{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:28:57Z","timestamp":1786987737805,"version":"build-2736575974"},"reference-count":128,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.det.2012.04.004","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T19:35:53Z","timestamp":1339184153000},"page":"389-404","source":"Crossref","is-referenced-by-count":31,"title":["Dysplastic Nevi"],"prefix":"10.1016","volume":"30","author":[{"given":"Michele J.","family":"Farber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Heilman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.det.2012.04.004_bib1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0046-8177(84)80310-X","article-title":"A\u00a0study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma","volume":"15","author":"Clark","year":"1984","journal-title":"Hum Pathol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib2","first-page":"229","article-title":"An exchange of views regarding the dysplastic nevus controversy","volume":"8","author":"Clark","year":"1989","journal-title":"Semin Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1365-2559.2009.03450.x","article-title":"Dysplastic naevi: an update","volume":"56","author":"Elder","year":"2010","journal-title":"Histopathology"},{"issue":"23","key":"10.1016\/j.det.2012.04.004_bib4","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMcp023017","article-title":"Dysplastic nevi","volume":"349","author":"Naeyaert","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"18","key":"10.1016\/j.det.2012.04.004_bib5","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.1997.03540420035026","article-title":"Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma","volume":"277","author":"Tucker","year":"1997","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archderm.1978.01640170032006","article-title":"Origin of familial malignant melanomas from heritable melanocytic lesions. \u2018The B-K mole syndrome\u2019","volume":"114","author":"Clark","year":"1978","journal-title":"Arch Dermatol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/jmg.15.5.352","article-title":"Familial atypical multiple mole-melanoma syndrome","volume":"15","author":"Lynch","year":"1978","journal-title":"J\u00a0Med Genet"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib8","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/1097-0142(19801015)46:8<1787::AID-CNCR2820460816>3.0.CO;2-S","article-title":"Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma","volume":"46","author":"Elder","year":"1980","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/00000372-199210000-00013","article-title":"Naming acquired melanocytic nevi. Common and dysplastic, normal and atypical, or Unna, Miescher, Spitz, and Clark?","volume":"14","author":"Ackerman","year":"1992","journal-title":"Am J Dermatopathol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib10","first-page":"1","article-title":"Diagnosis and treatment of early melanoma. NIH consensus development conference. January 27-29, 1992","volume":"10","year":"1992","journal-title":"Consens Statement"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00000372-198702000-00015","article-title":"Intraepithelial melanocytic neoplasia: a classification by pattern analysis of proliferations of atypical melanocytes","volume":"9","author":"Frankel","year":"1987","journal-title":"Am J Dermatopathol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00000372-199106000-00019","article-title":"Atypical melanocytic proliferations","volume":"13","author":"Sina","year":"1991","journal-title":"Am J Dermatopathol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00000372-199004000-00005","article-title":"Histological analysis of intraepidermal proliferations of atypical melanocytes","volume":"12","author":"Urso","year":"1990","journal-title":"Am J Dermatopathol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1067\/mjd.2002.121029","article-title":"Management of dysplastic nevi: a survey of fellows of the American Academy of Dermatology","volume":"46","author":"Tripp","year":"2002","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"8379","key":"10.1016\/j.det.2012.04.004_bib15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0140-6736(84)92235-9","article-title":"Prevalence of dysplastic naevi in a community practice","volume":"1","author":"Crutcher","year":"1984","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1097-0142(19910101)67:1<202::AID-CNCR2820670133>3.0.CO;2-H","article-title":"Yield from total skin examination and effectiveness of skin cancer awareness program. Findings in 874 new dermatology patients","volume":"67","author":"Lee","year":"1991","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib17","first-page":"1855","article-title":"Demographic study of clinically atypical (dysplastic) nevi in patients with melanoma and comparison subjects","volume":"45","author":"Nordlund","year":"1985","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2559.1988.tb01943.x","article-title":"The efficacy of histopathological criteria required for diagnosing dysplastic naevi","volume":"12","author":"Steijlen","year":"1988","journal-title":"Histopathology"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/1097-0142(19900715)66:2<387::AID-CNCR2820660232>3.0.CO;2-J","article-title":"Count of benign melanocytic nevi as a major indicator of risk for nonfamilial nodular and superficial spreading