volume":"19","author":"Guo","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.dci.2026.105662_bib7","series-title":"Developments in Aquaculture and Fisheries Science","first-page":"937","article-title":"Chapter 22 - scallops and scallop aquaculture in China","author":"Guo","year":"2016"},{"key":"10.1016\/j.dci.2026.105662_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbd.2017.10.003","article-title":"Genome-wide identification of 31 cytochrome P450 (CYP) genes in the freshwater rotifer Brachionus calyciflorus and analysis of their benzo[\u03b1]pyrene-induced expression patterns","volume":"25","author":"Han","year":"2018","journal-title":"Comp. Biochem. Physiol. D-Genomics Proteomics"},{"key":"10.1016\/j.dci.2026.105662_bib10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0003-9861(58)90436-3","article-title":"Pigments of rat liver microsomes","volume":"75","author":"Klingenberg","year":"1958","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.dci.2026.105662_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741148","article-title":"IKK2 modulates the innate immune response of Zhikong scallop (Chlamys farreri) to bacterial and viral stimuli through the MyD88-dependent toll-like receptor signaling pathway","volume":"591","author":"Li","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2026.105662_bib12","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.ijbiomac.2022.09.248","article-title":"Scallop interferon regulatory factor 1 interacts with myeloid differentiation primary response protein 88 and is crucial for antiviral innate immunity","volume":"222","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.dci.2026.105662_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pbiomolbio.2024.09.003","article-title":"Cytochrome P450 monooxygenase systems: diversity and plasticity for adaptive stress response","volume":"193","author":"Mokhosoev","year":"2024","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.dci.2026.105662_bib14","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2012.0430","article-title":"A world of cytochrome P450s","volume":"368","author":"Nelson","year":"2013","journal-title":"Philos. Trans. R. Soc. B-Biol. Sci."},{"key":"10.1016\/j.dci.2026.105662_bib15","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2012.0474","article-title":"The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s","volume":"368","author":"Nelson","year":"2013","journal-title":"Philos. Trans. R. Soc. B-Biol. Sci."},{"key":"10.1016\/j.dci.2026.105662_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pharmthera.2011.11.009","article-title":"Formation of P450\u00b7P450 complexes and their effect on P450 function","volume":"133","author":"Reed","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.dci.2026.105662_bib17","series-title":"Diseases of Bivalves","first-page":"175","article-title":"13 - herpesvirus infections in marine bivalves","author":"Renault","year":"2025"},{"key":"10.1016\/j.dci.2026.105662_bib18","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.dci.2026.105662_bib19","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1096\/fasebj.9.9.7601337","article-title":"The MAPK signaling cascade","volume":"9","author":"Seger","year":"1995","journal-title":"Faseb J"},{"key":"10.1016\/j.dci.2026.105662_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10499-025-01934-9","article-title":"Identification of the CYP gene family: insights into carotenoid metabolism associated with red shell in Meretrix meretrix","volume":"33","author":"Shi","year":"2025","journal-title":"Aquac. Int."},{"key":"10.1016\/j.dci.2026.105662_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00089","article-title":"The role of cytochromes P450 in infection","volume":"9","author":"Stavropoulou","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2026.105662_bib22","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1016\/j.celrep.2018.11.030","article-title":"ISRE-reporter mouse reveals high basal and induced type I IFN responses in inflammatory monocytes","volume":"25","author":"Uccellini","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.dci.2026.105662_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.dci.2015.09.006","article-title":"An LRR-only protein representing a new type of pattern recognition receptor in Chlamys farreri","volume":"54","author":"Wang","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105662_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbd.2024.101291","article-title":"Genome-wide analysis of the cytochrome P450 gene family in Pacific oyster Crassostrea gigas and their expression profiles during gonad development","volume":"52","author":"Wang","year":"2024","journal-title":"Comp. Biochem. Physiol. D-Genomics Proteomics"},{"key":"10.1016\/j.dci.2026.105662_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739730","article-title":"Assessment of germplasm resource and detection of genomic signature under artificial selection of Zhikong scallop (Chlamys farreri)","volume":"574","author":"Wang","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2026.105662_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2000-1-6-reviews3003","article-title":"Cytochromes P450: a success story","volume":"1","author":"Werck-Reichhart","year":"2000","journal-title":"Genome Biol."},{"key":"10.1016\/j.dci.2026.105662_bib27","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.fsi.2022.10.022","article-title":"Atrazine exposure induces necroptosis through the P450\/ROS pathway and causes inflammation in the gill of common carp (Cyprinus carpio L.)","volume":"131","author":"Xu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105662_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s44466-025-00019-9","article-title":"The IRF transcription factor family in type I interferon-mediated antiviral immunity and associated diseases","volume":"2","author":"Yanai","year":"2026","journal-title":"Immunity & Inflammation"},{"key":"10.1016\/j.dci.2026.105662_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136551","article-title":"RNA-seq analysis of LPS-induced immune priming in silkworms (Bombyx mori) and the role of cytochrome P450 detoxification system in the process","volume":"283","author":"Yi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.dci.2026.105662_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2019.105239","article-title":"Two novel CYP3A isoforms in marine mussel Mytilus coruscus: identification and response to cadmium and benzo[a]pyrene","volume":"214","author":"Zhang","year":"2019","journal-title":"Aquat. Toxicol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:04:48Z","timestamp":1785873888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X26001187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"alternative-id":["S0145305X26001187"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2026.105662","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The significant regulatory role of cytochrome P450 in the innate immune response of the Zhikong scallop (Chlamys farreri)","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2026.105662","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105662"}}