{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:15:37Z","timestamp":1792592137543,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":655,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.devcel.2011.08.005","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T10:07:43Z","timestamp":1318500463000},"page":"627-641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":181,"title":["A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis"],"prefix":"10.1016","volume":"21","author":[{"given":"Elisabetta","family":"Ferretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rediet","family":"Zewdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u00a0M.","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Karner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew\u00a0J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0J.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0J.","family":"Depew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Selleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2011.08.005_bib1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng.580","article-title":"A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4","volume":"42","author":"Beaty","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib2","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1242\/dev.005132","article-title":"Wnt signaling mediates regional specification in the vertebrate face","volume":"134","author":"Brugmann","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib3","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1242\/dev.02395","article-title":"Pbx1\/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression","volume":"133","author":"Capellini","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib4","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1242\/dev.048819","article-title":"Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1","volume":"137","author":"Capellini","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.devcel.2005.05.016","article-title":"Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system","volume":"9","author":"Carroll","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2011.08.005_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/dvg.20724","article-title":"Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center","volume":"49","author":"Compagnucci","year":"2011","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2011.08.005_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.0009-9163.2004.00225.x","article-title":"Taking it to the max: the genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology","volume":"65","author":"Cox","year":"2004","journal-title":"Clin. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib8","first-page":"447","article-title":"Patterning the neural crest derivatives during development of the vertebrate head: insights from avian studies","volume":"207","author":"Creuzet","year":"2005","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.devcel.2011.08.005_bib9","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/ajmg.a.33375","article-title":"Further evidence for the possible role of MEIS2 in the development of cleft palate and cardiac septum","volume":"152A","author":"Crowley","year":"2010","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.devcel.2011.08.005_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jez.b.21205","article-title":"Tweaking the hinge and caps: testing a model of the organization of jaws","volume":"310","author":"Depew","year":"2008","journal-title":"J.\u00a0Exp. Zoolog. B Mol. Dev. Evol."},{"key":"10.1016\/j.devcel.2011.08.005_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/dev.127.1.155","article-title":"Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins","volume":"127","author":"Ferretti","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1242\/dev.052803","article-title":"Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo","volume":"138","author":"Fossat","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0070-2153(08)00602-9","article-title":"The etiopathogenesis of cleft lip and cleft palate: usefulness and caveats of mouse models","volume":"84","author":"Gritli-Linde","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ydbio.2010.12.021","article-title":"Epithelial Wnt\/\u03b2-catenin signaling regulates palatal shelf fusion through regulation of Tgf\u03b23 expression","volume":"350","author":"He","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/dbio.2000.9732","article-title":"Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures","volume":"222","author":"H\u00e9bert","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib17","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/ng1903","article-title":"Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)","volume":"38","author":"Ingraham","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature01458","article-title":"Links between signal transduction, transcription and adhesion in epithelial bud development","volume":"422","author":"Jamora","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2011.08.005_bib19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/zeb.2007.0517","article-title":"Zebrafish Wnt9b synteny and expression during first and second arch, heart, and pectoral fin bud morphogenesis","volume":"5","author":"Jezewski","year":"2008","journal-title":"Zebrafish"},{"key":"10.1016\/j.devcel.2011.08.005_bib20","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/dvdy.20646","article-title":"Development of the upper lip: morphogenetic and molecular mechanisms","volume":"235","author":"Jiang","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2011.08.005_bib21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/bdra.20302","article-title":"Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A\/WySn mice, as confirmed by a genetic complementation test","volume":"76","author":"Juriloff","year":"2006","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.devcel.2011.08.005_bib22","first-page":"743","article-title":"Comparative genomics on Wnt3-Wnt9b gene cluster","volume":"15","author":"Katoh","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.devcel.2011.08.005_bib23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng985","article-title":"Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes","volume":"32","author":"Kondo","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib24","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/dvdy.20723","article-title":"Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice","volume":"235","author":"Lan","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2011.08.005_bib25","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1242\/dev.01676","article-title":"Distinct functions for Bmp signaling in lip and palate fusion in mice","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib26","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1073\/pnas.0434590100","article-title":"Mapping Wnt\/beta-catenin signaling during mouse development and in colorectal