{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:54:06Z","timestamp":1782993246539,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["theclinics.com","derm.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.det.2014.12.001","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T22:47:44Z","timestamp":1427755664000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Tips to Treat the 5 Most Common Nail Disorders"],"prefix":"10.1016","volume":"33","author":[{"given":"Matilde","family":"Iorizzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.det.2014.12.001_bib1","series-title":"Baran and Dawber\u2019s diseases of the nails and their management","year":"2012"},{"key":"10.1016\/j.det.2014.12.001_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2217\/14750708.1.1.159","article-title":"Treatment of nail disorders","volume":"1","author":"Piraccini","year":"2004","journal-title":"Therapy"},{"key":"10.1016\/j.det.2014.12.001_bib3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.clindermatol.2013.06.015","article-title":"Common nail disorders","volume":"31","author":"Shemer","year":"2013","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1473-2130.2004.00084.x","article-title":"Brittle nails","volume":"3","author":"Iorizzo","year":"2004","journal-title":"J\u00a0Cosmet Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000029915","article-title":"Age and sex variation in lipid composition of human fingernail plates","volume":"13","author":"Helmdach","year":"2000","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1016\/j.det.2014.12.001_bib6","first-page":"131","article-title":"Age-associated changes in integral cholesterol and cholesterol sulfate concentrations in human scalp hair and finger nail clippings","volume":"13","author":"Brosche","year":"2001","journal-title":"Aging"},{"key":"10.1016\/j.det.2014.12.001_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000247425","article-title":"Wet working conditions increase brittleness of nails, but do not cause it","volume":"185","author":"Lubach","year":"1992","journal-title":"Dermatology"},{"key":"10.1016\/j.det.2014.12.001_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-4632.2009.03978.x","article-title":"Nail plate cohesion seems to be water independent","volume":"48","author":"Duarte","year":"2009","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jaad.2007.02.004","article-title":"Water content and other aspects of brittle versus normal fingernails","volume":"57","author":"Stern","year":"2007","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib10","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0190-9622(90)70345-I","article-title":"Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy","volume":"23","author":"Colombo","year":"1990","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib11","first-page":"303","article-title":"Brittle nails: response to daily biotin supplementation","volume":"51","author":"Hochman","year":"1993","journal-title":"Cutis"},{"key":"10.1016\/j.det.2014.12.001_bib12","first-page":"782","article-title":"Vitamins and minerals: their role in nail health and disease","volume":"6","author":"Scheinfeld","year":"2007","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1473-2165.2006.00232.x","article-title":"Onychocosmeceuticals","volume":"5","author":"Haneke","year":"2006","journal-title":"J\u00a0Cosmet Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1473-2165.2007.00290.x","article-title":"Nail cosmetics in nail disorders","volume":"1","author":"Iorizzo","year":"2007","journal-title":"J\u00a0Cosmet Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib15","first-page":"1013","article-title":"Effects of\u00a0a novel nail lacquer based on hydroxypropyl-chitosan (HPCH) in subjects with fingernail onychoschizia","volume":"2","author":"Sparavigna","year":"2014","journal-title":"J\u00a0Dermatolog Clin Res"},{"key":"10.1016\/j.det.2014.12.001_bib16","unstructured":"Available at: www.nuvail-rx.com. Accessed May, 2014."},{"key":"10.1016\/j.det.2014.12.001_bib17","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1473-2165.2005.00313.x","article-title":"Side effects of nail cosmetics","volume":"4","author":"Baran","year":"2005","journal-title":"J\u00a0Cosmet Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.det.2006.01.005","article-title":"Nail diseases related to nail cosmetics","volume":"24","author":"Dahdah","year":"2006","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.det.2014.12.001_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2133.1982.tb04555.x","article-title":"Primary onycholysis of the big toenails: a review of 113 cases","volume":"106","author":"Baran","year":"1982","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib20","first-page":"226","article-title":"Simple onycholysis","volume":"87","author":"Daniel","year":"2011","journal-title":"Cutis"},{"key":"10.1016\/j.det.2014.12.001_bib21","first-page":"397","article-title":"Chronic paronychia and onycholysis: a 13 year experience","volume":"58","author":"Daniel","year":"1996","journal-title":"Cutis"},{"key":"10.1016\/j.det.2014.12.001_bib22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0190-9622(85)70077-1","article-title":"Onycholysis of the fingernails: evaluation and management","volume":"12","author":"Kechijian","year":"1985","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1468-3083.2011.04323.x","article-title":"Nail digital dermoscopy (onychoscopy) in the diagnosis of onychomycosis","volume":"27","author":"Piraccini","year":"2013","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2014.12.001_bib24","first-page":"325","article-title":"The disappearing nail bed: a possible outcome of onycholysis","volume":"76","author":"Daniel","year":"2005","journal-title":"Cutis"},{"key":"10.1016\/j.det.2014.12.001_bib25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1468-3083.2001.00177-6.x","article-title":"Acute paronychia: comparative treatment with topical antibiotic alone or in combination with corticosteroid","volume":"15","author":"Wollina","year":"2001","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2014.12.001_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1067\/mjd.2002.122191","article-title":"Topical steroids versus systemic antifungals in the treatment of chronic paronychia: an open, randomized double-blind and double dummy