{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T20:04:06Z","timestamp":1794513846316,"version":"4.9.1"},"reference-count":91,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Materials"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.dental.2022.11.013","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T07:44:45Z","timestamp":1669016685000},"page":"2014-2029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular and biochemical approach for understanding the transition of amorphous to crystalline calcium phosphate deposits in human teeth"],"prefix":"10.1016","volume":"38","author":[{"given":"Werner E.G.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meik","family":"Neufurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ushijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-2332","authenticated-orcid":false,"given":"Rafael","family":"Mu\u00f1oz-Esp\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-3959","authenticated-orcid":false,"given":"Lena-Katharina","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz C.","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-6314","authenticated-orcid":false,"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dental.2022.11.013_bib1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1177\/00220345900690031601","article-title":"Properties of alkaline phosphatase of the human dental pulp","volume":"69","author":"Goseki","year":"1990","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2022.11.013_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jbmr.1767","article-title":"Tooth root dentin mineralization defects in a mouse model of hypophosphatasia","volume":"28","author":"Foster","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.dental.2022.11.013_bib3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jbmr.3225","article-title":"Alkaline phosphatase: discovery and naming of our favorite enzyme","volume":"33","author":"Siller","year":"2018","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.dental.2022.11.013_bib4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/BCO.0b013e3282630851","article-title":"The role of alkaline phosphatase in mineralization","volume":"18","author":"Golub","year":"2007","journal-title":"Curr Opin Orthop"},{"key":"10.1016\/j.dental.2022.11.013_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.coph.2016.03.003","article-title":"Pyrophosphate: a key inhibitor of mineralisation","volume":"28","author":"Orriss","year":"2016","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.dental.2022.11.013_bib6","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1172\/JCI115805","article-title":"Alkaline phosphatase induces the mineralization of sheets of collagen implanted subcutaneously in the rat","volume":"89","author":"Beertsen","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.dental.2022.11.013_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00441-014-2106-3","article-title":"Tissue non-specific alkaline phosphatase production by human dental pulp stromal cells is enhanced by high density cell culture","volume":"361","author":"Tomlinson","year":"2015","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.dental.2022.11.013_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.joen.2015.10.003","article-title":"Age-related changes in the alkaline phosphatase activity of healthy and inflamed human dental pulp","volume":"42","author":"Aslantas","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2022.11.013_bib9","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1016\/j.actbio.2011.03.007","article-title":"Inorganic polymeric phosphate\/polyphosphate as an inducer of alkaline phosphatase and a modulator of intracellular Ca2+ level in osteoblasts (SaOS-2 cells) in vitro","volume":"7","author":"M\u00fcller","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2022.11.013_bib10","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.copbio.2012.01.018","article-title":"Bio-silica and bio-polyphosphate: applications in biomedicine (bone formation)","volume":"23","author":"Wang","year":"2012","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.dental.2022.11.013_bib11","doi-asserted-by":"crossref","first-page":"C587","DOI":"10.1152\/ajpcell.00056.2018","article-title":"Support of bone mineral deposition by regulation of pH","volume":"315","author":"Blair","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.dental.2022.11.013_bib12","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1039\/C8TB00241J","article-title":"Amorphous polyphosphate, a smart bioinspired nano-\/bio-material for bone and cartilage regeneration: towards a new paradigm in tissue engineering","volume":"6","author":"Wang","year":"2018","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.dental.2022.11.013_bib13","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.actbio.2013.08.025","article-title":"Enzyme-accelerated and structure-guided crystallization of Ca-carbonate: role of the carbonic anhydrase in the homologous system","volume":"10","author":"M\u00fcller","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2022.11.013_bib14","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/cbic.201500057","article-title":"Nonenzymatic transformation of amorphous CaCO3 into calcium phosphate mineral after exposure to sodium phosphate in vitro: Implications for in vivo hydroxyapatite bone formation","volume":"16","author":"M\u00fcller","year":"2015","journal-title":"ChemBioChem"},{"key":"10.1016\/j.dental.2022.11.013_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0167-4838(01)00193-5","article-title":"Mammalian