melanoma","volume":"66","author":"Grob","year":"1990","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0190-9622(87)70230-8","article-title":"Number of melanocytic nevi as a major risk factor for malignant melanoma","volume":"17","author":"Holly","year":"1987","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib21","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1067\/mjd.2003.106","article-title":"Evaluating invasive cutaneous melanoma: is the initial biopsy representative of the final depth?","volume":"48","author":"Ng","year":"2003","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/bjc.1998.81","article-title":"The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia","volume":"77","author":"Bataille","year":"1998","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2340\/0001555571518524","article-title":"Common and dysplastic naevi as risk factors for cutaneous malignant melanoma in a Swedish population","volume":"71","author":"Augustsson","year":"1991","journal-title":"Acta Derm Venereol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib24","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/1523-1747.ep12374298","article-title":"Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi, and actinic lentigines: multicenter case-control study of the central malignant melanoma registry of the German Dermatological Society","volume":"102","author":"Garbe","year":"1994","journal-title":"J\u00a0Invest Dermatol"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-4362.1989.tb04604.x","article-title":"Markers and relative risk in a German population for developing malignant melanoma","volume":"28","author":"Garbe","year":"1989","journal-title":"Int J Dermatol"},{"issue":"7","key":"10.1016\/j.det.2012.04.004_bib26","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1001\/archderm.1991.01680060069006","article-title":"Dysplastic nevi as risk markers of sporadic (nonfamilial) melanoma: a case-control study","volume":"127","author":"Halpern","year":"1991","journal-title":"Arch Dermatol"},{"issue":"8668","key":"10.1016\/j.det.2012.04.004_bib27","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0140-6736(89)91600-0","article-title":"Risk factors for melanoma","volume":"2","author":"MacKie","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.det.2012.04.004_bib28","first-page":"1855","article-title":"Independence of dysplastic nevi from total nevi in patients with melanoma and comparison subjects","volume":"45","author":"Roush","year":"1985","journal-title":"Cancer Res"},{"issue":"6535","key":"10.1016\/j.det.2012.04.004_bib29","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1136\/bmj.292.6535.1555","article-title":"Benign melanocytic naevi as a risk factor for malignant melanoma","volume":"292","author":"Swerdlow","year":"1986","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"8861","key":"10.1016\/j.det.2012.04.004_bib30","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/0140-6736(93)90758-9","article-title":"Accelerated detection with prospective surveillance for cutaneous malignant melanoma in high-risk groups","volume":"341","author":"MacKie","year":"1993","journal-title":"Lancet"},{"issue":"8581","key":"10.1016\/j.det.2012.04.004_bib31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0140-6736(88)91139-7","article-title":"Risk gradient\u00a0for malignant melanoma in individuals with dysplastic naevi","volume":"331","author":"Rigel","year":"1988","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib32","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1001\/archderm.1994.01690080068009","article-title":"Risk factors for melanoma incidence in prospective follow-up: the importance of atypical (dysplastic) nevi","volume":"130","author":"Schneider","year":"1994","journal-title":"Arch Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1524-4725.1991.tb01592.x","article-title":"Prospective follow-up for malignant melanoma in patients with atypical-mole (dysplastic-nevus) syndrome","volume":"17","author":"Tiersten","year":"1991","journal-title":"J\u00a0Dermatol Surg Oncol"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib34","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/archderm.1994.01690080059007","article-title":"Risk of cutaneous malignant melanoma in patients with \u2018classic\u2019 atypical-mole syndrome: a case-control study","volume":"130","author":"Marghoob","year":"1994","journal-title":"Arch Dermatol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib35","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/j.1365-2133.2006.07466.x","article-title":"Dysplastic naevi with moderate to severe histological dysplasia: a risk factor for melanoma","volume":"155","author":"Shors","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2012.04.004_bib36","doi-asserted-by":"crossref","first-page":"346S","DOI":"10.1038\/jid.1993.61","article-title":"A\u00a0cohort study of melanoma in patients with dysplastic nevi","volume":"100","author":"Halpern","year":"1993","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.det.2012.04.004_bib37","doi-asserted-by":"crossref","first-page":"350S","DOI":"10.1038\/jid.1993.62","article-title":"Risk of melanoma and other cancers in melanoma-prone families","volume":"100","author":"Tucker","year":"1993","journal-title":"J\u00a0Invest Dermatol"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib38","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0190-9622(95)90294-5","article-title":"Benign