{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:25:21Z","timestamp":1787199921517,"version":"build-2736575974"},"reference-count":222,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["AA24011002"],"award-info":[{"award-number":["AA24011002"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["cstc2021jcyj-cxtt0005"],"award-info":[{"award-number":["cstc2021jcyj-cxtt0005"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006250","name":"Southwest University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015946","name":"Southwest Medical University Institute of Cardiovascular Research","doi-asserted-by":"publisher","award":["SWU-XDZD22006"],"award-info":[{"award-number":["SWU-XDZD22006"]}],"id":[{"id":"10.13039\/501100015946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.dci.2026.105695","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:18:49Z","timestamp":1785194329000},"page":"105695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparative anti-viral immune strategies in insects and vertebrates: Insights from Bombyx mori"],"prefix":"10.1016","volume":"182","author":[{"given":"Muhammad Nadeem","family":"Abbas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Kausar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2026.105695_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1176966","article-title":"MicroRNAs reshape the immunity of insects in response to bacterial infection","volume":"14","author":"Abbas","year":"2023","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/genes14040895","article-title":"The potential biological roles of circular RNAs in the immune systems of insects to pathogen invasion","volume":"14","author":"Abbas","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.dci.2026.105695_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.dci.2017.12.003","article-title":"Suppressor of cytokine signaling 6 can enhance epidermal growth factor receptor signaling pathway in Bombyx mori (Dazao)","volume":"81","author":"Abbas","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103561","article-title":"Suppressors of cytokine signaling proteins as modulators of development and innate immunity of insects","volume":"104","author":"Abbas","year":"2020","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib6","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.4049\/jimmunol.0900592","article-title":"Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory","volume":"183","author":"Agarwal","year":"2009","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.tig.2022.02.009","article-title":"Taming transposable elements in vertebrates: from epigenetic silencing to domestication","volume":"38","author":"Almeida","year":"2022","journal-title":"Trends Genet."},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib9","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fonc.2020.01298","article-title":"LC3-Associated phagocytosis (LAP): a potentially influential mediator of efferocytosis-related tumor progression and aggressiveness","volume":"10","author":"Asare","year":"2020","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.dci.2026.105695_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107771","article-title":"Transcriptional control of interferon-stimulated genes","volume":"300","author":"Babadei","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib11","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth Factor-\u03b2 signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2026.105695_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1567459","article-title":"Interferon and immunity: the role of microRNA in viral evasion strategies","volume":"16","author":"Bayat","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13148-021-01126-1","article-title":"The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes","volume":"13","author":"Beacon","year":"2021","journal-title":"Clin. Epigenet."},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib14","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1128\/JVI.80.7.3189-3204.2006","article-title":"Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32","volume":"80","author":"Berro","year":"2006","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.104193","article-title":"Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections","volume":"29","author":"Bhat","year":"2024","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.dci.2026.105695_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41577-024-01083-9","article-title":"Understanding vertebrate immunity through comparative immunology","volume":"25","author":"Boehm","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-ento-033020-090410","article-title":"The interplay between viruses and RNAi pathways in insects","volume":"66","author":"Bonning","year":"2021","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.dci.2026.105695_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fmicb.2019.00051","article-title":"Evolution of immune systems from viruses and transposable elements","volume":"10","author":"Broecker","year":"2019","journal-title":"Front. Microbiol."},{"issue":"48","key":"10.1016\/j.dci.2026.105695_bib19","doi-asserted-by":"crossref","first-page":"24296","DOI":"10.1073\/pnas.1909183116","article-title":"A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in Drosophila","volume":"116","author":"Bronkhorst","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2026.105695_bib20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fimmu.2014.00459","article-title":"Evolution of innate immunity: clues from invertebrates via fish to mammals","volume":"5","author":"Buchmann","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/1471-2164-9-425","article-title":"Comparative genomics of small RNA regulatory pathway components in vector mosquitoes","volume":"9","author":"Campbell","year":"2008","journal-title":"BMC Genom."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib22","first-page":"1378","article-title":"Bmo-miR-3351 modulates glutathione content and inhibits BmNPV proliferation by targeting BmGSTe6 in Bombyx mori","volume":"31","author":"Cao","year":"2024","journal-title":"Insect Sci."},{"key":"10.1016\/j.dci.2026.105695_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104098","article-title":"Immune properties of invertebrate phenoloxidases","volume":"122","author":"Cerenius","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib24","article-title":"Transposable element repression using piRNAs, and its relevance to endogenous viral elements (EVEs) and immunity in insects","volume":"50","author":"Cerqueira de Araujo","year":"2022","journal-title":"Curr. Opin. Insect Sci."},{"issue":"8","key":"10.1016\/j.dci.2026.105695_bib25","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s12298-025-01611-4","article-title":"Strategies for plant-virus disease management from gene editing to nanotechnology","volume":"31","author":"Chaturvedi","year":"2025","journal-title":"Physiol. Mol. Biol. Plants"},{"issue":"8","key":"10.1016\/j.dci.2026.105695_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116155","article-title":"Insect dome receptor directly recognizes viral envelopes to activate JAK\/STAT signaling and induce conserved antiviral viperin expression","volume":"44","author":"Chen","year":"2025","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/imb.12566","article-title":"Specific genes related to nucleopolyhedrovirus in Bombyx mori susceptible and near-isogenic resistant strains through comparative transcriptome analysis","volume":"28","author":"Chen","year":"2019","journal-title":"Insect Mol. Biol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/insects14040309","article-title":"BmCBP catalyzes the acetylation of BmApoLp-II protein and regulates its stability in silkworm, Bombyx mori","volume":"14","author":"Chen","year":"2023","journal-title":"Insects"},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.aspen.2022.101879","article-title":"DNA hypermethylation level of ACTL6A may promote BmNPV infection in B. mori","volume":"25","author":"Chen","year":"2022","journal-title":"J. Asia Pac. Entomol."