{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:10:00Z","timestamp":1785798600578,"version":"3.56.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Clinics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.det.2021.08.002","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T08:42:42Z","timestamp":1634892162000},"page":"9-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Updated Approach to Patients with Multiple Caf\u00e9 au Lait Macules"],"prefix":"10.1016","volume":"40","author":[{"given":"Mohammed","family":"Albaghdadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My Linh","family":"Thibodeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lara-Corrales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.pcl.2010.07.002","article-title":"The diagnostic and clinical significance of caf\u00e9-au-lait macules","volume":"57","author":"Shah","year":"2010","journal-title":"Pediatr Clin North Am"},{"issue":"8","key":"10.1016\/j.det.2021.08.002_bib2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archdermatol.2009.169","article-title":"Predictive value of caf\u00e9 au lait macules at initial consultation in the diagnosis of neurofibromatosis type 1","volume":"145","author":"Nunley","year":"2009","journal-title":"Arch Dermatol"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib3","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.jaad.2017.02.027","article-title":"Predicting neurofibromatosis type 1 risk among children with isolated caf\u00e9-au-lait macules","volume":"76","author":"Ben-Shachar","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.det.2021.08.002_bib4","article-title":"Cutaneous findings in Fanconi Anemia","author":"Ruggiero","year":"2020","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1525-1470.1983.tb01093.x","article-title":"The incidence and significance of birthmarks in a cohort of 4,641 newborns","volume":"1","author":"Alper","year":"1983","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0733-8635(18)30774-5","article-title":"Neurofibromatosis and Albright\u2019s syndrome","volume":"5","author":"Riccardi","year":"1987","journal-title":"Dermatol Clin"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib7","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0190-9622(95)91331-9","article-title":"The Eastern Australian childhood nevus study: prevalence of atypical nevi, congenital nevus-like nevi, and other pigmented lesions","volume":"32","author":"Rivers","year":"1995","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1542\/peds.2007-3204","article-title":"Neurofibromatosis type 1 revisited","volume":"123","author":"Williams","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.det.2021.08.002_bib9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0190-9622(95)90338-0","article-title":"\u201cSunburn\u201d freckles, caf\u00e9-au-lait macules, and other pigmented lesions of schoolchildren: The Vancouver Mole Study","volume":"32","author":"McLean","year":"1995","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1542\/pir.22.3.82","article-title":"Caf\u00e9 au lait spots: the pediatrician\u2019s perspective","volume":"22","author":"Tekin","year":"2001","journal-title":"Pediatr Rev"},{"issue":"2","key":"10.1016\/j.det.2021.08.002_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1096-8628(19970516)70:2<138::AID-AJMG7>3.0.CO;2-U","article-title":"Type 1 neurofibromatosis: a descriptive analysis of the disorder in 1,728 patients","volume":"70","author":"Friedman","year":"1997","journal-title":"Am J Med Genet"},{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib12","doi-asserted-by":"crossref","first-page":"e20190660","DOI":"10.1542\/peds.2019-0660","article-title":"Health supervision for children with neurofibromatosis type 1","volume":"143","author":"Miller","year":"2019","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/archderm.141.1.71","article-title":"Prevalence of neurofibromatosis 1 in German children at elementary school enrollment","volume":"141","author":"Lammert","year":"2005","journal-title":"Arch Dermatol"},{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/jmg.27.5.307","article-title":"Segregation analysis of peripheral neurofibromatosis (NF1)","volume":"27","author":"Littler","year":"1990","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.det.2021.08.002_bib15","unstructured":"National Institutes of Health Consensus Development Conference Statement: neurofibromatosis. Bethesda, Md., USA, July 13-15, 1987. Neurofibromatosis 1988; 1(3):172-8."