{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:29:47Z","timestamp":1791934187367,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.det.2006.03.010","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T15:06:46Z","timestamp":1168441606000},"page":"375-379","source":"Crossref","is-referenced-by-count":33,"title":["Therapies for Onychomycosis: A Review"],"prefix":"10.1016","volume":"24","author":[{"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Q.","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.det.2006.03.010_bib1","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/S0190-9622(96)90063-8","article-title":"Special patient populations: onychomycosis in the diabetic patient","volume":"35","author":"Rich","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00152192-200511000-00007","article-title":"Health-related quality of life in diabetic patients with foot ulcers: literature review","volume":"32","author":"Goodridge","year":"2005","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"10.1016\/j.det.2006.03.010_bib3","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1136\/bmj.311.7015.1277","article-title":"Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology)","volume":"311","author":"Denning","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.det.2006.03.010_bib4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0190-9622(96)90664-7","article-title":"Onychomycosis caused by Scytalidium dimidiatum","volume":"35","author":"Elewski","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.7547\/87507315-87-12-551","article-title":"Traditional approaches to treatment of onychomycosis","volume":"87","author":"Markinson","year":"1997","journal-title":"J Am Podiatr Med Assoc"},{"key":"10.1016\/j.det.2006.03.010_bib6","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0190-9622(96)90066-3","article-title":"Traditional management of onychomycosis","volume":"35","author":"Daniel","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib7","series-title":"Baran and Dawber's diseases of the nails and their management","first-page":"129","article-title":"Fungal (onychomycosis) and other infections involving the nail apparatus","author":"Hay","year":"2001"},{"key":"10.1016\/j.det.2006.03.010_bib8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.7547\/87507315-90-10-491","article-title":"The dermatopharmacologic profile of ciclopirox 8% nail lacquer","volume":"90","author":"Bohn","year":"2000","journal-title":"J Am Podiatr Med Assoc"},{"key":"10.1016\/j.det.2006.03.010_bib9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/jac\/dki089","article-title":"Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans","volume":"55","author":"Sigle","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.det.2006.03.010_bib10","series-title":"Penlac (ciclopirox) topical solution 8%: product monograph","author":"Dermik Laboratories","year":"2005"},{"issue":"Suppl 1","key":"10.1016\/j.det.2006.03.010_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2230.1992.tb00278.x","article-title":"Comparative efficacy and safety of amorolfine nail lacquer 5% in onychomycosis, once-weekly versus twice-weekly","volume":"17","author":"Reinel","year":"1992","journal-title":"Clin Exp Dermatol"},{"issue":"Suppl 1","key":"10.1016\/j.det.2006.03.010_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2230.1992.tb00277.x","article-title":"Comparative efficacy and safety of amorolfine nail lacquer 2% versus 5% once weekly","volume":"17","author":"Lauharanta","year":"1992","journal-title":"Clin Exp Dermatol"},{"issue":"Suppl 1","key":"10.1016\/j.det.2006.03.010_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2230.1992.tb00274.x","article-title":"Determination of the subungual antifungal activity of amorolfine after 1 month's treatment in patients with onychomycosis: comparison of two nail lacquer formulations","volume":"17","author":"Mensing","year":"1992","journal-title":"Clin Exp Dermatol"},{"issue":"Suppl 1","key":"10.1016\/j.det.2006.03.010_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000247612","article-title":"Topical treatment of onychomycosis with amorolfine 5% nail lacquer: comparative efficacy and tolerability of once and twice weekly use","volume":"184","author":"Reinel","year":"1992","journal-title":"Dermatology"},{"key":"10.1016\/j.det.2006.03.010_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2165\/00003088-200140060-00005","article-title":"Pharmacokinetics of antifungal agents in onychomycoses","volume":"40","author":"Debruyne","year":"2001","journal-title":"Clin Pharmacokinet"},{"issue":"Suppl 39","key":"10.1016\/j.det.2006.03.010_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2133.1992.tb00001.x","article-title":"Terbinafine: mode of action and properties of the squalene epoxidase inhibition","volume":"126","author":"Ryder","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib17","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/S0190-9622(98)70491-8","article-title":"Once-weekly fluconazole (150, 300, or 450 mg) in the treatment of distal subungual onychomycosis of the fingernail","volume":"38","author":"Drake","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib18","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1136\/bmj.318.7190.1031","article-title":"Double blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis: the LION Study Group","volume":"318","author":"Evans","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.det.2006.03.010_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/09546630050517658","article-title":"Itraconazole pulse therapy is effective in dermatophyte onychomycosis of the toenail: a double-blind placebo-controlled study","volume":"11","author":"Gupta","year":"2000","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.det.2006.03.010_bib20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2133.1997.tb14902.x","article-title":"A double-blind, randomized study comparing itraconazole pulse therapy with continuous dosing for the treatment of toe-nail onychomycosis","volume":"136","author":"Havu","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1365-2133.2002.04639.x","article-title":"Long-term results in patients with onychomycosis treated with terbinafine or itraconazole","volume":"146","author":"Heikkila","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib22","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/S0190-9622(98)70492-X","article-title":"Once-weekly fluconazole (450 mg) for 4, 6, or 9 months of treatment for distal subungual onychomycosis of the toenail","volume":"38","author":"Ling","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib23","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1016\/S0190-9622(98)70490-6","article-title":"Once-weekly fluconazole (150, 300, or 450 mg) in the treatment of distal subungual onychomycosis of the toenail","volume":"38","author":"Scher","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1001\/archderm.138.3.353","article-title":"Long-term effectiveness of treatment with terbinafine vs itraconazole in onychomycosis: a 5-year blinded prospective follow-up study","volume":"138","author":"Sigurgeirsson","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib25","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jaad.2005.04.055","article-title":"Pulse versus continuous terbinafine for onychomycosis: a randomized, double-blind, controlled trial","volume":"53","author":"Warshaw","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib26","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/archderm.138.6.811","article-title":"Oral treatments for toenail onychomycosis: a systematic review","volume":"138","author":"Crawford","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1046\/j.1365-2133.2003.05728.x","article-title":"Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis","volume":"150","author":"Gupta","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1046\/j.1365-2133.2002.04825.x","article-title":"Terbinafine in fungal infections of the nails: a meta-analysis of randomized clinical trials","volume":"147","author":"Haugh","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/archderm.140.6.691","article-title":"The successful treatment of Trichophyton rubrum nail bed (distal subungual) onychomycosis with intermittent pulse-dosed terbinafine","volume":"140","author":"Zaias","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2006.03.010_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/09546630410018076","article-title":"Pulsed versus continuous terbinafine dosing in the treatment of dermatophyte onychomycosis","volume":"15","author":"Pavlotsky","year":"2004","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.det.2006.03.010_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/09546630410035329","article-title":"Combination therapy consisting of week pulses of oral terbinafine plus topical application of terbinafine cream in the treatment of onychomycosis","volume":"15","author":"Sanmano","year":"2004","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.det.2006.03.010_bib32","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0190-9622(03)02117-0","article-title":"Epidemiologic surveillance of cutaneous fungal infection in the United States from 1999 to 2002","volume":"50","author":"Foster","year":"2004","journal-title":"J Am Acad Dermatol"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863506000258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863506000258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T02:54:26Z","timestamp":1547088866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733863506000258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0733863506000258"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2006.03.010","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}