{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:07:17Z","timestamp":1772172437403,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Brain Research"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1016\/j.devbrainres.2003.10.016","type":"journal-article","created":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T10:17:38Z","timestamp":1078309058000},"page":"201-207","source":"Crossref","is-referenced-by-count":47,"title":["Prenatal cannabinoid exposure and gene expression for neural adhesion molecule L1 in the fetal rat brain"],"prefix":"10.1016","volume":"147","author":[{"given":"Mar\u0131\u0301a","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariluz","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"de Miguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Fern\u00e1ndez-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.devbrainres.2003.10.016_BIB1","series-title":"Atlas of Prenatal Rat Brain Development","author":"Altman","year":"1993"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1006\/mcne.2000.0879","article-title":"Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain","volume":"16","author":"Alvarez-Dolado","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1192\/bjp.178.2.101","article-title":"Pharmacology and effects of cannabis: a brief review","volume":"178","author":"Ashton","year":"2001","journal-title":"Br. J. Psychiatr."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3109\/10826089309062191","article-title":"The consequences of prenatal substance use for the developing fetus, newborn, and young child","volume":"28","author":"Behnke","year":"1993","journal-title":"Int. J. Addict."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB5","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/dev.125.16.3179","article-title":"Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development","volume":"125","author":"Berrendero","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0165-3806(94)90079-5","article-title":"Changes in tyrosine hydroxylase gene expression in mesencephalic catecholaminergic neurons of immature and adult male rats perinatally exposed to cannabinoids","volume":"81","author":"Bonnin","year":"1994","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s004410050948","article-title":"The role of cell adhesion molecule L1 in axonal extension, growth cone motility, and signal transduction","volume":"290","author":"Burden-Galley","year":"1997","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0024-3205(98)00341-5","article-title":"Perinatal \u03949-tetrahydrocannabinol exposure reduces proenkephalin gene expression in the caudate\u2013putamen of adult female rats","volume":"63","author":"Corchero","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/ng1197-346","article-title":"Disruption of the mouse L1 gene leads to malformations of the nervous system","volume":"17","author":"Dahme","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB10","first-page":"345","article-title":"Cannabinoid exposure: effects on development","volume":"8","author":"Dalterio","year":"1986","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB11","first-page":"119","article-title":"Maternal cannabinoid exposure and brain development: changes in the ontogeny of dopaminergic neurons","volume":"vol. IV","author":"Fern\u00e1ndez-Ruiz","year":"1992"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0024-3205(99)00295-7","article-title":"Role of endocannabinoids in brain development","volume":"65","author":"Fern\u00e1ndez-Ruiz","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0166-2236(99)01491-5","article-title":"The endogenous cannabinoid system and brain development","volume":"23","author":"Fern\u00e1ndez-Ruiz","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1054\/plef.2001.0360","article-title":"Endocannabinoids in the central nervous system\u2014an overview","volume":"66","author":"Fride","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0892-0362(00)00119-7","article-title":"A literature review of the consequences of prenatal marihuana exposure. An emerging theme of a deficiency in aspects of executive function","volume":"23","author":"Fried","year":"2001","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0014-5793(91)81350-H","article-title":"Demonstration of L1-related mRNAs in brain using DNA oligonucleotide probe","volume":"294","author":"Gaardsvoll","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0376-8716(96)01276-8","article-title":"Perinatal \u03949-tetrahydrocannabinol exposure in rats modifies the responsiveness of midbrain dopaminergic neurons in adulthood to a variety of challenges with dopaminergic drugs","volume":"42","author":"Garc\u0131\u0301a-Gil","year":"1996","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0006-8993(99)02322-7","article-title":"Cannabinoid CB1 receptors colocalize with tyrosine hydroxylase in cultured fetal mesencephalic neurons and their activation increases the levels of this enzyme","volume":"857","author":"Hern\u00e1ndez","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/(SICI)1097-4547(20000601)60:5<579::AID-JNR2>3.0.CO;2-#","article-title":"Differential expression of alternatively spliced neural cell adhesion molecule L1 isoforms during oligodendrocyte maturation","volume":"60","author":"Itoh","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB20","first-page":"1440","article-title":"Gene expression of neural cell adhesion molecule L1 in malignant gliomas and biological significance of L1 in glioma invasion","volume":"56","author":"Izumoto","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0006-8993(90)91322-8","article-title":"Effect of early exposure to \u03949-tetrahydrocannabinol on the levels of opioid peptides, gonadotropin-releasing hormone and substance P in the adult male rat brain","volume":"525","author":"Kumar","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB22","doi-asserted-by":"crossref","first-page":"32886","DOI":"10.1016\/S0021-9258(20)30074-0","article-title":"Expression