{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:27:33Z","timestamp":1792718853086,"version":"4.5.0"},"reference-count":127,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1329,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.devcel.2009.12.010","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T04:41:28Z","timestamp":1263962488000},"page":"8-23","source":"Crossref","is-referenced-by-count":900,"title":["Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development"],"prefix":"10.1016","volume":"18","author":[{"given":"Edward E.","family":"Morrisey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid L.M.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2009.12.010_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1371\/journal.pgen.0010010","article-title":"Fog2 is required for normal diaphragm and lung development in mice and humans","volume":"1","author":"Ackerman","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1165\/rcmb.2006-0211RC","article-title":"Gata4 is necessary for normal pulmonary lobar development","volume":"36","author":"Ackerman","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrg2166","article-title":"The Decapentaplegic morphogen gradient: from pattern formation to growth regulation","volume":"8","author":"Affolter","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib4","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1242\/dev.014498","article-title":"Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture","volume":"135","author":"Affolter","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib5","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1002\/dvdy.21293","article-title":"Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development","volume":"236","author":"Alejandre-Alc\u00e1zar","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2009.12.010_bib6","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nrg2102","article-title":"Network motifs: theory and experimental approaches","volume":"8","author":"Alon","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.devcel.2004.12.004","article-title":"Sprouty1 is a critical regulator of GDNF\/RET-mediated kidney induction","volume":"8","author":"Basson","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0098-2997(03)00039-6","article-title":"Importance of vitamin-A for lung function and development","volume":"24","author":"Biesalski","year":"2003","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.devcel.2009.12.010_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0022-5320(76)80071-8","article-title":"Intimate cell contacts at the epithelial\/mesenchymal interface in embryonic mouse lung","volume":"55","author":"Bluemink","year":"1976","journal-title":"J. Ultrastruct. Res."},{"key":"10.1016\/j.devcel.2009.12.010_bib10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","article-title":"PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis","volume":"85","author":"Bostr\u00f6m","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib11","doi-asserted-by":"crossref","first-page":"38R","DOI":"10.1203\/01.PDR.0000159630.35883.BE","article-title":"Control mechanisms of lung alveolar development and their disorders in bronchopulmonary dysplasia","volume":"57","author":"Bourbon","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.devcel.2009.12.010_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molmed.2009.02.003","article-title":"Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets","volume":"15","author":"Bourbon","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.devcel.2009.12.010_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.gde.2005.04.010","article-title":"Genetic players in esophageal atresia and tracheoesophageal fistula","volume":"15","author":"Brunner","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.devcel.2009.12.010_bib14","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1242\/dev.02310","article-title":"Regulation of early lung morphogenesis: questions, facts and controversies","volume":"133","author":"Cardoso","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib15","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1172\/JCI4786","article-title":"Mutation of the\u00a0mouse hepatocyte nuclear factor\/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry","volume":"102","author":"Chen","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.devcel.2009.12.010_bib16","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1242\/dev.006221","article-title":"Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction","volume":"134","author":"Chen","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib17","first-page":"2914","article-title":"SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production","volume":"119","author":"Chen","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.devcel.2009.12.010_bib18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1101\/gad.1026303","article-title":"Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung","volume":"17","author":"Chuang","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2009.12.010_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1097-2765(02)00459-8","article-title":"Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4","volume":"9","author":"Cirillo","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib20","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1172\/JCI31731","article-title":"Wnt\/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling","volume":"117","author":"Cohen","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.devcel.2009.12.010_bib21","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1172\/JCI38079","article-title":"Wnt signaling regulates smooth muscle precursor development in the lung via a tenascin C\/PDGFR pathway","volume":"119","author":"Cohen","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.devcel.2009.12.010_bib22","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1242\/dev.128.11.2095","article-title":"Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme","volume":"128","author":"Colvin","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1432-0436.2006.00106.x","article-title":"Renal branching morphogenesis: concepts, questions, and recent