{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:05:47Z","timestamp":1789635947332,"version":"4.0.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","award":["2024-4-042"],"award-info":[{"award-number":["2024-4-042"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.dci.2026.105723","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:51:55Z","timestamp":1787755915000},"page":"105723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genome-wide characterization of NOD-like receptor genes links NLR repertoire evolution to spleen immune responses after Aeromonas hydrophila challenge in the Chinese spiny frog (Quasipaa spinosa)"],"prefix":"10.1016","volume":"183","author":[{"given":"Zhi-Gang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Cheng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2026.105723_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1122586","article-title":"The role of NOD-like receptors in innate immunity","volume":"14","author":"Almeida-da-Silva","year":"2023","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.dci.2026.105723_bib2","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.molp.2020.06.009","article-title":"TBtools: an integrative toolkit developed for interactive analyses of big biological data","volume":"13","author":"Chen","year":"2020","journal-title":"Mol. Plant"},{"issue":"2","key":"10.1016\/j.dci.2026.105723_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.107","article-title":"Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp","volume":"2","author":"Chen","year":"2023","journal-title":"iMeta"},{"issue":"4","key":"10.1016\/j.dci.2026.105723_bib4","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/1755-0998.13560","article-title":"A chromosomal level genome sequence for Quasipaa spinosa (Dicroglossidae) reveals chromosomal evolution and population diversity","volume":"22","author":"Hu","year":"2022","journal-title":"Mol. Ecol. Resour."},{"key":"10.1016\/j.dci.2026.105723_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/psp.2013.56","article-title":"Application of ggplot2 to pharmacometric graphics","volume":"2","author":"Ito","year":"2013","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.dci.2026.105723_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.dci.2026.105723_bib7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2148-8-42","article-title":"A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish","volume":"8","author":"Laing","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.dci.2026.105723_bib8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.dci.2026.105723_bib9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.dci.2026.105723_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.sbi.2014.08.011","article-title":"Structural mechanisms in NLR inflammasome signaling","volume":"29","author":"Lechtenberg","year":"2014","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"W1","key":"10.1016\/j.dci.2026.105723_bib11","doi-asserted-by":"crossref","first-page":"W78","DOI":"10.1093\/nar\/gkae268","article-title":"Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool","volume":"52","author":"Letunic","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.dci.2026.105723_bib12","article-title":"Transcriptomic analysis of liver immune response in Chinese spiny frog (Quasipaa spinosa) infected with Proteus mirabilis","volume":"19","author":"Liu","year":"2024","journal-title":"Open Life Sci."},{"key":"10.1016\/j.dci.2026.105723_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109083","article-title":"Genome-wide identification, phylogenetic relationships and expression patterns of the NOD-like receptor (NLR) gene family in flounder (Paralichthys olivaceus)","volume":"141","author":"Liu","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2026.105723_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103719","article-title":"Functional differences of three CXCL10 homologues in the giant spiny frog Quasipaa spinosa","volume":"109","author":"Liu","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2026.105723_bib15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.dci.2026.105723_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.dci.2026.105723_bib17","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3390\/ijms25031515","article-title":"Genome-wide comparative analysis of SRCR gene superfamily in invertebrates reveals massive and independent gene expansions in the sponge and sea urchin","volume":"25","author":"Peng","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dci.2026.105723_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.dci.2026.105723_bib19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/biology14070840","article-title":"Full-length transcriptome sequencing and hsp gene family analysis provide new insights into the stress response mechanisms of Mystus guttatus","volume":"14","author":"Qin","year":"2025","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.dci.2026.105723_bib20","first-page":"102","article-title":"Isolation, identification, and pathological study of the pathogen causing hemorrhagic septicemia in Quasipaa spinosa","volume":"42","author":"Ren","year":"2023","journal-title":"Fish. Sci."},{"issue":"1882","key":"10.1016\/j.dci.2026.105723_bib21","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2022.0123","article-title":"The amphibian immune system","volume":"378","author":"Ruiz","year":"2023","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"4","key":"10.1016\/j.dci.2026.105723_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.23975\/bjvr.2024.152038.1118","article-title":"The dual threat of Aeromonas species: aquatic pathogens and emerging human health concerns","volume":"23","author":"Sleman","year":"2024","journal-title":"Basrah J. Vet. Res."},{"key":"10.1016\/j.dci.2026.105723_bib23","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Research"},{"key":"10.1016\/j.dci.2026.105723_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1665071","article-title":"NOD-like receptors in fish: evolution, structure, immune signaling, and targeting for aquaculture vaccine adjuvants","volume":"16","author":"Swain","year":"2025","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.dci.2026.105723_bib25","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol. Biol. Evol."},{"issue":"7","key":"10.1016\/j.dci.2026.105723_bib26","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1093\/nar\/gkr1293","article-title":"MCScanX: a toolkit for detection and evolutionary analysis of gene synteny and collinearity","volume":"40","author":"Wang","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.dci.2026.105723_bib27","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/s41596-024-00968-2","article-title":"Detection of colinear blocks and synteny and evolutionary analyses based on utilization of MCScanX","volume":"19","author":"Wang","year":"2024","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.dci.2026.105723_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/fishes9030091","article-title":"The mechanism of Elizabethkingia miricola infection of the black spotted frog as revealed by multi-omics analysis","volume":"9","author":"Wei","year":"2024","journal-title":"Fishes"},{"key":"10.1016\/j.dci.2026.105723_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2024.105263","article-title":"Characterization of NLRP3 inflammasome components in the endangered Chinese giant salamander (Andrias davidianus)","volume":"161","author":"Wei","year":"2024","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.dci.2026.105723_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12859-023-05237-9","article-title":"Study of the error correction capability of multiple sequence alignment algorithm (MAFFT) in DNA storage","volume":"24","author":"Xie","year":"2023","journal-title":"BMC Bioinf."},{"issue":"2","key":"10.1016\/j.dci.2026.105723_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/jwas.70085","article-title":"Characterization of NLRP3 isoforms in bullfrog Aquarana catesbeiana and their role in antibacterial immunity","volume":"57","author":"Yang","year":"2026","journal-title":"J. World Aquacult. Soc."},{"issue":"12","key":"10.1016\/j.dci.2026.105723_bib32","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3390\/biology13121038","article-title":"Genome-wide identification and expression of neuropeptides and their expression patterns after RNAi of CHH genes in Pacific white shrimp Litopenaeus vannamei","volume":"13","author":"Zhang","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.dci.2026.105723_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.739144","article-title":"Vitamin D serves as a modulator of immune organs in grass carp (Ctenopharyngodon idella) infected with Aeromonas hydrophila","volume":"565","author":"Zhang","year":"2023","journal-title":"Aquaculture"},{"issue":"7","key":"10.1016\/j.dci.2026.105723_bib34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/pathogens13070552","article-title":"Isolation, identification, and characterisation of a novel ST2378 Aeromonas hydrophila strain from naturally diseased frogs, Rana dybowskii","volume":"13","author":"Zhao","year":"2024","journal-title":"Pathogens"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X26001795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:47:54Z","timestamp":1789634874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X26001795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"alternative-id":["S0145305X26001795"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2026.105723","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide characterization of NOD-like receptor genes links NLR repertoire evolution to spleen immune responses after Aeromonas hydrophila challenge in the Chinese spiny frog (Quasipaa spinosa)","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2026.105723","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105723"}}