intestinal alkaline phosphatase acts as highly active exopolyphosphatase","volume":"1547","author":"Lorenz","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.dental.2022.11.013_bib16","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.actbio.2013.08.025","article-title":"Enzyme-accelerated and structure-guided crystallization of Ca-carbonate: role of the carbonic anhydrase in the homologous system","volume":"10","author":"M\u00fcller","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2022.11.013_bib17","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1021\/acs.cgd.9b00887","article-title":"Formation of hydroxyapatite via transformation of amorphous calcium phosphate in the presence of alginate additives","volume":"19","author":"Ucar","year":"2019","journal-title":"Cryst Growth Des"},{"key":"10.1016\/j.dental.2022.11.013_bib18","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/mabi.201500100","article-title":"Polyphosphate: a morphogenetically active implant material serving as metabolic fuel for bone regeneration","volume":"15","author":"M\u00fcller","year":"2015","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.dental.2022.11.013_bib19","doi-asserted-by":"crossref","first-page":"22198","DOI":"10.1016\/S0021-9258(17)31776-3","article-title":"Purification and characterization of an exopolyphosphatase activity from Saccharomyces cerevisiae","volume":"269","author":"Lorenz","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib20","doi-asserted-by":"crossref","first-page":"10996","DOI":"10.1016\/S0021-9258(19)78082-X","article-title":"A soluble exopolyphosphatase of Saccharomyces cerevisiae. Purification and characterization","volume":"269","author":"Wurst","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib21","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1128\/jb.177.4.898-906.1995","article-title":"The gene for a major exopolyphosphatase of Saccharomyces cerevisiae","volume":"177","author":"Wurst","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1016\/j.dental.2022.11.013_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/208365a0","article-title":"Intermediate states in the precipitation of hydroxyapatite","volume":"208","author":"Eanes","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.dental.2022.11.013_bib23","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1039\/C7TB01199G","article-title":"Detection of Posner's clusters during calcium phosphate nucleation: a molecular dynamics study","volume":"5","author":"Mancardi","year":"2017","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.dental.2022.11.013_bib24","doi-asserted-by":"crossref","first-page":"12373","DOI":"10.1039\/C7CP07720C","article-title":"Posner molecules: from atomic structure to nuclear spins","volume":"20","author":"Swift","year":"2018","journal-title":"Phys Chem Chem Phys"},{"key":"10.1016\/j.dental.2022.11.013_bib25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1021\/ar50092a003","article-title":"Synthetic amorphous calcium phosphate and its relation to bone mineral structure","volume":"8","author":"Betts","year":"1975","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.dental.2022.11.013_bib26","doi-asserted-by":"crossref","first-page":"8888","DOI":"10.1039\/C7OB02051A","article-title":"Hydroxyapatite: catalyst for a one-pot pentose formation","volume":"15","author":"Usami","year":"2017","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/ncomms2490","article-title":"Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate","volume":"4","author":"Habraken","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.dental.2022.11.013_bib28","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/nmat2900","article-title":"The role of prenucleation clusters in surface-induced calcium phosphate crystallization","volume":"9","author":"Dey","year":"2010","journal-title":"Nat Mater"},{"key":"10.1016\/j.dental.2022.11.013_bib29","first-page":"111","article-title":"Structure and chemistry of the apatites and othercalcium orthophosphates","volume":"Vol. 18","author":"Elliott","year":"2013"},{"key":"10.1016\/j.dental.2022.11.013_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.morpho.2015.12.001","article-title":"Aluminum and bone: review of new clinical circumstances associated with Al(3+) deposition in the calcified matrix of bone","volume":"100","author":"Chappard","year":"2016","journal-title":"Morphologie"},{"key":"10.1016\/j.dental.2022.11.013_bib31","first-page":"1","article-title":"Crystal structure of calcium vanadate-phosphate fluoride","author":"Dong","year":"2019","journal-title":"Powder Diffr"},{"key":"10.1016\/j.dental.2022.11.013_bib32","first-page":"14","article-title":"Hydroxyapatite in oral care products. A review","author":"Chen","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.dental.2022.11.013_bib33","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1152\/ajplegacy.1961.200.6.1296","article-title":"Mechanisms of calcification: role of collagen, polyphosphates, and phosphatase","volume":"200","author":"Fleish","year":"1961","journal-title":"Am J Physiol"},{"key":"10.1016\/j.dental.2022.11.013_bib34","series-title":"The biochemistry of inorganic polyphosphates","author":"Kulaev","year":"2004"},{"key":"10.1016\/j.dental.2022.11.013_bib35","series-title":"Inorganic polyphosphates - biochemistry, biology, biotechnology","author":"Schr\u00f6der","year":"1999"},{"key":"10.1016\/j.dental.2022.11.013_bib36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.matlet.2015.02.070","article-title":"A new