melanocytic lesions: risk markers or precursors of cutaneous melanoma?","volume":"33","author":"Skender-Kalnenas","year":"1995","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2012.04.004_bib39","series-title":"Cancer of the skin","first-page":"203","article-title":"Dysplastic nevi","author":"Salopek","year":"2005"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0733-8635(05)70271-0","article-title":"Differentiation of atypical moles (dysplastic nevi) from early melanomas by dermoscopy","volume":"19","author":"Salopek","year":"2001","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.det.2012.04.004_bib41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5694\/j.1326-5377.1997.tb138843.x","article-title":"A\u00a0high incidence of melanoma found in patients with multiple dysplastic naevi using photographic surveillance","volume":"167","author":"Kelly","year":"1997","journal-title":"Med J Aust"},{"key":"10.1016\/j.det.2012.04.004_bib42","series-title":"Color atlas of melanocytic lesions of the skin","first-page":"87","article-title":"Atypical (dysplastic) nevus","author":"Hofman-Wellenhof","year":"2007"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clindermatol.2008.09.008","article-title":"The \u2018dysplastic\u2019 nevus","volume":"27","author":"Friedman","year":"2009","journal-title":"Clin Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0190-9622(08)80006-0","article-title":"Atypical mole syndrome","volume":"22","author":"Kopf","year":"1990","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"9","key":"10.1016\/j.det.2012.04.004_bib45","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1001\/archderm.1991.01680080082006","article-title":"Dysplastic nevi: occurrence in first-and second-degree relatives of patients with \u2018sporadic\u2019 dysplastic nevus syndrome","volume":"127","author":"Crijns","year":"1991","journal-title":"Arch Dermatol"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib46","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0959-8049(05)80419-8","article-title":"Validity of the histopathological criteria used for diagnosing dysplastic naevi: an interobserver study by the pathology subgroup of the EORTC malignant melanoma cooperative group","volume":"29","author":"De Wit","year":"1993","journal-title":"Eur J Cancer"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib47","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/archderm.1997.03890440019002","article-title":"Reliability of the histopathologic diagnosis of melanocytic dysplasia","volume":"133","author":"Weinstock","year":"1997","journal-title":"Arch Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0046-8177(85)80218-5","article-title":"Dysplasia, dysplastic melanocytes, dysplastic nevi, the dysplastic nevus syndrome, and the relation between dysplastic nevi and malignant melanomas","volume":"16","author":"Ackerman","year":"1985","journal-title":"Hum Pathol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib49","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0046-8177(99)90191-0","article-title":"Correlating architectural disorder and cytologic atypia in Clark (dysplastic) melanocytic nevi","volume":"30","author":"Shea","year":"1999","journal-title":"Hum Pathol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib50","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1309\/KXJW-1UJE-BPG6-AXBV","article-title":"Critical analysis of histologic criteria for grading atypical (dysplastic) melanocytic nevi","volume":"115","author":"Pozo","year":"2001","journal-title":"Am J Clin Pathol"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib51","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/01.MP.0000082394.91761.E5","article-title":"Grading of atypia in nevi: correlation with melanoma risk","volume":"16","author":"Arumi-Uria","year":"2003","journal-title":"Mod Pathol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib52","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/path.1061","article-title":"Inter-observer variation in the histopathological diagnosis of clinically suspicious pigmented skin lesions","volume":"196","author":"Brochez","year":"2002","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.det.2012.04.004_bib53","doi-asserted-by":"crossref","first-page":"318S","DOI":"10.1038\/jid.1993.55","article-title":"Histopathologic recognition and grading of dysplastic melanocytic nevi: an interobserver agreement study","volume":"100","author":"Duncan","year":"1993","journal-title":"J\u00a0Invest Dermatol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib54","first-page":"188","article-title":"Cutaneous malignant melanoma and familial dysplastic nevi: evidence for autosomal dominance and pleiotropy","volume":"38","author":"Bale","year":"1986","journal-title":"Am J Hum Genet"},{"issue":"20","key":"10.1016\/j.det.2012.04.004_bib55","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/jnci\/dji312","article-title":"Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample","volume":"97","author":"Begg","year":"2005","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"12","key":"10.1016\/j.det.2012.04.004_bib56","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/jnci\/94.12.894","article-title":"Geographical variation in the penetrance of CDKN2A mutations for