{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:03:09Z","timestamp":1793419389388,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["308286\/2019\\u20137"],"award-info":[{"award-number":["308286\/2019\\u20137"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007511","name":"Rey Juan Carlos University","doi-asserted-by":"publisher","award":["C1PREDOC2022-PREDOC22\\u2013015"],"award-info":[{"award-number":["C1PREDOC2022-PREDOC22\\u2013015"]}],"id":[{"id":"10.13039\/501100007511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigacion","doi-asserted-by":"publisher","award":["PID2021\\u2013125216OB-I00"],"award-info":[{"award-number":["PID2021\\u2013125216OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Materials"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.dental.2025.08.004","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:02:47Z","timestamp":1755615767000},"page":"1465-1477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antimicrobial and physico-mechanical properties of a universal adhesive loaded with L-arginine-containing mesoporous silica nanoparticles (ArgC18@MSNs)"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-5186","authenticated-orcid":false,"given":"Daniel","family":"Jim\u00e9nez-D\u00edez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Navas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-2443","authenticated-orcid":false,"given":"Ra\u00fal","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-8733","authenticated-orcid":false,"given":"Rafael A.","family":"Garc\u00eda-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Ruiz-Linares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Mar\u00eda","family":"Ferrer-Luque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-4856","authenticated-orcid":false,"given":"Alessandro D.","family":"Loguercio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-4157","authenticated-orcid":false,"given":"Victoria","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-9559","authenticated-orcid":false,"given":"Laura","family":"Ceballos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dental.2025.08.004_bib1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/0022034520908533","article-title":"Global, regional, and national levels and trends in burden of oral conditions from 1990 to 2017: a systematic analysis for the global burden of disease 2017 study","volume":"99","author":"Bernabe","year":"2020","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.08.004_bib2","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1007\/s00784-019-03058-w","article-title":"When to intervene in the caries process? An expert Delphi consensus statement","volume":"23","author":"Schwendicke","year":"2019","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.bdj.2017.672","article-title":"Contemporary operative caries management: consensus recommendations on minimally invasive caries removal","volume":"223","author":"Banerjee","year":"2017","journal-title":"Br Dent J"},{"key":"10.1016\/j.dental.2025.08.004_bib4","first-page":"107","article-title":"Amalgam alternatives critically evaluated: effect of long-term thermomechanical loading on marginal quality, wear, and fracture behavior","volume":"22","author":"Frankenberger","year":"2020","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3390\/jfb15070173","article-title":"A historical perspective on dental composite restorative materials","volume":"15","author":"Ferracane","year":"2024","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.dental.2025.08.004_bib6","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.dental.2022.02.009","article-title":"Clinical performance of posterior resin composite restorations after up to 33 years","volume":"38","author":"Da Rosa Rodolpho","year":"2022","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib7","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00784-019-02894-0","article-title":"Secondary caries: prevalence, characteristics, and approach","volume":"24","author":"Nedeljkovic","year":"2020","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2024.105009","article-title":"Awareness of possible complications associated with direct composite restorations: a multinational survey among dentists from 13 countries with meta-analysis","volume":"145","author":"Lehmann","year":"2024","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000503309","article-title":"Terminology of dental caries and dental caries management: consensus report of a workshop organized by ORCA and Cariology Research Group of IADR","volume":"54","author":"Machiulskiene","year":"2020","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2025.08.004_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2024.105096","article-title":"Repair versus replacement of defective direct dental restorations: a multinational cross-sectional study with meta-analysis","volume":"148","author":"Hatipo\u011flu","year":"2024","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: a global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.dental.2025.08.004_bib12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.dental.2014.01.013","article-title":"Restorative dentistry and restorative materials over the next 20 years: a Delphi survey","volume":"30","author":"Seemann","year":"2014","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib13","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00784-020-03268-7","article-title":"Secondary caries: what is it, and how it can