{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T22:25:04Z","timestamp":1749853504895,"version":"3.33.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Discovery Today: Therapeutic Strategies"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.ddstr.2007.09.002","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T22:28:08Z","timestamp":1196807288000},"page":"183-187","source":"Crossref","is-referenced-by-count":11,"title":["Is there a need to identify new anti-emetic drugs?"],"prefix":"10.1016","volume":"4","author":[{"given":"Charles C.","family":"Horn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ddstr.2007.09.002_bib1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1517\/13543784.14.10.1191","article-title":"Neuronal nicotinic receptors as targets for novel analgesics","volume":"14","author":"Vincler","year":"2005","journal-title":"Exp. Opin. Investig. Drugs"},{"key":"10.1016\/j.ddstr.2007.09.002_bib2","first-page":"1136","article-title":"Selective phosphodiesterase 4 inhibitors in the treatment of allergy and inflammation","volume":"6","author":"Smith","year":"2005","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.ddstr.2007.09.002_bib3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.autneu.2006.01.008","article-title":"Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases","volume":"125","author":"Andrews","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ddstr.2007.09.002_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2006.07.009","article-title":"Treatment of nausea and vomiting: gaps in our knowledge","volume":"129","author":"Sanger","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ddstr.2007.09.002_bib5","first-page":"359","article-title":"The role of tachykinins and the tachykinin NK1 receptor in nausea and emesis","volume":"Vol. 164","author":"Andrews","year":"2004"},{"key":"10.1016\/j.ddstr.2007.09.002_bib6","series-title":"Management of Nausea and Vomiting in Cancer and Cancer Treatment Sudbury","first-page":"15","article-title":"Mechanisms of acute, delayed, and anticipatory emesis induced by anticancer therapies","author":"Rudd","year":"2005"},{"key":"10.1016\/j.ddstr.2007.09.002_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.autneu.2006.09.005","article-title":"Brain Fos expression during 48h after cisplatin treatment: neural pathways for acute and delayed visceral sickness","volume":"132","author":"Horn","year":"2007","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ddstr.2007.09.002_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.autneu.2006.07.012","article-title":"Pavlovian conditioning of nausea and vomiting","volume":"129","author":"Stockhorst","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.ddstr.2007.09.002_bib9","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1200\/JCO.2006.06.9591","article-title":"American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006","volume":"24","author":"Kris","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib10","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1200\/JCO.1989.7.8.1137","article-title":"Dose ranging phase I study of the serotonin antagonist GR38032F for prevention of cisplatin-induced nausea and vomiting","volume":"7","author":"Grunberg","year":"1989","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib11","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1002\/cncr.11320","article-title":"Establishing the dose of the oral NK1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting","volume":"97","author":"Chawla","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ddstr.2007.09.002_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (Capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ddstr.2007.09.002_bib13","first-page":"283","article-title":"Pharmacology of opioids","volume":"35","author":"Martin","year":"1983","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ddstr.2007.09.002_bib14","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/sj.bjp.0703428","article-title":"The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew","volume":"130","author":"Andrews","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib15","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0028-3908(91)90136-Y","article-title":"The actions of fentanyl to inhibit drug-induced emesis","volume":"30","author":"Barnes","year":"1991","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ddstr.2007.09.002_bib16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0024-3205(87)90229-3","article-title":"Suncus murinus: a new experimental model in emesis research","volume":"41","author":"Ueno","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/j.ddstr.2007.09.002_bib17","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.neuroimage.2006.06.059","article-title":"Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: relevance as a potential biomarker for detecting drug-induced emesis","volume":"33","author":"Chin","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.ddstr.2007.09.002_bib18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0361-9230(98)00092-6","article-title":"Physiological basis and pharmacology of motion sickness: an update","volume":"47","author":"Yates","year":"1998","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ddstr.2007.09.002_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1213\/01.ANE.0000068580.00245.95","article-title":"Consensus guidelines for managing postoperative nausea and vomiting","volume":"97","author":"Gan","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ddstr.2007.09.002_bib20","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/ajhp\/62.12.1247","article-title":"Prevention and treatment of postoperative nausea and vomiting","volume":"62","author":"Golembiewski","year":"2005","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.ddstr.2007.09.002_bib21","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1200\/JCO.1999.17.9.2971","article-title":"Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. American Society of Clinical Oncology","volume":"17","author":"Gralla","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib22","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0959-8049(02)00674-3","article-title":"Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists","volume":"39","author":"Hesketh","year":"2003","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ddstr.2007.09.002_bib23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00130404-200609000-00003","article-title":"New approaches to chemotherapy-induced nausea and vomiting: from neuropharmacology to clinical investigations","volume":"12","author":"Rubenstein","year":"2006","journal-title":"Cancer J."},{"key":"10.1016\/j.ddstr.2007.09.002_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1254\/jphs.FPJ05001X","article-title":"Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets","volume":"98","author":"Nakayama","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ddstr.2007.09.002_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1254\/jjp.85.70","article-title":"Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisplatin in Suncus murinus","volume":"85","author":"Horikoshi","year":"2001","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib26","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1213\/01.ane.0000263277.35140.a3","article-title":"A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting","volume":"104","author":"Gan","year":"2007","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ddstr.2007.09.002_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neulet.2004.11.015","article-title":"Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret","volume":"376","author":"King","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ddstr.2007.09.002_bib28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/bmj.323.7303.16","article-title":"Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review","volume":"323","author":"Tramer","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.ddstr.2007.09.002_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejphar.2006.12.008","article-title":"Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew)","volume":"559","author":"Chan","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib30","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.neuropharm.2005.06.009","article-title":"Effect of a selective GABA(B) receptor agonist baclofen on the mu-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects","volume":"49","author":"Suzuki","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ddstr.2007.09.002_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neulet.2005.08.062","article-title":"Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin","volume":"392","author":"Rudd","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ddstr.2007.09.002_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1254\/jjp.64.109","article-title":"Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus","volume":"64","author":"Okada","year":"1994","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/j.1460-9568.2007.05521.x","article-title":"V Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret","author":"Sharkey","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ddstr.2007.09.002_bib34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0028-3908(01)00182-4","article-title":"The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets","volume":"42","author":"Girod","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ddstr.2007.09.002_bib35","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00520-004-0755-6","article-title":"A phase II trial of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier Oncology Group study","volume":"13","author":"Navari","year":"2005","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.ddstr.2007.09.002_bib36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-8741(97)00054-8","article-title":"Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs","volume":"57","author":"Sharma","year":"1997","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ddstr.2007.09.002_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1399-6576.2006.01179.x","article-title":"Does esomeprazole prevent post-operative nausea and vomiting?","volume":"51","author":"Raeder","year":"2007","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.ddstr.2007.09.002_bib38","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/annonc\/mdg417","article-title":"Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron","volume":"14","author":"Gralla","year":"2003","journal-title":"Ann. Oncol."}],"container-title":["Drug Discovery Today: Therapeutic Strategies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1740677307000186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1740677307000186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:44:47Z","timestamp":1737614687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1740677307000186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S1740677307000186"],"URL":"https:\/\/doi.org\/10.1016\/j.ddstr.2007.09.002","relation":{},"ISSN":["1740-6773"],"issn-type":[{"type":"print","value":"1740-6773"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}