},{"issue":"20","key":"10.1016\/j.dci.2026.105695_bib30","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1038\/emboj.2013.203","article-title":"IFN\u03b2-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage","volume":"32","author":"Cheon","year":"2013","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib31","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001741","article-title":"The antiviral role of NF-\u03baB-mediated immune responses and their antagonism by viruses in insects","volume":"103","author":"Cheung","year":"2022","journal-title":"J. Gen. Virol."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01805-23","article-title":"Single-cell RNA-seq revealed heterogeneous responses and functional differentiation of hemocytes against white spot syndrome virus infection in Litopenaeus vannamei","volume":"98","author":"Cui","year":"2024","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib33","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.chom.2024.08.002","article-title":"Conservation of antiviral systems across domains of life reveals immune genes in humans","volume":"32","author":"Cury","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"12","key":"10.1016\/j.dci.2026.105695_bib34","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.3390\/v5123192","article-title":"Make yourself at home: viral hijacking of the PI3K\/Akt signaling pathway","volume":"5","author":"Diehl","year":"2013","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2007.07.039","article-title":"Antiviral immunity directed by small RNAs","volume":"130","author":"Ding","year":"2007","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.dci.2026.105695_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910464","article-title":"Regulation of B cell responses in SLE by three classes of interferons","volume":"22","author":"Domeier","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2026.105695_bib37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.antiviral.2016.03.009","article-title":"Establishment of a highly efficient virus-inducible CRISPR\/Cas9 system in insect cells","volume":"130","author":"Dong","year":"2016","journal-title":"Antivir. Res."},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib38","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ni1237","article-title":"The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila","volume":"6","author":"Dostert","year":"2005","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nbt.3155","article-title":"Inducible in vivo genome editing with CRISPR-Cas9","volume":"33","author":"Dow","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.70012","article-title":"PiRNAs, PiRNA-Like, and PIWI proteins in somatic cells: from genetic regulation to disease mechanisms","volume":"16","author":"Dudzik","year":"2025","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.dci.2026.105695_bib41","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/B978-0-12-396456-4.00002-X","article-title":"HijAkt: the PI3K\/Akt pathway in virus replication and pathogenesis","volume":"106","author":"Dunn","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib42","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.immuni.2024.02.019","article-title":"New frontiers in the cGAS-STING intracellular DNA-sensing pathway","volume":"57","author":"Dvorkin","year":"2024","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002481","article-title":"Tracing the evolutionary origins of antiviral immunity","volume":"22","author":"Eaglesham","year":"2024","journal-title":"PLoS Biol."},{"key":"10.1016\/j.dci.2026.105695_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106767","article-title":"Bifunctional HDAC and DNMT inhibitor induces viral mimicry activates the innate immune response in triple-negative breast cancer","volume":"197","author":"Fan","year":"2024","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.dci.2026.105695_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1123448","article-title":"Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update","volume":"14","author":"Fan","year":"2023","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.20112343","article-title":"Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response","volume":"209","author":"Fang","year":"2012","journal-title":"J. Exp. Med."},{"issue":"Pt 4","key":"10.1016\/j.dci.2026.105695_bib47","article-title":"Autophagy promotes replication of Bombyx mori Nucleopolyhedrovirus in insect cells","volume":"277","author":"Fei","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib48","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.immuni.2024.02.004","article-title":"The transcription factor NF-\u03baB orchestrates nucleosome remodeling during the primary response to toll-like receptor 4 signaling","volume":"57","author":"Feng","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2026.105695_bib49","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.3389\/fimmu.2020.02030","article-title":"Antimicrobial peptides as potential antiviral factors in Insect antiviral immune response","volume":"11","author":"Feng","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib50","first-page":"173","article-title":"Single-nucleus sequencing of silkworm larval brain reveals the key role of lysozyme in the antiviral immune response in brain hemocytes","volume":"16","author":"Feng","year":"2024","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.dci.2026.105695_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.645359","article-title":"Identification of silkworm hemocyte subsets and analysis of their response to baculovirus infection based on single-cell RNA sequencing","volume":"12","author":"Feng","year":"2021","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.dci.2026.105695_bib52","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41423-019-0280-7","article-title":"A host lncRNA regulates the innate immune response to an RNA virus","volume":"16","author":"Fukushima","year":"2019","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cells12030386","article-title":"Methods to assess proliferation of stimulated human lymphocytes in vitro: a narrative review","volume":"12","author":"Ganesan","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib54","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201798","article-title":"Single-nucleotide methylation specifically represses type I interferon in antiviral innate immunity","volume":"218","author":"Gao","year":"2021","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib55","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ncrna.2023.07.002","article-title":"MiRNAs and lncRNAs in the regulation of innate immune signaling","volume":"8","author":"Gareev","year":"2023","journal-title":"Noncoding RNA Res."