{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:17:46Z","timestamp":1782782266831,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.det.2017.11.006","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T13:32:00Z","timestamp":1511962320000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Rosacea Comorbidities"],"prefix":"10.1016","volume":"36","author":[{"given":"Nora","family":"Vera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nupur U.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Seminario-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.det.2017.11.006_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaad.2013.04.045","article-title":"New insights into rosacea pathophysiology: a review of recent findings","volume":"69","author":"Steinhoff","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib2","first-page":"694","article-title":"Why is rosacea considered to be an inflammatory disorder? The primary role, clinical relevance, and therapeutic correlations of abnormal innate immune response in rosacea-prone skin","volume":"11","author":"Del Rosso","year":"2012","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib3","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1365-2133.2005.06895.x","article-title":"Comorbidity of rosacea and depression: an analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Care Survey\u2013Outpatient Department data collected by the U.S. National Center for Health Statistics from 1995 to 2002","volume":"153","author":"Gupta","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/bjd.14930","article-title":"Rosacea and gastrointestinal disorders: a population-based cohort study","volume":"176","author":"Egeberg","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib5","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jaad.2015.11.004","article-title":"Clustering of autoimmune diseases in patients with rosacea","volume":"74","author":"Egeberg","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/bjc.2015.217","article-title":"Personal history of rosacea and risk of incident cancer among women in the US","volume":"113","author":"Li","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.det.2017.11.006_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jaad.2015.04.028","article-title":"Cardiovascular comorbidities in patients with rosacea: a nationwide case-control study from Taiwan","volume":"73","author":"Hua","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib8","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/01.ATV.0000223901.08459.57","article-title":"Involvement of the antimicrobial peptide LL-37 in human atherosclerosis","volume":"26","author":"Edfeldt","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.det.2017.11.006_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.ATV.21.4.473","article-title":"Paraoxonase and atherosclerosis","volume":"21","author":"Durrington","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.det.2017.11.006_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/jdv.12556","article-title":"Decreased serum paraoxonase and arylesterase activities in patients with rosacea","volume":"29","author":"Takci","year":"2015","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2017.11.006_bib11","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm1616","article-title":"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.det.2017.11.006_bib12","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1161\/CIRCRESAHA.112.265868","article-title":"Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice","volume":"110","author":"D\u00f6ring","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.det.2017.11.006_bib13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/28406","article-title":"Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis","volume":"394","author":"Shih","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.det.2017.11.006_bib14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.ATV.19.2.330","article-title":"Serum paraoxonase after myocardial infarction","volume":"19","author":"Ayub","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.det.2017.11.006_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0021-9150(91)90215-O","article-title":"Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus","volume":"86","author":"Mackness","year":"1991","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.det.2017.11.006_bib16","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jdv.12234","article-title":"Rosacea and cardiovascular risk factors: a case control study","volume":"28","author":"Duman","year":"2014","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2017.11.006_bib17","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jaad.2015.07.009","article-title":"Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner: results of a case-control study","volume":"73","author":"Rainer","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib18","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jaad.2016.02.1158","article-title":"Assessment of the risk of cardiovascular disease in patients with rosacea","volume":"75","author":"Egeberg","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-4632.2004.01918.x","article-title":"Severe rosacea associated with colon cancer recurrence","volume":"43","author":"Margolin","year":"2004","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib20","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1158\/1055-9965.EPI-06-0401","article-title":"Antibiotics and risk of breast cancer: up to 9 years of follow-up of 2.1 million women","volume":"15","author":"Friedman","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.det.2017.11.006_bib21","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archderm.1986.01660220013004","article-title":"Rosacea is not associated with skin cancer","volume":"122","author":"Dupont","year":"1986","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canep.2017.01.006","article-title":"Rosacea and risk of cancer in Denmark","volume":"47","author":"Egeberg","year":"2017","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.det.2017.11.006_bib23","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1001\/jamadermatol.2015.2230","article-title":"Genetic vs environmental factors that correlate with rosacea","volume":"151","author":"Aldrich","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/jid.2010.231","article-title":"Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection","volume":"131","author":"Barresi","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s13555-016-0106-9","article-title":"Erythema of rosacea impairs health-related quality of life: results of a meta-analysis","volume":"6","author":"Bewley","year":"2016","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.det.2017.11.006_bib26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaad.2014.05.036","article-title":"The psychological impact of rosacea and the influence of current management options","volume":"71","author":"Moustafa","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jaad.2016.08.055","article-title":"Prevalence and risk of migraine in patients with rosacea: a population-based cohort study","volume":"76","author":"Egeberg","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib28","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1001\/archderm.1994.01690110118022","article-title":"Rosacea: a reaction pattern associated with ocular lesions and migraine?","volume":"130","author":"Ramelet","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000246214","article-title":"Postmenopausal female rosacea patients are more disposed to react with migraine","volume":"193","author":"Berg","year":"1996","journal-title":"Dermatology"},{"key":"10.1016\/j.det.2017.11.006_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jaad.2013.03.027","article-title":"Migraine, triptans, and