{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:22Z","timestamp":1762875742780},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","derm.theclinics.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.det.2015.11.008","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T12:22:49Z","timestamp":1453983769000},"page":"147-157","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris"],"prefix":"10.1016","volume":"34","author":[{"given":"Alison M.","family":"Layton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.det.2015.11.008_bib1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1087-0024.2003.09108.x","article-title":"Dermatologists and office-based care of dermatologist disease in the 21st century","volume":"9","author":"Stern","year":"2004","journal-title":"J\u00a0Investig Dermatol Symp Proc"},{"key":"10.1016\/j.det.2015.11.008_bib2","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1016\/j.jaad.2009.01.019","article-title":"New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne Group","volume":"60","author":"Thiboutot","year":"2009","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2230.1994.tb01200.x","article-title":"A\u00a0clinical evaluation of acne scarring and its incidence","volume":"19","author":"Layton","year":"1994","journal-title":"Clin Exp Dermatol"},{"issue":"6","key":"10.1016\/j.det.2015.11.008_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2310\/7750.2007.00037","article-title":"Development and validation of a comprehensive acne severity scale","volume":"11","author":"Tan","year":"2007","journal-title":"J\u00a0Cutan Med Surg"},{"key":"10.1016\/j.det.2015.11.008_bib5","unstructured":"Bourdes V, Faure C, Petot L, et\u00a0al. Natural history of acne lesions and atrophic acne scars within a 6 month study period. Presented at American Academy of Dermatology. San Francisco, March 20\u201324, 2015."},{"key":"10.1016\/j.det.2015.11.008_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.det.2008.07.008","article-title":"Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: a status report","volume":"27","author":"Leyden","year":"2009","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.det.2015.11.008_bib7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1046\/j.1365-2133.2002.04690.x","article-title":"Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study","volume":"146","author":"Coates","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib8","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/S0140-6736(04)17591-0","article-title":"Comparison of five antimicrobial regimens for treatment of mild to moderate facial inflammatory acne vulgaris in the community: a randomized controlled trial","volume":"364","author":"Ozolins","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.det.2015.11.008_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0190-9622(83)70005-8","article-title":"Propionibacterium acnes resistance to antibiotics in acne patients","volume":"8","author":"Leyden","year":"1983","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2133.1989.tb01399.x","article-title":"Erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure","volume":"121","author":"Eady","year":"1989","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2133.2005.06614.x","article-title":"Treatment of acne with topical antibiotics: lessons from clinical studies","volume":"153","author":"Simonart","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1365-2133.1992.tb00104.x","article-title":"Antibiotic resistance patterns in coagulase negative staphylococci after treatment with topical erythromycin, benzoyl peroxide and combination therapy","volume":"126","author":"Harkaway","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/jac\/38.5.829","article-title":"Sequential antibiotic therapy for acne promotes the carriage of resistant staphylococci on the skin of contacts","volume":"38","author":"Miller","year":"1996","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.det.2015.11.008_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/1523-1747.ep12275004","article-title":"Long-term antibiotic therapy for acne vulgaris: effects on the bowel flora of patients and their relatives","volume":"85","author":"Adams","year":"1985","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib15","first-page":"s73","article-title":"The role of benzoyl peroxide in the new treatment paradigm for acne","volume":"12","author":"Kircik","year":"2013","journal-title":"J\u00a0Drugs Dermatol"},{"issue":"Suppl 45","key":"10.1016\/j.det.2015.11.008_bib16","first-page":"26","article-title":"Acne flare and isotretinoin\u2014incidence and treatment","volume":"133","author":"Clark","year":"1995","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-2133.1991.tb14751.x","article-title":"Ablation of whiteheads by cautery under topical anesthesia","volume":"125","author":"Pepall","year":"1991","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib18","first-page":"41","article-title":"A\u00a0review of the literature on benign intracranial hypertension associated with medication","volume":"11","author":"Griffin","year":"1992","journal-title":"Adverse Drug React Toxicol Rev"},{"key":"10.1016\/j.det.2015.11.008_bib19","first-page":"165","article-title":"Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne","volume":"55","author":"Lee","year":"1995","journal-title":"Cutis"},{"key":"10.1016\/j.det.2015.11.008_bib20","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/j.1552-4604.1983.tb01800.x","article-title":"Food increases the bioavailability of isotretinoin","volume":"23","author":"Colburn","year":"1983","journal-title":"J\u00a0Clin