{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:34:51Z","timestamp":1784309691372,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"MIUR Progetto Eccellenza"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cognitive Neuroscience"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.dcn.2020.100789","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T20:39:21Z","timestamp":1587587961000},"page":"100789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Repeated cocaine exposure during adolescence impairs recognition memory in early adulthood: A role for BDNF signaling in the perirhinal cortex"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-1384","authenticated-orcid":false,"given":"Francesca","family":"Mottarlini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Racagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-8456","authenticated-orcid":false,"given":"Paolo","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Caffino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dcn.2020.100789_bib0005","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0711863105","article-title":"BDNF is essential to promote persistence of long-term memory storage","author":"Bekinschtein","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dcn.2020.100789_bib0010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2017.08.008","article-title":"Spine dynamics_ are they all the same","volume":"96","author":"Berry","year":"2018","journal-title":"Neuron."},{"key":"10.1016\/j.dcn.2020.100789_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/nprot.2006.205","article-title":"Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study \u201crecognition memory.\u201d","author":"Bevins","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.dcn.2020.100789_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/S1053-8119(03)00113-7","article-title":"Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task","author":"Bolla","year":"2003","journal-title":"Neuroimage."},{"key":"10.1016\/j.dcn.2020.100789_bib0025","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.3864-08.2008","article-title":"The immediate early gene Arc\/Arg3.1: regulation, mechanisms, and function","author":"Bramham","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.dcn.2020.100789_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2016.05.013","article-title":"Mechanisms contributing to prefrontal cortex maturation during adolescence","author":"Caballero","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.dcn.2020.100789_bib0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12640-014-9472-1","article-title":"Long-term abstinence from developmental cocaine exposure alters Arc\/Arg3.1 modulation in the rat medial prefrontal cortex","volume":"26","author":"Caffino","year":"2014","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.dcn.2020.100789_bib0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/adb.12089","article-title":"Stress rapidly dysregulates the glutamatergic synapse in the prefrontal cortex of cocaine-withdrawn adolescent rats","volume":"20","author":"Caffino","year":"2015","journal-title":"Addict. Biol."},{"key":"10.1016\/j.dcn.2020.100789_bib0045","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.euroneuro.2015.05.002","article-title":"Short-term withdrawal from developmental exposure to cocaine activates the glucocorticoid receptor and alters spine dynamics","volume":"25","author":"Caffino","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.dcn.2020.100789_bib0050","doi-asserted-by":"crossref","DOI":"10.1007\/s12640-016-9683-8","article-title":"Developmental exposure to cocaine dynamically dysregulates cortical Arc\/Arg3.1 modulation in response to a challenge","author":"Caffino","year":"2017","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.dcn.2020.100789_bib0055","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s00213-017-4559-z","article-title":"A single cocaine exposure disrupts actin dynamics in the cortico-accumbal pathway of adolescent rats: modulation by a second cocaine injection","volume":"234","author":"Caffino","year":"2017","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.dcn.2020.100789_bib0060","article-title":"Repeated cocaine exposure dysregulates BDNF expression and signaling in the mesocorticolimbic pathway of the adolescent rat","author":"Caffino","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.dcn.2020.100789_bib0065","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuropharm.2018.08.006","article-title":"A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats","volume":"140","author":"Caffino","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.dcn.2020.100789_bib0070","article-title":"Increased cocaine self-administration in rats lacking the serotonin transporter: a role for glutamatergic signaling in the habenula","author":"Caffino","year":"2018","journal-title":"Addict. Biol."},{"key":"10.1016\/j.dcn.2020.100789_bib0075","doi-asserted-by":"crossref","DOI":"10.1002\/hipo.22033","article-title":"Differential BDNF signaling in dentate gyrus and perirhinal cortex during consolidation of recognition memory in the rat","author":"Callaghan","year":"2012","journal-title":"Hippocampus."},{"key":"10.1016\/j.dcn.2020.100789_bib0080","doi-asserted-by":"crossref","DOI":"10.1196\/annals.1440.010","article-title":"The adolescent brain","author":"Casey","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.dcn.2020.100789_bib0085","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1037\/h0077509","article-title":"Maternal stress and pituitary\u2013adrenal manipulations during pregnancy in rats: effects on morphology and sexual behavior of male offspring","volume":"92","author":"Chapman","year":"1978","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.dcn.2020.100789_bib0090","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuropharm.2003.09.024","article-title":"Chronic nicotine differentially alters cocaine-induced locomotor activity in adolescent vs. Adult male and female rats","volume":"46","author":"Collins","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.dcn.2020.100789_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2016.09.023","article-title":"Induction and blockade of adolescent cocaine-induced habits","author":"DePoy","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.dcn.2020.100789_bib0100","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1124\/mol.106.026302","article-title":"Corticostriatal up-regulation of activity-regulated cytoskeletal-associated protein expression after repeated exposure to cocaine","volume":"70","author":"Fumagalli","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.dcn.2020.100789_bib0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.euroneuro.2009.01.003","article-title":"Repeated stress prevents cocaine-induced activation of BDNF signaling in rat prefrontal