{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:27:28Z","timestamp":1791336448527,"version":"4.3.1"},"reference-count":190,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Discovery Today: Technologies"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.ddtec.2013.03.003","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T00:51:46Z","timestamp":1366764706000},"page":"e329-e342","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of symptomatic drug effects in Alzheimer's disease: strategies for prediction of efficacy in humans"],"prefix":"10.1016","volume":"10","author":[{"given":"J.","family":"Deguil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ravasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Auffret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Babiloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bartres Faz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bragulat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cass\u00e9-Perrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Colavito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Herrero Ezquerro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lamberty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lanteaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pemberton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pifferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Schenker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Blin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"tarragon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bordet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ddtec.2013.03.003_bib0005","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1212\/WNL.59.1.123","article-title":"Donepezil and flight simulator performance: effects on retention of complex skills","volume":"59","author":"Yesavage","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/WNN.0b013e3181799df1","article-title":"Effects of donepezil on verbal memory after semantic processing in healthy older adults","volume":"21","author":"FitzGerald","year":"2008","journal-title":"Cogn. Behav. Neurol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0015","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00213-005-0043-2","article-title":"Cholinergic enhancement of episodic memory in healthy young adults","volume":"182","author":"Gron","year":"2005","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/0269881104040248","article-title":"Neuropsychological test performance in healthy volunteers before and after donepezil administration","volume":"18","author":"Beglinger","year":"2004","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0025","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/01.jcp.0000155822.51962.b4","article-title":"Neuropsychological test performance in healthy elderly volunteers before and after donepezil administration: a randomized, controlled study","volume":"25","author":"Beglinger","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0030","doi-asserted-by":"crossref","first-page":"e24126","DOI":"10.1371\/journal.pone.0024126","article-title":"Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG\/fMRI biomarkers","volume":"6","author":"Balsters","year":"2011","journal-title":"PLoS ONE"},{"issue":"Pt 2","key":"10.1016\/j.ddtec.2013.03.003_bib0035","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/brain\/awm299","article-title":"Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health","volume":"131","author":"Bentley","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0040","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s002130050564","article-title":"Physostigmine results in an increased decrement in brain glucose consumption in Alzheimer's disease","volume":"136","author":"Blin","year":"1998","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0045","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/gps.1319","article-title":"Detecting effects of donepezil on visual selective attention using signal detection parameters in Alzheimer's disease","volume":"20","author":"Foldi","year":"2005","journal-title":"Int. J. Geriatr. Psychiatry"},{"issue":"Suppl 2","key":"10.1016\/j.ddtec.2013.03.003_bib0050","first-page":"43","article-title":"Alzheimer disease, attention, and the cholinergic system","volume":"9","author":"Lawrence","year":"1995","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0055","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/jnnp.2003.029074","article-title":"Size of the treatment effect on cognition of cholinesterase inhibition in Alzheimer's disease","volume":"75","author":"Rockwood","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0060","first-page":"29","article-title":"Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB","volume":"149","author":"Sahakian","year":"1993","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0065","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF02244644","article-title":"Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB","volume":"110","author":"Sahakian","year":"1993","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0070","first-page":"164","article-title":"Effect of donepezil on EEG spectral analysis in Alzheimer's disease","volume":"103","author":"Balkan","year":"2003","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0075","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1055\/s-2003-45118","article-title":"Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial","volume":"36","author":"Brassen","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/155005940203300209","article-title":"The effects of donepezil on quantitative EEG in patients with Alzheimer's disease","volume":"33","author":"Reeves","year":"2002","journal-title":"Clin. Electroencephalogr."