},{"key":"10.1016\/j.det.2021.08.002_bib16","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1997.03550010065042","article-title":"The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2","author":"Gutmann","year":"1997","journal-title":"J\u00a0Am Med Assoc"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib17","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1542\/peds.105.3.608","article-title":"Use of the National Institutes of Health criteria for diagnosis of neurofibromatosis 1 in children","volume":"105","author":"DeBella","year":"2000","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.spen.2006.01.005","article-title":"Clinical manifestations and management of neurofibromatosis type 1","volume":"13","author":"Tonsgard","year":"2006","journal-title":"Semin Pediatr Neurol"},{"issue":"4","key":"10.1016\/j.det.2021.08.002_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pediatrneurol.2004.11.002","article-title":"Neurofibromatosis 1: from lab bench to clinic","volume":"32","author":"Ward","year":"2005","journal-title":"Pediatr Neurol"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib20","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1542\/peds.90.6.924","article-title":"Diagnostic outcome in children with multiple cafe au lait spots","volume":"90","author":"Korf","year":"1992","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1098-1004(200006)15:6<541::AID-HUMU6>3.0.CO;2-N","article-title":"Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects","volume":"15","author":"Messiaen","year":"2000","journal-title":"Hum Mutat"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1086\/510781","article-title":"An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation","volume":"80","author":"Upadhyaya","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.det.2021.08.002_bib23","first-page":"1","article-title":"Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation","volume":"19","author":"Legius","year":"2021","journal-title":"Genet Med"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/gcc.20289","article-title":"Spectrum of single- and multiexon NF1 copy number changes in a cohort of 1,100 unselected NF1 patients","volume":"45","author":"Wimmer","year":"2006","journal-title":"Genes Chromosom Cancer"},{"issue":"11","key":"10.1016\/j.det.2021.08.002_bib25","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1212\/WNL.56.11.1433","article-title":"The clinical and diagnostic implications of mosaicism in the neurofibromatoses","volume":"56","author":"Ruggieri","year":"2001","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.det.2021.08.002_bib26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1086\/519562","article-title":"Molecular dissection of isolated disease features in mosaic neurofibromatosis type 1","volume":"81","author":"Maertens","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10.1016\/j.det.2021.08.002_bib27","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/archderm.1995.01690240131030","article-title":"More on the frequency of segmental neurofibromatosis","volume":"131","author":"Wolkenstein","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.det.2021.08.002_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/pde.12673","article-title":"Mosaic neurofibromatosis Type 1: a systematic review","volume":"33","author":"Garc\u00eda-Romero","year":"2016","journal-title":"Pediatr Dermatol"},{"issue":"8","key":"10.1016\/j.det.2021.08.002_bib29","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/1346-8138.12567","article-title":"Clinical features of 58 Japanese patients with mosaic neurofibromatosis 1","volume":"41","author":"Tanito","year":"2014","journal-title":"J\u00a0Dermatol"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib30","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/cge.12600","article-title":"Clinical presentations of 23 half-siblings from a mosaic neurofibromatosis type 1 sperm donor","volume":"89","author":"Ejerskov","year":"2016","journal-title":"Clin Genet"},{"issue":"19","key":"10.1016\/j.det.2021.08.002_bib31","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1001\/jama.2009.1663","article-title":"Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome","volume":"302","author":"Messiaen","year":"2009","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.det.2021.08.002_bib32","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ng2113","article-title":"Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype","volume":"39","author":"Brems","year":"2007","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/onc.2013.587","article-title":"SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia","volume":"34","author":"Pasmant","year":"2015","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/jmg.24.1.9","article-title":"Noonan syndrome","volume":"24","author":"Allanson","year":"1987","journal-title":"J\u00a0Med Genet"},{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib35","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1136\/jmg.2003.013466","article-title":"Clinical and molecular analysis of 30 patients with multiple lentigines LEOPARD syndrome","volume":"41","author":"Sarkozy","year":"2004","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.det.2021.08.002_bib36","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1017\/S1462399408000902","article-title":"Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway","volume":"10","author":"Tidyman","year":"2008","journal-title":"Expert Rev Mol Med"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib37","first-page":"521","article-title":"Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome","volume":"164","author":"Siegel","year":"2011","journal-title":"Br J