polyphosphate calcium material with morphogenetic activity","volume":"148","author":"M\u00fcller","year":"2015","journal-title":"Mater Lett"},{"key":"10.1016\/j.dental.2022.11.013_bib37","doi-asserted-by":"crossref","first-page":"13963","DOI":"10.1039\/c1jm11977j","article-title":"Reactivity of calcium phosphate nanoparticles prepared by flame spray synthesis as precursors for calcium phosphate cements","volume":"21","author":"Mohn","year":"2011","journal-title":"J Mater Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib38","doi-asserted-by":"crossref","DOI":"10.4161\/biom.25103","article-title":"Synthesis of spherical calcium phosphate particles for dental and orthopedic applications","volume":"3","author":"Bohner","year":"2013","journal-title":"Biomatter"},{"key":"10.1016\/j.dental.2022.11.013_bib39","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/polym9040120","article-title":"A novel biomimetic approach to repair enamel cracks\/carious damages and to reseal dentinal tubules by amorphous polyphosphate","volume":"9","author":"M\u00fcller","year":"2017","journal-title":"Polymers"},{"key":"10.1016\/j.dental.2022.11.013_bib40","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1021\/cr8002856","article-title":"Controlling mineral morphologies and structures in biological and synthetic systems","volume":"108","author":"Meldrum","year":"2008","journal-title":"Chem Rev"},{"key":"10.1016\/j.dental.2022.11.013_bib41","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1126\/science.1167221","article-title":"Materials science. Now you see them","volume":"322","author":"Meldrum","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.dental.2022.11.013_bib42","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.actbio.2015.11.060","article-title":"Amorphous polyphosphate-hydroxyapatite: a morphogenetically active substrate for bone-related SaOS-2 cells in vitro","volume":"31","author":"M\u00fcller","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.dental.2022.11.013_bib43","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-013-9833-4","article-title":"Modulation of the initial mineralization process of SaOS-2 cells by carbonic anhydrase activators and polyphosphate","volume":"94","author":"Wang","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.dental.2022.11.013_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201801170","article-title":"Transformation of amorphous polyphosphate nanoparticles into coacervate complexes: an approach for the encapsulation of mesenchymal stem cells","volume":"14","author":"M\u00fcller","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.dental.2022.11.013_bib45","first-page":"75","article-title":"Controuersiarum medicarum et philosophicarum","author":"Vall\u00e9s","year":"1606","journal-title":"Hanovia: Wechelianis apud Claud"},{"key":"10.1016\/j.dental.2022.11.013_bib46","first-page":"666","article-title":"Microscopical Observations of the Teeth and other Bones: Made and Communicated. Philosophical Transactions of the Royal Society 1678;12:1002-1003. Cited from: Foster BL. On the discovery of cementum","volume":"52","author":"van Leeuwenhoek","year":"2017","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.dental.2022.11.013_bib47","series-title":"Abhandlung von den Z\u00e4hnen des menschlichen K\u00f6rpers und deren Krankheiten","first-page":"15","author":"Pfaffs","year":"1756"},{"key":"10.1016\/j.dental.2022.11.013_bib48","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2741\/e286","article-title":"Dental pulp and dentin tissue engineering and regeneration: advancement and challenge","volume":"3","author":"Huang","year":"2011","journal-title":"Front Biosci"},{"key":"10.1016\/j.dental.2022.11.013_bib49","series-title":"Material-tissue interfacial phenomena","first-page":"205","article-title":"Morphologic and structural analysis of material-tissue interfaces relevant to dental reconstruction","author":"Purk","year":"2017"},{"key":"10.1016\/j.dental.2022.11.013_bib50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/cga.12169","article-title":"Odontoblasts: specialized hard-tissue-forming cells in the dentin-pulp complex","volume":"56","author":"Kawashima","year":"2016","journal-title":"Congenit Anom"},{"key":"10.1016\/j.dental.2022.11.013_bib51","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ajodo.2004.07.042","article-title":"Alkaline phosphatase activity in dental pulp of orthodontically treated teeth","volume":"128","author":"Perinetti","year":"2005","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10.1016\/j.dental.2022.11.013_bib52","unstructured":"Greeves N. Hydroxyapatite Ca5(OH)(PO4)3, https:\/\/www.chemtube3d.com\/sshydroxyapatite\/; 2021 [accessed 05 November 2021]."},{"key":"10.1016\/j.dental.2022.11.013_bib53","unstructured":"Siddi F. Blender by the Numbers \u2013 2020, https:\/\/www.blender.org\/news\/blender-by-the-numbers-2020\/; 2021 [accessed 07 July 2021]."