{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:00:27Z","timestamp":1785315627754,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Materials"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.dental.2026.07.015","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:27:13Z","timestamp":1785209233000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid and durable dentinal tubule occlusion via ion-mediated intratubular coprecipitation"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-7757","authenticated-orcid":false,"given":"Zhenzhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanji","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-3296","authenticated-orcid":false,"given":"Qi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-2412","authenticated-orcid":false,"given":"Mengqi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-7387","authenticated-orcid":false,"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-9642","authenticated-orcid":false,"given":"Xiaodong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-5295","authenticated-orcid":false,"given":"Qiaojie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dental.2026.07.015_bib1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s12274-022-4830-4","article-title":"The mechanism of dentine hypersensitivity: Stimuli-induced directional cation transport through dentinal tubules","volume":"16","author":"Chen","year":"2023","journal-title":"Nano Res"},{"issue":"4","key":"10.1016\/j.dental.2026.07.015_bib2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0300-5712(13)70002-2","article-title":"Dentine sensitivity: past, present and future","volume":"41","author":"Mantzourani","year":"2013","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.17219\/dmp\/143354","article-title":"Successful management of dentin hypersensitivity: a narrative review","volume":"59","author":"Ramli","year":"2022","journal-title":"Dent Med Probl"},{"key":"10.1016\/j.dental.2026.07.015_bib4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000360749","article-title":"Dentine hypersensitivity","volume":"25","author":"West","year":"2014","journal-title":"Monogr Oral Sci"},{"key":"10.1016\/j.dental.2026.07.015_bib5","doi-asserted-by":"crossref","DOI":"10.2991\/978-94-6463-932-2","article-title":"Advances in physical and chemical strategies for dentin hypersensitivity therapy","author":"Li","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.dental.2026.07.015_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105719","article-title":"Recent advances in the study of therapeutic materials and techniques for dentin hypersensitivity","volume":"156","author":"Dai","year":"2025","journal-title":"J Dent"},{"issue":"1","key":"10.1016\/j.dental.2026.07.015_bib7","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1007\/s00784-012-0898-7","article-title":"A decision tree for the management of exposed cervical dentin (ecd) and dentin hypersensitivity (dhs)","volume":"17","author":"Martens","year":"2013","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2026.07.015_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/573258","article-title":"The efficacy of strontium and potassium toothpastes in treating dentine hypersensitivity: a systematic review","volume":"2013","author":"Karim","year":"2013","journal-title":"Int J Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib9","first-page":"221","article-title":"Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity","volume":"69","author":"Canadian Advisory Board on Dentin H","year":"2003","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.dental.2026.07.015_bib10","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1039\/D4MH01927J","article-title":"A silk fibroin-based hydrogel desensitizer achieving 660 mum dentin tubule occlusion for dentin hypersensitivity treatment","volume":"12","author":"Xin","year":"2025","journal-title":"Mater Horiz"},{"key":"10.1016\/j.dental.2026.07.015_bib11","article-title":"Biomimetic janus particles induced in situ interfacial remineralization for dentin hypersensitivity","volume":"35","author":"Han","year":"2025","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.dental.2026.07.015_bib12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1600-0722.1997.tb02138.x","article-title":"Closing of dentinal tubules by Gluma desensitizer","volume":"105","author":"Sch\u00fcpbach","year":"1997","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.dental.2026.07.015_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s12903-022-02424-7","article-title":"Effectiveness and cytotoxicity of two desensitizing agents: a dentin permeability measurement and dentin barrier testing in vitro study","volume":"22","author":"Jiang","year":"2022","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.dental.2026.07.015_bib14","first-page":"1","article-title":"Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief","volume":"20","author":"Cummins","year":"2009","journal-title":"J Clin Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib15","article-title":"Effect of dentin desensitizer containing novel bioactive glass on the permeability of dentin","volume":"15","author":"Jang","year":"2022","journal-title":"Mater (Basel)"},{"key":"10.1016\/j.dental.2026.07.015_bib16","first-page":"201","article-title":"Penetration of varnishes into demineralized root dentine in vitro","volume":"31","author":"Arends","year":"1997","journal-title":"Caries Res"},{"issue":"1","key":"10.1016\/j.dental.2026.07.015_bib17","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1007\/s00784-012-0916-9","article-title":"The role