{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:46:30Z","timestamp":1789371990825,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.det.2007.01.012","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T11:13:35Z","timestamp":1176290015000},"page":"133-135","source":"Crossref","is-referenced-by-count":90,"title":["Anti-Inflammatory Activity of Tetracyclines"],"prefix":"10.1016","volume":"25","author":[{"given":"Guy","family":"Webster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Q.","family":"Del Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.det.2007.01.012_bib1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2133.1981.tb15317.x","article-title":"Inhibition of lipase production in Propionibacterium acnes by subminimal inhibitory concentrations of tetracyclines and erythromycin","volume":"104","author":"Webster","year":"1981","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1128\/AAC.21.5.770","article-title":"Suppression of polymorphonuclear leukocyte chemotactic factor production in Propionibacterium acnes by sub-minimal inhibitory concentrations of tetracyclines and erythromycin","volume":"21","author":"Webster","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.det.2007.01.012_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/1523-1747.ep12543487","article-title":"The effect of antimicrobial agents on chemotaxis","volume":"70","author":"Esterly","year":"1978","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib4","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/archderm.120.10.1308","article-title":"Neutrophil chemotaxis in patients with acne receiving tetracycline","volume":"120","author":"Esterly","year":"1984","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0765.1991.tb01626.x","article-title":"Suppression of human neutrophil functions by tetracycline","volume":"26","author":"Gabler","year":"1991","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.det.2007.01.012_bib6","first-page":"545","article-title":"Further evidence of therole of bivalent cations in leukocyte chemotaxis","volume":"25","author":"Goodheart","year":"1979","journal-title":"J Reticuloendothel Soc"},{"key":"10.1016\/j.det.2007.01.012_bib7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1001\/archderm.130.6.748","article-title":"Inhibition of in vitro granuloma formation by tetracyclines and ciprofloxacin: involvement of protein kinase C","volume":"130","author":"Webster","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib8","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00417-005-0212-3","article-title":"Tera fluid levels of MMP-8 are elevated in ocular rosacea\u2014treatment effect of oral doxycycline","volume":"244","author":"Maata","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.det.2007.01.012_bib9","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1167\/iovs.04-0929","article-title":"Doxycycline inhibits TGF-beta-1 induced MMP-9 via Smad and MAPK pathways in cultured human corneal epithelial cells","volume":"46","author":"Kim","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.det.2007.01.012_bib10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1600-0765.1984.tb01334.x","article-title":"Tetracyclines inhibit tissue collagenase activity a new mechanism in the treatment of periodontal disease","volume":"19","author":"Golub","year":"1984","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.det.2007.01.012_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/08959374980120011501","article-title":"Safety and efficacy of sub-antimicrobial doxycycline therapy in patients with adult periodontitis","volume":"12","author":"Ciancio","year":"1998","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.det.2007.01.012_bib12","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1161\/01.STR.0000129334.05181.b6","article-title":"Doxycycline suppresses cerebral MMP-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model","volume":"35","author":"Lee","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.det.2007.01.012_bib13","first-page":"773","article-title":"Doxycycline and other tetracyclines in the treatment of bone metastasis","volume":"14","author":"Saikali","year":"2004","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.det.2007.01.012_bib14","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1200\/JCO.2005.04.2614","article-title":"Randomized phase II trial of matrix metalloproteinase inhibitor col-3 in AIDS-related Kaposi's sarcoma","volume":"24","author":"Dezube","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.det.2007.01.012_bib15","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/ijc.21447","article-title":"Tetracycline analogs (doxycycline and col-3) induce caspase dependant and independent apoptosis in human cancer cells","volume":"118","author":"Onoda","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.det.2007.01.012_bib16","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1227\/00006123-200106000-00051","article-title":"Minocycline reduces traumatic brain injury\u2013mediated caspase 1 activation tissue damage, and neurological dysfunction","volume":"28","author":"Sanchez-Mejia","year":"2001","journal-title":"Neurosurgery"},{"key":"10.1016\/j.det.2007.01.012_bib17","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/80538","article-title":"Minocycline inhibits caspase 1 and caspase 3 expression and delays mortality in a transgenic mouse model of Huntington disease","volume":"6","author":"Chen","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.det.2007.01.012_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1001\/archderm.139.4.459","article-title":"Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne","volume":"139","author":"Skidmore","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib19","unstructured":"Del Rosso JQ, Webster GF, Jackson M, et\u00a0al. Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline USP capsules) administered once daily for treatment of rosacea. J Am Acad Dermatol, in press."},{"key":"10.1016\/j.det.2007.01.012_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/archderm.137.1.69","article-title":"The use of tetracyclines for treatment of sarcoidosis","volume":"137","author":"Bachelez","year":"2001","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib22","first-page":"199","article-title":"Sarcoidosis with giant parotomegaly","volume":"68","author":"Ohtsuka","year":"2001","journal-title":"Cutis"},{"key":"10.1016\/j.det.2007.01.012_bib23","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1046\/j.1365-2133.1999.02853.x","article-title":"Minocycline for the treatment of cutaneous silica granulomas","volume":"140","author":"Senet","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2007.01.012_bib24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000247454","article-title":"Minocycline in granulomatous cheilitis: experience with six cases","volume":"185","author":"Veller-Formosa","year":"1992","journal-title":"Dermatology"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863507000137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863507000137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T07:23:00Z","timestamp":1556349780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733863507000137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0733863507000137"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2007.01.012","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}