{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:06:05Z","timestamp":1792080365666,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Materials"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.dental.2011.07.007","type":"journal-article","created":{"date-parts":[[2011,8,28]],"date-time":"2011-08-28T10:52:18Z","timestamp":1314528738000},"page":"1055-1069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["Biomimetic remineralization of human dentin using promising innovative calcium-silicate hybrid \u201csmart\u201d materials"],"prefix":"10.1016","volume":"27","author":[{"given":"Maria Giovanna","family":"Gandolfi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Siboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Modena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra Dorigo","family":"De Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Prati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dental.2011.07.007_bib0005","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1021\/cr0782527","article-title":"Relationship between polyphosphate chemistry, biochemistry and apatite biomineralization","volume":"108","author":"Omelon","year":"2008","journal-title":"Chem Rev"},{"key":"10.1016\/j.dental.2011.07.007_bib0010","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000201593","article-title":"Biomechanical perspective on the remineralization of dentin","volume":"43","author":"Bertassoni","year":"2009","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0015","unstructured":"BSI (British Standards Institution). Terminology for the bio-nano interface. PAS132:2007, London, UK."},{"key":"10.1016\/j.dental.2011.07.007_bib0020","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0109-5641(02)00105-7","article-title":"Mechanical properties and biochemical activity of remineralizing resin-based Ca\u2013PO4 cements","volume":"19","author":"Dickens","year":"2003","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2011.07.007_bib0025","unstructured":"Dickens SH, Eichmiller FC. Remineralizing dental cements. Patent WO2005002531 (A1) 2005-01-13 and US200520720 (A1) 2005-01-13."},{"key":"10.1016\/j.dental.2011.07.007_bib0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/0022034509360155","article-title":"In vivo dentin remineralization by calcium-phosphate cement","volume":"89","author":"Peters","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0035","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1177\/154405910608500807","article-title":"Nano DCPA-wisker composites with high strength and Ca and PO4 release","volume":"85","author":"Xu","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.6028\/jres.108.017","article-title":"Amorphous calcium phosphate-based bioactive polymeric composites for mineralized tissue regeneration","volume":"108","author":"Skrtic","year":"2003","journal-title":"J Res Nat Inst Stand Technol"},{"key":"10.1016\/j.dental.2011.07.007_bib0045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000073398","article-title":"In vitro study of remineralization of dentin: effects of ions on mineral induction by decalcified dentin matrix","volume":"37","author":"Saito","year":"2003","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1023\/A:1015174726415","article-title":"Interaction between bioactive glasses and human dentin","volume":"13","author":"Efflandt","year":"2002","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.dental.2011.07.007_bib0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/00016350310008012","article-title":"Mineralization of dentin induced by treatment with bioactive glass S53P4 in vitro","volume":"62","author":"Forsback","year":"2004","journal-title":"Act Odontol Scand"},{"key":"10.1016\/j.dental.2011.07.007_bib0060","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.actbio.2007.04.003","article-title":"Remineralization of human dentin using ultrafine bioactive glass particles","volume":"3","author":"Vollenweider","year":"2007","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2011.07.007_bib0065","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1016\/j.biomaterials.2005.03.008","article-title":"Compound changes and tooth mineralization effects of glass ionomer cements containing bioactive glass (S53P4), an in vivo study","volume":"26","author":"Yli-Urpo","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2011.07.007_bib0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/01.DON.0000133155.04468.41","article-title":"Physicochemical basis of the biologic properties of mineral trioxide aggregate","volume":"31","author":"Sarkar","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2011.07.007_bib0075","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.biomaterials.2007.11.001","article-title":"Guided tissue remineralisation of partially demineralised human dentine","volume":"29","author":"Tay","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2011.07.007_bib0080","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1016\/j.biomaterials.2010.04.060","article-title":"Mineralization of reconstituted collagen using polyvinylphosphonic acid\/polyacrylic acid templating matrix protein analogues in the presence of calcium, phosphate and hydroxyl ions","volume":"31","author":"Kim","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2011.07.007_bib0085","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.actbio.2010.07.036","article-title":"Immobilization of a phosphonated analog of matrix phosphoproteins within cross-linked collagen as a templating mechanism for biomimetic mineralization","volume":"7","author":"Gu","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2011.07.007_bib0090","unstructured":"Torabinejad M, White DJ. US Patent Number 5,769,638; May 1995."