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib56","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41418-019-0297-6","article-title":"Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation","volume":"26","author":"Germic","year":"2019","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010202","article-title":"Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs","volume":"18","author":"Gestuveo","year":"2022","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2022.100132","article-title":"Tumor-infiltrating T cells can be expanded successfully from primary uveal melanoma after separation from their tumor environment","volume":"2","author":"Gezgin","year":"2022","journal-title":"Ophthalmol. Sci."},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/v17071017","article-title":"Regulation of bombyx mori-BmNPV protein interactions: study strategies and molecular mechanisms","volume":"17","author":"Guo","year":"2025","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib60","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1038\/s41467-020-16608-8","article-title":"MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host","volume":"11","author":"Guo","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0319290","article-title":"Zika virus modulates arthropod histone methylation for its survival in mosquito cells","volume":"20","author":"Harrell","year":"2025","journal-title":"PLoS One"},{"issue":"1\u20132","key":"10.1016\/j.dci.2026.105695_bib62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s13148-010-0003-5","article-title":"Histone deacetylases in viral infections","volume":"1","author":"Herbein","year":"2010","journal-title":"Clin. Epigenet."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib63","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000232","article-title":"NF-kappaB in the immune response of Drosophila","volume":"1","author":"Hetru","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib64","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3390\/v16050714","article-title":"piRNA-Guided transposon silencing and response to stress in Drosophila germline","volume":"16","author":"Ho","year":"2024","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41467-023-44175-1","article-title":"Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection","volume":"15","author":"Hou","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib66","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1534-5807(02)00376-3","article-title":"The Jak\/STAT pathway in model organisms: emerging roles in cell movement","volume":"3","author":"Hou","year":"2002","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib67","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","article-title":"Development and applications of CRISPR-Cas9 for genome engineering","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib68","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib69","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s00438-015-1065-z","article-title":"Transcriptome analysis of BmN cells following over-expression of BmSTAT","volume":"290","author":"Hu","year":"2015","journal-title":"Mol. Genet. Genom."},{"issue":"30","key":"10.1016\/j.dci.2026.105695_bib70","doi-asserted-by":"crossref","first-page":"11878","DOI":"10.1074\/jbc.RA117.000194","article-title":"Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase-mediated NF-\u03baB activation","volume":"293","author":"Hua","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.dci.2026.105695_bib71","first-page":"2246","article-title":"Circular RNAs-protein interactions: Functions, mechanisms, and identification","volume":"9","author":"Huang","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib72","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1186\/s12864-019-6146-7","article-title":"DNA methylomes and transcriptomes analysis reveal implication of host DNA methylation machinery in BmNPV proliferation in Bombyx mori","volume":"20","author":"Huang","year":"2019","journal-title":"BMC Genom."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib73","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41420-024-01895-7","article-title":"Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer","volume":"10","author":"Huang","year":"2024","journal-title":"Cell Death Discov."},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib74","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.tig.2017.09.002","article-title":"piRNA biogenesis in Drosophila melanogaster","volume":"33","author":"Huang","year":"2017","journal-title":"Trends Genet."},{"key":"10.1016\/j.dci.2026.105695_bib75","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jinsphys.2014.08.003","article-title":"MicroRNAs as mediators of insect host-pathogen interactions and immunity","volume":"70","author":"Hussain","year":"2014","journal-title":"J. Insect Physiol."},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib76","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1007\/s13346-025-01815-x","article-title":"Preclinical testing of antiviral siRNA therapeutics delivered in lipid nanoparticles in animal models - a comprehensive review","volume":"15","author":"Idres","year":"2025","journal-title":"Drug Deliv. Transl. Res."},{"issue":"7265","key":"10.1016\/j.dci.2026.105695_bib77","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.dci.2026.105695_bib78","series-title":"Biotechnology for Silkworm Crop Enhancement: Tools and Applications","first-page":"119","article-title":"Engineered disease resistance silkworm using genome editing","author":"Ito","year":"2024"},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib79","article-title":"Host response against virus infection in an insect: bidensovirus infection effect on Silkworm (Bombyx mori)","volume":"10","author":"Ito","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib80","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib81","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41559-022-01951-4","article-title":"Origins and diversification of animal innate immune responses against viral infections","volume":"7","author":"Iwama","year":"2023","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.dci.2026.105695_bib82","article-title":"Insights into the antiviral pathways of the silkworm Bombyx mori","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib83","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/imb.12386","article-title":"Bombyx mori epidermal growth factor receptor is required for nucleopolyhedrovirus replication","volume":"27","author":"Jin","year":"2018","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.dci.2026.105695_bib84","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fphys.2016.00553","article-title":"RNAi efficiency, systemic properties, and novel delivery methods for Pest insect control: what we know So far","volume":"7","author":"Joga","year":"2016","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115411","article-title":"Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria","volume":"44","author":"Johnston","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.dci.2026.105695_bib86","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijbiomac.2021.06.205","article-title":"A review on the DNA methyltransferase family of insects: aspect and prospects","volume":"186","author":"Kausar","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/arch.21435","article-title":"Role of Antheraea pernyi serpin 12 in prophenoloxidase activation and immune responses","volume":"97","author":"Kausar","year":"2018","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.dci.2026.105695_bib88","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.dci.2017.05.017","article-title":"Serpin-14 negatively regulates prophenoloxidase activation and expression of antimicrobial peptides in Chinese oak silkworm Antheraea pernyi","volume":"76","author":"Kausar","year":"2017","journal-title":"Dev. Comp. Immunol."