{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:05:47Z","timestamp":1789635947704,"version":"4.0.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJKQZ2021087"],"award-info":[{"award-number":["LJKQZ2021087"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJ212 410165069"],"award-info":[{"award-number":["LJ212 410165069"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2025-MS-272"],"award-info":[{"award-number":["2025-MS-272"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801973"],"award-info":[{"award-number":["31801973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.dci.2026.105721","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:20:41Z","timestamp":1787390441000},"page":"105721","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Molecular evolution and immune expression analysis of ELF transcription factors in Lethenteron reissneri"],"prefix":"10.1016","volume":"183","author":[{"given":"Jianing","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyv","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boting","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.dci.2026.105721_bib1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.coi.2007.08.003","article-title":"Evolution and development of immunological structures in the lamprey","volume":"19","author":"Amemiya","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.dci.2026.105721_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.expneurol.2014.03.013","article-title":"The systemic response to CNS injury","volume":"258","author":"Anthony","year":"2014","journal-title":"Exp. Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.dci.2026.105721_bib3","article-title":"Leukocytes: friend or foe","volume":"26","author":"Bellingan","year":"2000","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.dci.2026.105721_bib5","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1182\/blood-2010-09-309468","article-title":"Differential requirements for the Ets transcription factor ELF-1 in the development of NKT cells and NK cells","volume":"117","author":"Choi","year":"2011","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.dci.2026.105721_bib4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ydbio.2009.02.032","article-title":"ELF5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of ELF5","volume":"329","author":"Choi","year":"2009","journal-title":"Dev. Biol."},{"issue":"6","key":"10.1016\/j.dci.2026.105721_bib6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/genes13060961","article-title":"Transcriptome analysis reveals altered expression of genes involved in hypoxia, inflammation and immune regulation in Pdcd10-Depleted mouse endothelial cells","volume":"13","author":"Fusco","year":"2022","journal-title":"Genes"},{"issue":"3","key":"10.1016\/j.dci.2026.105721_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00005-006-0017-z","article-title":"ETS transcription factors and regulation of immunity","volume":"54","author":"Gallant","year":"2006","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"2","key":"10.1016\/j.dci.2026.105721_bib8","first-page":"304","article-title":"Tet2 loss leads to hyperactive innate immune signaling and myelodysplasia through ELF1-dependent epigenetic remodeling","volume":"175","author":"Garc\u00eda-Cao","year":"2018","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.dci.2026.105721_bib9","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-023-05013-1","article-title":"Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system","volume":"80","author":"Gonuguntla","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.dci.2026.105721_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13045-017-0446-7","article-title":"The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo","volume":"10","author":"Guan","year":"2017","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.dci.2026.105721_bib11","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/molbev\/mst012","article-title":"Building phylogenetic trees from molecular data with MEGA","volume":"30","author":"Hall","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.dci.2026.105721_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.molimm.2022.01.014","article-title":"Genome-wide identification and characterization of NLR genes in lamprey (Lethenteron reissneri) and their responses to lipopolysaccharide\/poly(I:C) challenge","volume":"143","author":"Hui","year":"2022","journal-title":"Mol. Immunol."},{"issue":"7","key":"10.1016\/j.dci.2026.105721_bib13","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1002\/ece3.3930","article-title":"A death in the family: sea lamprey (Petromyzon marinus) avoidance of confamilial alarm cues diminishes with phylogenetic distance","volume":"8","author":"Hume","year":"2018","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.dci.2026.105721_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.111016","article-title":"Comprehensive investigation of the IKK\u03b1 gene and TBK1 gene's identification, molecular evolution, and expression profiling in lampreys","volume":"168","author":"Lan","year":"2026","journal-title":"Fish Shellfish Immunol."},{"issue":"D1","key":"10.1016\/j.dci.2026.105721_bib15","doi-asserted-by":"crossref","first-page":"D493","DOI":"10.1093\/nar\/gkx922","article-title":"20 years of the SMART protein domain annotation resource","volume":"46","author":"Letunic","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.dci.2026.105721_bib16","first-page":"421","article-title":"ELF2 modulates LPS-induced acute lung injury by regulating macrophage polarization","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.dci.2026.105721_bib17","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.3390\/molecules23092191","article-title":"ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer","volume":"23","author":"Luk","year":"2018","journal-title":"Molecules"},{"issue":"8005","key":"10.1016\/j.dci.2026.105721_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41586-024-07070-3","article-title":"The hagfish genome and the evolution of vertebrates","volume":"627","author":"Marl\u00e9taz","year":"2024","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.dci.2026.105721_bib19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1089\/107999001750277925","article-title":"Lipopolysaccharide of Haemophilus influenzae induces interleukin-5 mRNA expression in human peripheral blood mononuclear cells","volume":"21","author":"Matsui","year":"2001","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.dci.2026.105721_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3389\/fneur.2017.00581","article-title":"Systemic and local cytokine profile following spinal cord injury in rats: a multiplex analysis","volume":"8","author":"Mukhamedshina","year":"2017","journal-title":"Front. Neurol."},{"issue":"D1","key":"10.1016\/j.dci.2026.105721_bib21","doi-asserted-by":"crossref","first-page":"D1025","DOI":"10.1093\/nar\/gkab1091","article-title":"Genomicus in 2022: comparative tools for thousands of genomes and reconstructed ancestors","volume":"50","author":"Nguyen","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.dci.2026.105721_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/01926230590522365","volume":"33","author":"Parker","year":"2005","journal-title":"Liver immunobiology. Toxicol Pathol."