{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:50:47Z","timestamp":1792680647872,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.det.2018.02.003","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T06:10:13Z","timestamp":1521526213000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Prurigo Nodularis and Its Management"],"prefix":"10.1016","volume":"36","author":[{"given":"Claudia","family":"Zeidler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Yosipovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"St\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.det.2018.02.003_bib1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00105-014-2753-z","article-title":"Prurigo. Clinical definition and classification","volume":"65","author":"Schedel","year":"2014","journal-title":"Hautarzt"},{"key":"10.1016\/j.det.2018.02.003_bib2","article-title":"European Academy of Dermatology and Venereology European Prurigo Project: expert consensus on the definition, classification and terminology of chronic prurigo","author":"Pereira","year":"2017","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000246715","article-title":"Prurigo nodularis consists of two distinct forms: early-onset atopic and late-onset non-atopic","volume":"190","author":"Tanaka","year":"1995","journal-title":"Dermatology"},{"key":"10.1016\/j.det.2018.02.003_bib4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1468-3083.2012.04481.x","article-title":"Prurigo as a symptom of atopic and non-atopic diseases: aetiological survey in a consecutive cohort of 108 patients","volume":"27","author":"Iking","year":"2013","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib5","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jaad.2016.05.035","article-title":"Retrospective analysis of data from an itch center: integrating validated tools in the electronic health record","volume":"75","author":"Mollanazar","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib6","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2230.2006.02211.x","article-title":"Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch","volume":"31","author":"Schneider","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/0009922808321899","article-title":"Prurigo nodularis in a 9-year-old girl","volume":"48","author":"Amer","year":"2009","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.det.2018.02.003_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1525-1470.2012.01740.x","article-title":"Atopic dermatitis in African American children: addressing unmet needs of a common disease","volume":"29","author":"Vachiramon","year":"2012","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib9","first-page":"38","article-title":"Prurigo nodularis: a benign dermatosis derived from a persistent pruritus","volume":"16","author":"Vaidya","year":"2008","journal-title":"Acta Dermatovenerol Croat"},{"issue":"5","key":"10.1016\/j.det.2018.02.003_bib10","first-page":"481","article-title":"Le neurone de la lichenification circonscrite nodulaire chronique (lichen ruber obtusus corne prurigo nodularis)","volume":"81","author":"Pautrier","year":"1954","journal-title":"Annales de Dermatologic Syph"},{"key":"10.1016\/j.det.2018.02.003_bib11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1600-0560.2009.01484.x","article-title":"Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients","volume":"37","author":"Weigelt","year":"2010","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.det.2018.02.003_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1365-2133.2011.10306.x","article-title":"Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigo nodularis skin as a potential sign of subclinical cutaneous neuropathy","volume":"165","author":"Schuhknecht","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00105-006-1125-8","article-title":"Neurophysiology of pruritus","volume":"57","author":"Raap","year":"2006","journal-title":"Hautarzt"},{"key":"10.1016\/j.det.2018.02.003_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2004.12.019","article-title":"Gene expression and regulation of nerve growth factor in atopic dermatitis mast cells and the human mast cell line-1","volume":"161","author":"Groneberg","year":"2005","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.det.2018.02.003_bib15","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00403-001-0285-8","article-title":"Increased nerve growth factor- and tyrosine kinase A-like immunoreactivities in prurigo nodularis skin \u2013 an exploration of the cause of neurohyperplasia","volume":"293","author":"Johansson","year":"2002","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.det.2018.02.003_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1600-0560.1998.tb01718.x","article-title":"Histamine-containing mast cells and their relationship to NGFr-immunoreactive nerves in prurigo nodularis: a reappraisal","volume":"25","author":"Liang","year":"1998","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.det.2018.02.003_bib17","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jaci.2005.10.033","article-title":"IL-31: a new\u00a0link between T cells and pruritus in atopic skin inflammation","volume":"117","author":"Sonkoly","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.det.2018.02.003_bib18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/exd.12222","article-title":"A\u00a0single dose of interleukin-31 (IL-31) causes continuous itch-associated scratching behaviour in mice","volume":"22","author":"Arai","year":"2013","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jaci.2008.05.047","article-title":"Correlation of IL-31 serum levels with severity of atopic dermatitis","volume":"122","author":"Raap","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.det.2018.02.003_bib20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A\u00a0sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"15","key":"10.1016\/j.det.2018.02.003_bib21","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2174\/0929867043364748","article-title":"Tachykinins and tachykinin receptors: structure and activity