Pharmacol"},{"issue":"11","key":"10.1016\/j.det.2015.11.008_bib21","first-page":"17","article-title":"Face to face with oral isotretinoin; a closer look at the spectrum of therapeutic outcomes and why some patients need repeated courses","volume":"5","author":"Del Rosso","year":"2012","journal-title":"J\u00a0Clin Aesthet Dermatol"},{"issue":"4","key":"10.1016\/j.det.2015.11.008_bib22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jaad.2006.08.048","article-title":"Guidelines of care for acne vulgaris management","volume":"56","author":"Strauss","year":"2007","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2015.11.008_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/derm.1.3.9364","article-title":"The use of isotretinoin in acne","volume":"1","author":"Layton","year":"2009","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.det.2015.11.008_bib24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1365-4632.2011.05409.x","article-title":"High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life","volume":"51","author":"Cryulnik","year":"2012","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib25","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000249320","article-title":"The relapses of cystic acne after isotretinoin treatment are age-related: a long-term follow up study","volume":"172","author":"Harms","year":"1986","journal-title":"Dermatologica"},{"key":"10.1016\/j.det.2015.11.008_bib26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0025-7125(16)31398-0","article-title":"Therapy of acne","volume":"66","author":"Olsen","year":"1982","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.det.2015.11.008_bib27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00003495-199448010-00006","article-title":"Acne: a review of optimum treatment","volume":"48","author":"Sykes","year":"1994","journal-title":"Drugs"},{"issue":"9","key":"10.1016\/j.det.2015.11.008_bib28","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/archdermatol.2009.186","article-title":"Interaction of topical sulfacetamide and topical Dapsone with benzoyl peroxide","volume":"145","author":"Dubina","year":"2009","journal-title":"Arch Dermatol"},{"issue":"Suppl 52","key":"10.1016\/j.det.2015.11.008_bib29","first-page":"8","article-title":"Congenital alopecia areata","volume":"139","author":"Martin","year":"1998","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"6","key":"10.1016\/j.det.2015.11.008_bib30","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/bjd.13191","article-title":"A\u00a0treatment for severe nodular acne: a randomised investigator-blinded, controlled, non-inferiority trial comparing fixed-dose Adapalene\/BPO plus doxycycline vs oral isotretinoin","volume":"171","author":"Tan","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib31","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/sj.jid.5701160","article-title":"Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes","volume":"128","author":"Pelle","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib32","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1111\/jdv.12403","article-title":"Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomised, controlled comparative study","volume":"28","author":"Lee","year":"2014","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"issue":"31","key":"10.1016\/j.det.2015.11.008_bib33","first-page":"37","article-title":"Oral spironolactone in post-teenage female patients with acne vulgaris practical considerations for the clinical based on current data and clinical experience","volume":"5","author":"Kim","year":"2012","journal-title":"Clin Aesthet"},{"key":"10.1016\/j.det.2015.11.008_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2133.1986.tb05722.x","article-title":"Oral spironolactone: an effective treatment for acne vulgaris in women","volume":"115","author":"Muhlemann","year":"1986","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2133.1984.tb04045.x","article-title":"Oral spironolactone improves acne vulgaris and reduces sebum excretion","volume":"111","author":"Goodfellow","year":"1984","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib36","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1001\/archderm.134.9.1162-a","article-title":"Adverse effects of spironolactone therapy in women with acne","volume":"134","author":"Lubbos","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib37","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.clindermatol.2004.03.010","article-title":"Acne: hormonal concepts and therapy","volume":"22","author":"Thiboutot","year":"2004","journal-title":"Clin Dermatol"},{"issue":"4","key":"10.1016\/j.det.2015.11.008_bib38","article-title":"Spironolactone versus placebo or in combination with steroids for hirsutism and\/or acne","author":"Farquhar","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.det.2015.11.008_bib39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaad.2007.09.024","article-title":"Efficacy and tolerance of acne treated with both spironolactone and a combined contraceptive containing drospirenone","volume":"58","author":"Krunic","year":"2008","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib40","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0140-6736(75)92645-8","article-title":"Breast cancer associated with administration of spironolactone","volume":"1","author":"Loube","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.det.2015.11.008_bib41","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archderm.1968.01610160023005","article-title":"Gram negative folliculitis in acne","volume":"98","author":"Fulton","year":"1968","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib42","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2133.1973.tb08015.x","article-title":"Gram