{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:40Z","timestamp":1788870220606,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3119,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM08798"],"award-info":[{"award-number":["T32 GM08798"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.devcel.2004.11.015","type":"journal-article","created":{"date-parts":[[2005,1,4]],"date-time":"2005-01-04T07:16:53Z","timestamp":1104823013000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["lin-35 Rb Acts in the Major Hypodermis to Oppose Ras-Mediated Vulval Induction in C. elegans"],"prefix":"10.1016","volume":"8","author":[{"given":"Toshia R.","family":"Myers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Greenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2004.11.015_BIB1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/348693a0","article-title":"The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily","volume":"348","author":"Aroian","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2004.11.015_BIB2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/348503a0","article-title":"Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction","volume":"348","author":"Beitel","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2004.11.015_BIB3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0960-9822(02)00844-8","article-title":"C. elegans class B synthetic multivulva genes act in G(1) regulation","volume":"12","author":"Boxem","year":"2002","journal-title":"Curr. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2004.11.015_BIB5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0896-6273(04)00246-6","article-title":"Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position","volume":"42","author":"B\u00fclow","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.devcel.2004.11.015_BIB6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1097-2765(01)00194-0","article-title":"dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development","volume":"7","author":"Ceol","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2004.11.015_BIB7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S1534-5807(04)00065-6","article-title":"A new class of C. elegans synMuv genes implicates a Tip60\/NuA4-like HAT complex as a negative regulator of Ras signaling","volume":"6","author":"Ceol","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2004.11.015_BIB8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1534-5807(04)00021-8","article-title":"The lateral signal for LIN-12\/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins","volume":"6","author":"Chen","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2004.11.015_BIB9","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0960-9822(01)00596-6","article-title":"C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification","volume":"11","author":"Chen","year":"2001","journal-title":"Curr. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1526-968X(200004)26:4<279::AID-GENE100>3.0.CO;2-C","article-title":"The synthetic multivulval genes of C. elegans","volume":"26","author":"Fay","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2004.11.015_BIB11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1101\/gad.952302","article-title":"fzr-1 and lin-35\/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen","volume":"16","author":"Fay","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.devcel.2004.11.015_BIB12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/genetics\/110.1.17","article-title":"Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans","volume":"110","author":"Ferguson","year":"1985","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2004.11.015_BIB13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/genetics\/123.1.109","article-title":"The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways","volume":"123","author":"Ferguson","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2004.11.015_BIB14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/326259a0","article-title":"A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans","volume":"326","author":"Ferguson","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2004.11.015_BIB15","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1242\/jcs.01227","article-title":"Molecular mechanisms of E2F-dependent activation and pRB-mediated repression","volume":"117","author":"Frolov","year":"2004","journal-title":"J. Cell Sci"},{"key":"10.1016\/j.devcel.2004.11.015_BIB16","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1128\/MCB.17.4.2301","article-title":"cis regulatory requirements for hypodermal cell-specific expression of the Caenorhabditis elegans cuticle collagen gene dpy-7","volume":"17","author":"Gilleard","year":"1997","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB17","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1101\/gad.981602","article-title":"Activation of Wnt signaling bypasses the requirement for RTK\/Ras signaling during C. elegans vulval induction","volume":"16","author":"Gleason","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.devcel.2004.11.015_BIB18","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1101\/gad.5.12a.2188","article-title":"Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene","volume":"5","author":"Han","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/j.devcel.2004.11.015_BIB19","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/genetics\/141.3.989","article-title":"The ncl-1 gene and genetic mosaics of Caenorhabditis elegans","volume":"141","author":"Hedgecock","year":"1995","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2004.11.015_BIB20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/348169a0","article-title":"Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis","volume":"348","author":"Herman","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2004.11.015_BIB21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/358470a0","article-title":"The gene lin-3 encodes an inductive signal for vulval development in C. elegans","volume":"358","author":"Hill","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2004.11.015_BIB22","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1101\/gad.13.22.2958","article-title":"The RING finger\/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans","volume":"13","author":"Hsieh","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.devcel.2004.11.015_BIB23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0168-9525(97)01005-6","article-title":"Vulval development in Caenorhabditis elegans","volume":"13","author":"Kornfeld","year":"1997","journal-title":"Trends Genet"},{"key":"10.1016\/j.devcel.2004.11.015_BIB24","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0092-8674(00)81722-5","article-title":"lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48","volume":"95","author":"Lu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2004.11.015_BIB25","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/genetics\/155.3.1127","article-title":"Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif","volume":"155","author":"Mel\u00e9ndez","year":"2000","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2004.11.015_BIB26","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1242\/dev.124.20.3965","article-title":"The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development","volume":"124","author":"Okkema","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.devcel.2004.11.015_BIB27","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.cub.2004.07.059","article-title":"EFF-1 is sufficient to initiate and execute tissue-specific cell fusion in C. elegans","volume":"14","author":"Shemer","year":"2004","journal-title":"Curr. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0960-9822(00)00343-2","article-title":"NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans","volume":"10","author":"Solari","year":"2000","journal-title":"Curr. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0012-1606(83)90201-4","article-title":"The embryonic cell lineage of the nematode Caenorhabditis elegans","volume":"100","author":"Sulston","year":"1983","journal-title":"Dev. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB30","doi-asserted-by":"crossref","first-page":"R311","DOI":"10.1016\/j.cub.2004.03.052","article-title":"Vulval development","volume":"14","author":"Sundaram","year":"2004","journal-title":"Curr. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)81186-1","article-title":"MAP kinase signaling specificity mediated by the LIN-1 Ets\/LIN-31 WH transcription factor complex during C. elegans vulval induction","volume":"93","author":"Tan","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2004.11.015_BIB32","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1242\/dev.126.15.3449","article-title":"The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway","volume":"126","author":"Thomas","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.devcel.2004.11.015_BIB33","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1242\/dev.127.24.5277","article-title":"The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination","volume":"127","author":"von Zelewsky","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.devcel.2004.11.015_BIB34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0070-2153(01)51006-6","article-title":"Pattern formation during C. elegans vulval induction","volume":"51","author":"Wang","year":"2001","journal-title":"Curr. Top. Dev. Biol"},{"key":"10.1016\/j.devcel.2004.11.015_BIB35","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1242\/dev.00701","article-title":"Investigating C. elegans development through mosaic analysis","volume":"130","author":"Yochem","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.devcel.2004.11.015_BIB36","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/genetics\/149.3.1323","article-title":"A new marker for mosaic analysis in Caenorhabditis elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis","volume":"149","author":"Yochem","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2004.11.015_BIB37","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.1091639","article-title":"Crosstalk between the EGFR and LIN-12\/Notch pathways in C. elegans vulval development","volume":"303","author":"Yoo","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.devcel.2004.11.015_BIB38","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.1073\/pnas.100127597","article-title":"An efficient recombination system for chromosome engineering in Escherichia coli","volume":"97","author":"Yu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580704004228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580704004228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:14:06Z","timestamp":1761520446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580704004228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S1534580704004228"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2004.11.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1023285.323076","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1023285.270642","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"lin-35 Rb Acts in the Major Hypodermis to Oppose Ras-Mediated Vulval Induction in C. elegans","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2004.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}