{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:18:51Z","timestamp":1791314331424,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1719,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["3749"],"award-info":[{"award-number":["3749"]}],"id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00c3\u00b6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-05-BLAN-0231-01"],"award-info":[{"award-number":["ANR-05-BLAN-0231-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.devcel.2008.09.011","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T09:54:33Z","timestamp":1226483673000},"page":"714-724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["Plasticity and Errors of a Robust Developmental System in Different Environments"],"prefix":"10.1016","volume":"15","author":[{"given":"Christian","family":"Braendle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2008.09.011_bib1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cub.2005.06.022","article-title":"High local genetic diversity and low outcrossing rate in Caenorhabditis elegans natural populations","volume":"15","author":"Barri\u00e8re","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2008.09.011_bib2","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1242\/dev.00497","article-title":"The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS\/MAPK signalling during olfaction and vulval development","volume":"130","author":"Battu","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.devcel.2008.09.011_bib3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.1055642","article-title":"Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C.\u00a0elegans vulval development","volume":"291","author":"Berset","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.09.011_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0070-2153(07)80005-6","article-title":"Mechanisms and evolution of environmental responses in Caenorhabditis elegans","volume":"80","author":"Braendle","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.devcel.2008.09.011_bib5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1006\/dbio.1996.8471","article-title":"Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal","volume":"182","author":"Clandinin","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2008.09.011_bib6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0960-9822(01)00202-0","article-title":"Polymorphism and evolution of vulval precursor cell lineages within two nematode genera, Caenorhabditis and Oscheius","volume":"11","author":"Delattre","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2008.09.011_bib7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature02697","article-title":"High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome","volume":"430","author":"Denver","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2008.09.011_bib8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/sj.hdy.6801079","article-title":"Hakuna Nematoda: genetic and phenotypic diversity in African isolates of Caenorhabditis elegans and C.\u00a0briggsae","volume":"100","author":"Dolgin","year":"2007","journal-title":"Heredity"},{"key":"10.1016\/j.devcel.2008.09.011_bib9","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1242\/dev.125.18.3667","article-title":"The \u03b2-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development","volume":"125","author":"Eisenmann","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.devcel.2008.09.011_bib10","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1534-5807(03)00292-2","article-title":"Self-enhanced ligand degradation underlies robustness of morphogen gradients","volume":"5","author":"Eldar","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2008.09.011_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2007.03.016","article-title":"The SynMuv genes of Caenorhabditis elegans in vulval development and beyond","volume":"306","author":"Fay","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2008.09.011_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cub.2006.12.024","article-title":"Cryptic quantitative evolution of the vulva intercellular signaling network in Caenorhabditis","volume":"17","author":"F\u00e9lix","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2008.09.011_bib13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/genetics\/110.1.17","article-title":"Identification and characterization of\u00a022 genes that affect the vulval cell lineages of Caenorhabditis elegans","volume":"110","author":"Ferguson","year":"1985","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2008.09.011_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1086\/432265","article-title":"The evolutionary genetics of canalization","volume":"80","author":"Flatt","year":"2005","journal-title":"Q. Rev. Biol."},{"key":"10.1016\/j.devcel.2008.09.011_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrg1426","article-title":"Uncovering cryptic genetic variation","volume":"5","author":"Gibson","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2008.09.011_bib16","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1073\/pnas.0506476103","article-title":"Intercellular coupling amplifies fate segregation during Caenorhabditis elegans vulval development","volume":"103","author":"Giurumescu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2008.09.011_bib17","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1101\/gad.981602","article-title":"Activation of\u00a0Wnt signaling bypasses the requirement for RTK\/Ras signaling during C.\u00a0elegans vulval induction","volume":"16","author":"Gleason","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2008.09.011_bib18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/346197a0","article-title":"Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans","volume":"346","author":"Greenwald","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2008.09.011_bib19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0092-8674(83)90377-X","article-title":"The lin-12 locus specifies cell fates in Caenorhabditis elegans","volume":"34","author":"Greenwald","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.09.011_bib20","series-title":"Phenotypic Integration: Studying the Ecology and Evolution of Complex Phenotypes","article-title":"Evolvability, stabilizing selection, and the problem of stasis","author":"Hansen","year":"2004"},{"key":"10.1016\/j.devcel.2008.09.011_bib21","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/415798a","article-title":"Establishment of\u00a0developmental precision and proportions in the early Drosophila embryo","volume":"415","author":"Houchmandzadeh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2008.09.011_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1567-133X(02)00055-8","article-title":"Gene