advances","volume":"74","author":"Costantini","year":"2006","journal-title":"Differentiation"},{"key":"10.1016\/j.devcel.2009.12.010_bib24","doi-asserted-by":"crossref","first-page":"C171","DOI":"10.1152\/ajpcell.00226.2003","article-title":"Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium","volume":"287","author":"Daniely","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib25","first-page":"326","article-title":"The effects of intermittent starvation on lung development in suckling rats","volume":"117","author":"Das","year":"1984","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.devcel.2009.12.010_bib26","doi-asserted-by":"crossref","first-page":"e1516","DOI":"10.1371\/journal.pone.0001516","article-title":"Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling","volume":"3","author":"De Langhe","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.devcel.2009.12.010_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ydbio.2006.01.020","article-title":"Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung","volume":"293","author":"del Moral","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib28","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1165\/ajrcmb.16.5.9160839","article-title":"Early fetal development of lung vasculature","volume":"16","author":"deMello","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0955-0674(03)00004-8","article-title":"Negative receptor signalling","volume":"15","author":"Dikic","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib30","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.devcel.2008.03.003","article-title":"Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis","volume":"14","author":"Ewald","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib31","first-page":"286","article-title":"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine","volume":"198","author":"Fukushige","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/dbio.2000.0112","article-title":"Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells","volume":"230","author":"Gale","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1126\/science.1065175","article-title":"Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4","volume":"295","author":"Gaudet","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.devcel.2009.12.010_bib34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.devcel.2009.06.005","article-title":"Wnt2\/2b and \u03b2-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut","volume":"17","author":"Goss","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physrev.00022.2006","article-title":"Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted","volume":"87","author":"Greenlee","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.devcel.2009.12.010_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1164\/rccm.200904-0643ED","article-title":"Does low birth weight confer a lifelong respiratory disadvantage?","volume":"180","author":"Greenough","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.devcel.2009.12.010_bib37","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1242\/dev.029249","article-title":"Notch signaling promotes airway mucous metaplasia and inhibits alveolar development","volume":"136","author":"Guseh","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib38","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1073\/pnas.0510839103","article-title":"Dicer function is essential for lung epithelium morphogenesis","volume":"103","author":"Harris","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.12.010_bib39","doi-asserted-by":"crossref","first-page":"16287","DOI":"10.1073\/pnas.0902274106","article-title":"beta-Catenin promotes respiratory progenitor identity in mouse foregut","volume":"106","author":"Harris-Johnson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.12.010_bib40","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.devcel.2004.11.002","article-title":"The versatile roles of \u201caxon guidance\u201d cues in tissue morphogenesis","volume":"7","author":"Hinck","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib41","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1242\/dev.034157","article-title":"sonic hedgehog is required in pulmonary endoderm for atrial septation","volume":"136","author":"Hoffmann","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib42","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0012-1606(03)00114-3","article-title":"Heparan sulfate-FGF10 interactions during lung morphogenesis","volume":"258","author":"Izvolsky","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib43","doi-asserted-by":"crossref","first-page":"L370","DOI":"10.1152\/ajplung.00242.2004","article-title":"BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways","volume":"288","author":"Jeffery","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib44","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nn.2208","article-title":"Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition","volume":"11","author":"Kageyama","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.devcel.2009.12.010_bib45","doi-asserted-by":"crossref","first-page":"L521","DOI":"10.1152\/ajplung.00212.2003","article-title":"Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development","volume":"286","author":"Kalinichenko","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib46","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ng.400","article-title":"Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis","volume":"41","author":"Karner","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib47","first-page":"131","article-title":"Cell proliferation in the mammalian lung","volume":"22","author":"Kauffman","year":"1980","journal-title":"Int. Rev. Exp. Pathol."