{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:03:54Z","timestamp":1793318634529,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Materials"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.dental.2018.02.008","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T19:12:02Z","timestamp":1521227522000},"page":"868-878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cellular differentiation, bioactive and mechanical properties of experimental light-curing pulp protection materials"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-8776","authenticated-orcid":false,"given":"Salvatore","family":"Sauro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6002-8465","authenticated-orcid":false,"given":"Ashvin","family":"Babbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borzo","family":"Gharibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-9967","authenticated-orcid":false,"given":"Victor Pinheiro","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Marins","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidiany Karla","family":"Azevedo Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0091-7348","authenticated-orcid":false,"given":"Avijit","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dental.2018.02.008_bib0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0022034516639276","article-title":"Managing caries lesions: consensus recommendations on terminology","volume":"28","author":"Innes","year":"2016","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.dental.2018.02.008_bib0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.dental.2015.03.013","article-title":"Influence of phosphoproteins\u2019 biomimetic analogs on remineralization of mineral-depleted resin\u2013dentin interfaces created with ion-releasing resin-based systems","volume":"31","author":"Sauro","year":"2015","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0015","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1016\/S0142-9612(02)00147-3","article-title":"An evaluation of accelerated Portland cement as a restorative material","volume":"23","author":"Abdullah","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2018.02.008_bib0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0022034516639271","article-title":"Managing caries lesions: consensus recommendations on carious tissue removal","volume":"28","author":"Schwendicke","year":"2016","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.dental.2018.02.008_bib0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.bdj.2017.672","article-title":"Contemporary operative caries management: consensus recommendations on minimally invasive caries removal","volume":"223","author":"Banerjee","year":"2017","journal-title":"Br Dent J"},{"key":"10.1016\/j.dental.2018.02.008_bib0030","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/0022034515571415","article-title":"Efficacy of calcium silicate indirect pulp capping; a randomized controlled clinical trial","volume":"94","author":"Hashem","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2018.02.008_bib0035","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1016\/j.actbio.2010.03.021","article-title":"Biomimetic remineralization as a progressive dehydration mechanism of collagen matrices\u2014implications in the aging of resin\u2013dentin bonds","volume":"6","author":"Kim","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2018.02.008_bib0040","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jbm.820230703","article-title":"Bioceramics and the origin of life","volume":"23","author":"Hench","year":"1989","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.dental.2018.02.008_bib0045","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How useful is SBF in predicting in vivo bone bioactivity","volume":"27","author":"Kokubo","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2018.02.008_bib0050","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1365-2591.2005.01028.x","article-title":"The chemical constitution and biocompatibility of accelerated Portland cement for endodontic use","volume":"38","author":"Camilleri","year":"2005","journal-title":"Int Endod J"},{"key":"10.1016\/j.dental.2018.02.008_bib0055","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jdent.2013.05.003","article-title":"Investigation of biodentine as dentine replacement material","volume":"41","author":"Camilleri","year":"2013","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2018.02.008_bib0060","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.joen.2009.03.006","article-title":"Mineral trioxide aggregate obturation: a review and case series","volume":"35","author":"Bogen","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2018.02.008_bib0065","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.joen.2009.11.012","article-title":"Physical and chemical properties of new-generation endodontic materials","volume":"36","author":"Porter","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2018.02.008_bib0070","first-page":"44","article-title":"Mechanical properties of new dental pulp-capping materials","volume":"64","author":"Nielsen","year":"2016","journal-title":"Gen Dent"},{"key":"10.1016\/j.dental.2018.02.008_bib0075","first-page":"137","article-title":"Cytotoxicity of resin-based light-cured liners","volume":"22","author":"Hebling","year":"2009","journal-title":"Am J Dent"},{"key":"10.1016\/j.dental.2018.02.008_bib0080","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10856-006-0432-z","article-title":"The story of bioglass","volume":"17","author":"Hench","year":"2006","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.dental.2018.02.008_bib0085","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2341\/10-225-L","article-title":"Effects