{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:32:38Z","timestamp":1791613958033,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-T32-AI07047"],"award-info":[{"award-number":["NIH-T32-AI07047"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI065474"],"award-info":[{"award-number":["R01-AI065474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.devcel.2009.09.009","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T03:14:24Z","timestamp":1258514064000},"page":"699-711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":519,"title":["A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting"],"prefix":"10.1016","volume":"17","author":[{"given":"Timothy S.","family":"Gomez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Billadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2009.09.009_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200312055","article-title":"Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor","volume":"165","author":"Arighi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ceb.2008.03.009","article-title":"Retromer","volume":"20","author":"Bonifacino","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cell.2008.05.032","article-title":"WHAMM is an Arp2\/3 complex activator that binds microtubules and functions in ER to Golgi transport","volume":"134","author":"Campellone","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib4","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.cub.2004.09.077","article-title":"Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides","volume":"14","author":"Carlton","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib5","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ncb1007-1110","article-title":"The many faces of actin: matching assembly factors with cellular structures","volume":"9","author":"Chhabra","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nrm2427","article-title":"Endosomal sorting and signalling: an emerging role for sorting nexins","volume":"9","author":"Cullen","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib7","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1073\/pnas.0610275104","article-title":"WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP)","volume":"104","author":"de la Fuente","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.09.009_bib8","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.devcel.2009.09.010","article-title":"The Arp2\/3 activator WASH controls the fission of endosomes through a large multiprotein complex","volume":"17","author":"Derivery","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib9","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1073\/pnas.0400628101","article-title":"Purification and architecture of the ubiquitous Wave complex","volume":"101","author":"Gautreau","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.09.009_bib10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrm2026","article-title":"The ARP2\/3 complex: an actin nucleator comes of age","volume":"7","author":"Goley","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)00001-1","article-title":"T cell activation and the cytoskeleton: you can't have one without the other","volume":"97","author":"Gomez","year":"2008","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.devcel.2009.09.009_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni1168","article-title":"Dynamin 2 regulates T\u00a0cell activation by controlling actin polymerization at the immunological synapse","volume":"6","author":"Gomez","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.devcel.2009.09.009_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.immuni.2007.01.008","article-title":"Formins regulate the actin-related protein 2\/3 complex-independent polarization of the centrosome to the immunological synapse","volume":"26","author":"Gomez","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.devcel.2009.09.009_bib14","doi-asserted-by":"crossref","first-page":"15173","DOI":"10.1073\/pnas.0409558102","article-title":"Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2","volume":"102","author":"Griffin","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.09.009_bib15","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1091\/mbc.e03-09-0711","article-title":"A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking","volume":"15","author":"Gullapalli","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib16","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1091\/mbc.11.12.4105","article-title":"Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes","volume":"11","author":"Haft","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncb1105","article-title":"Abi1 is essential for the formation and activation of a WAVE2 signalling complex","volume":"6","author":"Innocenti","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib18","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1091\/mbc.10.7.2191","article-title":"Mapmodulin, cytoplasmic dynein, and microtubules enhance the transport of mannose 6-phosphate receptors from endosomes to the trans-golgi network","volume":"10","author":"Itin","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrm1940","article-title":"Harnessing actin dynamics for clathrin-mediated endocytosis","volume":"7","author":"Kaksonen","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib20","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1073\/pnas.0409120102","article-title":"Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation","volume":"102","author":"Leng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.09.009_bib21","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1371\/journal.pgen.0030237","article-title":"Human subtelomeric WASH genes encode a new subclass of the WASP family","volume":"3","author":"Linardopoulou","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.devcel.2009.09.009_bib22","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1242\/dev.035246","article-title":"Wash functions downstream of Rho and\u00a0links\u00a0linear and branched actin nucleation factors","volume":"136","author":"Liu","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.09.009_bib23","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1600-0854.2004.00225.x","article-title":"Association of Cdc42\/N-WASP\/Arp2\/3 signaling pathway with Golgi membranes","volume":"5","author":"Matas","year":"2004","journal-title":"Traffic"},{"key":"10.1016\/j.devcel.2009.09.009_bib24","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1091\/mbc.8.7.1361","article-title":"The yeast actin-related protein Arp2p is required for the internalization step of endocytosis","volume":"8","author":"Moreau","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0960-9822(98)70396-3","article-title":"The WASp homologue Las17p functions with the WIP homologue End5p\/verprolin and is essential for endocytosis in yeast","volume":"8","author":"Naqvi","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cub.2005.11.036","article-title":"The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T\u00a0cell activation","volume":"16","author":"Nolz","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib27","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1091\/mbc.e07-11-1189","article-title":"Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes","volume":"19","author":"Perez-Victoria","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","article-title":"Cellular motility driven by assembly and disassembly of actin filaments","volume":"112","author":"Pollard","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2009.09.009_bib29","doi-asserted-by":"crossref","first-page":"14671","DOI":"10.1073\/pnas.94.26.14671","article-title":"WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells","volume":"94","author":"Ramesh","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.09.009_bib30","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1128\/MCB.00156-06","article-title":"Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors","volume":"27","author":"Rojas","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib31","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1084\/jem.20062647","article-title":"Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1","volume":"204","author":"Sakata","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.devcel.2009.09.009_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200312034","article-title":"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer","volume":"165","author":"Seaman","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib33","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1242\/jcs.016709","article-title":"SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2","volume":"121","author":"Shin","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.devcel.2009.09.009_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ceb.2005.12.003","article-title":"Protein complexes regulating Arp2\/3-mediated actin assembly","volume":"18","author":"Stradal","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrm2069","article-title":"The WASP-WAVE protein network: connecting the membrane to the cytoskeleton","volume":"8","author":"Takenawa","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib36","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ncb1656","article-title":"SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment","volume":"9","author":"Traer","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib37","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/ncb1153","article-title":"The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor","volume":"6","author":"Verges","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2009.09.009_bib38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1242\/jcs.03302","article-title":"A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer","volume":"120","author":"Wassmer","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.devcel.2009.09.009_bib39","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1038\/ncb0402-e97","article-title":"Adhesion assembly, disassembly and turnover in migrating cells\u2013over and over and over again","volume":"4","author":"Webb","year":"2002","journal-title":"Nat. Cell Biol."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580709003918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580709003918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:21:10Z","timestamp":1761520870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580709003918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S1534580709003918"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2009.09.009","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1419956.896054","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2009.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2009.09.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}