the risk of developing rosacea: a population-based study within the United Kingdom","volume":"69","author":"Spoendlin","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib31","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jamaneurol.2016.0022","article-title":"Exploring the association between rosacea and Parkinson disease","volume":"73","author":"Egeberg","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.det.2017.11.006_bib32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/WCO.0b013e32833821c1","article-title":"An update on the blood vessel in migraine","volume":"23","author":"Brennan","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.det.2017.11.006_bib33","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1152\/ajpregu.00298.2014","article-title":"Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation","volume":"308","author":"Chen","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.det.2017.11.006_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejphar.2012.04.023","article-title":"A\u00a0possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine","volume":"685","author":"Manna","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.det.2017.11.006_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbr.2016.01.048","article-title":"Evaluation of the antidepressant- and anxiolytic-like activity of \u03b1-spinasterol, a plant derivative with TRPV1 antagonistic effects, in mice","volume":"303","author":"Socala","year":"2016","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.det.2017.11.006_bib36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/jnnp-2014-308813","article-title":"TRPV1, CGRP and SP in scalp arteries of patients suffering from chronic migraine","volume":"86","author":"Del Fiacco","year":"2015","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.det.2017.11.006_bib37","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/jid.2011.424","article-title":"Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea","volume":"132","author":"Sulk","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib38","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1523\/JNEUROSCI.5490-08.2009","article-title":"Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential","volume":"29","author":"Meng","year":"2009","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.det.2017.11.006_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ana.410330109","article-title":"The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats","volume":"33","author":"Goadsby","year":"1993","journal-title":"Ann Neurol"},{"key":"10.1016\/j.det.2017.11.006_bib40","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jamadermatol.2014.4728","article-title":"Clinical, histologic, and molecular analysis of differences between erythematotelangiectatic rosacea and telangiectatic photoaging","volume":"151","author":"Helfrich","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/jdv.13748","article-title":"Feelings of stigmatization in patients with rosacea","volume":"31","author":"Halioua","year":"2017","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2017.11.006_bib42","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1468-3083.2012.04549.x","article-title":"Willingness to pay and quality of life in patients with rosacea","volume":"27","author":"Beikert","year":"2013","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2017.11.006_bib43","first-page":"692","article-title":"The quality of life impact of acne and rosacea compared to other major medical conditions","volume":"13","author":"Cresce","year":"2014","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/bmj.1.6000.21","article-title":"Rosacea and migraine","volume":"1","author":"Tan","year":"1976","journal-title":"Br Med J"},{"key":"10.1016\/j.det.2017.11.006_bib45","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ana.24645","article-title":"Patients with rosacea have increased risk of dementia","volume":"79","author":"Egeberg","year":"2016","journal-title":"Ann Neurol"},{"key":"10.1016\/j.det.2017.11.006_bib46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2230.2004.01461.x","article-title":"Remission of rosacea induced by reduction of gut transit time","volume":"29","author":"Kendall","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib47","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cgh.2008.02.054","article-title":"Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication","volume":"6","author":"Parodi","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.det.2017.11.006_bib48","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jaad.2012.11.038","article-title":"Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin","volume":"68","author":"Weinstock","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib49","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MCG.0b013e3182040eb2","article-title":"Rosacea in Crohn\u2019s disease: effect of rifaximin","volume":"45","author":"Weinstock","year":"2011","journal-title":"J\u00a0Clin Gastroenterol"},{"issue":"3","key":"10.1016\/j.det.2017.11.006_bib50","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1016\/j.jaad.2016.01.059","article-title":"The role of small intestinal bacterial overgrowth in rosacea: a 3-year follow-up","volume":"75","author":"Drago","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib51","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaad.2016.08.022","article-title":"Inflammatory bowel disease is associated with an increased risk of inflammatory skin diseases: a population-based cross-sectional study","volume":"76","author":"Kim","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2017.11.006_bib52","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/MIB.0000000000000644","article-title":"Rosacea in patients with ulcerative colitis and Crohn\u2019s disease: a population-based case-control study","volume":"22","author":"Spoendlin","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.det.2017.11.006_bib53","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaad.2016.11.065","article-title":"Risk of inflammatory bowel disease in patients with rosacea: results from a nationwide cohort study in Taiwan","volume":"76","author":"Wu","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib54","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.14352","article-title":"Rosacea is associated with Helicobacter pylori: a systematic review and meta-analysis","author":"J\u00f8rgensen","year":"2017","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2017.11.006_bib55","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1365-4362.2003.01817.x","article-title":"Incidence of anti-Helicobacter pylori and anti-CagA antibodies in rosacea patients","volume":"42","author":"Argenziano","year":"2003","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.det.2017.11.006_bib56","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/jid.2015.53","article-title":"Assessment of the genetic basis of rosacea by genome-wide association study","volume":"135","author":"Chang","year":"2015","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073386351730164X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073386351730164X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T17:52:21Z","timestamp":1535219541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073386351730164X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S073386351730164X"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2017.11.006","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosacea Comorbidities","name":"articletitle","label":"Article Title"},{"value":"Dermatologic Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.det.2017.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}