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000063576","article-title":"Quantitative EEG changes in Alzheimer patients during long-term donepezil therapy","volume":"46","author":"Rodriguez","year":"2002","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0090","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/155005940603700112","article-title":"QEEG monitoring of Alzheimer's disease treatment: a preliminary report of three case studies","volume":"37","author":"Sneddon","year":"2006","journal-title":"Clin. EEG Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000119246","article-title":"The use of diurnal vigilance changes in the EEG to verify vigilance-enhancing effects of memantine in a clinical pharmacological study","volume":"33","author":"Schulz","year":"1996","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/WNP.0b013e3181727c95","article-title":"Diagnostic usefulness of cognitive auditory event-related p300 subcomponents in patients with Alzheimers disease?","volume":"25","author":"Juckel","year":"2008","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0105","first-page":"349","article-title":"The effects of donepezil on the P300 auditory and visual cognitive evoked potentials of patients with Alzheimer's disease","volume":"7","author":"Reeves","year":"1999","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00002826-200101000-00007","article-title":"Donepezil, rivastigmine, and vitamin E in Alzheimer disease: a combined P300 event-related potentials\/neuropsychologic evaluation over 6 months","volume":"24","author":"Thomas","year":"2001","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/0891988702250561","article-title":"Long-term effects of donepezil on P300 auditory event-related potentials in patients with Alzheimer's disease","volume":"16","author":"Katada","year":"2003","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0120","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00702-003-0817-9","article-title":"The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients","volume":"110","author":"Werber","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0125","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1176\/appi.ajp.162.4.676","article-title":"Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?","volume":"162","author":"Hashimoto","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0130","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1176\/appi.ajp.160.11.2003","article-title":"Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease","volume":"160","author":"Krishnan","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0135","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1136\/jnnp.2007.141648","article-title":"Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine","volume":"79","author":"Schmidt","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0140","first-page":"1006","article-title":"Cortical activation during cholinesterase-inhibitor treatment in Alzheimer disease: preliminary findings from a pharmaco-fMRI study","volume":"13","author":"Kircher","year":"2005","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0145","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3174\/ajnr.A1359","article-title":"Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging","volume":"30","author":"Petrella","year":"2009","journal-title":"Am. J. Neuroradiol."},{"issue":"Pt 7","key":"10.1016\/j.ddtec.2013.03.003_bib0150","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/brain\/awh177","article-title":"Cholinergic enhancement of frontal lobe activity in mild cognitive impairment","volume":"127","author":"Saykin","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neulet.2009.03.043","article-title":"Evidence for glutamatergic neurotransmission in cognitive control in an auditory attention task","volume":"454","author":"van Wageningen","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00019442-200303000-00007","article-title":"Donepezil HCl (E2020) maintains functional brain activity in patients with Alzheimer disease: results of a 24-week, double-blind, placebo-controlled study","volume":"11","author":"Tune","year":"2003","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00213-006-0408-1","article-title":"Effects of donepezil on cortical metabolic response to activation during (18)FDG-PET in Alzheimer's disease: a double-blind cross-over trial","volume":"187","author":"Teipel","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0170","first-page":"419","article-title":"Transgenic mouse models of Alzheimer's disease: phenotype and application","volume":"14","author":"Higgins","year":"2003","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0175","series-title":"Transgenic Mouse Models of Alzheimer's Disease: Behavioral Testing and Considerations","author":"Bryan","year":"2009"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0925","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Sturchler-Pierrat","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00213-004-2132-z","article-title":"Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model","volume":"180","author":"Van Dam","year":"2005","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.euroneuro.2005.06.005","article-title":"Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model","volume":"16","author":"Van Dam","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0930","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits. Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0190","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00213-005-2230-6","article-title":"Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease","volume":"181","author":"Dong","year":"2005","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0935","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80974-5","article-title":"Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins","volume":"19","author":"Borchelt","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0195","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1124\/jpet.104.071027","article-title":"Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease","volume":"311","author":"Minkeviciene","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0940","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0200","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1523\/JNEUROSCI.5242-10.2011","article-title":"Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept)","volume":"31","author":"Romberg","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0945","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nm0198-097","article-title":"Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes","volume":"4","author":"Holcomb","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0950","doi-asserted-by":"crossref","first-page":"e27068","DOI":"10.1371\/journal.pone.0027068","article-title":"Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1","volume":"6","author":"Platt","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0205","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1042\/BST0390874","article-title":"FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease","volume":"39","author":"Platt","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0210","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainres.2010.05.084","article-title":"Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models","volume":"1347","author":"Nicholson","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0215","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3233\/JAD-2010-100879","article-title":"EEG, activity, and