tumors","volume":"100","author":"Maretto","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2011.08.005_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng0298-136","article-title":"An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination","volume":"18","author":"Meyers","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib28","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.ajhg.2008.03.005","article-title":"TFAP2A mutations result in branchio-oculo-facial syndrome","volume":"82","author":"Milunsky","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2005.10.032","article-title":"Hox cofactors in vertebrate development","volume":"291","author":"Moens","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/tera.1420210115","article-title":"Cleft palate in domestic animals: epidemiologic features","volume":"21","author":"Mulvihill","year":"1980","journal-title":"Teratology"},{"key":"10.1016\/j.devcel.2011.08.005_bib31","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1086\/382196","article-title":"Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family","volume":"74","author":"Niemann","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib32","first-page":"575","article-title":"Relations and interactions between cranial mesoderm and neural crest populations","volume":"207","author":"Noden","year":"2005","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.devcel.2011.08.005_bib33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.devcel.2011.04.010","article-title":"\u03b2-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4","volume":"20","author":"Paek","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2011.08.005_bib34","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1038\/onc.2008.315","article-title":"The p53 family and programmed cell death","volume":"27","author":"Pietsch","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.devcel.2011.08.005_bib35","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.242","article-title":"Disruption of an AP2-alpha binding site in an IRF6 enhancer is associated with cleft lip","volume":"11","author":"Rahimov","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ydbio.2010.11.012","article-title":"Ectodermal Wnt\/\u03b2-catenin signaling shapes the mouse face","volume":"349","author":"Reid","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib37","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0002-9440(10)63392-5","article-title":"Pbx3 deficiency results in central hypoventilation","volume":"165","author":"Rhee","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.devcel.2011.08.005_bib38","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ng1894","article-title":"Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch","volume":"38","author":"Richardson","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib39","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1073\/pnas.0607956104","article-title":"Impaired FGF signaling contributes to cleft lip and palate","volume":"104","author":"Riley","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2011.08.005_bib40","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4161\/cc.6.3.3796","article-title":"p63-associated disorders","volume":"6","author":"Rinne","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.devcel.2011.08.005_bib41","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1523\/JNEUROSCI.19-20-08954.1999","article-title":"Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells","volume":"19","author":"Rowitch","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.devcel.2011.08.005_bib42","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1242\/dev.128.18.3543","article-title":"Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation","volume":"128","author":"Selleri","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib43","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1128\/MCB.24.12.5324-5331.2004","article-title":"The TALE homeodomain protein Pbx2 is not essential for development and long-term survival","volume":"24","author":"Selleri","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib44","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/dev.037440","article-title":"Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion","volume":"136","author":"Song","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.08.005_bib46","first-page":"563","article-title":"Facial and visceral arch development in the mouse embryo: a study by scanning electron microscopy","volume":"124","author":"Tamarin","year":"1977","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.devcel.2011.08.005_bib47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ydbio.2008.06.030","article-title":"Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling","volume":"321","author":"Thomason","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib48","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1172\/JCI40266","article-title":"Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice","volume":"120","author":"Thomason","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2011.08.005_bib49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0070-2153(09)88004-6","article-title":"Hox genes and segmentation of the vertebrate hindbrain","volume":"88","author":"T\u00fcmpel","year":"2009","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib50","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1242\/dev.033910","article-title":"Towards an integrated view of Wnt signaling in development","volume":"136","author":"van Amerongen","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.08.005_bib51","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.devcel.2011.03.011","article-title":"Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation","volume":"20","author":"Vitobello","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2011.08.005_bib52","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ydbio.2010.11.004","article-title":"The canonical Wnt\/\u03b2-catenin signaling pathway regulates Fgf signaling for early facial development","volume":"349","author":"Wang","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.08.005_bib53","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/19539","article-title":"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development","volume":"398","author":"Yang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2011.08.005_bib54","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1056\/NEJMoa032909","article-title":"Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate","volume":"351","author":"Zucchero","year":"2004","journal-title":"N.\u00a0Engl. J. Med."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580711003170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580711003170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:23:46Z","timestamp":1761521026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580711003170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S1534580711003170"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2011.08.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13014956.14331054","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2011.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}