be controlled, detected, and managed?","volume":"24","author":"Askar","year":"2020","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/0022034516628506","article-title":"Psychological interventions for poor oral health: a systematic review","volume":"95","author":"Werner","year":"2016","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.08.004_bib15","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1177\/00220345231182357","article-title":"Developing bioactive dental resins for restorative dentistry","volume":"102","author":"Melo","year":"2023","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.08.004_bib16","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.dental.2024.10.004","article-title":"Current approaches to produce durable biomaterials: trends in polymeric materials for restorative dentistry applications","volume":"40","author":"Pfeifer","year":"2024","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib17","first-page":"6B","article-title":"Antibacterial dental restorative materials: a review","volume":"31","author":"Chen","year":"2018","journal-title":"Am J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib18","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.dental.2015.08.155","article-title":"A systematic review about antibacterial monomers used in dental adhesive systems: current status and further prospects","volume":"31","author":"Cocco","year":"2015","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib19","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.3390\/molecules25215047","article-title":"Advances of anti-caries nanomaterials","volume":"25","author":"Chen","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.dental.2025.08.004_bib20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.dental.2025.04.007","article-title":"Mesoporous silica nanoparticles for improved mechanical properties and stability in bioactive dental resin composites","volume":"41","author":"Sun","year":"2025","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib21","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.3390\/ijms24076349","article-title":"Mesoporous silica nanoparticles as a potential nanoplatform: therapeutic applications and considerations","volume":"24","author":"Djayanti","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dental.2025.08.004_bib22","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.dental.2018.11.012","article-title":"The role of polymerization in adhesive dentistry","volume":"35","author":"Cadenaro","year":"2019","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/0022034517735294","article-title":"Potential uses of arginine in dentistry","volume":"29","author":"Nascimento","year":"2018","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.dental.2025.08.004_bib24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000499037","article-title":"Critical appraisal of oral pre- and probiotics for caries prevention and care","volume":"53","author":"Zaura","year":"2019","journal-title":"Caries Res"},{"key":"10.1016\/j.dental.2025.08.004_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/08927014.2020.1802587","article-title":"Effect of arginine on microorganisms involved in dental caries: a systematic literature review of in vitro studies","volume":"36","author":"Miranda","year":"2020","journal-title":"Biofouling"},{"key":"10.1016\/j.dental.2025.08.004_bib26","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.dental.2020.05.012","article-title":"Antibacterial and mechanical properties of arginine-containing glass ionomer cements","volume":"36","author":"Bijle","year":"2020","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib27","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.3390\/ma14164391","article-title":"Incorporation of arginine to commercial orthodontic light-cured resin cements-physical, adhesive, and antibacterial properties","volume":"14","author":"Geraldeli","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.dental.2025.08.004_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105822","article-title":"Arginine-modified orthodontic resin cement inhibits cariogenic bacterial-fungal co-adherence and enamel hardness loss","volume":"159","author":"Ma","year":"2025","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib29","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2024.vol38.0078","article-title":"Effect of adding arginine at different concentrations to experimental orthodontic resins: an in vitro study","volume":"38","author":"Santos","year":"2024","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.dental.2025.08.004_bib30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jdent.2017.05.024","article-title":"A new arginine-based dental adhesive system: formulation, mechanical and anti-caries properties","volume":"63","author":"Geraldeli","year":"2017","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01714-0","article-title":"L-arginine-containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria","volume":"20","author":"L\u00f3pez-Ruiz","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.dental.2025.08.004_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2024.104992","article-title":"Formulation of arginine-loaded mesoporous silica nanoparticles (Arg@MSNs) modified orthodontic adhesive","volume":"145","author":"An","year":"2024","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib33","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1002\/adfm.201505073","article-title":"New