sleep architecture in a transgenic AbetaPPswe\/PSEN1A246E Alzheimer's disease mouse","volume":"22","author":"Jyoti","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0220","doi-asserted-by":"crossref","first-page":"e27068","DOI":"10.1371\/journal.pone.0027068","article-title":"Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1","volume":"6","author":"Platt","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0225","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1002\/jnr.21713","article-title":"Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging","volume":"86","author":"Scholtzova","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0230","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0166-4328(97)00214-3","article-title":"A new continuous alternation task in T-maze detects hippocampal dysfunction in mice. A strain comparison and lesion study","volume":"95","author":"Gerlai","year":"1998","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0235","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1037\/0735-7044.108.1.100","article-title":"T-maze spontaneous alternation rate is decreased in S100 beta transgenic mice","volume":"108","author":"Gerlai","year":"1994","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbr.2003.08.004","article-title":"The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse","volume":"151","author":"Spowart-Manning","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0245","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.nlm.2011.07.004","article-title":"The cognitive cost of sleep lost","volume":"96","author":"McCoy","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0250","first-page":"107","article-title":"Cerebral blood flow velocity and psychomotor performance during acute hypoxia","volume":"77","author":"Blogg","year":"2006","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0255","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1523\/JNEUROSCI.0007-04.2004","article-title":"Functional imaging of working memory after 24 hr of total sleep deprivation","volume":"24","author":"Chee","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0260","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2869.2006.00497.x","article-title":"Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy","volume":"15","author":"Gottselig","year":"2006","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0265","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3357\/ASEM.2396.2009","article-title":"Executive functions and the ability to sustain vigilance during sleep loss","volume":"80","author":"Killgore","year":"2009","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0270","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.neuroimage.2009.08.067","article-title":"Sleep deprivation and its effects on object-selective attention","volume":"49","author":"Chee","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0275","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1365-2869.2009.00740.x","article-title":"The impact of sleep duration and subject intelligence on declarative and motor memory performance: how much is enough?","volume":"18","author":"Tucker","year":"2009","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0280","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nn1851","article-title":"A deficit in the ability to form new human memories without sleep","volume":"10","author":"Yoo","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0285","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuroimage.2005.12.001","article-title":"Functional imaging of working memory following normal sleep and after 24 and 35h of sleep deprivation: correlations of fronto-parietal activation with performance","volume":"31","author":"Chee","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0290","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bandc.2005.10.001","article-title":"Effects of sleep deprivation on Color-Word, Emotional, and Specific Stroop interference and on self-reported anxiety","volume":"60","author":"Sagaspe","year":"2006","journal-title":"Brain Cogn."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0295","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/sleep\/26.2.117","article-title":"The cumulative cost of additional wakefulness: dose\u2013response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation","volume":"26","author":"Van Dongen","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0300","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1365-2869.2000.00225.x","article-title":"Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24h of sleep deprivation on waking human regional brain activity","volume":"9","author":"Thomas","year":"2000","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0305","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.0610712104","article-title":"Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation","volume":"104","author":"Chee","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0310","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuroimage.2004.11.029","article-title":"Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone","volume":"25","author":"Choo","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0315","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/sleep\/28.4.433","article-title":"Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation","volume":"28","author":"Mu","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0320","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/sleep\/28.1.55","article-title":"Decreased cortical response to verbal working memory following sleep deprivation","volume":"28","author":"Mu","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0325","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1365-2869.2001.00245.x","article-title":"Increased cerebral response during a divided attention task following sleep deprivation","volume":"10","author":"Drummond","year":"2001","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0330","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11682-011-9115-6","article-title":"The effect of sleep deprivation on BOLD activity elicited by a divided attention task","volume":"5","author":"Jackson","year":"2011","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0335","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0013-4694(81)90225-X","article-title":"Sleep deprivation: effect on sleep stages and EEG power density in