},{"key":"10.1016\/j.devcel.2009.12.010_bib48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.10.1.60","article-title":"The T\/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary","volume":"10","author":"Kimura","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2009.12.010_bib49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.cellbio.21.012704.132806","article-title":"Planar cell polarization: an emerging model points in the right direction","volume":"21","author":"Klein","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib50","doi-asserted-by":"crossref","first-page":"8216","DOI":"10.1128\/MCB.23.22.8216-8225.2003","article-title":"The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice","volume":"23","author":"Lebel","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/dbio.2002.0729","article-title":"Wnt5a participates in distal lung morphogenesis","volume":"248","author":"Li","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ydbio.2005.08.035","article-title":"Wnt5a regulates Shh and Fgf10 signaling during lung development","volume":"287","author":"Li","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib53","doi-asserted-by":"crossref","first-page":"36257","DOI":"10.1074\/jbc.M806786200","article-title":"Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways","volume":"283","author":"Li","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2009.12.010_bib54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ydbio.2008.07.021","article-title":"Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis","volume":"322","author":"Li","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib55","doi-asserted-by":"crossref","first-page":"L81","DOI":"10.1152\/ajplung.2000.279.1.L81","article-title":"Retinoic acid stimulates immature lung fibroblast growth via a PDGF-mediated autocrine mechanism","volume":"279","author":"Liebeskind","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib56","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1242\/dev.124.20.3943","article-title":"Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development","volume":"124","author":"Lindahl","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib57","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/1717","article-title":"Sonic hedgehog is essential to foregut development","volume":"20","author":"Litingtung","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0012-1606(03)00359-2","article-title":"Role for ETS domain transcription factors Pea3\/Erm in mouse lung development","volume":"261","author":"Liu","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib59","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cub.2004.05.020","article-title":"Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis","volume":"14","author":"Liu","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib60","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ydbio.2007.12.003","article-title":"Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis","volume":"314","author":"Liu","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib61","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ydbio.2007.08.007","article-title":"Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells","volume":"310","author":"Lu","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1086\/316947","article-title":"BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension","volume":"68","author":"Machado","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib63","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1152\/physrev.00028.2006","article-title":"Transcriptional control of lung morphogenesis","volume":"87","author":"Maeda","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.devcel.2009.12.010_bib64","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.128.12.2397","article-title":"Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations","volume":"128","author":"Mahlapuu","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib65","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1242\/dev.01795","article-title":"Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage","volume":"132","author":"Mailleux","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib66","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature07005","article-title":"The branching programme of mouse lung development","volume":"453","author":"Metzger","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2009.12.010_bib67","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1101\/gad.12.20.3156","article-title":"Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless","volume":"12","author":"Min","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2009.12.010_bib68","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng1116","article-title":"Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome","volume":"33","author":"Neptune","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib69","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1056\/NEJM200108023450502","article-title":"Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred","volume":"345","author":"Newman","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.devcel.2009.12.010_bib70","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/(SICI)1097-0177(199810)213:2<228::AID-AJA8>3.0.CO;2-I","article-title":"Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in\u00a0vitro","volume":"213","author":"Nogawa","year":"1998","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2009.12.010_bib71","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1242\/dev.01678","article-title":"Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation","volume":"132","author":"Okubo","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib72","doi-asserted-by":"crossref","first-page":"L141","DOI":"10.1152\/ajplung.00148.2004","article-title":"Distal angiogenesis: a new concept for lung vascular morphogenesis","volume":"288","author":"Parera","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib73","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0960-9822(98)70446-4","article-title":"Sonic hedgehog regulates branching morphogenesis in the mammalian lung","volume":"8","author":"Pepicelli","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib74","doi-asserted-by":"crossref","first-page":"L299","DOI":"10.1152\/ajplung.00008.2009","article-title":"FGF signaling is required for myofibroblast differentiation during alveolar regeneration","volume":"297","author":"Perl","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/gene.20093","article-title":"Normal lung development and function after Sox9 inactivation in the respiratory epithelium","volume":"41","author":"Perl","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2009.12.010_bib76","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0925-4773(00)00432-9","article-title":"Notch\/Delta expression in the developing mouse lung","volume":"98","author":"Post","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2009.12.010_bib77","doi-asserted-by":"crossref","first-page":"R2336","DOI":"10.1152\/ajpregu.2000.279.6.R2336","article-title":"Swim bladder gas gland cells produce surfactant: in\u00a0vivo and in culture","volume":"279","author":"Prem","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib78","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/bies.10177","article-title":"Developmental