},{"key":"10.1016\/j.dental.2011.07.007_bib0095","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.joen.2009.09.009","article-title":"Mineral trioxide aggregate: a comprehensive literature review\u2014part III clinical applications, drawbacks and mechanism of action","volume":"36","author":"Parirokh","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2011.07.007_bib0100","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00784-009-0356-3","article-title":"Kinetics of apatite formation on a calcium-silicate cement for root-end filling during ageing in physiological-like phosphate solutions","volume":"14","author":"Gandolfi","year":"2010","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.dental.2011.07.007_bib0105","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.joen.2009.12.007","article-title":"ESEM-EDX Raman techniques to study ProRoot MTA and calcium-silicate cements in wet conditions and in real-time","volume":"36","author":"Gandolfi","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2011.07.007_bib0110","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1365-2591.2010.01768.x","article-title":"Apatite-forming ability of ProRoot MTA","volume":"43","author":"Gandolfi","year":"2010","journal-title":"Int Endod J"},{"key":"10.1016\/j.dental.2011.07.007_bib0255","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molstruc.2010.12.058","article-title":"Vibrational investigation on the in vitro bioactivity of commercial and experimental calcium-silicate cements for root-end endodontic therapy","volume":"993","author":"Taddei","year":"2011","journal-title":"J Mol Struct"},{"key":"10.1016\/j.dental.2011.07.007_bib0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joen.2009.09.006","article-title":"Mineral trioxide aggregate: a comprehensive literature review\u2014part I chemical, physical and antibacterial properties","volume":"36","author":"Parirokh","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2011.07.007_bib0125","unstructured":"ISO 23317. In vitro evaluation for apatite-forming ability of implant materials; 2007."},{"key":"10.1016\/j.dental.2011.07.007_bib0130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.joen.2009.09.010","article-title":"Mineral trioxide aggregate: a comprehensive literature review\u2014part II leakage and biocompatibility studies","volume":"36","author":"Torabinejad","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2011.07.007_bib0135","unstructured":"3M Vitrebond Liner\/base. Technical Product Profile Update. http:\/\/multimedia.3m.com\/mws\/mediawebserver?66666UuZjcFSLXTtmxfX4Xs6EVuQEcuZgVs6EVs6E666666--."},{"key":"10.1016\/j.dental.2011.07.007_bib0140","unstructured":"ASTM International C266-07. Standard test method for time of setting of hydraulic cement paste by Gillmore needles; 2007."},{"key":"10.1016\/j.dental.2011.07.007_bib0145","series-title":"Specification for dental canal sealing materials: ISO 6876","author":"ISO 6876, International Organization for Standardization","year":"2002"},{"key":"10.1016\/j.dental.2011.07.007_bib0150","unstructured":"ISO 10993-18. Biological evaluation of medical devices part 18: chemical characterization of materials; 2005."},{"key":"10.1016\/j.dental.2011.07.007_bib0155","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.molstruc.2008.11.002","article-title":"Vibrational study on the bioactivity of Portland cement-based materials for endodontic use","volume":"924\u2013926","author":"Taddei","year":"2009","journal-title":"J Mol Structure"},{"key":"10.1016\/j.dental.2011.07.007_bib0160","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1002\/jrs.2333","article-title":"Ageing of calcium silicate cements for endodontic use in simulated body fluids: a micro-Raman study","volume":"40","author":"Taddei","year":"2009","journal-title":"J Raman Spectrosc"},{"key":"10.1016\/j.dental.2011.07.007_bib0165","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1023\/B:JMSM.0000026101.53272.86","article-title":"Apatite formation on collagen fibrils in the presence of polyacrylic acid","volume":"15","author":"Girija","year":"2004","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.dental.2011.07.007_bib0170","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/(SICI)1097-4628(19990516)72:7<971::AID-APP13>3.0.CO;2-N","article-title":"Bioartificial materials based on blends of collagen and poly(acrylic acid)","volume":"72","author":"Barbani","year":"1999","journal-title":"J Appl Polym Sci"},{"key":"10.1016\/j.dental.2011.07.007_bib0175","first-page":"5","article-title":"An updated understanding of the mechanism of dental decay and its prevention","volume":"14","author":"Featherstone","year":"1990","journal-title":"Nutr Q"},{"key":"10.1016\/j.dental.2011.07.007_bib0180","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/10454411910020030101","article-title":"Mechanistic aspects of the interactions between fluoride and dental enamel","volume":"2","author":"ten Cate","year":"1991","journal-title":"Crit Rev Oral Biol Med."