man","volume":"51","author":"Borbely","year":"1981","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0340","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0006-8993(93)90579-C","article-title":"Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation","volume":"626","author":"Dijk","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0345","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1365-2869.2000.00192.x","article-title":"Zolpidem and sleep deprivation: different effect on EEG power spectra","volume":"9","author":"Landolt","year":"2000","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0350","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/sleep\/16.2.100","article-title":"Repeated partial sleep deprivation progressively changes in EEG during sleep and wakefulness","volume":"16","author":"Brunner","year":"1993","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000077933","article-title":"Auditory event-related potentials and psychological changes during sleep deprivation","volume":"50","author":"Lee","year":"2004","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0360","first-page":"1143","article-title":"The P300 event-related potential. The effects of sleep deprivation","volume":"34","author":"Morris","year":"1992","journal-title":"J. Occup. Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0365","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.lfs.2012.06.012","article-title":"Modafinil improves event related potentials P300 and contingent negative variation after 24h sleep deprivation","volume":"91","author":"Ray","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0370","doi-asserted-by":"crossref","first-page":"11369","DOI":"10.1523\/JNEUROSCI.4045-08.2008","article-title":"Cholinergic augmentation modulates visual task performance in sleep-deprived young adults","volume":"28","author":"Chuah","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0375","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/sleep\/32.8.999","article-title":"Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation","volume":"32","author":"Chuah","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0380","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/hup.1248","article-title":"Effects of donepezil on cognitive performance after sleep deprivation","volume":"26","author":"Dodds","year":"2011","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0385","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-079X.2009.00704.x","article-title":"Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats","volume":"47","author":"Chang","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0390","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2004.05.032","article-title":"Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus","volume":"1018","author":"Guan","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0395","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12013-010-9098-8","article-title":"The mechanism and characterization of learning and memory impairment in sleep-deprived mice","volume":"58","author":"Xu","year":"2010","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0400","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1152\/jn.00218.2005","article-title":"Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning","volume":"94","author":"Hairston","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0405","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1111\/j.1460-9568.2006.04808.x","article-title":"Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation","volume":"23","author":"Tartar","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0410","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2869.2008.00714.x","article-title":"Experimental sleep fragmentation impairs spatial reference but not working memory in Fischer\/Brown Norway rats","volume":"18","author":"Ward","year":"2009","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0415","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2869.2009.00799.x","article-title":"Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation","volume":"19","author":"Hagewoud","year":"2010","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0420","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pbb.2007.07.006","article-title":"Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice","volume":"88","author":"Pierard","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0425","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/1098-1063(2001)11:1<8::AID-HIPO1015>3.0.CO;2-7","article-title":"Hippocampus and contextual fear conditioning: recent controversies and advances","volume":"11","author":"Anagnostaras","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0430","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1101\/lm.48803","article-title":"Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning","volume":"10","author":"Graves","year":"2003","journal-title":"Learn. Mem."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0435","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2869.2010.00895.x","article-title":"Sleep deprivation impairs contextual fear conditioning and attenuates subsequent behavioural, endocrine and neuronal responses","volume":"20","author":"Hagewoud","year":"2010","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0440","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbr.2008.03.011","article-title":"Aspects of learned fear related to the hippocampus are sleep-dependent","volume":"191","author":"Ruskin","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0445","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1515\/REVNEURO.2004.15.4.231","article-title":"Higher order memories for objects encountered in different spatio-temporal contexts in mice: evidence for episodic memory","volume":"15","author":"Dere","year":"2004","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0450","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuron.2008.11.024","article-title":"Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss","volume":"61","author":"Halassa","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0455","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1080\/07420520902926025","article-title":"Sleep deprivation in the dark period does not impair memory in OF1 mice","volume":"26","author":"Palchykova","year":"2009","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0460","first-page":"69","article-title":"Sleep deprivation in rats produces attentional impairments on a 5-choice serial reaction time task","volume":"29","author":"Cordova","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0465","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/sleep\/30.1.52","article-title":"Experimental