{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:31:05Z","timestamp":1774521065647,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/15384\\u20135"],"award-info":[{"award-number":["2019\/15384\\u20135"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["19\/2551\\u20130002268\\u20139"],"award-info":[{"award-number":["19\/2551\\u20130002268\\u20139"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"FAPERGS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Materials"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.dental.2025.04.002","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T07:01:57Z","timestamp":1744873317000},"page":"721-729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dental adhesives incorporated with alkyl trimethyl ammonium bromide-loaded titanium oxide nanotubes for sustained bioactive and anti-biofilm protection"],"prefix":"10.1016","volume":"41","author":[{"given":"Isadora Martini","family":"Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaliano Gomes","family":"Ara\u00fajo-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Balbinot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virg\u00ednia Serra","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-1925","authenticated-orcid":false,"given":"Lamia","family":"Mokeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson Damiani","family":"Scholten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Anne Sampaio","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio Mezzomo","family":"Collares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dental.2025.04.002_bib1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0022034514544217","article-title":"Longevity of posterior composite restorations: a systematic review and meta-analysis","volume":"93","author":"Opdam","year":"2014","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.04.002_bib2","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2017.vol31.0056","article-title":"Should my composite restorations last forever? Why are they failing?","volume":"31","author":"Demarco","year":"2017","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.dental.2025.04.002_bib3","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1177\/0022034517720658","article-title":"New resins for dental composites","volume":"96","author":"Fugolin","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.04.002_bib4","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1177\/00220345231182357","article-title":"Developing bioactive dental resins for restorative dentistry","volume":"102","author":"Melo","year":"2023","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.04.002_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.dental.2010.10.020","article-title":"Resin composite--state of the art. Dent Mater Off Publ Acad","volume":"27","author":"Ferracane","year":"2011","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib6","first-page":"167","article-title":"In situ antimicrobial activity and inhibition of secondary caries of self-etching adhesives containing an antibacterial agent and\/or fluoride","volume":"28","author":"Pinto","year":"2015","journal-title":"Am J Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib7","first-page":"293","article-title":"Effect of a fluoride- and bromide-containing adhesive system on enamel around composite restorations under high cariogenic challenge in situ","volume":"11","author":"Pinto","year":"2009","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib8","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2019.vol33.0010","article-title":"Evaluation of an antibacterial orthodontic adhesive incorporated with niobium-based bioglass: an in situ study","volume":"33","author":"Degrazia","year":"2019","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.dental.2025.04.002_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5731\/pdajpst.2012.00866","article-title":"In vitro antifungal efficacy of biguanides and quaternary ammonium compounds against cleanroom fungal isolates","volume":"66","author":"Vijayakumar","year":"2012","journal-title":"PDA J Pharm Sci Technol"},{"key":"10.1016\/j.dental.2025.04.002_bib10","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/jam.14242","article-title":"Killing of spores of Bacillus species by cetyltrimethylammonium bromide","volume":"126","author":"Dong","year":"2019","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.dental.2025.04.002_bib11","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.joen.2012.03.007","article-title":"The effect of detergents on the antibacterial activity of disinfecting solutions in dentin","volume":"38","author":"Wang","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2025.04.002_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.joen.2013.11.020","article-title":"Antibacterial and anti-biofilm activity of AH plus with chlorhexidine and cetrimide","volume":"40","author":"Bail\u00f3n-S\u00e1nchez","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.dental.2025.04.002_bib13","first-page":"399","article-title":"Chemical, mechanical and biological properties of an adhesive resin with alkyl trimethyl ammonium bromide-loaded halloysite nanotubes","volume":"22","author":"Garcia","year":"2020","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12941-014-0041-5","article-title":"Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm","volume":"13","author":"Ruiz-Linares","year":"2014","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"10.1016\/j.dental.2025.04.002_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.dental.2018.03.014","article-title":"Antibacterial quaternary ammonium compounds in dental materials: a systematic