negative folliculitis\u2014a complication of antibiotic therapy in acne vulgaris","volume":"88","author":"Leyden","year":"1973","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib43","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archderm.1989.01670160119036","article-title":"Testosterone and anabolic steroids and acne fulminans","volume":"125","author":"Heydenreich","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib44","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2230.1995.tb01391.x","article-title":"Gymnasium acne","volume":"20","author":"Collins","year":"1995","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/bjsm.31.1.54","article-title":"Gym and tonic: a profile of 100 male steroid users","volume":"31","author":"Evans","year":"1997","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.det.2015.11.008_bib46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5694\/j.1326-5377.2000.tb125667.x","article-title":"Anabolic-androgenic steroids: medical assessment of present, past and potential users","volume":"173","author":"O'Sullivan","year":"2000","journal-title":"Med J Aust"},{"key":"10.1016\/j.det.2015.11.008_bib47","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00228-003-0633-z","article-title":"The anti-doping hot-line, a means to capture the abuse of doping agents in the Swedish society and a new service function in clinical pharmacology","volume":"59","author":"Eklof","year":"2003","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.det.2015.11.008_bib48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2230.2005.02023.x","article-title":"Acne induced by \u2018Sus\u2019 and \u2018Deca\u2019","volume":"31","author":"Walker","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib49","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1610-0387.2007.06176.x","article-title":"Abuse of anabolic-androgenic steroids and bodybuilding acne: an underestimated health problem","volume":"5","author":"Melnik","year":"2007","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.det.2015.11.008_bib50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1742-481X.2010.00676.x","article-title":"Severe ulcerated \u2018bodybuilding acne\u2019 caused by anabolic steroid use and exacerbated by isotretinoin","volume":"7","author":"Voelcker","year":"2010","journal-title":"Int Wound J"},{"key":"10.1016\/j.det.2015.11.008_bib51","first-page":"163","article-title":"Prevalence of anabolic steroid use and associated factors among body-builders in Hamadan, west province of Iran","volume":"14","author":"Razavi","year":"2014","journal-title":"J\u00a0Res Health Sci"},{"key":"10.1016\/j.det.2015.11.008_bib52","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2340\/00015555673640","article-title":"Effect of androgenic and anabolic steroids on the sebaceous gland in power athletes","volume":"67","author":"Kiraly","year":"1987","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2015.11.008_bib53","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00000372-198712000-00008","article-title":"Effect of testosterone and anabolic steroids on the size of sebaceous glands in power athletes","volume":"9","author":"Kiraly","year":"1987","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.det.2015.11.008_bib54","first-page":"21","article-title":"The effect of testosterone and anabolic steroids on the skin surface lipids and the population of Propionibacterium acnes in young postpubertal men","volume":"68","author":"Kiraly","year":"1988","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2015.11.008_bib55","first-page":"113","article-title":"Effects of anabolic-androgenic steroids on the pilosebaceous unit","volume":"50","author":"Scott","year":"1992","journal-title":"Cutis"},{"key":"10.1016\/j.det.2015.11.008_bib56","first-page":"70","article-title":"Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes","volume":"90","author":"Silverberg","year":"2012","journal-title":"Cutis"},{"key":"10.1016\/j.det.2015.11.008_bib57","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000345102","article-title":"Acne and whey protein supplementation among bodybuilders","volume":"225","author":"Simonart","year":"2012","journal-title":"Dermatology"},{"key":"10.1016\/j.det.2015.11.008_bib58","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1590\/abd1806-4841.20132024","article-title":"Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of Joao Pessoa - PB","volume":"88","author":"Pontes Tde","year":"2013","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.det.2015.11.008_bib59","first-page":"158","article-title":"Supplementation prevalence and adverse effects in physical exercise practitioners","volume":"29","author":"Da Silva","year":"2014","journal-title":"Nutr Hosp"},{"issue":"2","key":"10.1016\/j.det.2015.11.008_bib60","first-page":"210","article-title":"Vitamin B-12 induced acnes","volume":"24","author":"Dupre","year":"1979","journal-title":"Cutis"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863515001473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863515001473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:59:25Z","timestamp":1718326765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733863515001473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0733863515001473"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2015.11.008","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris","name":"articletitle","label":"Article Title"},{"value":"Dermatologic Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.det.2015.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}