},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib89","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib90","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/nar\/gks1275","article-title":"The comprehensive epigenome map of piRNA clusters","volume":"41","author":"Kawaoka","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.dci.2026.105695_bib91","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.ibmb.2008.03.007","article-title":"Bombyx small RNAs: genomic defense system against transposons in the silkworm, Bombyx mori","volume":"38","author":"Kawaoka","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2026.105695_bib92","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ijbiomac.2020.02.296","article-title":"Niemann-Pick type C1 regulates cholesterol transport and metamorphosis in silkworm, Bombyx mori (Dazao)","volume":"152","author":"Ke","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.dci.2026.105695_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2021.104831","article-title":"Epigenetic reprogramming mechanisms of immunity during influenza A virus infection","volume":"23","author":"Keshavarz","year":"2021","journal-title":"Microb. Infect."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib94","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00015-23","article-title":"MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets","volume":"36","author":"Kimura","year":"2023","journal-title":"Clin. Microbiol. Rev."},{"issue":"24","key":"10.1016\/j.dci.2026.105695_bib95","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1016\/j.jmb.2013.10.006","article-title":"Insect antiviral innate immunity: pathways, effectors, and connections","volume":"425","author":"Kingsolver","year":"2013","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib96","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.cell.2009.07.014","article-title":"The <em>Drosophila<\/em> HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters","volume":"138","author":"Klattenhoff","year":"2009","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib97","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.dci.2026.105695_bib98","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.105011","article-title":"Current insights into insect immune memory","volume":"14","author":"Krej\u010dov\u00e1","year":"2025","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib99","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae1288","article-title":"Enhanced RNAi does not provide efficient innate antiviral immunity in mice","volume":"53","author":"Kulmann","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"Supplement_1","key":"10.1016\/j.dci.2026.105695_bib100","doi-asserted-by":"crossref","first-page":"94.18","DOI":"10.4049\/jimmunol.184.Supp.94.18","article-title":"Viral immune evasion: HSV-1 immediate early protein ICP0 inhibits TLR2-driven NF-kB activation (94.18)","volume":"184","author":"Kurt-Jones","year":"2010","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib101","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1128\/JVI.00238-16","article-title":"Analysis of the contribution of hemocytes and autophagy to drosophila antiviral immunity","volume":"90","author":"Lamiable","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.dci.2026.105695_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104285","article-title":"Innate immune memory in invertebrates: concept and potential mechanisms","volume":"127","author":"Lanz-Mendoza","year":"2022","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib103","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1101\/gad.209841.112","article-title":"Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state","volume":"27","author":"Le Thomas","year":"2013","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib104","doi-asserted-by":"crossref","DOI":"10.3390\/v16020197","article-title":"Epigenetic control of innate immunity: consequences of acute respiratory virus infection","volume":"16","author":"Lefkowitz","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.dci.2026.105695_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.802149","article-title":"The influence of host miRNA binding to RNA within RNA viruses on virus multiplication","volume":"12","author":"Lei","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/insects14060515","article-title":"TGF-\u03b2 type II receptor punt suppresses antimicrobial peptide expression and influences development in Tribolium castaneum","volume":"14","author":"Li","year":"2023","journal-title":"Insects"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib107","doi-asserted-by":"crossref","DOI":"10.1002\/arch.21724","article-title":"Functional analysis of Dicer-2 gene in Bombyx mori resistance to BmNPV virus","volume":"105","author":"Li","year":"2020","journal-title":"Arch. Insect Biochem. Physiol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib108","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2174\/0929866523666161129114520","article-title":"Identification of tyrosine kinase src responsible for antimicrobial peptides production in Bombyx mori","volume":"24","author":"Li","year":"2017","journal-title":"Protein Pept. Lett."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib109","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11262-024-02078-3","article-title":"The potential emerging role of piRNA\/PIWI complex in virus infection","volume":"60","author":"Li","year":"2024","journal-title":"Virus Genes"},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007245","article-title":"Bombyx mori histone methyltransferase BmAsh2 is essential for silkworm piRNA-mediated sex determination","volume":"14","author":"Li","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.dci.2026.105695_bib111","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1485951","article-title":"Downregulation of BmSTAT transcription factor promoted nucleopolyhedrovirus replication in Bombyx mori","volume":"15","author":"Liang","year":"2024","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib112","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/imb.12821","article-title":"LincRNA_XR209691.3 could promote Bombyx mori nucleopolyhedrovirus replication by interacting with BmHSP70","volume":"32","author":"Lin","year":"2023","journal-title":"Insect Mol. Biol."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib113","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032777","article-title":"Evolution of JAK-STAT pathway components: mechanisms and role in immune system development","volume":"7","author":"Liongue","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2026.105695_bib114","article-title":"The emerging role of STING in insect innate immune responses and pathogen evasion strategies","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib115","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.molimm.2015.02.018","article-title":"Immune signaling pathways activated in response to different pathogenic micro-organisms in Bombyx mori","volume":"65","author":"Liu","year":"2015","journal-title":"Mol. Immunol."