drug-structure-directing agent concept: inherent pharmacological activity combined with templating solid and hollow-shell mesostructured silica nanoparticles","volume":"26","author":"Morales","year":"2016","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.110935","article-title":"Engineering hollow mesoporous silica nanoparticles to increase cytotoxicity","volume":"112","author":"P\u00e9rez-Garnes","year":"2020","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"10.1016\/j.dental.2025.08.004_bib35","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.3390\/ijms22157968","article-title":"Kidney-protector lipidic cilastatin derivatives as structure-directing agents for the synthesis of mesoporous silica nanoparticles for drug delivery","volume":"22","author":"Martinez-Erro","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dental.2025.08.004_bib36","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1039\/D1TB00481F","article-title":"L-Dopa release from mesoporous silica nanoparticles engineered through the concept of drug-structure-directing agents for Parkinson\u2019s disease","volume":"9","author":"Morales","year":"2021","journal-title":"J Mater Chem B Mater Biol Med"},{"key":"10.1016\/j.dental.2025.08.004_bib37","doi-asserted-by":"crossref","first-page":"12376","DOI":"10.1021\/acsanm.4c00393","article-title":"Mitoxantrone-derivative drug structure-directing agent for the synthesis of magnetic mesoporous silica nanoparticles for breast cancer treatment","volume":"7","author":"Roman\u00ed-Cubells","year":"2024","journal-title":"ACS Appl Nano Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib38","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1007\/s00784-023-04929-z","article-title":"Effectiveness of conservative instrumentation in root canal disinfection","volume":"27","author":"Usta","year":"2023","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib39","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1128\/AEM.02000-08","article-title":"Image analysis software based on color segmentation for characterization of viability and physiological activity of biofilms","volume":"75","author":"Ch\u00e1vez de Paz","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.dental.2025.08.004_bib40","unstructured":"ISO 4049. Dentistry\u2014polymer-based restorative materials; 2019."},{"key":"10.1016\/j.dental.2025.08.004_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jdent.2019.01.012","article-title":"Biological, mechanical and adhesive properties of universal adhesives containing zinc and copper nanoparticles","volume":"82","author":"Guti\u00e9rrez","year":"2019","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib42","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3390\/ma17050984","article-title":"Influence of specimen dimension, water immersion protocol, and surface roughness on water sorption and solubility of resin-based restorative materials","volume":"17","author":"da Silva","year":"2024","journal-title":"Materials"},{"key":"10.1016\/j.dental.2025.08.004_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2020.103369","article-title":"How we are assessing the developing antibacterial resin-based dental materials? A scoping review","volume":"99","author":"Ibrahim","year":"2020","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib44","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1007\/s10096-019-03641-9","article-title":"Oral microbial biofilms: an update","volume":"38","author":"Mosaddad","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.dental.2025.08.004_bib45","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.archoralbio.2017.06.026","article-title":"Effect of arginine on the growth and biofilm formation of oral bacteria","volume":"82","author":"Huang","year":"2017","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.dental.2025.08.004_bib46","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1099\/mic.0.075267-0","article-title":"Nanoscale characterization of effect of L-arginine on Streptococcus mutans biofilm adhesion by atomic force microscopy","volume":"160","author":"Sharma","year":"2014","journal-title":"Microbiology"},{"key":"10.1016\/j.dental.2025.08.004_bib47","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1128\/JB.00021-16","article-title":"L-arginine modifies the exopolysaccharide matrix and thwarts Streptococcus mutans outgrowth within mixed-species oral biofilms","volume":"198","author":"He","year":"2016","journal-title":"J Bacteriol"},{"key":"10.1016\/j.dental.2025.08.004_bib48","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1177\/0022034517707512","article-title":"Arginine improves pH homeostasis via metabolism and microbiome modulation","volume":"96","author":"Agnello","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2025.08.004_bib49","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00248-014-0535-x","article-title":"Stability and resilience of oral microcosms toward acidification and Candida outgrowth by arginine supplementation","volume":"69","author":"Koopman","year":"2015","journal-title":"Micro Ecol"},{"key":"10.1016\/j.dental.2025.08.004_bib50","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00295-17","article-title":"Arginine exposure decreases acidogenesis in long-term oral biofilm microcosms","volume":"2","author":"Ledder","year":"2017","journal-title":"mSphere"},{"key":"10.1016\/j.dental.2025.08.004_bib51","doi-asserted-by":"crossref","first-page":"7206","DOI":"10.1038\/s41598-017-07042-w","article-title":"Ecological