review","volume":"34","author":"Makvandi","year":"2018","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4012\/dmj.2017-096","article-title":"Quaternary ammonium compounds in dental restorative materials","volume":"37","author":"Zhang","year":"2018","journal-title":"Dent Mater J"},{"key":"10.1016\/j.dental.2025.04.002_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0109-5641(02)00060-X","article-title":"Antibacterial activity and bonding characteristics of an adhesive resin containing antibacterial monomer MDPB","volume":"19","author":"Imazato","year":"2003","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.archoralbio.2017.09.016","article-title":"Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules","volume":"84","author":"Genari","year":"2017","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.dental.2025.04.002_bib19","first-page":"2667","article-title":"Ionic liquid-loaded microcapsules doped into dental resin infiltrants","volume":"6","author":"Cuppini","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib20","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.dental.2019.02.018","article-title":"Halloysite nanotubes loaded with alkyl trimethyl ammonium bromide as antibacterial agent for root canal sealers","volume":"35","author":"Monteiro","year":"2019","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.dental.2020.11.004","article-title":"Titanium dioxide nanotubes with triazine-methacrylate monomer to improve physicochemical and biological properties of adhesives","volume":"37","author":"St\u00fcrmer","year":"2021","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib22","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.2147\/IJN.S108847","article-title":"TiO2 nanotube platforms for smart drug delivery: a review","volume":"11","author":"Wang","year":"2016","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.dental.2025.04.002_bib23","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.actbio.2010.11.018","article-title":"Effect of titania-based surface modification of polyethylene terephthalate on bone-implant bonding and peri-implant tissue reaction","volume":"7","author":"Saito","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2025.04.002_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.actbio.2016.02.007","article-title":"Bioactivity of sol-gel-derived TiO2 coating on polyetheretherketone: in vitro and in vivo studies","volume":"35","author":"Shimizu","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2025.04.002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijadhadh.2024.103718","article-title":"Influence of titanium dioxide nanotubes with alkyl ammonium alkyl bromide on the physicochemical properties and adhesion of experimental adhesive resins to dentin","volume":"132","author":"Ara\u00fajo-Neto","year":"2024","journal-title":"Int J Adhes Adhes"},{"key":"10.1016\/j.dental.2025.04.002_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.molcata.2013.12.012","article-title":"TiO2 nanomaterials: highly active catalysts for the oxidation of hydrocarbons","volume":"383\u2013384","author":"Qadir","year":"2014","journal-title":"J Mol Catal Chem"},{"key":"10.1016\/j.dental.2025.04.002_bib27","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1177\/0022034519835203","article-title":"Ionic liquid-stabilized titania quantum dots applied in adhesive resin","volume":"98","author":"Garcia","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.04.002_bib28","unstructured":"International Organization for Standardization. ISO 4049:2009 \u2013 Polymer-based restorative materials. https:\/\/www.iso.org\/standard\/42898.html (accessed February 27, 2025)."},{"key":"10.1016\/j.dental.2025.04.002_bib29","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1016\/j.dental.2020.11.022","article-title":"Antibacterial response of oral microcosm biofilm to nano-zinc oxide in adhesive resin","volume":"37","author":"Garcia","year":"2021","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2020.103472","article-title":"Wollastonite as filler of an experimental dental adhesive","volume":"102","author":"Bendary","year":"2020","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib31","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How useful is SBF in predicting in vivo bone bioactivity?","volume":"27","author":"Kokubo","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.dental.2025.04.002_bib32","unstructured":"International Organization for Standardization. ISO 10993-5:2009 - Biological evaluation of medical devices \u2014 Part 5: Tests for in vitro cytotoxicity n.d. https:\/\/www.iso.org\/standard\/36406.html (accessed February 27, 2025)."},{"key":"10.1016\/j.dental.2025.04.002_bib33","first-page":"125","article-title":"Influence of 2-hydroxyethyl methacrylate concentration on polymer network of adhesive resin","volume":"13","author":"Collares","year":"2011","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib34","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.dental.2024.05.016","article-title":"The influence of filler load in 3D printing resin-based composites","volume":"40","author":"Zattera","year":"2024","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jmbbm.2012.01.018","article-title":"Mechanical properties and degree of conversion of etch-and-rinse and self-etch adhesive systems cured by a quartz tungsten halogen lamp and a light-emitting diode","volume":"12","author":"Gaglianone","year":"2012","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib36","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.dental.2014.07.007","article-title":"Clinical effectiveness of contemporary adhesives for the restoration of non-carious cervical lesions. A systematic