of neural axon adhesion molecule L1 in the developing and adult rat brain","volume":"269","author":"Liljelund","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0165-6147(99)01339-5","article-title":"Pharmacological and biochemical interactions between opioids and cannabinoids","volume":"20","author":"Manzanares","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0892-0362(87)90023-7","article-title":"Neonatal administration of \u03949-tetrahydrocannabinol alters the neurochemical response to stress in the adult Fischer-344 rat","volume":"9","author":"Mokler","year":"1987","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-2999(96)00753-4","article-title":"Effect of maternal \u03949-tetrahydrocannabinol on developing serotonergic system","volume":"316","author":"Molina-Holgado","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/334701a0","article-title":"Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin","volume":"334","author":"Moos","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB27","first-page":"73","article-title":"Psychoactive and non-psychoactive cannabinoids and their effects on reproductive neuroendocrine parameters","volume":"vol. 2","author":"Murphy","year":"1990"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0091-3057(94)90110-4","article-title":"Motor behavior and nigrostriatal dopaminergic activity in adult rats perinatally exposed to cannabinoids","volume":"47","author":"Navarro","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0166-4328(96)00176-3","article-title":"Perinatal cannabinoid exposure modifies the sociosexual approach behavior and the mesolimbic dopaminergic activity of adult male rats","volume":"75","author":"Navarro","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB30","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2741\/1014","article-title":"Cellular signalling mechanisms of neural cell adhesion molecules","volume":"8","author":"Panicker","year":"2003","journal-title":"Front. Biosci."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-3806(99)00170-4","article-title":"Prenatal \u03949-tetrahydrocannabinol exposure modifies proenkephalin gene expression in the fetal rat brain: sex-dependent differences","volume":"120","author":"P\u00e9rez-Rosado","year":"2000","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/10298420290023936","article-title":"Changes in prodynorphin and POMC gene expression in several brain regions of rat fetuses prenatally exposed to \u03949-tetrahydrocannabinol","volume":"4","author":"P\u00e9rez-Rosado","year":"2002","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB33","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0306-4522(91)90329-M","article-title":"Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons","volume":"43","author":"Rodr\u0131\u0301guez de Fonseca","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1098-2396(199707)26:3<317::AID-SYN12>3.0.CO;2-S","article-title":"Atypical location of cannabinoid receptors in white matter areas during rat brain development","volume":"26","author":"Romero","year":"1997","journal-title":"Synapse"},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB35","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.115.2.473","article-title":"Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes","volume":"115","author":"Saad","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB36","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1471-4159.1986.tb04533.x","article-title":"Probable identity of NILE glycoprotein and the high-molecular-weight component of L1 antigen","volume":"47","author":"Sajovic","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB37","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1073\/pnas.82.4.1276","article-title":"Involvement of the nerve growth factor-inducible large external glycoprotein (NILE) in neurite fasciculation in primary cultures of rat brain","volume":"82","author":"Stallcup","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0006-8993(95)00255-O","article-title":"Perinatal exposure to \u03949-tetrahydrocannabinol (\u03949-THC) leads to changes in opioid-related behavioral patterns in rats","volume":"680","author":"Vela","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0006-8993(98)00766-5","article-title":"Maternal exposure to \u03949-tetrahydrocannabinol facilitates morphine self-administration and changes \u03bc opioid receptor binding in brain regions related to drug reinforcement in adult offspring female rats","volume":"807","author":"Vela","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0091-3057(86)90384-9","article-title":"Changes in brain catecholamine mechanisms following perinatal exposure to marihuana","volume":"25","author":"Walters","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0091-3057(88)90300-0","article-title":"Perinatal exposure to cannabinoids alters neurochemical development in the rat brain","volume":"29","author":"Walters","year":"1988","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.devbrainres.2003.10.016_BIB42","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0166-2236(95)93896-6","article-title":"Mutations in the cell adhesion molecule L1 cause mental retardation","volume":"18","author":"Wong","year":"1995","journal-title":"Trends Neurosci."}],"container-title":["Developmental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165380604000380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165380604000380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:23:22Z","timestamp":1623716602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165380604000380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":42,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0165380604000380"],"URL":"https:\/\/doi.org\/10.1016\/j.devbrainres.2003.10.016","relation":{},"ISSN":["0165-3806"],"issn-type":[{"value":"0165-3806","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}