},{"issue":"15","key":"10.1016\/j.dci.2026.105695_bib116","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf743","article-title":"Antiviral RNA silencing in mammals: the importance of selecting the appropriate experimental model","volume":"53","author":"Liu","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib117","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00658-23","article-title":"Virus hijacking of host epigenetic machinery to impair immune response","volume":"97","author":"Locatelli","year":"2023","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib118","doi-asserted-by":"crossref","DOI":"10.70322\/immune.2025.10002","article-title":"Cell-autonomous and non-cell-autonomous antiviral immunity via siRNA-Directed RNAi in Drosophila melanogaster","volume":"1","author":"Luan","year":"2025","journal-title":"Immune Discov."},{"issue":"24","key":"10.1016\/j.dci.2026.105695_bib119","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415836","article-title":"Current scenario of exogenously induced RNAi for lepidopteran agricultural Pest control: from dsRNA design to topical application","volume":"23","author":"Lucena-Leandro","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib120","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41392-024-01934-w","article-title":"The JAK-STAT pathway: from structural biology to cytokine engineering","volume":"9","author":"Lv","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114460","article-title":"The architecture of silk-secreting organs during the final larval stage of silkworms revealed by single-nucleus and spatial transcriptomics","volume":"43","author":"Ma","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.dci.2026.105695_bib122","article-title":"Leaning into the bite: the piRNA pathway as an exemplar for the genetic engineering need in mosquitoes","volume":"10","author":"Macias","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.dci.2026.105695_bib123","doi-asserted-by":"crossref","DOI":"10.1007\/s42977-025-00281-3","article-title":"RNA interference (RNAi) for insect pest management: understanding mechanisms, strategies, challenges and future prospects","author":"Mahanta","year":"2025","journal-title":"Biol. Futur."},{"issue":"8","key":"10.1016\/j.dci.2026.105695_bib124","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100941","article-title":"Slicing and dicing viruses: antiviral RNA interference in mammals","volume":"38","author":"Maillard","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.dci.2026.105695_bib125","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15990","article-title":"Regulation of Drosophila hematopoietic sites by Activin-\u03b2 from active sensory neurons","volume":"8","author":"Makhijani","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00360-022-01468-z","article-title":"Insect phenoloxidase and its diverse roles: melanogenesis and beyond","volume":"193","author":"Marieshwari","year":"2023","journal-title":"J. Comp. Physiol. B"},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114678","article-title":"An evolutionary perspective to innate antiviral immunity in animals","volume":"43","author":"Marques","year":"2024","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114678","article-title":"An evolutionary perspective to innate antiviral immunity in animals","volume":"43","author":"Marques","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.dci.2026.105695_bib129","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mib.2016.05.002","article-title":"The diversity of insect antiviral immunity: insights from viruses","volume":"32","author":"Marques","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"issue":"19","key":"10.1016\/j.dci.2026.105695_bib130","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1128\/JVI.01180-16","article-title":"Epstein-barr virus oncoprotein LMP1 mediates epigenetic changes in host gene expression through PARP1","volume":"90","author":"Martin","year":"2016","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib131","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s12602-024-10391-4","article-title":"Antimicrobial peptides: mechanism, expressions, and optimization strategies","volume":"17","author":"Miao","year":"2025","journal-title":"Probiotics Antimicrob. Proteins"},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib132","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1603\/0022-0493(2007)100[939:GCOINB]2.0.CO;2","article-title":"Genetic characterization of Iranian native Bombyx mori strains using amplified fragment length polymorphism markers","volume":"100","author":"Mirhoseini","year":"2007","journal-title":"J. Econ. Entomol."},{"key":"10.1016\/j.dci.2026.105695_bib133","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.628429","article-title":"The macroautophagy machinery in MHC restricted antigen presentation","volume":"12","author":"M\u00fcnz","year":"2021","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib134","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.cell.2014.04.031","article-title":"The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila","volume":"157","author":"Mohn","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.dci.2026.105695_bib135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.856457","article-title":"Advances in the immune regulatory role of non-coding RNAs (miRNAs and lncRNAs) in insect-pathogen interactions","volume":"13","author":"Moure","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib136","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201823","article-title":"Epigenetic signals that direct cell type-specific interferon beta response in mouse cells","volume":"6","author":"Muckenhuber","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.dci.2026.105695_bib137","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cois.2021.10.004","article-title":"The emerging role of epigenetic mechanisms in insect defense against pathogens","volume":"49","author":"Mukherjee","year":"2022","journal-title":"Curr. Opin. Insect Sci."},{"key":"10.1016\/j.dci.2026.105695_bib138","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.3389\/fimmu.2020.01276","article-title":"Antigen cross-presentation by macrophages","volume":"11","author":"Muntjewerff","year":"2020","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib139","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s00018-017-2453-9","article-title":"Innate and intrinsic antiviral immunity in Drosophila","volume":"74","author":"Mussabekova","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"issue":"19","key":"10.1016\/j.dci.2026.105695_bib140","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261286","article-title":"The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression","volume":"136","author":"Naeli","year":"2023","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib141","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ibmb.2005.01.014","article-title":"Melanogenesis and associated cytotoxic reactions: Applications to insect innate immunity","volume":"35","author":"Nappi","year":"2005","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib142","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13148-019-0654-9","article-title":"Control of viral infections by epigenetic-targeted therapy","volume":"11","author":"Nehme","year":"2019","journal-title":"Clin. Epigenet."