},{"key":"10.1016\/j.dental.2022.11.013_bib54","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib55","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/cancers5030762","article-title":"Influence of levamisole and other angiogenesis inhibitors on angiogenesis and endothelial cell morphology in vitro","volume":"5","author":"Friis","year":"2013","journal-title":"Cancers"},{"key":"10.1016\/j.dental.2022.11.013_bib56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0009-8981(70)90057-4","article-title":"L-homoarginine; an inhibitor of serum \"bone and liver\" alkaline phosphatase","volume":"29","author":"Fishman","year":"1970","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.dental.2022.11.013_bib57","first-page":"903","article-title":"Hydroxyapatite synthesis methodologies: an overview","volume":"2","author":"Nayak","year":"2010","journal-title":"Int J Chem Tech Res"},{"key":"10.1016\/j.dental.2022.11.013_bib58","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.actbio.2020.10.023","article-title":"Amplified morphogenetic and bone forming activity of amorphous versus crystalline calcium phosphate\/polyphosphate","volume":"118","author":"M\u00fcller","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2022.11.013_bib59","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj0970095","article-title":"Kinetic behaviour of calf-intestinal alkaline phosphatase with 4-methylumbelliferyl phosphate","volume":"97","author":"Fernley","year":"1965","journal-title":"Biochem J"},{"key":"10.1016\/j.dental.2022.11.013_bib60","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.dental.2017.04.009","article-title":"Bifunctional dentifrice: amorphous polyphosphate a regeneratively active sealant with potent anti-Streptococcus mutans activity","volume":"33","author":"M\u00fcller","year":"2017","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2022.11.013_bib61","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0039-9140(00)00618-4","article-title":"About a synthetic saliva for in vitro studies","volume":"53","author":"Gal","year":"2001","journal-title":"Talanta"},{"key":"10.1016\/j.dental.2022.11.013_bib62","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/1877610801002010040","article-title":"Biomedical implants: corrosion and its prevention - A review","volume":"2","author":"Manivasagam","year":"2010","journal-title":"Recent Patents Corr Sci"},{"key":"10.1016\/j.dental.2022.11.013_bib63","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.171557","article-title":"Metal and polymer-mediated synthesis of porous crystalline hydroxyapatite nanocomposites for environmental remediation","volume":"5","author":"Manatunga","year":"2018","journal-title":"R Soc Open Sci"},{"key":"10.1016\/j.dental.2022.11.013_bib64","series-title":"Statistics for veterinary and animal science","first-page":"85","author":"Petrie","year":"2013"},{"key":"10.1016\/j.dental.2022.11.013_bib65","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2741\/e281","article-title":"Dentin: structure, composition and mineralization","volume":"3","author":"Goldberg","year":"2011","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.dental.2022.11.013_bib66","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/febs.13552","article-title":"Mineralization of bone-related SaOS-2 cells under physiological hypoxic conditions","volume":"283","author":"M\u00fcller","year":"2016","journal-title":"FEBS J"},{"key":"10.1016\/j.dental.2022.11.013_bib67","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1081\/PB-100104910","article-title":"The activities of carbonic anhydrase and alkaline phosphatase in ancient human bones. Purification and characterization of outer peripheral, cytosolic, inner peripheral, and integral CA","volume":"31","author":"Demir","year":"2001","journal-title":"Prep Biochem Biotechnol"},{"key":"10.1016\/j.dental.2022.11.013_bib68","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1177\/00220345880670100501","article-title":"Histochemical demonstration of carbonic anhydrase activity in the odontogenic cells of the rat incisor","volume":"67","author":"Sugimoto","year":"1988","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2022.11.013_bib69","first-page":"325","article-title":"Histochemical characterization of alkaline phosphatase in developing rat teeth and bone","volume":"86","author":"Hasselgren","year":"1978","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.dental.2022.11.013_bib70","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbrc.2010.02.116","article-title":"A survey of carbonic anhydrase mRNA expression in enamel cells","volume":"393","author":"Lacruz","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.dental.2022.11.013_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096007","article-title":"Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation","volume":"9","author":"Reibring","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.dental.2022.11.013_bib72","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1039\/C9AN01588D","article-title":"Fourier transform infrared spectroscopy of developing bone mineral: from amorphous precursor to mature crystal","volume":"145","author":"Querido","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.dental.2022.11.013_bib73","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.pc.46.100195.002421","article-title":"Nucleation: measurements, theory, and atmospheric applications","volume":"46","author":"Laaksonen","year":"1995","journal-title":"Annu Rev Phys Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib74","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1126\/science.227.4682.51","article-title":"Transformation of amorphous calcium phosphate to crystalline dahllite in the radular teeth of chitons","volume":"227","author":"Lowenstam","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.dental.2022.11.013_bib75","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11706-009-0036-x","article-title":"Overview of the amorphous precursor phase strategy in biomineralization","volume":"3","author":"Weiner","year":"2009","journal-title":"Front Mater Sci China"},{"key":"10.1016\/j.dental.2022.11.013_bib76","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1021\/j100615a007","article-title":"Growth