of fluoride in the preventive management of dentin hypersensitivity and root caries","volume":"17","author":"Petersson","year":"2013","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.dental.2026.07.015_bib18","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1007\/s10103-022-03583-3","article-title":"Effect of sodium fluoride varnish, Gluma, and Er,Cr:YSGG laser in dentin hypersensitivity treatment: a 6-month clinical trial","volume":"37","author":"Forouzande","year":"2022","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.dental.2026.07.015_bib19","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1177\/00220345251334377","article-title":"An anti-saliva contamination bonding strategy based on polycation assembly","volume":"104","author":"Shu","year":"2025","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2026.07.015_bib20","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1177\/00220345231161006","article-title":"Release of interface confined water significantly improves dentin bonding","volume":"102","author":"Pan","year":"2023","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2026.07.015_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/00220345251408838","article-title":"Redistribution effect of demineralized dentin on hydrophobic monomers","author":"Xu","year":"2026","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2026.07.015_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.micron.2011.08.003","article-title":"Insights into the structure and composition of the peritubular dentin organic matrix and the lamina limitans","volume":"43","author":"Bertassoni","year":"2012","journal-title":"Micron"},{"key":"10.1016\/j.dental.2026.07.015_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2741\/e281","article-title":"Dentin: structure, composition and mineralization","volume":"3","author":"Goldberg","year":"2011","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.dental.2026.07.015_bib24","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/j.actbio.2012.02.022","article-title":"The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale","volume":"8","author":"Bertassoni","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.dental.2026.07.015_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.dental.2025.10.006","article-title":"One-step vs. two-step deposition of CaF2 nanoparticles: from the perspective of confined water release and bonding effectiveness improvement","volume":"42","author":"Xu","year":"2026","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2026.07.015_bib26","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.dental.2025.12.009","article-title":"Multifunctional CuS nanoparticle deposition for enhanced dentin bonding: synergistic dehydration, MMP inhibition and antibacterial action","volume":"42","author":"Yang","year":"2026","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2026.07.015_bib27","article-title":"Polyaspartic acid-calcium-lanthanum complexes induce antibacterial remineralization of dentin and in-depth occlusion of dentinal tubules","volume":"12","author":"Zhu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.dental.2026.07.015_bib28","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/00220345241309340","article-title":"In-depth occlusion of dentinal tubules induced by polyaspartic acid-calcium and magnesium complexes","volume":"104","author":"Shen","year":"2025","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2026.07.015_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127780","article-title":"In-depth occlusion of dentine tubules via the application of (poly-l-aspartic acid)\u2011strontium and phosphate\/fluoride to treat dentine hypersensitivity","volume":"254","author":"Xu","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.dental.2026.07.015_bib30","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1039\/D5TB00584A","article-title":"Facile ag(+)-assisted bonding strategy to build a low-defect hybrid layer with intrinsic antibacterial and enzymolysis inhibitory properties","volume":"13","author":"Cheng","year":"2025","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.dental.2026.07.015_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.167575","article-title":"Photo-programmable AgCl@Ag nanoparticles enable sequential antibacterial action and durable dentin bonding for deep caries management","volume":"522","author":"Luo","year":"2025","journal-title":"Chem Eng J"},{"key":"10.1016\/j.dental.2026.07.015_bib32","doi-asserted-by":"crossref","first-page":"51775","DOI":"10.1021\/acsami.1c15787","article-title":"Reconstruction of a demineralized dentin matrix via rapid deposition of CaF2 nanoparticles in situ promotes dentin bonding","volume":"13","author":"Xu","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.dental.2026.07.015_bib33","article-title":"In-depth occlusion of dentinal tubules and rapid remineralization of demineralized dentin induced by polyelectrolyte-calcium complexes","volume":"12","author":"Zhou","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.dental.2026.07.015_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201903973","article-title":"Amyloid-like rapid surface modification for antifouling and in-depth remineralization of dentine tubules to treat dental hypersensitivity","volume":"31","author":"Li","year":"2019","journal-title":"Adv Mater"},{"key":"10.1016\/j.dental.2026.07.015_bib35","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1021\/acsbiomaterials.9b00619","article-title":"Therapeutic management of demineralized dentin surfaces using a mineralizing adhesive to seal and mineralize