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib143","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00589-20","article-title":"Epstein-barr virus LMP1 promotes Syntenin-1- and hrs-induced extracellular vesicle formation for its own secretion to increase cell proliferation and migration","volume":"11","author":"Nkosi","year":"2020","journal-title":"mBio"},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib144","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00424-021-02641-z","article-title":"Long non-coding RNAs: novel regulators of cellular physiology and function","volume":"474","author":"Oo","year":"2022","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib145","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.it.2019.09.003","article-title":"piRNA-Guided CRISPR-like immunity in eukaryotes","volume":"40","author":"Ophinni","year":"2019","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib146","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41576-018-0073-3","article-title":"PIWI-interacting RNAs: small RNAs with big functions","volume":"20","author":"Ozata","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib147","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1371\/journal.pbio.0030041","article-title":"SIRT1 regulates HIV transcription via Tat deacetylation","volume":"3","author":"Pagans","year":"2005","journal-title":"PLoS Biol."},{"issue":"12","key":"10.1016\/j.dci.2026.105695_bib148","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011184","article-title":"A novel chimeric RNA originating from BmCPV S4 and Bombyx mori HDAC11 transcripts regulates virus proliferation","volume":"19","author":"Pan","year":"2023","journal-title":"PLoS Pathog."},{"issue":"46","key":"10.1016\/j.dci.2026.105695_bib149","doi-asserted-by":"crossref","first-page":"18915","DOI":"10.1073\/pnas.1205231109","article-title":"Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway","volume":"109","author":"Paradkar","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib150","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1097-2765(00)80181-1","article-title":"Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter","volume":"3","author":"Parekh","year":"1999","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib151","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000196","article-title":"Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression","volume":"4","author":"Pauli","year":"2008","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib152","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00914-25","article-title":"Cellular miRNAs and viruses: trends in miRNA sequestering and target de-repression","volume":"99","author":"Powell","year":"2025","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib153","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0167-5699(99)01447-4","article-title":"Cytotoxic T lymphocytes, chemokines and antiviral immunity","volume":"20","author":"Price","year":"1999","journal-title":"Immunol. Today"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib154","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010313","article-title":"Serpin-4 negatively regulates prophenoloxidase activation and antimicrobial peptide synthesis in the silkworm, Bombyx mori","volume":"25","author":"Qie","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib155","doi-asserted-by":"crossref","first-page":"9158","DOI":"10.1038\/s41467-024-53468-y","article-title":"The role of polymers in enabling RNAi-based technology for sustainable pest management","volume":"15","author":"Quilez-Molina","year":"2024","journal-title":"Nat. Commun."},{"issue":"16","key":"10.1016\/j.dci.2026.105695_bib156","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.cub.2011.06.057","article-title":"piRNA production requires Heterochromatin formation in drosophila","volume":"21","author":"Rangan","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.dci.2026.105695_bib157","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.3389\/fimmu.2020.01030","article-title":"Regulation of MAVS expression and signaling function in the antiviral innate immune response","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104010","article-title":"Genetic determinants of antiviral immunity in dipteran insects - compiling the experimental evidence","volume":"119","author":"Rosendo Machado","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib159","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008524","article-title":"Imd pathway-specific immune assays reveal NF-\u03baB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells","volume":"15","author":"Russell","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055458","article-title":"Dicer-2 processes diverse viral RNA species","volume":"8","author":"Sabin","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.dci.2026.105695_bib161","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.2007.60","article-title":"Dynamic evolution of the innate immune system in Drosophila","volume":"39","author":"Sackton","year":"2007","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.dci.2026.105695_bib162","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.immuni.2021.09.013","article-title":"Unlocking the therapeutic potential of antiviral RNAi","volume":"54","author":"Sanchez-David","year":"2021","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib163","doi-asserted-by":"crossref","DOI":"10.3390\/v14071442","article-title":"PIWI proteins play an antiviral role in lepidopteran cell lines","volume":"14","author":"Santos","year":"2022","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib164","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1038\/s41598-018-20848-6","article-title":"Insights into RNAi-based antiviral immunity in Lepidoptera: acute and persistent infections in Bombyx mori and Trichoplusia ni cell lines","volume":"8","author":"Santos","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijmm.2017.10.014","article-title":"LC3-associated phagocytosis in microbial pathogenesis","volume":"308","author":"Schille","year":"2018","journal-title":"Int. J. Med. Microbiol."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib166","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003154","article-title":"Old cytokine, new tricks: a refined model of interferon's antiviral activity","volume":"23","author":"Schoggins","year":"2025","journal-title":"PLoS Biol."