of calcium phosphate on hydroxyapatite crystals. Effect of supersaturation and ionic medium","volume":"78","author":"Nancollas","year":"1974","journal-title":"J Phys Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib77","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s10853-006-1467-8","article-title":"Calcium orthophosphates","volume":"42","author":"Dorozhkin","year":"2007","journal-title":"J Mater Sci"},{"key":"10.1016\/j.dental.2022.11.013_bib78","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1152\/physrev.00030.2016","article-title":"Dental enamel formation and implications for oral health and disease","volume":"97","author":"Lacruz","year":"2017","journal-title":"Physiol Rev"},{"key":"10.1016\/j.dental.2022.11.013_bib79","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s004180050103","article-title":"Immunolocalization of tissue non-specific alkaline phosphatase in mice","volume":"107","author":"Hoshi","year":"1997","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.dental.2022.11.013_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000259495","article-title":"The chemical behaviour of calcium polyphosphates in enamel and dentine","volume":"1","author":"Newesely","year":"1967","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2022.11.013_bib81","doi-asserted-by":"crossref","first-page":"12337","DOI":"10.1021\/acs.chemrev.9b00460","article-title":"Inorganic polyphosphates as storage for and generator of metabolic energy in the extracellular matrix","volume":"119","author":"M\u00fcller","year":"2019","journal-title":"Chem Rev"},{"key":"10.1016\/j.dental.2022.11.013_bib82","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/B978-0-08-055294-1.00142-2","article-title":"Layered double hydroxides as controlled release materials","volume":"4","author":"Choy","year":"2011","journal-title":"Comp Biomater"},{"key":"10.1016\/j.dental.2022.11.013_bib83","doi-asserted-by":"crossref","first-page":"15872","DOI":"10.1074\/jbc.M701116200","article-title":"Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity","volume":"282","author":"Addison","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib84","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0254-0584(03)00098-1","article-title":"31P MAS NMR and FTIR analyses on the structure of CuO-containing sodium poly- and meta-phosphate glasses","volume":"80","author":"Shih","year":"2003","journal-title":"Mater Chem Phys"},{"key":"10.1016\/j.dental.2022.11.013_bib85","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1159\/000260890","article-title":"Measurements of alkaline phosphatase activity in fetal bovine enamel","volume":"19","author":"Salling","year":"1985","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2022.11.013_bib86","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1177\/002215549904701206","article-title":"Differential expression and activity of tissue-nonspecific alkaline phosphatase (TNAP) in rat odontogenic cells in vivo","volume":"47","author":"Hotton","year":"1999","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.dental.2022.11.013_bib87","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.3390\/app10124155","article-title":"Real time in vivo confocal microscopic analysis of the enamel remineralization by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a clinical proof-of-concept study","volume":"10","author":"Contaldo","year":"2020","journal-title":"Appl Sci"},{"key":"10.1016\/j.dental.2022.11.013_bib88","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/jbmr.2411","article-title":"The enamel protein amelotin is a promoter of hydroxyapatite mineralization","volume":"30","author":"Abbarin","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.dental.2022.11.013_bib89","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1902\/jop.2000.71.1.31","article-title":"Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor beta1 release of periodontal ligament and gingival fibroblasts","volume":"71","author":"Van der Pauw","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.dental.2022.11.013_bib90","doi-asserted-by":"crossref","first-page":"20960","DOI":"10.1074\/jbc.M117.788240","article-title":"Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution","volume":"292","author":"Sunden","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dental.2022.11.013_bib91","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1538-7836.2008.03219.x","article-title":"Elevated platelet and leukocyte response to oral bacteria in periodontitis","volume":"7","author":"Nicu","year":"2009","journal-title":"J Thromb Haemost"}],"container-title":["Dental Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564122003116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564122003116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T22:53:08Z","timestamp":1758840788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0109564122003116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":91,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0109564122003116"],"URL":"https:\/\/doi.org\/10.1016\/j.dental.2022.11.013","relation":{},"ISSN":["0109-5641"],"issn-type":[{"value":"0109-5641","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular and biochemical approach for understanding the transition of amorphous to crystalline calcium phosphate deposits in human teeth","name":"articletitle","label":"Article Title"},{"value":"Dental Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dental.2022.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}