sleep fragmentation impairs attentional set-shifting in rats","volume":"30","author":"McCoy","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0470","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/sleep\/1.4.369","article-title":"Effects of sleep deprivation on sleepiness, sleep intensity, and subsequent sleep in the rat","volume":"1","author":"Friedman","year":"1979","journal-title":"Sleep"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0475","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1152\/jn.2000.84.4.1888","article-title":"Topography of EEG dynamics after sleep deprivation in mice","volume":"84","author":"Huber","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0480","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0166-4328(90)90161-7","article-title":"The effect of 3-h and 6-h sleep deprivation on sleep and EEG spectra of the rat","volume":"36","author":"Tobler","year":"1990","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0485","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00702-009-0333-7","article-title":"Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review","volume":"117","author":"Guse","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0490","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ymeth.2007.02.001","article-title":"Noninvasive brain stimulation with transcranial magnetic or direct current stimulation (TMS\/tDCS) \u2013 from insights into human memory to therapy of its dysfunction","volume":"44","author":"Sparing","year":"2008","journal-title":"Methods"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0495","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0168-5597(94)90124-4","article-title":"Finding the depth of magnetic brain stimulation: a re-evaluation","volume":"93","author":"Rudiak","year":"1994","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0500","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1097\/00001756-199405000-00034","article-title":"Induction of a recall deficit by rapid-rate transcranial magnetic stimulation","volume":"5","author":"Grafman","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0505","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/S0028-3932(03)00131-3","article-title":"Effects of repetitive transcranial magnetic stimulation on memory subtypes: a controlled study","volume":"41","author":"Rami","year":"2003","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0510","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nn0901-948","article-title":"Prefrontal cortex in long-term memory: an \u2018interference\u2019 approach using magnetic stimulation","volume":"4","author":"Rossi","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0515","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1155\/2006\/793256","article-title":"rTMS for PTSD: induced merciful oblivion or elimination of abnormal hypermnesia?","volume":"17","author":"Rossi","year":"2006","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0520","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.1523\/JNEUROSCI.0703-04.2004","article-title":"Age-related functional changes of prefrontal cortex in long-term memory: a repetitive transcranial magnetic stimulation study","volume":"24","author":"Rossi","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0525","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1162\/089892903322370771","article-title":"The role of prefrontal cortex in verbal episodic memory: rTMS evidence","volume":"15","author":"Sandrini","year":"2003","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0530","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainres.2010.04.041","article-title":"Paired-pulse transcranial magnetic stimulation over the dorsolateral prefrontal cortex interferes with episodic encoding and retrieval for both verbal and non-verbal materials","volume":"1344","author":"Gagnon","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0535","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/cercor\/bhh002","article-title":"Prefrontal cortex asymmetry for memory encoding of words and abstract shapes","volume":"14","author":"Floel","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0540","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuroscience.2005.05.037","article-title":"Interfering with working memory in humans","volume":"139","author":"Mottaghy","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0545","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/cercor\/12.4.369","article-title":"Segregation of areas related to visual working memory in the prefrontal cortex revealed by rTMS","volume":"12","author":"Mottaghy","year":"2002","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0550","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/cercor\/11.7.606","article-title":"Parieto-frontal interactions in visual-object and visual-spatial working memory: evidence from transcranial magnetic stimulation","volume":"11","author":"Oliveri","year":"2001","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0555","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.neuropsychologia.2010.12.010","article-title":"Magnetic stimulation of the dorsolateral prefrontal cortex dissociates fragile visual short-term memory from visual working memory","volume":"49","author":"Sligte","year":"2011","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0560","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1097\/00001756-200411150-00024","article-title":"The role of the right dorsolateral prefrontal cortex in visual change awareness","volume":"15","author":"Turatto","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0565","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jpsychires.2005.06.001","article-title":"Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex affects divided attention immediately after cessation of stimulation","volume":"40","author":"Wagner","year":"2006","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0570","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0010-9452(08)70413-1","article-title":"Differential effects of transcranial magnetic stimulation of left and right posterior parietal cortex on mental rotation tasks","volume":"42","author":"Feredoes","year":"2006","journal-title":"Cortex"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0575","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1162\/jocn.2006.18.10.1712","article-title":"Repetitive transcranial magnetic stimulation dissociates working memory manipulation from retention functions in the prefrontal, but not posterior parietal, cortex","volume":"18","author":"Postle","year":"2006","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0580","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1567-424X(09)70006-6","article-title":"Studying higher cerebral functions by transcranial magnetic stimulation","volume":"59","author":"Terao","year":"2006","journal-title":"Suppl. Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0585","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0304-3940(00)01146-0","article-title":"Spatial working memory performance after high-frequency repetitive transcranial magnetic stimulation of the left and right posterior parietal cortex in humans","volume":"287","author":"Kessels","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0590","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3410\/B1-81","article-title":"Transcranial magnetic stimulation studies of visuospatial attentional control","volume":"1","author":"Szczepanski","year":"2009","journal-title":"F1000 Biol. Rep."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0595","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ana.20604","article-title":"Cerebellar transcranial magnetic stimulation impairs verbal working memory","volume":"58","author":"Desmond","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0600","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5507\/bp.2010.020","article-title":"Transcranial magnetic stimulation of the cerebellum","volume":"154","author":"Minks","year":"2010","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0605","first-page":"241","article-title":"Transcranial magnetic stimulation \u2013 a new tool for functional imaging of the brain","volume":"27","author":"Ilmoniemi","year":"1999","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0610","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/1522-2586(200006)11:6<569::AID-JMRI1>3.0.CO;2-3","article-title":"BOLD-f MRI response to single-pulse transcranial magnetic stimulation (TMS)","volume":"11","author":"Bohning","year":"2000","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0615","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1097\/00001756-199708180-00027","article-title":"Imaging human intra-cerebral connectivity by PET during TMS","volume":"8","author":"Fox","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0620","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1097\/00001756-199711100-00024","article-title":"Neuronal responses to magnetic stimulation reveal cortical reactivity and connectivity","volume":"8","author":"Ilmoniemi","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0625","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1388-2457(01)00721-0","article-title":"Ipsi- and contralateral EEG reactions to transcranial magnetic stimulation","volume":"113","author":"Komssi","year":"2002","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0630","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1046\/j.0953-816x.2001.01757.x","article-title":"Cortico-cortical connectivity of the human mid-dorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation","volume":"14","author":"Paus","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0635","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1523\/JNEUROSCI.17-09-03178.1997","article-title":"Transcranial magnetic stimulation during positron emission tomography: a new method for studying connectivity of the human cerebral cortex","volume":"17","author":"Paus","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0640","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1212\/WNL.54.4.956","article-title":"Lasting cortical activation after repetitive TMS of the motor cortex: a glucose metabolic study","volume":"54","author":"Siebner","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0645","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1152\/jn.2001.85.6.2624","article-title":"Cerebral blood-flow changes induced by paired-pulse transcranial magnetic stimulation of the primary motor cortex","volume":"85","author":"Strafella","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0650","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0304-3940(00)00798-9","article-title":"Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation","volume":"280","author":"Mottaghy","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0655","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0926-6410(02)00196-9","article-title":"Modulation of a brain-behavior relationship in verbal working memory by rTMS","volume":"15","author":"Mottaghy","year":"2003","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0660","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jneumeth.2004.06.016","article-title":"A new device and protocol for combining TMS and online recordings of EEG and evoked potentials","volume":"141","author":"Thut","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0665","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.clinph.2006.04.010","article-title":"Electroencephalographic recording during transcranial magnetic stimulation in humans and animals","volume":"117","author":"Ives","year":"2006","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0670","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/155005940803900308","article-title":"Effects of rTMS on an auditory oddball task: a pilot study of cortical plasticity and the EEG","volume":"39","author":"Cooper","year":"2008","journal-title":"Clin. EEG Neurosci."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0675","first-page":"1359","article-title":"Effect of transcranial magnetic stimulation on P300 of event-related potential","volume":"2009","author":"Iwahashi","year":"2009","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0680","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/00004691-200107000-00003","article-title":"EEG modification induced by repetitive transcranial magnetic stimulation","volume":"18","author":"Okamura","year":"2001","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0685","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(02)01077-7","article-title":"High frequency repetitive transcranial magnetic over the medial cerebellum induces a shift in the prefrontal electroencephalography gamma spectrum: a pilot study in humans","volume":"336","author":"Schutter","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0690","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.brainresbull.2006.11.002","article-title":"Effect of chronic and acute low-frequency repetitive transcranial magnetic stimulation on spatial memory in rats","volume":"71","author":"Li","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0695","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/bem.20211","article-title":"Modulation