melanoma","volume":"94","author":"Bishop","year":"2002","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"12","key":"10.1016\/j.det.2012.04.004_bib57","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/jnci\/92.12.1006","article-title":"Genotype-phenotype relationships in US melanoma-prone families with CDKN2A and CDK4 mutations","volume":"92","author":"Goldstein","year":"2000","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib58","first-page":"490","article-title":"CDKN2A mutations in Spanish cutaneous malignant melanoma families and patients with multiple melanomas and other neoplasia","volume":"36","author":"Ruiz","year":"1999","journal-title":"J\u00a0Med Genet"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib59","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/ng.411","article-title":"Genome-wide association study identifies 3 loci associated with melanoma risk","volume":"41","author":"Bishop","year":"2009","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.det.2012.04.004_bib60","first-page":"889","article-title":"Gene-covariate interaction between dysplastic nevi and the CDKN2A gene in American melanoma-prone families","volume":"9","author":"Goldstein","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1523-1747.2000.00823.x","article-title":"Genotype\/phenotype and penetrance studies in melanoma families with germline CDKN2A mutations","volume":"114","author":"Bishop","year":"2000","journal-title":"J\u00a0Invest Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2230.2004.01656.x","article-title":"Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome","volume":"30","author":"Celebi","year":"2005","journal-title":"Clin Exp Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00008390-199902000-00004","article-title":"Melanoma development in relation to non-functional p16\/INK4A protein and dysplastic naevus syndrome in Swedish melanoma kindreds","volume":"9","author":"Hashemi","year":"1999","journal-title":"Melanoma Res"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib64","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0046-8177(98)90221-0","article-title":"Allelic deletion at chromosome 9p21 (p16) and 17p13 (p53) in microdissected sporadic dysplastic nevus","volume":"29","author":"Park","year":"1998","journal-title":"Hum Pathol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib65","first-page":"243","article-title":"Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma","volume":"158","author":"Sini","year":"2008","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib66","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1006\/bbrc.1997.7212","article-title":"Genetic alterations of p16INK4a and p53 genes in sporadic dysplastic nevus","volume":"237","author":"Lee","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib67","first-page":"1005","article-title":"Hereditary dysplastic nevus syndrome: lymphoid cell ultraviolet hypermutability in association with increased melanoma susceptibility","volume":"46","author":"Perera","year":"1986","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib68","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000249275","article-title":"Dysplastic nevus syndrome: Ultraviolet hypermutability confirmed in\u00a0vitro by elevated sister chromatid exchanges","volume":"173","author":"Jung","year":"1986","journal-title":"Dermatologica"},{"issue":"20","key":"10.1016\/j.det.2012.04.004_bib69","first-page":"4637","article-title":"Hypermutability of UV-treated plasmids in dysplastic nevus\/familial melanoma cell lines","volume":"57","author":"Moriwaki","year":"1997","journal-title":"Cancer Res"},{"issue":"21","key":"10.1016\/j.det.2012.04.004_bib70","first-page":"5918","article-title":"Ultraviolet mutagenesis in a plasmid vector replicated in lymphoid cells from a patient with the melanoma-prone disorder dysplastic nevus syndrome","volume":"49","author":"Seetharam","year":"1989","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0921-8777(98)00009-3","article-title":"Impaired DNA repair capacity\u00a0in skin fibroblasts from various hereditary cancer-prone syndromes","volume":"407","author":"Abrahams","year":"1998","journal-title":"Mutat Res"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib72","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-0749.1991.tb00435.x","article-title":"Dysplastic melanocytic nevi contain high levels of pheomelanin: quantitative comparison of pheomelanin\/eumelanin levels between normal skin, common nevi, and dysplastic nevi","volume":"4","author":"Salopek","year":"1991","journal-title":"Pigment Cell Res"},{"issue":"7","key":"10.1016\/j.det.2012.04.004_bib73","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1034\/j.1600-0560.2001.280702.x","article-title":"Comprehensive analysis of 112 melanocytic skin lesions demonstrates microsatellite instability in melanomas and dysplastic nevi, but not in benign nevi","volume":"28","author":"Hussein","year":"2001","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.det.2012.04.004_bib74","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/978-3-642-59410-6_14","article-title":"Loss of heterozygosity and microsatellite instability in acquired melanocytic nevi: towards a molecular definition of the dysplastic nevus","volume":"160","author":"Rubben","year":"2002","journal-title":"Recent Results Cancer Res"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib75","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<255::AID-IJC16>3.0.CO;2-L","article-title":"Detection