relationships","volume":"11","author":"Almeida","year":"2004","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.det.2018.02.003_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jdermsci.2010.03.020","article-title":"Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis","volume":"58","author":"Haas","year":"2010","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.det.2018.02.003_bib23","doi-asserted-by":"crossref","first-page":"e10968","DOI":"10.1371\/journal.pone.0010968","article-title":"Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy","volume":"5","author":"Stander","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.det.2018.02.003_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1034\/j.1600-0560.2000.027007359.x","article-title":"CGRP-immunoreactive nerves in prurigo nodularis\u2013an exploration of neurogenic inflammation","volume":"27","author":"Liang","year":"2000","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.det.2018.02.003_bib25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2340\/00015555-2232","article-title":"Intraepidermal nerve fibre density is decreased in lesional and inter-lesional prurigo nodularis and reconstitutes on healing of lesions","volume":"96","author":"Bobko","year":"2016","journal-title":"Acta Derm Venereol"},{"issue":"10","key":"10.1016\/j.det.2018.02.003_bib26","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/exd.13343","article-title":"There is no functional small-fiber neuropathy in prurigo nodularis despite neuroanatomical alterations","volume":"26","author":"Pereira","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib27","first-page":"610","article-title":"Prurigo nodularis: introduction of a re-defined classification and Prurigo Activity Score (PAS)","volume":"93","author":"Schedel","year":"2013","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib28","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2340\/00015555-1400","article-title":"European guideline on chronic pruritus","volume":"92","author":"Weisshaar","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib29","first-page":"241","article-title":"The impact of pruritus on the quality of life of patients undergoing dialysis: a single centre cohort study","volume":"22","author":"Tessari","year":"2009","journal-title":"J\u00a0Nephrol"},{"key":"10.1016\/j.det.2018.02.003_bib30","first-page":"12","article-title":"Phenotypes of atopic dermatitis","volume":"9","author":"Pugliarello","year":"2011","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.det.2018.02.003_bib31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2310\/7750.2014.14018","article-title":"Pemphigoid nodularis","volume":"19","author":"Al-Salhi","year":"2015","journal-title":"J\u00a0Cutan Med Surg"},{"key":"10.1016\/j.det.2018.02.003_bib32","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2133.1997.tb14953.x","article-title":"Pemphigoid nodularis: a report of three cases and review of the literature","volume":"136","author":"Cliff","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib33","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/bjd.13717","article-title":"Management of bullous pemphigoid: the European Dermatology Forum Consensus in collaboration with the European Academy of Dermatology and Venereology","volume":"172","author":"Feliciani","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s11255-015-1208-5","article-title":"Epidemiology and determinants of pruritus in pre-dialysis chronic kidney disease patients","volume":"48","author":"Solak","year":"2016","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.det.2018.02.003_bib35","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s00105-014-2756-9","article-title":"Clinical features and prurigo nodularis in nephrogenic pruritus","volume":"65","author":"Bohme","year":"2014","journal-title":"Hautarzt"},{"key":"10.1016\/j.det.2018.02.003_bib36","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2340\/00015555-2280","article-title":"Clinical findings and provision of care in haemodialysis patients with chronic itch: new results from the German Epidemiological Haemodialysis Itch Study","volume":"96","author":"Hayani","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib37","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/jdv.12664","article-title":"High prevalence of cutaneous manifestations in the elderly with diabetes mellitus: an institution-based cross-sectional study in Taiwan","volume":"29","author":"Tseng","year":"2015","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00000372-198204000-00002","article-title":"Perforating folliculitis of hemodialysis","volume":"4","author":"White","year":"1982","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.det.2018.02.003_bib39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00000372-198204000-00001","article-title":"Perforating folliculitis in association with hemodialysis","volume":"4","author":"Hurwitz","year":"1982","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.det.2018.02.003_bib40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2340\/00015555-2492","article-title":"Acquired reactive perforating dermatosis is a variant of prurigo nodularis","volume":"97","author":"Kestner","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib41","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00105-014-2755-x","article-title":"Prurigo nodularis: its association with dermatoses and systemic disorders","volume":"65","author":"Mettang","year":"2014","journal-title":"Hautarzt"},{"key":"10.1016\/j.det.2018.02.003_bib42","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.trstmh.2011.04.001","article-title":"Predictive values of prurigo nodularis and herpes zoster for HIV infection and immunosuppression requiring HAART in French Guiana","volume":"105","author":"Magand","year":"2011","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.det.2018.02.003_bib43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.medmal.2009.01.002","article-title":"Can antiretroviral treatment eradicate Prurigo nodularis in HIV infected patients?","volume":"39","author":"Ouattara","year":"2009","journal-title":"Med Mal