cortex","volume":"19","author":"Fumagalli","year":"2009","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.dcn.2020.100789_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2008.10.009","article-title":"Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling","author":"Gao","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.dcn.2020.100789_bib0115","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00213-012-2840-8","article-title":"Dynamic modulation of basic Fibroblast Growth Factor (FGF-2) expression in the rat brain following repeated exposure to cocaine during adolescence","volume":"225","author":"Giannotti","year":"2013","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.dcn.2020.100789_bib0120","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1017\/S1461145713001454","article-title":"Prolonged abstinence from developmental cocaine exposure dysregulates BDNF and its signaling network in the medial prefrontal cortex of adult rats","volume":"17","author":"Giannotti","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.dcn.2020.100789_bib0125","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00213-014-3708-x","article-title":"A single exposure to cocaine during development elicits regionally-selective changes in basal basic Fibroblast Growth Factor (FGF-2) gene expression and alters the trophic response to a second injection","volume":"232","author":"Giannotti","year":"2015","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.dcn.2020.100789_bib0130","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1007\/s00213-016-4315-9","article-title":"Region-specific effects of developmental exposure to cocaine on fibroblast growth factor-2 expression in the rat brain","volume":"233","author":"Giannotti","year":"2016","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.dcn.2020.100789_bib0135","doi-asserted-by":"crossref","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications","author":"Goldstein","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.dcn.2020.100789_bib0140","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2730-11.2012","article-title":"Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity","author":"Gourley","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.dcn.2020.100789_bib0145","doi-asserted-by":"crossref","DOI":"10.1038\/nature19766","article-title":"Autocrine BDNF-TrkB signalling within a single dendritic spine","author":"Harward","year":"2016","journal-title":"Nature."},{"key":"10.1016\/j.dcn.2020.100789_bib0150","doi-asserted-by":"crossref","DOI":"10.1007\/PL00005483","article-title":"Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli","author":"Jentsch","year":"1999","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.dcn.2020.100789_bib0155","doi-asserted-by":"crossref","DOI":"10.1038\/nrn1517","article-title":"PDZ domain proteins of synapses","author":"Kim","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.dcn.2020.100789_bib0160","article-title":"Activation of Trk neurotrophin receptors in the absence of neurotrophins","author":"Lee","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dcn.2020.100789_bib0165","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2017.00233","article-title":"Long-term effects of intermittent adolescent alcohol exposure in male and female rats","author":"Marco","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.dcn.2020.100789_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2017.06.002","article-title":"Plasticity mechanisms of memory consolidation and reconsolidation in the perirhinal cortex","author":"Miranda","year":"2018","journal-title":"Neuroscience."},{"key":"10.1016\/j.dcn.2020.100789_bib0175","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0293-17.2017","article-title":"Molecular mechanisms in perirhinal cortex selectively necessary for discrimination of overlapping memories, but independent of memory persistence","author":"Miranda","year":"2017","journal-title":"eneuro."},{"key":"10.1016\/j.dcn.2020.100789_bib0180","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1101\/lm.046797.117","article-title":"Chemogenetic activation of the perirhinal cortex reverses methamphetamine-induced memory deficits and reduces relapse","author":"Peters","year":"2018","journal-title":"Learn. Mem."},{"key":"10.1016\/j.dcn.2020.100789_bib0185","doi-asserted-by":"crossref","DOI":"10.1503\/jpn.170082","article-title":"Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex","author":"Prini","year":"2018","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.dcn.2020.100789_bib0190","doi-asserted-by":"crossref","DOI":"10.1002\/hipo.20669","article-title":"From learning to forgetting: behavioral, circuitry, and molecular properties define the different functional states of the recognition memory trace","author":"Romero-Granados","year":"2010","journal-title":"Hippocampus."},{"key":"10.1016\/j.dcn.2020.100789_bib0195","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.23-01-00349.2003","article-title":"Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects","author":"Saarelainen","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.dcn.2020.100789_bib0200","doi-asserted-by":"crossref","DOI":"10.1002\/hipo.20763","article-title":"Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats","author":"Seoane","year":"2011","journal-title":"Hippocampus."},{"key":"10.1016\/j.dcn.2020.100789_bib0205","doi-asserted-by":"crossref","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.dcn.2020.100789_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2011.02.014","article-title":"Aberrant learning and memory in addiction","author":"Torregrossa","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.dcn.2020.100789_bib0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.addbeh.2006.06.032","article-title":"Cognitive impulsivity in cocaine and heroin polysubstance abusers","author":"Verdejo-Garc\u00eda","year":"2007","journal-title":"Addict. Behav."},{"key":"10.1016\/j.dcn.2020.100789_bib0220","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1346-04.2004","article-title":"Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe","author":"Winters","year":"2004","journal-title":"J. Neurosci."}],"container-title":["Developmental Cognitive Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878929320300372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878929320300372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:36:29Z","timestamp":1761816989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878929320300372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":44,"alternative-id":["S1878929320300372"],"URL":"https:\/\/doi.org\/10.1016\/j.dcn.2020.100789","relation":{},"ISSN":["1878-9293"],"issn-type":[{"value":"1878-9293","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated cocaine exposure during adolescence impairs recognition memory in early adulthood: A role for BDNF signaling in the perirhinal cortex","name":"articletitle","label":"Article Title"},{"value":"Developmental Cognitive Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dcn.2020.100789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100789"}}