of microsatellite alterations in the spectrum of melanocytic nevi in patients with or without individual or family history of melanoma","volume":"86","author":"Birindelli","year":"2000","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib76","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00000372-199506000-00002","article-title":"Interleukin (IL)-1 alpha- and -1 beta-, IL-6-, and tumor necrosis factor-alpha-like immunoreactivities in human common and dysplastic nevocellular nevi and malignant melanoma","volume":"17","author":"Ahmed","year":"1995","journal-title":"Am J Dermatopathol"},{"issue":"Suppl 2","key":"10.1016\/j.det.2012.04.004_bib77","first-page":"136","article-title":"Antigens associated with tumor progression in melanocytic neoplasia","author":"Elder","year":"1992","journal-title":"Pigment Cell Res"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib78","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5858\/2001-125-0208-CDEIDN","article-title":"Cyclin D1 expression in dysplastic nevi: an immunohistochemical study","volume":"125","author":"Ewanowich","year":"2001","journal-title":"Arch Pathol Lab Med"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib79","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00000372-199212000-00002","article-title":"Immunohistochemical localization of cytokines in nevi","volume":"14","author":"Fleming","year":"1992","journal-title":"Am J Dermatopathol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib80","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/hyb.1996.15.141","article-title":"Tumor antigen expression in compound dysplastic nevi and superficial spreading melanoma defined by a panel of nevomelanoma monoclonal antibodies","volume":"15","author":"Lazzaro","year":"1996","journal-title":"Hybridoma"},{"key":"10.1016\/j.det.2012.04.004_bib81","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.2741\/A341","article-title":"Molecular events in melanoma development and progression","volume":"3","author":"Meier","year":"1998","journal-title":"Front Biosci"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib82","first-page":"235","article-title":"Adhesion molecule profile and malignancy of melanocytic lesions","volume":"3","author":"Moretti","year":"1993","journal-title":"Melanoma Res"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib83","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/1523-1747.ep12398575","article-title":"Expression and distribution of transforming growth factor-\u03b1 within melanocytic lesions","volume":"103","author":"Nanney","year":"1994","journal-title":"J\u00a0Invest Dermatol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00008390-199504000-00005","article-title":"Immunohistochemical analysis of the N-ras p21 and the p53 proteins in naevi, primary tumours and metastases of human cutaneous malignant melanoma: increased immunopositivity in hereditary melanoma","volume":"5","author":"Platz","year":"1995","journal-title":"Melanoma Res"},{"issue":"12","key":"10.1016\/j.det.2012.04.004_bib85","first-page":"1733","article-title":"Molecular analysis of melanoma precursor lesions","volume":"7","author":"Wang","year":"1996","journal-title":"Cell Growth Differ"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib86","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng1054","article-title":"High frequency of BRAF mutations in nevi","volume":"33","author":"Pollock","year":"2003","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib87","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00000372-200310000-00001","article-title":"BRAF mutation: a frequent event in benign, atypical, and malignant melanocytic lesions of the skin","volume":"25","author":"Uribe","year":"2003","journal-title":"Am J Dermatopathol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib88","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1046\/j.1523-1747.2003.12559.x","article-title":"Mutations of the BRAF gene in benign and malignant melanocytic lesions","volume":"121","author":"Yazdi","year":"2003","journal-title":"J\u00a0Invest Dermatol"},{"issue":"12","key":"10.1016\/j.det.2012.04.004_bib89","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0895-4356(98)00070-5","article-title":"Bias in the assessment of family history of melanoma and its association with dysplastic nevi in a case-control study","volume":"51","author":"Weinstock","year":"1998","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib90","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1067\/mjd.2002.120471","article-title":"Cutaneous melanoma in childhood and adolescence: an analysis of 36 patients","volume":"46","author":"Schmid-Wendtner","year":"2002","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib91","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1525-1470.2000.01772.x","article-title":"The frequency of histologically dysplastic nevi in 199 pediatric patients","volume":"17","author":"Haley","year":"2000","journal-title":"Pediatr Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib92","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1001\/jama.2011.990","article-title":"Prevention of melanoma with regular sunscreen use","volume":"306","author":"Robinson","year":"2011","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.det.2012.04.004_bib93","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1002\/cncr.10605","article-title":"A\u00a0natural