effect of arginine on oral microbiota","volume":"7","author":"Zheng","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.dental.2025.08.004_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121835","article-title":"L-arginine destabilizes oral multi-species biofilm communities developed in human saliva","volume":"10","author":"Kolderman","year":"2015","journal-title":"PLOS One"},{"key":"10.1016\/j.dental.2025.08.004_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2020.103875","article-title":"Chemistry of novel and contemporary resin-based dental adhesives","volume":"110","author":"Dressano","year":"2020","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib54","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/jfb13040190","article-title":"Benzyldimethyldodecyl ammonium chloride doped dental adhesive: impact on core\u2019s properties, biosafety, and antibacterial\/bonding performance after aging","volume":"13","author":"Mokeem","year":"2022","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.dental.2025.08.004_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.111894","article-title":"Formulation of pH-sensitive chlorhexidine-loaded\/mesoporous silica nanoparticles modified experimental dentin adhesive","volume":"122","author":"Akram","year":"2021","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"10.1016\/j.dental.2025.08.004_bib56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdent.2018.08.012","article-title":"Chlorhexidine-encapsulated mesoporous silica-modified dentin adhesive","volume":"78","author":"Yan","year":"2018","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib57","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1007\/s00784-022-04589-5","article-title":"The influence of inorganic fillers on the light transmission through resin-matrix composites during the light-curing procedure: an integrative review","volume":"26","author":"Fidalgo-Pereira","year":"2022","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib58","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1021\/acs.molpharmaceut.2c00728","article-title":"Development of proanthocyanidin-loaded mesoporous silica nanoparticles for improving dental adhesion","volume":"19","author":"Alkhazaleh","year":"2022","journal-title":"Mol Pharm"},{"key":"10.1016\/j.dental.2025.08.004_bib59","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.dental.2020.08.006","article-title":"Nanotechnology in dentistry: present and future perspectives on dental nanomaterials","volume":"36","author":"Jandt","year":"2020","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib60","first-page":"395","article-title":"Long-term evaluation of bonding performance of universal adhesives based on different dentinal moisture levels","volume":"24","author":"Nonato","year":"2022","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib61","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.dental.2020.03.007","article-title":"Chlorhexidine-modified nanotubes and their effects on the polymerization and bonding performance of a dental adhesive","volume":"36","author":"Kalagi","year":"2020","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib62","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.actbio.2012.01.013","article-title":"Effects of functional monomers and photo-initiators on the degree of conversion of a dental adhesive","volume":"8","author":"Oguri","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2025.08.004_bib63","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2341\/19-146-L","article-title":"Effect of the photo-initiator system contained in universal adhesives on radicular dentin bonding","volume":"45","author":"Carvalho","year":"2020","journal-title":"Oper Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib64","first-page":"257","article-title":"Long-term evaluation of dentin bonding properties of the photoinitiator system contained in universal adhesives used in fiber-post luting procedures","volume":"25","author":"Moreira","year":"2023","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib65","first-page":"407","article-title":"Early phase enamel bond performance of a two-step adhesive containing a primer derived from a universal adhesive","volume":"24","author":"Iwase","year":"2022","journal-title":"J Adhes Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2023.106353","article-title":"Light transmittance through resin-matrix composite onlays adhered to resin-matrix cements or flowable composites","volume":"151","author":"Fidalgo-Pereira","year":"2024","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib67","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.dental.2015.12.017","article-title":"Effect of curing light emission spectrum on the nanohardness and elastic modulus of two bulk-fill resin composites","volume":"32","author":"Issa","year":"2016","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib68","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1007\/s00784-020-03605-w","article-title":"Biocompatibility, mechanical, and bonding properties of a dental adhesive modified with antibacterial monomer and cross-linker","volume":"25","author":"Moussa","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2023.105817","article-title":"Antibacterial and fluorescent clear aligner attachment resin modified with chlorhexidine loaded mesoporous silica nanoparticles and zinc oxide quantum