paradigms in terminal lung development","volume":"24","author":"Prodhan","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.devcel.2009.12.010_bib79","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1432-0436.2006.00096.x","article-title":"Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps","volume":"74","author":"Que","year":"2006","journal-title":"Differentiation"},{"key":"10.1016\/j.devcel.2009.12.010_bib80","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.003855","article-title":"Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm","volume":"134","author":"Que","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib81","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1073\/pnas.0808649105","article-title":"Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development","volume":"105","author":"Que","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.12.010_bib82","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1242\/dev.034629","article-title":"Multiple roles for Sox2 in the developing and adult mouse trachea","volume":"136","author":"Que","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib83","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1242\/dev.015495","article-title":"Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme","volume":"135","author":"Rajagopal","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib84","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ydbio.2007.04.033","article-title":"Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development","volume":"307","author":"Ramasamy","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib85","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1242\/dev.02407","article-title":"Epithelial stem cells of the lung: privileged few or opportunities for many?","volume":"133","author":"Rawlins","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib86","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1073\/pnas.0610770104","article-title":"Lung development and repair: contribution of the ciliated lineage","volume":"104","author":"Rawlins","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.12.010_bib87","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1242\/dev.037317","article-title":"The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells","volume":"136","author":"Rawlins","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib88","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib89","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ydbio.2008.06.009","article-title":"The transmembrane protein TMEM16A is required for normal development of the murine trachea","volume":"321","author":"Rock","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib90","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2009.12.010_bib91","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/dbio.2000.9880","article-title":"Coordinated expression of Hoxb genes and signaling molecules during development of the chick respiratory tract","volume":"227","author":"Sakiyama","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib92","doi-asserted-by":"crossref","first-page":"L71","DOI":"10.1152\/ajplung.90452.2008","article-title":"Emerging pulmonary vasculature lacks fate specification","volume":"296","author":"Schwarz","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib93","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.semcdb.2009.03.018","article-title":"Cell division orientation and planar cell polarity pathways","volume":"20","author":"Segalen","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib94","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/5096","article-title":"Fgf10 is essential for limb and lung formation","volume":"21","author":"Sekine","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib95","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1242\/dev.01570","article-title":"Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung","volume":"132","author":"Serls","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib96","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1242\/dev.129.20.4831","article-title":"Wnt7b regulates mesenchymal proliferation and vascular development in the lung","volume":"129","author":"Shu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib97","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ydbio.2005.04.014","article-title":"Wnt\/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung","volume":"283","author":"Shu","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib98","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1242\/dev.02846","article-title":"Foxp2 and Foxp1 cooperatively regulate lung and esophagus development","volume":"134","author":"Shu","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib99","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1203\/01.PDR.0000151315.81106.D3","article-title":"Alveolarization in retinoic acid receptor-beta-deficient mice","volume":"57","author":"Snyder","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.devcel.2009.12.010_bib100","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1128\/MCB.24.15.6635-6644.2004","article-title":"Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling","volume":"24","author":"Sock","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib101","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ajhg.2009.05.005","article-title":"Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations","volume":"84","author":"Stankiewicz","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2009.12.010_bib102","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.physiol.59.1.89","article-title":"Cellular and molecular mechanisms of pulmonary vascular remodeling","volume":"59","author":"Stenmark","year":"1997","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib103","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1006\/dbio.1999.9380","article-title":"HNF-3\/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in\u00a0vivo","volume":"213","author":"Tichelaar","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib104","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/dvdy.1124","article-title":"Spatial and temporal distribution of nerves, ganglia, and smooth muscle during the early pseudoglandular stage of fetal mouse lung