history of melanomas and dysplastic nevi","volume":"94","author":"Tucker","year":"2002","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib94","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0190-9622(93)70151-I","article-title":"Natural history of dysplastic nevi","volume":"29","author":"Halpern","year":"1993","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib95","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0161-6420(86)33684-4","article-title":"Ocular findings in patients with dysplastic nevus syndrome","volume":"93","author":"Rodriguez-Sains","year":"1986","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib96","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/ijc.2910600509","article-title":"Risk of ocular melanoma in relation to cutaneous and iris naevi","volume":"60","author":"Bataille","year":"1995","journal-title":"Int J Cancer"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib97","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1001\/archderm.139.8.1067","article-title":"Ocular melanoma: a review and the relationship to cutaneous melanoma","volume":"139","author":"Hurst","year":"2003","journal-title":"Arch Dermatol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib98","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/1523-1747.ep12392754","article-title":"Are atypical\u00a0nevi a risk factor for uveal melanoma? A case-control study","volume":"103","author":"Van Hees","year":"1994","journal-title":"J\u00a0Invest Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib99","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1470-2045(02)00679-4","article-title":"Diagnostic accuracy of dermoscopy","volume":"3","author":"Kittler","year":"2002","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1067\/mjd.2003.281","article-title":"Dermoscopy of pigmented skin lesions: results of a consensus meeting via the internet","volume":"48","author":"Argenziano","year":"2003","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib101","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0738-081X(02)00217-1","article-title":"Dermoscopic classification of Clark's nevi (atypical\u00a0melanocytic nevi)","volume":"20","author":"Hofmann-Wellenhof","year":"2002","journal-title":"Clin Dermatol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib102","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.0007-0963.2004.05892.x","article-title":"Melanomas detected with the aid of total cutaneous photography","volume":"150","author":"Feit","year":"2004","journal-title":"Br J Dermatol"},{"issue":"8","key":"10.1016\/j.det.2012.04.004_bib103","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/archderm.141.8.998","article-title":"Incidence of new and changed nevi and melanomas detected using baseline images and dermoscopy in patients at high risk for melanoma","volume":"141","author":"Banky","year":"2005","journal-title":"Arch Dermatol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib104","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1067\/mjd.2003.283","article-title":"Early melanoma detection: nonuniform dermoscopic features and growth","volume":"48","author":"Lucas","year":"2003","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib105","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jaad.2008.10.065","article-title":"Strategies for early melanoma detection: approaches to the patient with nevi","volume":"60","author":"Goodson","year":"2009","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib106","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1001\/archderm.144.4.476","article-title":"The diagnostic performance of expert dermoscopists vs a computer-vision system on small-diameter melanomas","volume":"144","author":"Friedman","year":"2008","journal-title":"Arch Dermatol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib107","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/archdermatol.2010.302","article-title":"The performance of MelaFind: a prospective multicenter study","volume":"147","author":"Monheit","year":"2011","journal-title":"Arch Dermatol"},{"issue":"10","key":"10.1016\/j.det.2012.04.004_bib108","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1200\/JCO.1999.17.10.3245","article-title":"Counseling and DNA testing for individuals perceived\u00a0to be genetically predisposed to melanoma: a consensus statement of the Melanoma Genetics Consortium","volume":"17","author":"Kefford","year":"1999","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib109","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jaad.2009.03.039","article-title":"Clinical genetic testing for familial melanoma in Italy: a cooperative study","volume":"61","author":"Bruno","year":"2009","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib110","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1067\/mjd.2001.117044","article-title":"Guidelines of care for primary cutaneous melanoma","volume":"45","author":"Sober","year":"2001","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib111","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jaad.2008.05.027","article-title":"Biopsy of the pigmented lesion\u2014when and how","volume":"59","author":"Tran","year":"2008","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib112","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1440-0960.2005.00144.x","article-title":"Dysplastic