dentin, dentinal tubules, and odontoblast processes","volume":"5","author":"Shi","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.dental.2026.07.015_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105812","article-title":"Dentin permeability and tubule occlusion of dentin treated with naf and tif(4) varnishes compared to elmex opti-namel and biomin f toothpastes under simulated pulp pressure","volume":"159","author":"Mosquim","year":"2025","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2341\/06-69","article-title":"Effect of pulp pressure on the micropermeability and sealing ability of etch & rinse and self-etching adhesives","volume":"32","author":"Rosales-Leal","year":"2007","journal-title":"Oper Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jdent.2016.03.005","article-title":"The influence of intrinsic water permeation on different dentin bonded interfaces formation","volume":"48","author":"Sartori","year":"2016","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib39","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/ar.1092240206","article-title":"Dentin matrix proteins: Composition and possible functions in calcification","volume":"224","author":"Linde","year":"1989","journal-title":"Anat Rec"},{"key":"10.1016\/j.dental.2026.07.015_bib40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0300-5712(96)00065-6","article-title":"The dentin substrate: structure and properties related to bonding","volume":"25","author":"Marshall","year":"1997","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib41","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1177\/00220345211018405","article-title":"Biomineralization of enamel and dentin mediated by matrix proteins","volume":"100","author":"Moradian-Oldak","year":"2021","journal-title":"J Dent Res"},{"key":"10.1016\/j.dental.2026.07.015_bib42","first-page":"9","article-title":"Dynamic balance of non-collagenous proteins in dentine mineralisation","volume":"28","author":"Shen","year":"2025","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.dental.2026.07.015_bib43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.dental.2025.10.006","article-title":"One-step vs. Two-step deposition of caf(2) nanoparticles: from the perspective of confined water release and bonding effectiveness improvement","volume":"42","author":"Xu","year":"2026","journal-title":"Dent Mater"},{"key":"10.1016\/j.dental.2026.07.015_bib44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1875-595X.2005.tb00063.x","article-title":"Tooth brushing, tooth wear and dentine hypersensitivity--are they associated?","volume":"55","author":"Addy","year":"2005","journal-title":"Int Dent J"},{"key":"10.1016\/j.dental.2026.07.015_bib45","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jdent.2015.10.014","article-title":"The effect of toothbrush abrasion force on dentine hypersensitivity in-vitro","volume":"43","author":"Sehmi","year":"2015","journal-title":"J Dent"},{"key":"10.1016\/j.dental.2026.07.015_bib46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1034\/j.1600-051X.2002.290411.x","article-title":"Cervical tooth wear and sensitivity: erosion, softening and rehardening of dentine; effects of pH, time and ultrasonication","volume":"29","author":"Vanuspong","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.dental.2026.07.015_bib47","article-title":"Dentin erosion: method validation and efficacy of fluoride protection","volume":"5","author":"Carey","year":"2017","journal-title":"Dent J (Basel)"},{"key":"10.1016\/j.dental.2026.07.015_bib48","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1186\/s12903-023-03319-x","article-title":"Effects of a commercial whitening toothpaste containing hydrogen peroxide and citric acid on dentin abrasion and erosion","volume":"23","author":"Kim","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.dental.2026.07.015_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cden.2018.08.011","article-title":"Evidence-based dentistry update on silver diamine fluoride","volume":"63","author":"Crystal","year":"2019","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.dental.2026.07.015_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2021.685557","article-title":"Global oral health policies and guidelines: using silver diamine fluoride for caries control","volume":"2","author":"Gao","year":"2021","journal-title":"Front Oral Health"},{"key":"10.1016\/j.dental.2026.07.015_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2022.873157","article-title":"Revisiting fluoride in the twenty-first century: safety and efficacy considerations","volume":"3","author":"Duffin","year":"2022","journal-title":"Front Oral Health"}],"container-title":["Dental Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S010956412600388X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S010956412600388X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:20:29Z","timestamp":1785313229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S010956412600388X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":51,"alternative-id":["S010956412600388X"],"URL":"https:\/\/doi.org\/10.1016\/j.dental.2026.07.015","relation":{},"ISSN":["0109-5641"],"issn-type":[{"value":"0109-5641","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid and durable dentinal tubule occlusion via ion-mediated intratubular coprecipitation","name":"articletitle","label":"Article Title"},{"value":"Dental Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dental.2026.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Academy of Dental Materials. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}