Infect"},{"key":"10.1016\/j.det.2018.02.003_bib44","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/dth.12028","article-title":"Neuropathic itch: diagnosis and management","volume":"26","author":"Stumpf","year":"2013","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.det.2018.02.003_bib45","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1468-3083.2006.02007.x","article-title":"Prurigo nodularis in healed herpes zoster scar: an isotopic response","volume":"21","author":"De","year":"2007","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib46","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/bjd.12483","article-title":"Brachioradial pruritus: Mayo Clinic experience over the past decade","volume":"169","author":"Mirzoyev","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib47","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2340\/00015555-0305","article-title":"Clinical classification of itch: a position paper of the international forum for the study of itch","volume":"87","author":"Stander","year":"2007","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib48","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2340\/00015555-1506","article-title":"Self-inflicted lesions in dermatology: terminology and classification\u2013a position paper from the European Society for Dermatology and Psychiatry (ESDaP)","volume":"93","author":"Gieler","year":"2013","journal-title":"Acta Derm Venereol"},{"issue":"8","key":"10.1016\/j.det.2018.02.003_bib49","first-page":"860","article-title":"S2k guidelines for the diagnosis and treatment of chronic pruritus - update - short version","volume":"15","author":"St\u00e4nder","year":"2017","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.det.2018.02.003_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/09546630903386606","article-title":"An occlusive dressing containing betamethasone valerate 0.1% for the treatment of prurigo nodularis","volume":"21","author":"Saraceno","year":"2010","journal-title":"J\u00a0Dermatolog Treat"},{"key":"10.1016\/j.det.2018.02.003_bib51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2310\/7750.2009.08082","article-title":"Update on intralesional steroid: focus on dermatoses","volume":"14","author":"Richards","year":"2010","journal-title":"J\u00a0Cutan Med Surg"},{"key":"10.1016\/j.det.2018.02.003_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00128071-200405020-00003","article-title":"Prurigo: diagnosis and management","volume":"5","author":"Wallengren","year":"2004","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000355671","article-title":"Evaluation of the antipruritic effects of topical pimecrolimus in non-atopic prurigo nodularis: results of a randomized, hydrocortisone-controlled, double-blind phase II trial","volume":"227","author":"Siepmann","year":"2013","journal-title":"Dermatology"},{"key":"10.1016\/j.det.2018.02.003_bib54","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archderm.136.6.807","article-title":"Double-blind, right\/left comparison of calcipotriol ointment and betamethasone ointment in the treatment of prurigo nodularis","volume":"136","author":"Wong","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib55","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1067\/mjd.2001.110059","article-title":"Treatment of prurigo nodularis with topical capsaicin","volume":"44","author":"Stander","year":"2001","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.0906-6705.2004.0178.x","article-title":"Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures","volume":"13","author":"Stander","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib57","first-page":"115","article-title":"Amitriptyline\/ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster","volume":"14","author":"Griffin","year":"2015","journal-title":"J\u00a0Drugs Dermatol"},{"issue":"4","key":"10.1016\/j.det.2018.02.003_bib58","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jaad.2016.10.030","article-title":"Topical ketamine-amitriptyline-lidocaine for chronic pruritus: a retrospective study assessing efficacy and tolerability","volume":"76","author":"Lee","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib59","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1468-3083.2010.03865.x","article-title":"UVB 308-nm excimer light and bath PUVA: combination therapy is very effective in the treatment of prurigo nodularis","volume":"25","author":"Hammes","year":"2011","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib60","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1016\/j.jaad.2014.09.050","article-title":"Successful use of a modified Goeckerman regimen in the treatment of generalized prurigo nodularis","volume":"72","author":"Sorenson","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jaad.2008.11.024","article-title":"Topical tar: back to the\u00a0future","volume":"61","author":"Paghdal","year":"2009","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib62","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s00105-009-1730-4","article-title":"Antipruritic efficacy of a high-dosage antihistamine therapy. Results of a retrospectively analysed case series","volume":"60","author":"Schulz","year":"2009","journal-title":"Hautarzt"},{"key":"10.1016\/j.det.2018.02.003_bib63","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/dth.12094","article-title":"Combination therapy of fexofenadine and montelukast is effective in prurigo nodularis and pemphigoid nodularis","volume":"27","author":"Shintani","year":"2014","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.det.2018.02.003_bib64","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1093\/ndt\/gfh496","article-title":"Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial","volume":"19","author":"Gunal","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.det.2018.02.003_bib65","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1529-8019.2010.01314.x","article-title":"Therapeutic hotline: treatment of prurigo nodularis and lichen simplex chronicus with gabapentin","volume":"23","author":"Gencoglan","year":"2010","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.det.2018.02.003_bib66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jcpt.12005","article-title":"Treatment