naevi: to shave, or not to shave? A retrospective study of the use of the shave biopsy technique in the initial management of dysplastic naevi","volume":"46","author":"Armour","year":"2005","journal-title":"Australas J Dermatol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib113","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jaad.2009.06.080","article-title":"Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi","volume":"62","author":"Goodson","year":"2010","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib114","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/SMJ.0b013e3181904289","article-title":"The role of observation in the management of atypical nevi","volume":"102","author":"Kmetz","year":"2009","journal-title":"South Med J"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archderm.1981.01650020031020","article-title":"Topical chemotherapy of dysplastic melanocytic nevi with 5% fluorouracil","volume":"117","author":"Bondi","year":"1981","journal-title":"Arch Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib116","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1001\/archderm.135.3.290","article-title":"Treatment of benign and atypical nevi with the normal-mode ruby laser and the Q-switched ruby laser: clinical improvement but failure to completely eliminate nevomelanocytes","volume":"135","author":"Duke","year":"1999","journal-title":"Arch Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib117","first-page":"56","article-title":"Treatment of dysplastic nevi with 5% imiquimod cream, a pilot study","volume":"5","author":"Dusza","year":"2006","journal-title":"J\u00a0Drugs Dermatol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib118","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1001\/archderm.1990.01670280078014","article-title":"The effect of topical tretinoin on dysplastic nevi: a preliminary trial","volume":"126","author":"Edwards","year":"1990","journal-title":"Arch Dermatol"},{"issue":"2","key":"10.1016\/j.det.2012.04.004_bib119","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0190-9622(89)70031-1","article-title":"Effect of oral isotretinoin on dysplastic nevi","volume":"20","author":"Edwards","year":"1989","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.det.2012.04.004_bib120","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1200\/JCO.1994.12.5.1028","article-title":"Effects of topical tretinoin on dysplastic nevi","volume":"12","author":"Halpern","year":"1994","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"10.1016\/j.det.2012.04.004_bib121","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0190-9622(86)70239-9","article-title":"Role of topical tretinoin in melanoma and dysplastic nevi","volume":"15","author":"Meyskens","year":"1986","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib122","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archderm.143.3.379","article-title":"Treatment of atypical nevi with imiquimod 5% cream","volume":"143","author":"Somani","year":"2007","journal-title":"Arch Dermatol"},{"issue":"6","key":"10.1016\/j.det.2012.04.004_bib123","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00008390-199812000-00009","article-title":"Effect of topical tretinoin under occlusion on atypical naevi","volume":"8","author":"Stam-Posthuma","year":"1998","journal-title":"Melanoma Res"},{"issue":"7","key":"10.1016\/j.det.2012.04.004_bib124","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/archderm.136.7.915","article-title":"Laser treatment of pigmented lesions\u20142000: how far have we gone?","volume":"136","author":"Stratigos","year":"2000","journal-title":"Arch Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib125","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1684\/ejd.2010.0933","article-title":"Melanoma after laser therapy of pigmented lesions\u2014circumstances and outcome","volume":"20","author":"Zipser","year":"2010","journal-title":"Eur J Dermatol"},{"issue":"1","key":"10.1016\/j.det.2012.04.004_bib126","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0190-9622(94)70005-2","article-title":"Sunlight: a major factor associated with the development of melanocytic nevi in Australian schoolchildren","volume":"30","author":"Kelly","year":"1994","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2012.04.004_bib127","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1200\/JCO.2010.28.7078","article-title":"Reduced melanoma after regular sunscreen use: randomized trial follow-up","volume":"29","author":"Green","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"22","key":"10.1016\/j.det.2012.04.004_bib128","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1001\/jama.283.22.2955","article-title":"Broad-spectrum sunscreen use and the development of new nevi in white children: a randomized control trial","volume":"283","author":"Gallagher","year":"2000","journal-title":"JAMA"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863512000368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863512000368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:17:55Z","timestamp":1714004275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733863512000368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":128,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0733863512000368"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2012.04.004","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}