expression markers for Caenorhabditis elegans vulval cells","volume":"2","author":"Inoue","year":"2002","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.devcel.2008.09.011_bib23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2004.09.001","article-title":"C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17\/Frizzled in Wnt signaling","volume":"118","author":"Inoue","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.09.011_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0092-8674(95)90317-8","article-title":"Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates","volume":"82","author":"Katz","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.09.011_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0092-8674(95)90302-X","article-title":"A perfect vulva every time: Gradients and signalling cascades in C. elegans","volume":"82","author":"Kenyon","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.09.011_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.8.1.60","article-title":"unc-101, a gene required for many aspects of C. elegans development and behavior, encodes a clathrin-associated protein","volume":"8","author":"Lee","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2008.09.011_bib27","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/nature03509","article-title":"Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics","volume":"434","author":"Lucchetta","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2008.09.011_bib28","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1073\/pnas.0702207104","article-title":"The frailty of adaptive hypotheses for the origins of organismal complexity","volume":"104","author":"Lynch","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2008.09.011_bib29","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0169-5347(02)02596-X","article-title":"A single mode of canalization","volume":"17","author":"Meiklejohn","year":"2002","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.devcel.2008.09.011_bib30","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1242\/dev.00670","article-title":"Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein G\u03b1q and excitable cells in C. elegans","volume":"130","author":"Moghal","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.devcel.2008.09.011_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1525-142X.2003.03035.x","article-title":"A mechanistic study of evolvability using the mitogen-activated protein kinase cascade","volume":"5","author":"Nijhout","year":"2003","journal-title":"Evol. Dev."},{"key":"10.1016\/j.devcel.2008.09.011_bib32","doi-asserted-by":"crossref","unstructured":"Sternberg, P.W. (2005). Vulval development, In Wormbook, the C. elegans Research Community, ed. (http:\/\/www.wormbook.org\/chapters\/www_vulvaldev\/vulvaldev.html). 10.1895\/wormbook.1891.1896.1891.","DOI":"10.1895\/wormbook.1.6.1"},{"key":"10.1016\/j.devcel.2008.09.011_bib33","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(86)90842-1","article-title":"Pattern formation during vulval development in Caenorhabditis elegans","volume":"44","author":"Sternberg","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2008.09.011_bib34","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1038\/sj.emboj.7601137","article-title":"Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development","volume":"25","author":"Stetak","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2008.09.011_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1046\/j.1525-142x.2001.003002109.x","article-title":"Developmental system drift and flexibility in evolutionary trajectories","volume":"3","author":"True","year":"2001","journal-title":"Evol. Dev."},{"key":"10.1016\/j.devcel.2008.09.011_bib36","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/j.0014-3820.2000.tb00557.x","article-title":"The fitness effects of spontaneous mutations in Caenorhabditis elegans","volume":"54","author":"Vassilieva","year":"2000","journal-title":"Evolution"},{"key":"10.1016\/j.devcel.2008.09.011_bib37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/35018085","article-title":"The segment polarity network is a robust developmental module","volume":"406","author":"von Dassow","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2008.09.011_bib38","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/150563a0","article-title":"Canalization of development and the inheritance of acquired characters","volume":"150","author":"Waddington","year":"1942","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2008.09.011_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mod.2005.11.003","article-title":"Transcriptional upregulation of the C. elegans Hox gene lin-39 during vulval cell fate specification","volume":"123","author":"Wagmaister","year":"2006","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2008.09.011_bib40","series-title":"Robustness and Evolvability In Living Systems","author":"Wagner","year":"2005"},{"key":"10.1016\/j.devcel.2008.09.011_bib41","series-title":"The Nematode Caenorhabditis elegans","author":"Wood","year":"1988"},{"key":"10.1016\/j.devcel.2008.09.011_bib42","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1126\/science.1119481","article-title":"LIN-12\/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans","volume":"310","author":"Yoo","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.09.011_bib43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.1091639","article-title":"Crosstalk between the EGFR and\u00a0LIN-12\/Notch pathways in C. elegans vulval development","volume":"303","author":"Yoo","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.devcel.2008.09.011_bib44","doi-asserted-by":"crossref","first-page":"10086","DOI":"10.1073\/pnas.0610799104","article-title":"Evolution of robustness in the signaling network of Pristionchus vulva development","volume":"104","author":"Zauner","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580708003936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580708003936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:18:47Z","timestamp":1761520727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580708003936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1534580708003936"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2008.09.011","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1142006.751075","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1142006.599122","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasticity and Errors of a Robust Developmental System in Different Environments","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2008.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}