of common dental materials used in preventive or operative dentistry on dentin permeability and remineralization","volume":"36","author":"Sauro","year":"2011","journal-title":"Oper Dent"},{"key":"10.1016\/j.dental.2018.02.008_bib0090","first-page":"90","article-title":"Overview of the clinical evidence for use of NovaMin in providing relief from the pain of dentin hypersensitivity","volume":"22","author":"Gendreau","year":"2011","journal-title":"J Clin Dent"},{"key":"10.1016\/j.dental.2018.02.008_bib0095","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.dental.2015.02.002","article-title":"Surface pre-conditioning with bio-active glass air-abrasion can enhance enamel white spot lesion remineralisation","volume":"31","author":"Milly","year":"2015","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0100","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s10856-012-4606-6","article-title":"Therapeutic effects of novel resin bonding systems containing bioactive glasses on mineral-depleted areas within the bonded-dentine interface","volume":"23","author":"Sauro","year":"2012","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.dental.2018.02.008_bib0105","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1039\/c3tb00205e","article-title":"Remineralisation properties of innovative light-curable resin-based dental materials containing bioactive micro-fillers","volume":"1","author":"Sauro","year":"2013","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.dental.2018.02.008_bib0110","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/01694243.2016.1221251","article-title":"Flexural strength of nano-hybrid resin composite as a function of light attenuation distance and specimen dimension","volume":"31","author":"El-Askary","year":"2017","journal-title":"J Adhes Sci Technol"},{"key":"10.1016\/j.dental.2018.02.008_bib0115","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.dental.2017.04.013","article-title":"Academy of dental materials guidance-resin composites: part I-mechanical properties","volume":"33","author":"IIlie","year":"2017","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0120","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/08959374970110042301","article-title":"Raman spectroscopy in dental research: a short review of recent studies","volume":"11","author":"Tsuda","year":"1997","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.dental.2018.02.008_bib0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13287-017-0552-z","article-title":"Human mesenchymal stem cells maintain their phenotype, multipotentiality, and genetic stability when cultured using a defined xeno-free human plasma fraction","volume":"8","author":"Bl\u00e1zquez-Prunera","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.dental.2018.02.008_bib0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jdent.2017.02.008","article-title":"Degradation of optical and surface properties of resin-based composites with distinct nanoparticle sizes but equivalent surface area","volume":"59","author":"Salgado","year":"2017","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2018.02.008_bib0135","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.dental.2005.05.005","article-title":"Hygroscopic and hydrolytic effects in dental polymer networks","volume":"22","author":"Ferracane","year":"2006","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0140","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jcis.2005.02.047","article-title":"AAS, XRPD, SEM\/EDS, and FTIR characterization of Zn2+ retention by calcite, calcite\u2013kaolinite, and calcite\u2013clinoptilolite minerals","volume":"286","author":"Shahwan","year":"2005","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.dental.2018.02.008_bib0145","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3390\/ma2041929","article-title":"Structure\u2013composition\u2013property relationships in polymeric amorphous calcium phosphate-based dental composites","volume":"2","author":"O\u2019Donnell","year":"2009","journal-title":"Materials"},{"key":"10.1016\/j.dental.2018.02.008_bib0150","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1016\/S0142-9612(01)00071-0","article-title":"Effect of polyacrylic acid on the apatite formation of a bioactive ceramic in a simulated body fluid: fundamental examination of the possibility of obtaining bioactive glass-ionomer cements for orthopaedic use","volume":"22","author":"Kamitakahara","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2018.02.008_bib0155","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s10971-011-2665-7","article-title":"Effect of pH and temperature on the morphology and phases of co-precipitated hydroxyapatite","volume":"61","author":"Le","year":"2012","journal-title":"J Sol Gel Sci Technol"},{"key":"10.1016\/j.dental.2018.02.008_bib0160","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0142-9612(00)00166-6","article-title":"Kinetics of hydroxyapatite precipitation at pH 10\u201311","volume":"22","author":"Liu","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2018.02.008_bib0165","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.dental.2015.09.020","article-title":"Cytotoxicity and osteogenic potential of silicate calcium cements as potential protective materials for pulpal revascularization","volume":"31","author":"Bortoluzzi","year":"2015","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0170","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.dental.2015.04.016","article-title":"Evaluation of cell responses toward adhesives with different photoinitiating systems","volume":"31","author":"Van