},{"issue":"12","key":"10.1016\/j.dci.2026.105721_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114260","article-title":"A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model","volume":"9","author":"Rahim","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.dci.2026.105721_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/cmi.2016.3","article-title":"Liver immunology and its role in inflammation and homeostasis","volume":"13","author":"Robinson","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.dci.2026.105721_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4049\/jimmunol.172.1.144","article-title":"Analysis of gene expression and Ig transcription in PU.1\/Spi-B-deficient progenitor B cell lines","volume":"172","author":"Schweitzer","year":"2004","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.dci.2026.105721_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007634","article-title":"The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response","volume":"15","author":"Seifert","year":"2019","journal-title":"PLoS Pathog."},{"issue":"16","key":"10.1016\/j.dci.2026.105721_bib27","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1016\/j.ejca.2005.08.013","article-title":"ETS transcription factors and their emerging roles in human cancer","volume":"41","author":"Seth","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.dci.2026.105721_bib28","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/35099076","article-title":"The ETS-domain transcription factor family","volume":"2","author":"Sharrocks","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dci.2026.105721_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109222","article-title":"Role of HIF in fish inflammation","volume":"143","author":"Shi","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105721_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fsi.2022.07.010","article-title":"Identification of multifunctionality of the PmE74 gene and development of SNPs associated with low salt tolerance in Penaeus monodon","volume":"128","author":"Si","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"15\u201317","key":"10.1016\/j.dci.2026.105721_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7748\/ns2008.12.23.15.47.c6738","article-title":"An overview of the immune system","volume":"23","author":"Storey","year":"2008","journal-title":"Nurs. Stand."},{"issue":"4","key":"10.1016\/j.dci.2026.105721_bib32","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.fsi.2013.07.026","article-title":"Identification and characterization of a novel I\u03baB-\u03b5-like gene from lamprey (Lampetra japonica) with a role in immune response","volume":"35","author":"Su","year":"2013","journal-title":"Fish Shellfish Immunol"},{"issue":"6","key":"10.1016\/j.dci.2026.105721_bib33","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/jeb.14181","article-title":"Understanding the evolution of immune genes in jawed vertebrates","volume":"36","author":"Vinkler","year":"2023","journal-title":"J. Evol. Biol."},{"issue":"10","key":"10.1016\/j.dci.2026.105721_bib34","first-page":"6452","article-title":"ELF-1 binds to a critical element in a second CD4 enhancer","volume":"14","author":"Wurster","year":"1994","journal-title":"Mol. Cell Biol."},{"issue":"13","key":"10.1016\/j.dci.2026.105721_bib36","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.3390\/ijms20133357","article-title":"Determination of the role and active sites of PKC-Delta-Like from Lamprey in innate immunity","volume":"20","author":"Xu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.dci.2026.105721_bib35","first-page":"263","article-title":"Lamprey: a model for vertebrate evolutionary research","volume":"37","author":"Xu","year":"2016","journal-title":"Zool. Res."},{"key":"10.1016\/j.dci.2026.105721_bib37","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.4049\/jimmunol.1000718","article-title":"Cutting edge: expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells","volume":"185","author":"Yamada","year":"2010","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.dci.2026.105721_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251810004","article-title":"ETS transcription factors in immune cells and immune-related diseases","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2026.105721_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molimm.2024.06.001","article-title":"Identification and evolution of PDK-1-like involving lamprey innate immunity","volume":"172","author":"Yin","year":"2024","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.dci.2026.105721_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41559-023-02299-z","article-title":"Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences","volume":"8","author":"Yu","year":"2024","journal-title":"Nat. Ecol. Evol."},{"issue":"2","key":"10.1016\/j.dci.2026.105721_bib41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/md20020145","article-title":"Expression of the antimicrobial peptide Piscidin 1 and neuropeptides in fish gill and skin: a potential participation in Neuro-Immune interaction","volume":"20","author":"Zaccone","year":"2022","journal-title":"Mar. Drugs"},{"issue":"10","key":"10.1016\/j.dci.2026.105721_bib42","first-page":"2765","article-title":"ELF2 is a negative regulator of LPS-induced inflammatory responses in macrophages by targeting TNFAIP3","volume":"207","author":"Zhang","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2026.105721_bib43","article-title":"ELF3 promotes the development of psoriasis through transcriptional up-regulation of ADAM8 expression","author":"Zhang","year":"2025","journal-title":"Immunol. Lett."},{"issue":"5","key":"10.1016\/j.dci.2026.105721_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00004-25","article-title":"The ELF3-TRIM22-MAVS signaling axis regulates type I interferon and antiviral responses","volume":"99","author":"Zhao","year":"2025","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.dci.2026.105721_bib46","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/1755-0998.13279","article-title":"Chromosome-level genome assembly of Lethenteron reissneri provides insights into lamprey evolution","volume":"21","author":"Zhu","year":"2021","journal-title":"Mol. Ecol. Resour."},{"issue":"9","key":"10.1016\/j.dci.2026.105721_bib45","first-page":"847","article-title":"Lamprey: an important animal model of evolution and disease research","volume":"42","author":"Zhu","year":"2020","journal-title":"Yi chuan = Hereditas"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:47:59Z","timestamp":1789634879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X26001771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":46,"alternative-id":["S0145305X26001771"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2026.105721","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular evolution and immune expression analysis of ELF transcription factors in Lethenteron reissneri","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2026.105721","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105721"}}