},{"key":"10.1016\/j.dental.2011.07.007_bib0185","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.archoralbio.2006.11.008","article-title":"Micromorphological and micronanalytical characterization of stagnating and progressing root caries lesions","volume":"52","author":"Arnold","year":"2007","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.dental.2011.07.007_bib0190","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1177\/00220345010800050401","article-title":"Remineralization of caries lesions extending into dentin","volume":"80","author":"ten Cate","year":"2001","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0195","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000109086","article-title":"Effects of ozone and sodium hypochlorite on caries-like lesions in dentin","volume":"41","author":"Zaura","year":"2007","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0200","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000016614","article-title":"Relationship between mineral distributions in dentine lesions and subsequent remineralization in vitro","volume":"34","author":"Kawasaki","year":"2000","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0205","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jdent.2007.05.008","article-title":"Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro","volume":"35","author":"Rahiotis","year":"2007","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2011.07.007_bib0210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.vibspec.2005.02.015","article-title":"Infrared spectroscopic characterization of mineralized tissues","volume":"38","author":"Boskey","year":"2005","journal-title":"Vib Spectrosc"},{"key":"10.1016\/j.dental.2011.07.007_bib0215","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.dental.2005.04.036","article-title":"Fluoride release and absorption at different pH from glass-ionomer cements","volume":"22","author":"Gandolfi","year":"2006","journal-title":"Dental Mater"},{"key":"10.1016\/j.dental.2011.07.007_bib0220","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.dental.2006.01.022","article-title":"Review on fluoride-releasing restorative materials\u2014fluoride release and uptake characteristics, antibacterial activity and influence on caries formation","volume":"23","author":"Wiegand","year":"2007","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2011.07.007_bib0225","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/0022034509357172","article-title":"Failure of a glass ionomer to remineralize apatite-depleted dentin","volume":"89","author":"Kim","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0230","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.actbio.2009.03.030","article-title":"Development of remineralizing, antibacterial dental materials","volume":"5","author":"Mehdawi","year":"2009","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2011.07.007_bib0235","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1016\/S0142-9612(01)00071-0","article-title":"Effect of polyacrylic acid on the apatite formation of a bioactive ceramic in a simulated body fluid: fundamental examination of the possibility of obtaining bioactive glass-ionomer cements for orthopaedic use","volume":"22","author":"Kamitakahara","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2011.07.007_bib0240","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jbm.b.30193","article-title":"Manipulation of nanoneedle and nanosphere apatite\/poly(acrylic acid) nanocomposites","volume":"73B","author":"Liou","year":"2005","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.dental.2011.07.007_bib0245","first-page":"138340","article-title":"Biomimetic remineralization of human dentin using promising innovative calcium-silicates hybrid \u201cSmart\u201d materials","volume":"89B","author":"Gandolfi","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2011.07.007_bib0260","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1016\/j.dental.2011.03.011","article-title":"Development of the foremost light-curable calcium-silicate MTA cement as root-end in oral surgery. Chemical\u2013physical properties, bioactivity and biological behaviour","volume":"27","author":"Gandolfi","year":"2011","journal-title":"Dental Mater"}],"container-title":["Dental Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564111001813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564111001813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T20:13:13Z","timestamp":1758831193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0109564111001813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0109564111001813"],"URL":"https:\/\/doi.org\/10.1016\/j.dental.2011.07.007","relation":{},"ISSN":["0109-5641"],"issn-type":[{"value":"0109-5641","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic remineralization of human dentin using promising innovative calcium-silicate hybrid \u201csmart\u201d materials","name":"articletitle","label":"Article Title"},{"value":"Dental Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dental.2011.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}