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib167","doi-asserted-by":"crossref","DOI":"10.3390\/v11050448","article-title":"Antiviral RNAi in insects and mammals: parallels and differences","volume":"11","author":"Schuster","year":"2019","journal-title":"Viruses"},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib168","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1186\/gb-2010-11-6-r59","article-title":"The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates","volume":"11","author":"Sela","year":"2010","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112344","article-title":"Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons","volume":"42","author":"Sharma","year":"2023","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib170","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.immuni.2009.02.009","article-title":"Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus","volume":"30","author":"Shelly","year":"2009","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib171","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ymeth.2014.01.020","article-title":"The regulation and functions of MAPK pathways in Drosophila","volume":"68","author":"Shilo","year":"2014","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib172","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010632","article-title":"The piRNA cluster torimochi is an expanding transposon in cultured silkworm cells","volume":"19","author":"Shoji","year":"2023","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib173","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.cell.2012.10.040","article-title":"Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression","volume":"151","author":"Sienski","year":"2012","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.dci.2026.105695_bib174","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1101\/gad.909001","article-title":"NF-kappaB signaling pathways in mammalian and insect innate immunity","volume":"15","author":"Silverman","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.dci.2026.105695_bib175","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.micro.112408.134243","article-title":"Viruses, microRNAs, and host interactions","volume":"64","author":"Skalsky","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"issue":"42","key":"10.1016\/j.dci.2026.105695_bib176","doi-asserted-by":"crossref","first-page":"17841","DOI":"10.1073\/pnas.0905006106","article-title":"An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense","volume":"106","author":"Souza-Neto","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"24","key":"10.1016\/j.dci.2026.105695_bib177","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2400378121","article-title":"Epitranscriptomic cytidine methylation of the hepatitis B viral RNA is essential for viral reverse transcription and particle production","volume":"121","author":"Su","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6121","key":"10.1016\/j.dci.2026.105695_bib178","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib179","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-065X.2008.00737.x","article-title":"Innate immunity to virus infection","volume":"227","author":"Takeuchi","year":"2009","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib180","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.molmed.2016.11.003","article-title":"MicroRNA regulation of RNA virus replication and pathogenesis","volume":"23","author":"Trobaugh","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib181","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.immuni.2009.09.015","article-title":"A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy","volume":"31","author":"Turtle","year":"2009","journal-title":"Immunity"},{"issue":"21","key":"10.1016\/j.dci.2026.105695_bib182","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.R700009200","article-title":"Toll-like receptors and Type I interferons","volume":"282","author":"Uematsu","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.dci.2026.105695_bib183","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1101\/gad.1793309","article-title":"The role of RNAi and microRNAs in animal virus replication and antiviral immunity","volume":"23","author":"Umbach","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.dci.2026.105695_bib184","first-page":"1","article-title":"Chapter one - insecticidal proteins and RNAi in the control of insects","volume":"65","author":"V\u00e9lez","year":"2023"},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib185","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/15476286.2020.1845505","article-title":"The role of lncRNAs in innate immunity and inflammation","volume":"18","author":"Walther","year":"2021","journal-title":"RNA Biol."},{"key":"10.1016\/j.dci.2026.105695_bib186","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jip.2015.04.001","article-title":"Transcriptome analysis of the brain of the silkworm Bombyx mori infected with Bombyx mori nucleopolyhedrovirus: a new insight into the molecular mechanism of enhanced locomotor activity induced by viral infection","volume":"128","author":"Wang","year":"2015","journal-title":"J. Invertebr. Pathol."},{"issue":"11","key":"10.1016\/j.dci.2026.105695_bib187","article-title":"Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID","volume":"4","author":"Wang","year":"2023","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib188","doi-asserted-by":"crossref","DOI":"10.3390\/v10010014","article-title":"Bombyx mori nuclear polyhedrosis virus (BmNPV) induces host cell autophagy to benefit infection","volume":"10","author":"Wang","year":"2017","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib189","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/eji.202048975","article-title":"Epigenetic regulation in antiviral innate immunity","volume":"51","author":"Wang","year":"2021","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011823","article-title":"JAK\/STAT signaling regulated intestinal regeneration defends insect pests against pore-forming toxins produced by Bacillus thuringiensis","volume":"20","author":"Wang","year":"2024","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib191","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101210","article-title":"Heritable genome editing with CRISPR\/Cas9 in the silkworm, Bombyx mori","volume":"9","author":"Wei","year":"2014","journal-title":"PLoS One"},{"issue":"7888","key":"10.1016\/j.dci.2026.105695_bib192","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41586-021-04142-6","article-title":"Untimely TGF\u03b2 responses in COVID-19 limit antiviral functions of NK cells","volume":"600","author":"Witkowski","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib193","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16357-7","article-title":"DNA methylation in silkworm genome may provide insights into epigenetic regulation of response to Bombyx mori cypovirus infection","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dci.2026.105695_bib194","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molimm.2019.03.013","article-title":"Overexpression of bmo-miR-2819 suppresses BmNPV replication by regulating the BmNPV ie-1 gene in Bombyx mori","volume":"109","author":"Wu","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2023.104043","article-title":"Single-nucleus sequencing of silkworm larval midgut reveals the immune escape strategy of BmNPV in the midgut during the late stage of infection","volume":"164","author":"Xia","year":"2024","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2026.105695_bib196","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-ento-011613-161940","article-title":"Advances in silkworm studies accelerated by the genome sequencing of Bombyx mori","volume":"59","author":"Xia","year":"2014","journal-title":"Annu. Rev. Entomol."},{"issue":"4","key":"10.1016\/j.dci.2026.105695_bib197","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.chom.2012.08.011","article-title":"Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila","volume":"12","author":"Xu","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib198","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/nsr\/nwz064","article-title":"Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis","volume":"6","author":"Xu","year":"2019","journal-title":"Natl. Sci. Rev."