dots","volume":"141","author":"Cao","year":"2023","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib70","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.dental.2017.07.012","article-title":"Synthesis of wrinkled mesoporous silica and its reinforcing effect for dental resin composites","volume":"33","author":"Wang","year":"2017","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/jfb16020042","article-title":"Preservation strategies for interfacial integrity in restorative dentistry: a non-comprehensive literature review","volume":"16","author":"Pfeifer","year":"2025","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.dental.2025.08.004_bib72","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jcis.2018.01.072","article-title":"Hyaluronated mesoporous silica nanoparticles for active targeting: influence of conjugation method and hyaluronic acid molecular weight on the nanovector properties","volume":"516","author":"Ricci","year":"2018","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.dental.2025.08.004_bib73","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.dental.2005.11.020","article-title":"Water sorption\/solubility of dental adhesive resins","volume":"22","author":"Malacarne","year":"2006","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib74","doi-asserted-by":"crossref","first-page":"690","DOI":"10.2341\/20-239-L","article-title":"Nanofiller particles and bonding durability, water sorption, and solubility of universal adhesives","volume":"46","author":"Ara\u00fajo-Neto","year":"2021","journal-title":"Oper Dent"},{"key":"10.1016\/j.dental.2025.08.004_bib75","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1007\/s00784-022-04625-4","article-title":"Meta-analytical analysis on components released from resin-based dental materials","volume":"26","author":"De Angelis","year":"2022","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib76","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.actbio.2018.02.020","article-title":"Esterase from a cariogenic bacterium hydrolyzes dental resins","volume":"71","author":"Huang","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2025.08.004_bib77","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.dental.2017.04.013","article-title":"Academy of Dental Materials guidance-resin composites: Part I-Mechanical properties","volume":"33","author":"Ilie","year":"2017","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2021.105017","article-title":"A universal adhesive containing copper nanoparticles improves the stability of hybrid layer in a cariogenic oral environment: an in situ study","volume":"126","author":"Vidal","year":"2022","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib79","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3390\/polym13132169","article-title":"Synergistic effect of bioactive inorganic fillers in enhancing properties of dentin adhesives-a review","volume":"13","author":"Farooq","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.dental.2025.08.004_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105153","article-title":"Mechanical characterization and adhesive properties of a dental adhesive modified with a polymer antibiotic conjugate","volume":"129","author":"Sabatini","year":"2022","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib81","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.dental.2007.06.019","article-title":"Class I and class II restorations of resin composite: an FE analysis of the influence of modulus of elasticity on stresses generated by occlusal loading","volume":"24","author":"Asmussen","year":"2008","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2025.08.004_bib82","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00784-016-1810-7","article-title":"Effect of indomethacin-loaded nanocapsules incorporation in a dentin adhesive resin","volume":"21","author":"Genari","year":"2017","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2025.08.004_bib83","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.3390\/coatings12081094","article-title":"Degradation and stabilization of resin-dentine interfaces in polymeric dental adhesives: an updated review","volume":"12","author":"Amin","year":"2022","journal-title":"Coatings"},{"key":"10.1016\/j.dental.2025.08.004_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105610","article-title":"Antibacterial and metalloproteinase-inhibited zinc-doped bioactive glass nanoparticles for enhancing dentin adhesion","volume":"154","author":"Cao","year":"2025","journal-title":"J Dent"}],"container-title":["Dental Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S010956412500733X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S010956412500733X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:22:22Z","timestamp":1772806942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S010956412500733X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":84,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S010956412500733X"],"URL":"https:\/\/doi.org\/10.1016\/j.dental.2025.08.004","relation":{},"ISSN":["0109-5641"],"issn-type":[{"value":"0109-5641","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial and physico-mechanical properties of a universal adhesive loaded with L-arginine-containing mesoporous silica nanoparticles (ArgC18@MSNs)","name":"articletitle","label":"Article Title"},{"value":"Dental Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dental.2025.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The Academy of Dental Materials.","name":"copyright","label":"Copyright"}]}}