Landuyt","year":"2015","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0175","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.dental.2009.06.016","article-title":"The influence of various light curing units on the cytotoxicity of dental adhesives","volume":"25","author":"Sigusch","year":"2009","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0180","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1016\/j.biomaterials.2003.11.048","article-title":"Effects of BisGMA on glutathione metabolism and apoptosis in human gingival fibroblasts in vitro","volume":"25","author":"Engelmann","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2018.02.008_bib0185","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.dental.2015.01.007","article-title":"Cytotoxicity of dimethyl sulfoxide (DMSO) in direct contact with odontoblast-like cells","volume":"31","author":"Hebling","year":"2015","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2018.02.008_bib0190","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1016\/j.biomaterials.2004.09.019","article-title":"Preparation and characteristics of a calcium magnesium silicate (bredigite) bioactive ceramic","volume":"26","author":"Wu","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2018.02.008_bib0195","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.actbio.2008.04.014","article-title":"Biological response of human bone cells to zinc-modified Ca\u2013Si-based ceramics","volume":"4","author":"Ramaswamy","year":"2008","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2018.02.008_bib0200","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1016\/j.biomaterials.2007.04.002","article-title":"The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties","volume":"28","author":"Wu","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2018.02.008_bib0205","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/0006-2952(87)90471-0","article-title":"Stimulatory effect of zinc on bone formation in tissue culture","volume":"36","author":"Yamaguchi","year":"1987","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.dental.2018.02.008_bib0210","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.actbio.2011.03.027","article-title":"Bioinorganics and biomaterials. Bone repair","volume":"7","author":"Habibovic","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2018.02.008_bib0215","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/jn\/110.8.1581","article-title":"Zinc deficiency and bone formation in guinea pig alveolar implants","volume":"110","author":"Hsieh","year":"1980","journal-title":"J Nutr"},{"key":"10.1016\/j.dental.2018.02.008_bib0220","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1210\/endo-114-5-1860","article-title":"Effect of zinc deficiency on serum somatomedin levels and skeletal growth in young rats","volume":"114","author":"Oner","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.dental.2018.02.008_bib0225","article-title":"In vitro and in vivo evaluation of zinc-modified Ca\u2013Si-based ceramic coating for bone implants","volume":"8","author":"Yu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dental.2018.02.008_bib0230","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1079\/PNS19980039","article-title":"Molecular biological approaches to nutrient\u2013gene interactions","volume":"57","author":"Chesters","year":"1998","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.dental.2018.02.008_bib0235","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1079\/PNS19980045","article-title":"A role of zinc in the regulation of gene expression","volume":"57","author":"Cousins","year":"1998","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.dental.2018.02.008_bib0240","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0928-4931(02)00108-X","article-title":"Zinc-releasing calcium phosphate for stimulating bone formation","volume":"22","author":"Ito","year":"2002","journal-title":"Mater Sci Eng C Biomim Supramol Syst"},{"key":"10.1016\/j.dental.2018.02.008_bib0245","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/(SICI)1097-4636(200005)50:2<184::AID-JBM13>3.0.CO;2-3","article-title":"Stimulatory effect of zinc-releasing calcium phosphate implant on bone formation in rabbit femora","volume":"50","author":"Kawamura","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.dental.2018.02.008_bib0250","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cap.2004.10.006","article-title":"Zinc-containing tricalcium phosphate and related materials for promoting bone formation","volume":"5","author":"Ito","year":"2005","journal-title":"Curr Appl Phys"},{"key":"10.1016\/j.dental.2018.02.008_bib0255","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.bone.2009.11.003","article-title":"Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation","volume":"46","author":"Kwun","year":"2010","journal-title":"Bone"}],"container-title":["Dental Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564117311910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564117311910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T20:26:12Z","timestamp":1758831972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0109564117311910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0109564117311910"],"URL":"https:\/\/doi.org\/10.1016\/j.dental.2018.02.008","relation":{},"ISSN":["0109-5641"],"issn-type":[{"value":"0109-5641","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular differentiation, bioactive and mechanical properties of experimental light-curing pulp protection materials","name":"articletitle","label":"Article Title"},{"value":"Dental Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dental.2018.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}