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib199","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41392-023-01468-7","article-title":"Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer","volume":"8","author":"Xue","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.dci.2026.105695_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2021.107537","article-title":"Integrative analysis of circRNA\/miRNA\/mRNA regulatory network reveals the potential immune function of circRNAs in the Bombyx mori fat body","volume":"179","author":"Yin","year":"2021","journal-title":"J. Invertebr. Pathol."},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib201","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/ncb2316","article-title":"miRNA-mediated feedback inhibition of JAK\/STAT morphogen signalling establishes a cell fate threshold","volume":"13","author":"Yoon","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxs101","article-title":"Autophagy and selective deployment of Atg proteins in antiviral defense","volume":"25","author":"Yordy","year":"2013","journal-title":"Int. Immunol."},{"issue":"17","key":"10.1016\/j.dci.2026.105695_bib203","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713228","article-title":"The expression of P35 plays a key role in the difference in apoptosis induced by AcMNPV infection in different Spodoptera exigua cell lines","volume":"24","author":"Yu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.dci.2026.105695_bib204","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021533","article-title":"The plant viruses and molecular farming: how beneficial they might be for human and animal health?","volume":"24","author":"Zahmanova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.dci.2026.105695_bib205","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0409181102","article-title":"The Toll pathway is important for an antiviral response in Drosophila","volume":"102","author":"Zambon","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.dci.2026.105695_bib206","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1462-5822.2006.00688.x","article-title":"RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster","volume":"8","author":"Zambon","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.dci.2026.105695_bib207","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115978","article-title":"Long non-coding RNAs and immune cells: Unveiling the role in viral infections","volume":"170","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.dci.2026.105695_bib208","first-page":"525","article-title":"[Long non-coding RNAs: emerging regulators of antiviral innate immune responses]","volume":"40","author":"Zhang","year":"2018","journal-title":"Yi Chuan"},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib209","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab397","article-title":"RNA-RNA interactions between SARS-CoV-2 and host benefit viral development and evolution during COVID-19 infection","volume":"23","author":"Zhang","year":"2022","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.dci.2026.105695_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2020.107323","article-title":"Analysis of lncRNA-mediated gene regulatory network of Bombyx mori in response to BmNPV infection","volume":"170","author":"Zhang","year":"2020","journal-title":"J. Invertebr. Pathol."},{"issue":"1","key":"10.1016\/j.dci.2026.105695_bib211","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gene.2015.11.027","article-title":"Identification, gene expression and immune function of the novel Bm-STAT gene in virus-infected Bombyx mori","volume":"577","author":"Zhang","year":"2016","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib212","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011266","article-title":"The JAK-STAT pathway promotes persistent viral infection by activating apoptosis in insect vectors","volume":"19","author":"Zhang","year":"2023","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.dci.2026.105695_bib213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/arch.21777","article-title":"Identification of long noncoding RNAs in silkworm larvae infected with Bombyx mori cypovirus","volume":"106","author":"Zhang","year":"2021","journal-title":"Arch. Insect Biochem. Physiol."},{"issue":"9","key":"10.1016\/j.dci.2026.105695_bib214","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ibmb.2011.04.006","article-title":"Antiviral, anti-parasitic, and cytotoxic effects of 5,6-dihydroxyindole (DHI), a reactive compound generated by phenoloxidase during insect immune response","volume":"41","author":"Zhao","year":"2011","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2026.105695_bib215","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.dci.2018.05.021","article-title":"Enhanced antiviral immunity against Bombyx mori cytoplasmic polyhedrosis virus via overexpression of peptidoglycan recognition protein S2 in transgenic silkworms","volume":"87","author":"Zhao","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105695_bib216","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104116","article-title":"RNAi-based immunity in insects against baculoviruses and the strategies of baculoviruses involved in siRNA and miRNA pathways to weaken the defense","volume":"122","author":"Zhao","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.dci.2026.105695_bib217","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf188","article-title":"BmNPV interacts with super-enhancer regions of the host chromatin to hijack cellular transcription machinery","volume":"53","author":"Zhao","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dci.2026.105695_bib218","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1108104","article-title":"ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect, Bactrocera dorsalis","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Genet."},{"issue":"Pt 2","key":"10.1016\/j.dci.2026.105695_bib219","article-title":"CRISPR\/Cas9-mediated disruption of orf76 as an antiviral therapy against BmNPV in the transgenic silkworm","volume":"278","author":"Zhu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"22","key":"10.1016\/j.dci.2026.105695_bib220","doi-asserted-by":"crossref","first-page":"11473","DOI":"10.1128\/JVI.01695-15","article-title":"Viral Small-RNA analysis of Bombyx mori larval midgut during persistent and pathogenic cytoplasmic polyhedrosis virus infection","volume":"89","author":"Zografidis","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.dci.2026.105695_bib221","first-page":"173","article-title":"Antiviral immunity: Origin and evolution in vertebrates","author":"Zou","year":"2016"},{"issue":"10","key":"10.1016\/j.dci.2026.105695_bib222","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1007\/s11033-023-08699-5","article-title":"The acetyltransferase BmCBP changes the acetylation modification of BmSP3 and affects its protein expression in silkworm, Bombyx mori","volume":"50","author":"Zu","year":"2023","journal-title":"Mol. Biol. Rep."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:59:35Z","timestamp":1787198375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X26001515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":222,"alternative-id":["S0145305X26001515"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2026.105695","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative anti-viral immune strategies in insects and vertebrates: Insights from Bombyx mori","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2026.105695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105695"}}