{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:03:41Z","timestamp":1784124221196,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.dci.2026.105677","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:10:08Z","timestamp":1783350608000},"page":"105677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Scallop toll-like receptor engages in complex interactions with diverse MyD88 proteins and orchestrates host innate immune responses"],"prefix":"10.1016","volume":"181","author":[{"given":"Jilv","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vengatesen","family":"Thiyagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2026.105677_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.fsi.2006.08.018","article-title":"Molecular cloning and expression of a toll receptor in the giant tiger shrimp, Penaeus monodon","volume":"23","author":"Arts","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ni1253","article-title":"Are innate immune signaling pathways in plants and animals conserved?","volume":"6","author":"Ausubel","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nature02761","article-title":"Inferences, questions and possibilities in toll-like receptor signalling","volume":"430","author":"Beutler","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.dci.2026.105677_bib5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/0022034510381264","article-title":"TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk","volume":"90","author":"Brown","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.dci.2026.105677_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-virology-100114-054952","article-title":"Viruses as winners in the game of life","volume":"3","author":"Cobi\u00e1n G\u00fcemes","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.dci.2026.105677_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cbpb.2008.06.014","article-title":"The enhanced immune protection of Zhikong scallop Chlamys farreri on the secondary encounter with listonella anguillarum","volume":"151","author":"Cong","year":"2008","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2026.105677_bib8","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cell.2006.02.001","article-title":"The evolution of adaptive immune systems","volume":"124","author":"Cooper","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.dci.2026.105677_bib9","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.dci.2007.11.004","article-title":"Toll-like receptor genes (TLRs) from Capitella capitata and Helobdella robusta (Annelida)","volume":"32","author":"Davidson","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fsi.2012.11.009","article-title":"Immune responses and gene expression in hepatopancreas from Macrobrachium rosenbergii challenged by a novel pathogen spiroplasma MR-1008","volume":"34","author":"Du","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.272.5258.50","article-title":"The instructive role of innate immunity in the acquired immune response","volume":"272","author":"Fearon","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.dci.2026.105677_bib12","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-like receptors and the control of immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.dci.2026.105677_bib13","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.it.2004.10.001","article-title":"Evolution of innate and adaptive immunity: can we draw a line?","volume":"25","author":"Flajnik","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nri3713","article-title":"Assembly and localization of toll-like receptor signalling complexes","volume":"14","author":"Gay","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/978-981-13-3065-0_18","article-title":"PRR function of innate immune receptors in recognition of bacteria or bacterial ligands","volume":"1112","author":"Gulati","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.dci.2026.105677_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ydbio.2006.08.065","article-title":"The immune gene repertoire encoded in the purple sea urchin genome","volume":"300","author":"Hibino","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.dci.2026.105677_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109697","article-title":"A newly identified scallop MyD88 interacts with TLR and functions in innate immunity","volume":"151","author":"Huang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","article-title":"TLR signaling","volume":"19","author":"Kawai","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741148","article-title":"IKK2 modulates the innate immune response of zhikong scallop (Chlamys farreri) to bacterial and viral stimuli through the MyD88-dependent toll-like receptor signaling pathway","volume":"591","author":"Li","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.dci.2026.105677_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.dci.2026.105677_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128319","article-title":"A molluscan IRF interacts with IKK\u03b1\/\u03b2 family protein and modulates NF-\u03baB and MAPK activity","volume":"256","author":"Ma","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.dci.2026.105677_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dci.2016.02.012","article-title":"Characterization and functional analysis of two inhibitor of apoptosis genes in Zhikong scallop Chlamys farreri","volume":"60","author":"Miao","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: tir-domain-containing adaptors in toll-like receptor signalling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fimmu.2012.00079","article-title":"The role of TLR2 in infection and immunity","volume":"3","author":"Oliveira-Nascimento","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12862-021-01927-1","article-title":"The evolution of the metazoan toll receptor family and its expression during protostome development","volume":"21","author":"Or\u00fas-Alcalde","year":"2021","journal-title":"BMC Ecol. Evol."},{"key":"10.1016\/j.dci.2026.105677_bib27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.fsi.2006.05.003","article-title":"Molecular cloning and expression of a toll receptor gene homologue from Zhikong scallop, Chlamys farreri","volume":"22","author":"Qiu","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msad133","article-title":"Bivalves present the largest and Most diversified repertoire of toll-like receptors in the animal kingdom, suggesting broad-spectrum pathogen recognition in marine waters","volume":"40","author":"Saco","year":"2023","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.dci.2026.105677_bib29","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/intimm\/13.7.933","article-title":"Discrimination of bacterial lipoproteins by toll-like receptor 6","volume":"13","author":"Takeuchi","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4049\/jimmunol.169.1.10","article-title":"Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins","volume":"169","author":"Takeuchi","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35085597","article-title":"TAK1 is a ubiquitin-dependent kinase of MKK and IKK","volume":"412","author":"Wang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.dci.2026.105677_bib32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.dci.2015.05.011","article-title":"The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri","volume":"52","author":"Wang","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.fsi.2017.12.064","article-title":"The various components implied the diversified toll-like receptor (TLR) signaling pathway in mollusk Chlamys farreri","volume":"74","author":"Wang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib34","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.fsi.2013.07.044","article-title":"Two novel toll genes (EsToll1 and EsToll2) from Eriocheir sinensis are differentially induced by lipopolysaccharide, peptidoglycan and zymosan","volume":"35","author":"Yu","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.fsi.2010.12.023","article-title":"A Crassostrea gigas toll-like receptor and comparative analysis of TLR pathway in invertebrates","volume":"30","author":"Zhang","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105677_bib36","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s11427-016-0325-6","article-title":"Innate recognition of microbial-derived signals in immunity and inflammation","volume":"59","author":"Zhang","year":"2016","journal-title":"Sci. China Life Sci."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:04:10Z","timestamp":1784120650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X26001333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"alternative-id":["S0145305X26001333"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2026.105677","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scallop toll-like receptor engages in complex interactions with diverse MyD88 proteins and orchestrates host innate immune responses","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2026.105677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105677"}}