study","volume":"47","author":"Tosti","year":"2002","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib27","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1365-2133.2008.08988.x","article-title":"Efficacy and safety of tacrolimus ointment 0.1% vs. betamethasone 17-valerate 0.1% in the treatment of chronic paronychia: an unblinded randomized study","volume":"160","author":"Rigopoulos","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib28","first-page":"29","article-title":"Ecocel Plus Cream: combination of anti-inflammatory, antimicrobial and sealing effects in the treatment of fingernail chronic paronychia: clinical study on 18 cases","volume":"16","author":"Piraccini","year":"2014","journal-title":"Esperienze Dermatologiche"},{"key":"10.1016\/j.det.2014.12.001_bib29","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.2165\/11318180-000000000-00000","article-title":"Nail psoriasis: clinical presentation and best practice recommendations","volume":"69","author":"Edwards","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.det.2014.12.001_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1046\/j.1365-2133.1998.02462.x","article-title":"Calcipotriol ointment in nail psoriasis: a controlled double blind comparison with betamethasone dipropionate and salicylic acid","volume":"139","author":"Tosti","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib31","first-page":"279","article-title":"Calcipotriol used as monotherapy or combination therapy with betamethasone dipropionate in the treatment of nail psoriasis","volume":"88","author":"Tzung","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2014.12.001_bib32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2340\/00015555-0195","article-title":"Treatment of psoriatic nails with tazarotene cream 0.1% vs clobetasol propionate 0.05% cream: a double-blind study","volume":"87","author":"Rigopoulos","year":"2007","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2014.12.001_bib33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ad.2012.04.008","article-title":"Nail psoriasis: treatment with tazarotene 0.1% hydrophilic ointment","volume":"103","author":"Fischer-Levancini","year":"2012","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.det.2014.12.001_bib34","first-page":"755","article-title":"Corticosteroid-induced \u201cdisappearing digit\u201d","volume":"23","author":"Wolf","year":"1990","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2133.1998.02031.x","article-title":"A\u00a0simplified protocol of steroid injection for psoriatic nail dystrophy","volume":"138","author":"de Berker","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1001\/archdermatol.2008.600","article-title":"Evaluation of the efficacy of acitretin therapy for nail psoriasis","volume":"145","author":"Tosti","year":"2009","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib37","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0190-9622(95)90189-2","article-title":"Low dose short term cyclosporine versus etretinate in psoriasis: improvement of skin, nail and joint involvement","volume":"32","author":"Mahrle","year":"1995","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib38","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1468-3083.2010.03927.x","article-title":"Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study","volume":"9","author":"Gumusel","year":"2011","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2014.12.001_bib39","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1517\/14712598.2013.851192","article-title":"Biologic agents in nail psoriasis: efficacy data and considerations","volume":"13","author":"Kyriakou","year":"2013","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.det.2014.12.001_bib40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/09546630701657187","article-title":"Review of antifungal therapy, part II: treatment rationale, including specific patient population","volume":"19","author":"Baran","year":"2008","journal-title":"J\u00a0Dermatolog Treat"},{"key":"10.1016\/j.det.2014.12.001_bib41","first-page":"875","article-title":"Today\u2019s treatment option for onychomycosis","volume":"8","author":"Iorizzo","year":"2010","journal-title":"JDDG"},{"key":"10.1016\/j.det.2014.12.001_bib42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/pde.12064","article-title":"Onychomycosis does not always require systemic treatment for cure: a trial using topical therapy","volume":"3","author":"Fallon Friedlander","year":"2013","journal-title":"Pediatr Dermatoe"},{"key":"10.1016\/j.det.2014.12.001_bib43","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1468-3083.2009.03164.x","article-title":"An innovative water-soluble biopolymer improves efficacy of ciclopirox nail lacquer in the management of onychomycosis","volume":"23","author":"Baran","year":"2009","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2014.12.001_bib44","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jaad.2012.10.013","article-title":"Efinaconazole 10% solution in the treatment of toenail onychomycosis: two phase III multicenter, randomized, double-blind studies","volume":"68","author":"Elewski","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2014.12.001_bib45","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1517\/14656566.2014.921158","article-title":"Tavaborole for the treatment of onychomycosis","volume":"10","author":"Elewski","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.det.2014.12.001_bib46","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.clindermatol.2013.06.010","article-title":"Improved efficacy in onychomycosis treatment","volume":"31","author":"Gupta","year":"2013","journal-title":"Clin Dermatol"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073386351400148X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073386351400148X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T22:59:59Z","timestamp":1537743599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073386351400148X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S073386351400148X"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2014.12.001","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tips to Treat the 5 Most Common Nail Disorders","name":"articletitle","label":"Article Title"},{"value":"Dermatologic Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.det.2014.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}