of learning and hippocampal, neuronal plasticity by repetitive transcranial magnetic stimulation (rTMS)","volume":"27","author":"Ahmed","year":"2006","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0700","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0031-9384(90)90216-Q","article-title":"Memory for conditioned taste aversions is diminished by transcranial magnetic stimulation","volume":"48","author":"Kling","year":"1990","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0705","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2006.10.054","article-title":"The influence of low-frequency rTMS on EEG of rats","volume":"412","author":"Li","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0710","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/026988110201600408","article-title":"Evaluation of tests of central nervous system performance after hypoxemia for a model for cognitive impairment","volume":"16","author":"van der Post","year":"2002","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0715","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/0310057X9302100208","article-title":"Cognitive function during moderate hypoxaemia","volume":"21","author":"Noble","year":"1993","journal-title":"Anaesth. Intensive Care"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0720","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/01688638908400886","article-title":"Isocapnic hypoxemia and neuropsychological functioning","volume":"11","author":"Berry","year":"1989","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0725","first-page":"1004","article-title":"The effects of mild hypoxia on a logical reasoning task","volume":"56","author":"Green","year":"1985","journal-title":"Aviat. Space Environ. Med."},{"issue":"Pt 1","key":"10.1016\/j.ddtec.2013.03.003_bib0730","first-page":"891","article-title":"Performance during mild acute hypoxia","volume":"65","author":"Paul","year":"1994","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0735","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1152\/jappl.1993.74.4.1735","article-title":"Cognitive performance and event-related brain potentials under simulated high altitudes","volume":"74","author":"Kida","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0740","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.clinph.2008.02.021","article-title":"Effects of moderate hypobaric hypoxia on evoked categorical visuocognitive responses","volume":"119","author":"Tsarouchas","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0745","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.sleep.2007.12.003","article-title":"Performance impairment during four days partial sleep deprivation compared with the acute effects of alcohol and hypoxia","volume":"10","author":"Elmenhorst","year":"2009","journal-title":"Sleep Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0750","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1080\/00140138708966040","article-title":"The effects of hypoxia on reaction time and movement time components of a perceptual-motor task","volume":"30","author":"Fowler","year":"1987","journal-title":"Ergonomics"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0755","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/00140138208924940","article-title":"The effects of hypoxia on serial response time","volume":"25","author":"Fowler","year":"1982","journal-title":"Ergonomics"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0760","first-page":"67","article-title":"Effects of the novel neuroprotective agent, riluzole, on human brain function and behavior: II. Double-blind, placebo-controlled EEG mapping and psychometric studies under hypoxia","volume":"18","author":"Saletu","year":"1996","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0765","first-page":"666","article-title":"Inspired carbon dioxide during hypoxia: effects on task performance and cerebral oxygen saturation","volume":"78","author":"Van Dorp","year":"2007","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0770","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0013-4694(88)90002-8","article-title":"Quantitative EEG changes due to hypobaric hypoxia in normal subjects","volume":"69","author":"Kraaier","year":"1988","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0775","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02252925","article-title":"Brain protection of nicergoline against hypoxia: EEG brain mapping and psychometry","volume":"2","author":"Saletu","year":"1990","journal-title":"J. Neural Transm. Park. Dis. Dement. Sect."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0780","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0013-4694(91)90197-C","article-title":"Quantitative EEG during progressive hypocarbia and hypoxia. Hyperventilation-induced EEG changes reconsidered","volume":"79","author":"Van der Worp","year":"1991","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0785","first-page":"645","article-title":"A comparison of visual and auditory reaction time and P300 latency thresholds to acute hypoxia","volume":"66","author":"Fowler","year":"1995","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0790","first-page":"113","article-title":"Event related potential (ERP) P300 after 6 months residence at 4115 meter","volume":"134","author":"Thakur","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0795","first-page":"30","article-title":"Effects of simulated high altitude exposure on long-latency event-related brain potentials and performance","volume":"64","author":"Wesensten","year":"1993","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0800","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1152\/japplphysiol.00069.2007","article-title":"Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans","volume":"104","author":"Binks","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0805","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/00004647-199808000-00011","article-title":"Changes of cerebral blood flow during short-term exposure to normobaric hypoxia","volume":"18","author":"Buck","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0810","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1365-201x.2000.00649.x","article-title":"Effects of acute hypobaric hypoxia on regional cerebral blood flow distribution: a single photon emission computed tomography study in humans","volume":"168","author":"Pagani","year":"2000","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0815","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1748-1716.2011.02264.x","article-title":"Impact of