Dermatol"},{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib38","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.3892\/mmr.2016.5760","article-title":"Molecular screening strategies for NF1-like syndromes with caf\u00e9-au-lait macules (Review)","volume":"14","author":"Zhang","year":"2016","journal-title":"Mol Med Rep"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib39","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1525-1470.2012.01858.x","article-title":"Association of piebaldism, multiple caf\u00e9-au-lait macules, and intertriginous freckling: clinical evidence of a common pathway between KIT and sprouty-related, Ena\/vasodilator-stimulated phosphoprotein homology-1 domain containing protein 1 (SPRED1)","volume":"30","author":"Chiu","year":"2013","journal-title":"Pediatr Dermatol"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib40","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/bjd.14694","article-title":"Report of a child with sporadic familial progressive hyper- and hypopigmentation caused by a novel KITLG mutation","volume":"175","author":"Zhang","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.det.2021.08.002_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.clindermatol.2020.03.005","article-title":"Caf\u00e9 au lait spots: when and how to pursue their genetic origins","author":"Lalor","year":"2020","journal-title":"Clin Dermatol"},{"issue":"2","key":"10.1016\/j.det.2021.08.002_bib42","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000247313","article-title":"Cutaneous findings in ring chromosome 7 syndrome","volume":"186","author":"Rotern","year":"1993","journal-title":"Dermatology"},{"issue":"2","key":"10.1016\/j.det.2021.08.002_bib43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/humu.20657","article-title":"RNA-based mutation analysis identifies an unusual MSH6 splicing defect and circumvents PMS2 pseudogene interference","volume":"29","author":"Etzler","year":"2008","journal-title":"Hum Mutat"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib44","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.jaad.2012.12.950","article-title":"Dermatologic manifestations of ataxia-telangiectasia syndrome","volume":"68","author":"Greenberger","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"12","key":"10.1016\/j.det.2021.08.002_bib45","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/archderm.1997.03890480059008","article-title":"Skin abnormalities in neurofibromatosis 2","volume":"133","author":"Mautner","year":"1997","journal-title":"Arch Dermatol"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib46","first-page":"603","article-title":"A\u00a0clinical study of Type 2 neurofibromatosis","volume":"84","author":"Evans","year":"1992","journal-title":"Q\u00a0J Med"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2005-837581","article-title":"Earliest clinical manifestations and natural history of neurofibromatosis type 2 (NF2) in childhood: a study of 24 patients","volume":"36","author":"Ruggieri","year":"2005","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.det.2021.08.002_bib48","first-page":"743","article-title":"Osteitis fibrosa cystica\u202f: the case of a nine year old girl who also exhibits precocious puberty, multiple pigmentation of the skin and hyperthyroidism","volume":"52","author":"Mccune","year":"1936","journal-title":"Am J Dis Child"},{"issue":"2","key":"10.1016\/j.det.2021.08.002_bib49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2133.1994.tb02903.x","article-title":"Melanotic macules following Blaschko\u2019s lines in McCune-Albright syndrome","volume":"130","author":"Rieger","year":"1994","journal-title":"Br J Dermatol"},{"issue":"9","key":"10.1016\/j.det.2021.08.002_bib50","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jama.1968.03140350028006","article-title":"Melanotic Macules in Albright\u2019s syndrome and in neurofibromatosis","volume":"205","author":"Benedict","year":"1968","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.det.2021.08.002_bib51","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1136\/archdischild-2016-312001","article-title":"Cutaneous manifestations of tuberous sclerosis complex and the paediatrician\u2019s role","volume":"102","author":"Cardis","year":"2017","journal-title":"Arch Dis Child"},{"issue":"12","key":"10.1016\/j.det.2021.08.002_bib52","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1046\/j.1365-4362.1998.00495.x","article-title":"Skin lesions in children with tuberous sclerosis complex: Their prevalence, natural course, and diagnostic significance","volume":"37","author":"J\u00f3\u017awiak","year":"1998","journal-title":"Int J Dermatol"},{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib53","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/ajmg.1320450518","article-title":"Autosomal dominant multiple cafe-au-lait spots and neurofibromatosis-1: evidence of non-linkage","volume":"45","author":"Charrow","year":"1993","journal-title":"Am J Med Genet"},{"issue":"12","key":"10.1016\/j.det.2021.08.002_bib54","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/jmg.32.12.985","article-title":"Familial