development","volume":"221","author":"Tollet","year":"2001","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2009.12.010_bib105","doi-asserted-by":"crossref","first-page":"29532","DOI":"10.1074\/jbc.M801565200","article-title":"Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung","volume":"283","author":"Tsao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2009.12.010_bib106","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1242\/dev.034884","article-title":"Notch signaling controls the balance of ciliated and secretory cell fates in developing airways","volume":"136","author":"Tsao","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib107","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","article-title":"Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters","volume":"132","author":"Ventura","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2009.12.010_bib108","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-2007-994376","article-title":"Vitamin A deficiency and severe bronchopulmonary dysplasia in very low birthweight infants","volume":"13","author":"Verma","year":"1996","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.devcel.2009.12.010_bib109","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0925-4773(02)00451-3","article-title":"New insights into saccular development and vascular formation in lung allografts under the renal capsule","volume":"120","author":"Vu","year":"2003","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2009.12.010_bib110","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/dev.00966","article-title":"Foxa2 regulates alveolarization and goblet cell hyperplasia","volume":"131","author":"Wan","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib111","doi-asserted-by":"crossref","first-page":"13809","DOI":"10.1074\/jbc.M414122200","article-title":"Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis","volume":"280","author":"Wan","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2009.12.010_bib112","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1242\/dev.127.12.2695","article-title":"Bmp4 and Fgf10 play\u00a0opposing roles during lung bud morphogenesis","volume":"127","author":"Weaver","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib113","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0012-1606(03)00117-9","article-title":"Tissue interactions pattern the mesenchyme of the embryonic mouse lung","volume":"258","author":"Weaver","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib114","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1242\/dev.125.18.3615","article-title":"FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung","volume":"125","author":"Weinstein","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib115","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1242\/dev.004879","article-title":"FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network","volume":"134","author":"White","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib116","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1002\/dvdy.21643","article-title":"Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity","volume":"237","author":"Wilkinson","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2009.12.010_bib117","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1242\/dev.02141","article-title":"The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature","volume":"132","author":"Wilm","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib118","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.resp.2007.10.004","article-title":"Developmental regulation of lumenal lung fluid and electrolyte transport","volume":"159","author":"Wilson","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib119","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ydbio.2009.04.035","article-title":"Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers","volume":"331","author":"Winata","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib120","doi-asserted-by":"crossref","first-page":"46911","DOI":"10.1074\/jbc.M307977200","article-title":"Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung","volume":"278","author":"Wongtrakool","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2009.12.010_bib121","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ydbio.2007.04.042","article-title":"Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis","volume":"308","author":"Yamamoto","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib122","doi-asserted-by":"crossref","first-page":"L191","DOI":"10.1152\/ajplung.00385.2005","article-title":"Hop\u00a0functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression","volume":"291","author":"Yin","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.devcel.2009.12.010_bib123","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ydbio.2008.04.009","article-title":"An FGF-WNT gene regulatory network controls lung mesenchyme development","volume":"319","author":"Yin","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2009.12.010_bib124","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.022087","article-title":"A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney","volume":"136","author":"Yu","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib125","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1172\/JCI37041","article-title":"Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy","volume":"119","author":"Zaghloul","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.devcel.2009.12.010_bib126","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/dev.02720","article-title":"GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in\u00a0vivo","volume":"134","author":"Zhang","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2009.12.010_bib127","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/ng.157","article-title":"A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration","volume":"40","author":"Zhang","year":"2008","journal-title":"Nat. Genet."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580709005279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580709005279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T10:33:00Z","timestamp":1634725980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580709005279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":127,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S1534580709005279"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2009.12.010","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}