{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:33:38Z","timestamp":1791326018324,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1750,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100002322","name":"Schlumberger Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005326","name":"Yale University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM49370"],"award-info":[{"award-number":["GM49370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.devcel.2008.08.017","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T11:49:53Z","timestamp":1224071393000},"page":"617-626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila"],"prefix":"10.1016","volume":"15","author":[{"given":"Huaping","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria","family":"Kambris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lemaitre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2008.08.017_bib1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.08.017_bib2","doi-asserted-by":"crossref","first-page":"10698","DOI":"10.1073\/pnas.92.23.10698","article-title":"Role of the integument in insect defense: pro-phenol oxidase cascade in the cuticular matrix","volume":"92","author":"Ashida","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2008.08.017_bib3","doi-asserted-by":"crossref","first-page":"14337","DOI":"10.1073\/pnas.95.24.14337","article-title":"Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes","volume":"95","author":"Braun","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2008.08.017_bib4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bbrc.2005.10.042","article-title":"The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila","volume":"338","author":"Castillejo-Lopez","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.devcel.2008.08.017_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.0105-2896.2004.00116.x","article-title":"The prophenoloxidase-activating system in invertebrates","volume":"198","author":"Cerenius","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.devcel.2008.08.017_bib6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1534-5807(02)00267-8","article-title":"An immune-responsive Serpin regulates the melanization cascade in Drosophila","volume":"3","author":"De Gregorio","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2008.08.017_bib7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0896-6273(03)00094-1","article-title":"Integrating the molecular and cellular basis of odor coding in the Drosophila antenna","volume":"37","author":"Dobritsa","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.devcel.2008.08.017_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gene.10150","article-title":"GAL4 system in Drosophila: a fly geneticist's Swiss army knife","volume":"34","author":"Duffy","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2008.08.017_bib9","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/emboj\/17.5.1217","article-title":"A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway","volume":"17","author":"Ferrandon","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2008.08.017_bib10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri2194","article-title":"The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections","volume":"7","author":"Ferrandon","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.devcel.2008.08.017_bib11","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.cell.2006.10.046","article-title":"Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors","volume":"127","author":"Gottar","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.08.017_bib12","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1117311","article-title":"A direct role for dual oxidase in Drosophila gut immunity","volume":"310","author":"Ha","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.08.017_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.embor.7400592","article-title":"Prophenoloxidase activation is not required for survival to microbial infections in Drosophila","volume":"7","author":"Leclerc","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.devcel.2008.08.017_bib14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1046-2023(03)00051-3","article-title":"Making a better RNAi vector for Drosophila: use of intron spacers","volume":"30","author":"Lee","year":"2003","journal-title":"Methods"},{"key":"10.1016\/j.devcel.2008.08.017_bib15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.devcel.2008.08.017_bib16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene cassette spatzle\/Toll\/cactus controls the potent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.08.017_bib17","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.285.5435.1917","article-title":"Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila","volume":"285","author":"Levashina","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.08.017_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1126\/science.1072391","article-title":"Activation of Drosophila Toll during fungal infection by a blood serine protease","volume":"297","author":"Ligoxygakis","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.08.017_bib19","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1093\/emboj\/cdf661","article-title":"A serpin mutant links Toll activation to melanization in the host defence of Drosophila","volume":"21","author":"Ligoxygakis","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2008.08.017_bib20","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/genetics\/153.4.1789","article-title":"Genetic characterization of cytological region 77A-D harboring the presenilin gene of Drosophila melanogaster","volume":"153","author":"Lukinova","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2008.08.017_bib21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: a renewed sense of self","volume":"296","author":"Matzinger","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.08.017_bib22","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.1089035","article-title":"Spatiotemporal rescue of memory dysfunction in Drosophila","volume":"302","author":"McGuire","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.08.017_bib23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2008.08.017_bib24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1056\/NEJM200008033430506","article-title":"Innate immunity","volume":"343","author":"Medzhitov","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.devcel.2008.08.017_bib25","doi-asserted-by":"crossref","first-page":"15050","DOI":"10.1073\/pnas.261408198","article-title":"A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila","volume":"98","author":"Morin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2008.08.017_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0925-4773(98)00157-9","article-title":"Gal4 in the Drosophila female germline","volume":"78","author":"Rorth","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2008.08.017_bib27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ydbio.2006.03.019","article-title":"The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation","volume":"295","author":"Scherfer","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2008.08.017_bib28","doi-asserted-by":"crossref","first-page":"13705","DOI":"10.1073\/pnas.212301199","article-title":"Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd\/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae","volume":"99","author":"Takehana","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2008.08.017_bib29","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1038\/sj.emboj.7600466","article-title":"Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity","volume":"23","author":"Takehana","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2008.08.017_bib30","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M601642200","article-title":"Two proteases defining a melanization cascade in the immune system of Drosophila","volume":"281","author":"Tang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2008.08.017_bib31","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1074-7613(00)00072-8","article-title":"Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia","volume":"13","author":"Tzou","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.devcel.2008.08.017_bib32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0580-9517(02)31028-6","article-title":"Methods for studying infection and immunity in Drosophila","volume":"31","author":"Tzou","year":"2001","journal-title":"Methods Microbiol."},{"key":"10.1016\/j.devcel.2008.08.017_bib33","series-title":"Hemocytic and Humoral Immunity in Arthropods","first-page":"89","article-title":"Antifungal cellular defense mechanisms in insects","author":"Vey","year":"1986"},{"key":"10.1016\/j.devcel.2008.08.017_bib34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.iac.2006.08.004","article-title":"Structure and function of C1-inhibitor","volume":"26","author":"Wagenaar-Bos","year":"2006","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.devcel.2008.08.017_bib35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0168-9525(03)00194-X","article-title":"Evolution in black and white: genetic control of pigment patterns in Drosophila","volume":"19","author":"Wittkopp","year":"2003","journal-title":"Trends Genet."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580708003419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580708003419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:20:05Z","timestamp":1761520805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580708003419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S1534580708003419"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2008.08.017","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2008.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}