review","volume":"30","author":"Peumans","year":"2014","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2020.103369","article-title":"How we are assessing the developing antibacterial resin-based dental materials? A scoping review","volume":"99","author":"Ibrahim","year":"2020","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib38","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/0022034516683395","article-title":"Models of caries formation around dental composite restorations","volume":"96","author":"Ferracane","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.04.002_bib39","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cden.2017.06.001","article-title":"An overview of dental adhesive systems and the dynamic tooth-adhesive interface","volume":"61","author":"Bedran-Russo","year":"2017","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.dental.2025.04.002_bib40","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1177\/0022034513504436","article-title":"Cariogenic bacteria degrade dental resin composites and adhesives","volume":"92","author":"Bourbia","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.04.002_bib41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.actbio.2018.02.020","article-title":"Esterase from a cariogenic bacterium hydrolyzes dental resins","volume":"71","author":"Huang","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2025.04.002_bib42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.dental.2005.05.005","article-title":"Hygroscopic and hydrolytic effects in dental polymer networks","volume":"22","author":"Ferracane","year":"2006","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib43","unstructured":"Hansen Solubility Parameters | Hansen Solubility Parameters n.d. https:\/\/hansen-solubility.com\/ (accessed February 27, 2025)."},{"key":"10.1016\/j.dental.2025.04.002_bib44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0109-5641(91)90056-5","article-title":"Radiopacity of restorations and detection of secondary caries","volume":"7","author":"Espelid","year":"1991","journal-title":"Dent Mater Publ Acad Dent Mater"},{"key":"10.1016\/j.dental.2025.04.002_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/jfb11010007","article-title":"Cerium dioxide particles to tune radiopacity of dental adhesives: microstructural and physico-chemical evaluation","volume":"11","author":"Garcia","year":"2020","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.dental.2025.04.002_bib46","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/nano14030274","article-title":"Dentine remineralisation induced by \u201cbioactive\u201d materials through mineral deposition: an in vitro study","volume":"14","author":"Kunert","year":"2024","journal-title":"Nanomater Basel Switz"},{"key":"10.1016\/j.dental.2025.04.002_bib47","first-page":"136","article-title":"The potential of conventional and bulk-fill bioactive composites to inhibit the development of caries lesions around restorations","volume":"36","author":"Silva","year":"2023","journal-title":"Am J Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijadhadh.2020.102790","article-title":"Adhesive system with alpha-tricalcium phosphate addition for mineral deposition on caries-affected dentin","volume":"105","author":"Schiroky","year":"2021","journal-title":"Int J Adhes Adhes"},{"key":"10.1016\/j.dental.2025.04.002_bib49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0022034516639271","article-title":"Managing carious lesions: consensus recommendations on carious tissue removal","volume":"28","author":"Schwendicke","year":"2016","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.dental.2025.04.002_bib50","first-page":"7","article-title":"Bonding to sound and caries-affected dentin: a systematic review and meta-analysis","volume":"20","author":"Isolan","year":"2018","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib51","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jdent.2016.07.016","article-title":"Bonding performance of experimental bioactive\/biomimetic self-etch adhesives doped with calcium-phosphate fillers and biomimetic analogs of phosphoproteins","volume":"52","author":"Abuna","year":"2016","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.04.002_bib52","first-page":"652","article-title":"Antibacterial and remineralizing fillers in experimental orthodontic adhesives","volume":"12","author":"Ferreira","year":"2019","journal-title":"Mater Basel Switz"},{"key":"10.1016\/j.dental.2025.04.002_bib53","first-page":"504","article-title":"Tube-shaped nanostructures for enhancing resin-based dental materials: a landscape of evidence and research advancement","volume":"4","author":"Garcia","year":"2023","journal-title":"Smart Mater Med"}],"container-title":["Dental Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564125005950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0109564125005950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:17:38Z","timestamp":1774516658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0109564125005950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0109564125005950"],"URL":"https:\/\/doi.org\/10.1016\/j.dental.2025.04.002","relation":{},"ISSN":["0109-5641"],"issn-type":[{"value":"0109-5641","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dental adhesives incorporated with alkyl trimethyl ammonium bromide-loaded titanium oxide nanotubes for sustained bioactive and anti-biofilm protection","name":"articletitle","label":"Article Title"},{"value":"Dental Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dental.2025.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Academy of Dental Materials. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}