of prurigo nodularis with pregabalin","volume":"38","author":"Mazza","year":"2013","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.det.2018.02.003_bib67","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-4362.2003.01831.x","article-title":"The role of gabapentin in treating diseases with cutaneous manifestations and pain","volume":"42","author":"Scheinfeld","year":"2003","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib68","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2340\/00015555-1353","article-title":"Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review","volume":"92","author":"Phan","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib69","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/hep.27582","article-title":"The pruritus of cholestasis: facts","volume":"61","author":"Bergasa","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.det.2018.02.003_bib70","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2340\/00015555-0553","article-title":"Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study","volume":"89","author":"Stander","year":"2009","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib71","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jaad.2005.12.010","article-title":"Butorphanol for treatment of intractable pruritus","volume":"54","author":"Dawn","year":"2006","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.det.2018.02.003_bib72","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/jid.2014.398","article-title":"Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei: a pharmacological fMRI study","volume":"135","author":"Papoiu","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"issue":"6","key":"10.1016\/j.det.2018.02.003_bib73","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1590\/abd1806-4841.20164878","article-title":"Psychotropics in different causes of itch: systematic review with controlled studies","volume":"91","author":"Brasileiro","year":"2016","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib74","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1610-0387.2008.06745.x","article-title":"Antipruritic effect of cyclosporine microemulsion in prurigo nodularis: results of a case series","volume":"6","author":"Siepmann","year":"2008","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.det.2018.02.003_bib75","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/ced.12365","article-title":"Prurigo nodularis: retrospective study of 13 cases managed with methotrexate","volume":"39","author":"Spring","year":"2014","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib76","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000331577","article-title":"Thalidomide in 42 patients with prurigo nodularis Hyde","volume":"223","author":"Andersen","year":"2011","journal-title":"Dermatology"},{"key":"10.1016\/j.det.2018.02.003_bib77","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2340\/00015555-0997","article-title":"Efficacy of thalidomide in the treatment of prurigo nodularis","volume":"91","author":"Taefehnorooz","year":"2011","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.det.2018.02.003_bib78","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jaad.2015.09.039","article-title":"Thalidomide for the treatment of chronic refractory pruritus","volume":"74","author":"Sharma","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib79","first-page":"360","article-title":"Use of lenalidomide in treating refractory prurigo nodularis","volume":"12","author":"Liu","year":"2013","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib80","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1001\/archdermatol.2011.2918","article-title":"Treatment of refractory prurigo nodularis with lenalidomide","volume":"148","author":"Kanavy","year":"2012","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib81","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2133.2011.10587.x","article-title":"Atopic prurigo nodularis responds to intravenous immunoglobulins","volume":"166","author":"Feldmeyer","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2018.02.003_bib82","unstructured":"St\u00e4nder S, Kwon P, Luger TA. Randomized, double-blind, placebo-controlled, study of the neurokinin-1 receptor (NK1-R) antagonist serlopitant in subjects with prurigo nodularis (PN). Annual Meeting of the American Association of Dermatology 2017). Orlando, March 3\u20137, 2017."},{"key":"10.1016\/j.det.2018.02.003_bib83","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12882-015-0043-3","article-title":"Pharmacokinetics of nalbuphine hydrochloride extended release tablets in hemodialysis patients with exploratory effect on pruritus","volume":"16","author":"Hawi","year":"2015","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.det.2018.02.003_bib84","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1056\/NEJMoa1606490","article-title":"Anti-interleukin-31 receptor A antibody for atopic dermatitis","volume":"376","author":"Ruzicka","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.det.2018.02.003_bib85","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1056\/NEJMe1616072","article-title":"Ditching the itch with anti-type 2 cytokine therapies for atopic dermatitis","volume":"376","author":"Schneider","year":"2017","journal-title":"N\u00a0Engl J Med"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863518300147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733863518300147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T04:17:30Z","timestamp":1719893850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733863518300147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0733863518300147"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2018.02.003","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prurigo Nodularis and Its Management","name":"articletitle","label":"Article Title"},{"value":"Dermatologic Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.det.2018.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}