acute hypobaric hypoxia on blood flow distribution in brain","volume":"202","author":"Pagani","year":"2011","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0820","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1152\/jappl.1991.70.4.1720","article-title":"Metabolic and work efficiencies during exercise in Andean natives","volume":"70","author":"Hochachka","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0825","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/096032719601500407","article-title":"Morphological alterations in the hippocampus following hypobaric hypoxia","volume":"15","author":"Shukitt-Hale","year":"1996","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0830","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0163-1047(05)80023-8","article-title":"Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion","volume":"62","author":"Shukitt-Hale","year":"1994","journal-title":"Behav. Neural Biol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0835","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuroscience.2009.02.086","article-title":"Acetyl-l-carnitine (ALCAR) prevents hypobaric hypoxia-induced spatial memory impairment through extracellular related kinase-mediated nuclear factor erythroid 2-related factor 2 phosphorylation","volume":"161","author":"Barhwal","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0840","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejphar.2007.05.063","article-title":"Acetyl-L-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats","volume":"570","author":"Barhwal","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0845","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.nbd.2008.12.006","article-title":"Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment","volume":"34","author":"Hota","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0850","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.nlm.2008.01.003","article-title":"Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia","volume":"89","author":"Hota","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0855","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuint.2007.04.003","article-title":"Differential temporal response of hippocampus, cortex and cerebellum to hypobaric hypoxia: a biochemical approach","volume":"51","author":"Hota","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0860","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.physbeh.2007.05.051","article-title":"N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia","volume":"92","author":"Jayalakshmi","year":"2007","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0865","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2008.01.007","article-title":"Hypobaric hypoxia induces dendritic plasticity in cortical and hippocampal pyramidal neurons in rat brain","volume":"189","author":"Maiti","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0870","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2009.03.026","article-title":"Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia","volume":"203","author":"Muthuraju","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0875","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0031-9384(95)02107-8","article-title":"Tyrosine administration prevents hypoxia-induced decrements in learning and memory","volume":"59","author":"Shukitt-Hale","year":"1996","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0880","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neuroscience.2006.11.037","article-title":"Hypobaric hypoxia-induced dendritic atrophy of hippocampal neurons is associated with cognitive impairment in adult rats","volume":"145","author":"Titus","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0885","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jnr.20860","article-title":"Intermittent hypoxia impairs performance of adult mice in the two-way shuttle box but not in the Morris water maze","volume":"84","author":"Zhang","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0890","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.brainres.2008.06.081","article-title":"Nitric oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory impairment during acute hypobaric hypoxia","volume":"1230","author":"Udayabanu","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0895","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1213\/01.ane.0000265555.57472.49","article-title":"Physostigmine reverses cognitive dysfunction caused by moderate hypoxia in adult mice","volume":"105","author":"Bekker","year":"2007","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0900","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1213\/01.ane.0000198637.36539.c1","article-title":"Isoflurane preserves spatial working memory in adult mice after moderate hypoxia","volume":"102","author":"Bekker","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0905","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/ANA.0b013e3181920d28","article-title":"Nimodipine prevents transient cognitive dysfunction after moderate hypoxia in adult mice","volume":"21","author":"Haile","year":"2009","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0910","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/nlme.1999.3947","article-title":"Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning","volume":"74","author":"Viu","year":"2000","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ddtec.2013.03.003_bib0915","series-title":"Proceedings of Measuring Behavior","article-title":"Epidural EEG recordings using microchips in behavioural context","author":"Platt","year":"2010"},{"key":"10.1016\/j.ddtec.2013.03.003_bib0920","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/MNM.0b013e3283447292","article-title":"Use of [18F]fluorodeoxyglucose and the ATLAS small animal PET scanner to examine cerebral functional activation by whisker stimulation in unanesthetized rats","volume":"32","author":"Ravasi","year":"2011","journal-title":"Nucl. Med. Commun."}],"container-title":["Drug Discovery Today: Technologies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1740674913000279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1740674913000279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T18:20:32Z","timestamp":1644862832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1740674913000279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":190,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1740674913000279"],"URL":"https:\/\/doi.org\/10.1016\/j.ddtec.2013.03.003","relation":{},"ISSN":["1740-6749"],"issn-type":[{"value":"1740-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}