caf\u00e9 au lait spots: a variant of neurofibromatosis type 1","volume":"32","author":"Abeliovich","year":"1995","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.det.2021.08.002_bib56","doi-asserted-by":"crossref","DOI":"10.1111\/1346-8138.13169","article-title":"Diagnostic value of multiple caf\u00e9-au-lait macules for neurofibromatosis 1 in Chinese children","author":"Yao","year":"2016","journal-title":"J\u00a0Dermatol"},{"issue":"6 I","key":"10.1016\/j.det.2021.08.002_bib57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0190-9622(99)70075-7","article-title":"The diagnostic value of cafe-au-lait macules","volume":"40","author":"Landau","year":"1999","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.det.2021.08.002_bib58","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/ajmg.a.33235","article-title":"Speech-language characteristics of children with neurofibromatosis type 1","volume":"152","author":"Thompson","year":"2010","journal-title":"Am J Med Genet A"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib59","doi-asserted-by":"crossref","first-page":"e1642","DOI":"10.1542\/peds.2013-1868","article-title":"Neurofibromatosis type 1 and autism spectrum disorder","volume":"132","author":"Garg","year":"2013","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.det.2021.08.002_bib60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/1087054707299398","article-title":"Early grade repetition and inattention associated with neurofibromatosis type 1","volume":"11","author":"Coud","year":"2007","journal-title":"J\u00a0Atten Disord"},{"issue":"4","key":"10.1016\/j.det.2021.08.002_bib61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1096-8628(19991203)87:4<317::AID-AJMG7>3.0.CO;2-X","article-title":"Neurofibromatosis type I growth charts","volume":"87","author":"Clementi","year":"1999","journal-title":"Am J Med Genet"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib62","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/jamadermatol.2013.6434","article-title":"Juvenile xanthogranuloma and nevus anemicus in the diagnosis of neurofibromatosis type 1","volume":"150","author":"Ferrari","year":"2014","journal-title":"JAMA Dermatol"},{"issue":"5","key":"10.1016\/j.det.2021.08.002_bib63","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jaad.2013.06.039","article-title":"Nevus anemicus in neurofibromatosis type 1: a potential new diagnostic criterion","volume":"69","author":"Marque","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"6","key":"10.1016\/j.det.2021.08.002_bib64","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ejim.2014.04.004","article-title":"Is it time to change the neurofibromatosis 1 diagnostic criteria?","volume":"25","author":"Tadini","year":"2014","journal-title":"Eur J Intern Med"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00125817-200205000-00002","article-title":"Cardiovascular disease in neurofibromatosis 1: Report of the NF1 Cardiovascular Task Force","volume":"4","author":"Friedman","year":"2002","journal-title":"Genet Med"},{"issue":"1","key":"10.1016\/j.det.2021.08.002_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-020-1310-3","article-title":"Neurofibromatosis 1 French national guidelines based on an extensive literature review since 1966","volume":"15","author":"Bergqvist","year":"2020","journal-title":"Orphanet J Rare Dis"},{"issue":"10","key":"10.1016\/j.det.2021.08.002_bib67","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1007\/s00381-020-04731-2","article-title":"Current status of MEK inhibitors in the treatment of plexiform neurofibromas","volume":"36","author":"Gross","year":"2020","journal-title":"Child\u2019s Nerv Syst"},{"issue":"3","key":"10.1016\/j.det.2021.08.002_bib68","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ajmg.a.20650","article-title":"Outcomes of systematic screening for optic pathway tumors in children with Neurofibromatosis Type 1","volume":"127A","author":"Blazo","year":"2004","journal-title":"Am J Med Genet"},{"issue":"4","key":"10.1016\/j.det.2021.08.002_bib69","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00439-017-1766-y","article-title":"Emerging genotype\u2013phenotype relationships in patients with large NF1 deletions","volume":"136","author":"Kehrer-Sawatzki","year":"2017","journal-title":"Hum Genet"}],"container-title":["Dermatologic Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073386352100067X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073386352100067X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:45:14Z","timestamp":1760006714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073386352100067X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S073386352100067X"],"URL":"https:\/\/doi.org\/10.1016\/j.det.2021.08.002","relation":{},"ISSN":["0733-8635"],"issn-type":[{"value":"0733-8635","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Updated Approach to Patients with Multiple Caf\u00e9 au Lait Macules","name":"articletitle","label":"Article Title"},{"value":"Dermatologic Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.det.2021.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}