{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:09:08Z","timestamp":1791050948527,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":539,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["1-FY08-421"],"award-info":[{"award-number":["1-FY08-421"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011856","name":"Mauritius Research Council","doi-asserted-by":"publisher","award":["U117512772"],"award-info":[{"award-number":["U117512772"]}],"id":[{"id":"10.13039\/501100011856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS039421"],"award-info":[{"award-number":["R01 NS039421"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.devcel.2011.12.023","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T11:15:23Z","timestamp":1331550923000},"page":"585-596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Disruption of SoxB1-Dependent Sonic hedgehog Expression in the Hypothalamus Causes Septo-optic Dysplasia"],"prefix":"10.1016","volume":"22","author":[{"given":"Li","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solsire\u00a0E.","family":"Zevallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Rizzoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsu","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Lovell-Badge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas\u00a0J.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2011.12.023_bib1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/bdra.20447","article-title":"Fetal ethanol exposure activates protein kinase A and impairs Shh expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly","volume":"82","author":"Aoto","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.devcel.2011.12.023_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ydbio.2008.11.022","article-title":"Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis","volume":"327","author":"Aoto","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.12.023_bib3","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1101\/gad.13.23.3092","article-title":"The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain","volume":"13","author":"Bertuzzi","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2011.12.023_bib4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1242\/dev.056465","article-title":"Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary","volume":"138","author":"Bharti","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2007.08.046","article-title":"TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors","volume":"311","author":"Brinkmeier","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.12.023_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","author":"Chiang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2011.12.023_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1001\/archneur.1993.00540070083022","article-title":"Midline cerebral dysgenesis, dysfunction of the hypothalamic-pituitary axis, and fetal alcohol effects","volume":"50","author":"Coulter","year":"1993","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.devcel.2011.12.023_bib8","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1242\/dev.00515","article-title":"Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development","volume":"130","author":"Dakubo","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(00)80334-7","article-title":"Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm","volume":"90","author":"Dale","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2011.12.023_bib10","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1101\/gad.932601","article-title":"Temporal regulation of a paired-like homeodomain repressor\/TLE corepressor complex and a related activator is required for pituitary organogenesis","volume":"15","author":"Dasen","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2011.12.023_bib11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/477","article-title":"Mutations in the homeobox gene HESX1\/Hesx1 associated with septo-optic dysplasia in human and mouse","volume":"19","author":"Dattani","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.12.023_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ydbio.2007.02.001","article-title":"Noggin regulates Bmp4 activity during pituitary induction","volume":"305","author":"Davis","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.12.023_bib13","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1242\/dev.009324","article-title":"Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network","volume":"135","author":"Dessaud","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib14","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity","volume":"75","author":"Echelard","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2011.12.023_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.125.6.1005","article-title":"Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary","volume":"125","author":"Ericson","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1119(02)00393-1","article-title":"Characterization of cis-regulatory elements of the homeobox gene Xanf-1","volume":"285","author":"Eroshkin","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.devcel.2011.12.023_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ng1120","article-title":"Mutations in SOX2 cause anophthalmia","volume":"33","author":"Fantes","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.12.023_bib18","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nn.2397","article-title":"Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh","volume":"12","author":"Favaro","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.devcel.2011.12.023_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neuron.2011.04.020","article-title":"Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors","volume":"70","author":"Flandin","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.devcel.2011.12.023_bib20","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.devcel.2008.07.003","article-title":"Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly","volume":"15","author":"Geng","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2011.12.023_bib21","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1172\/JCI38937","article-title":"Pathogenesis of holoprosencephaly","volume":"119","author":"Geng","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"issue":"Suppl 1","key":"10.1016\/j.devcel.2011.12.023_bib22","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/S0039-6257(99)00067-3","article-title":"Optic nerve morphology may reveal adverse events during prenatal and perinatal life\u2014digital image analysis","volume":"44","author":"Hellstr\u00f6m","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.devcel.2011.12.023_bib23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1242\/dev.01705","article-title":"New insights into craniofacial morphogenesis","volume":"132","author":"Helms","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1242\/dev.02239","article-title":"A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers","volume":"133","author":"Jeong","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib25","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/ng.230","article-title":"Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein","volume":"40","author":"Jeong","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.12.023_bib26","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/MOP.0b013e32833f56d5","article-title":"Holoprosencephaly: recommendations for diagnosis and management","volume":"22","author":"Kauvar","year":"2010","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.devcel.2011.12.023_bib27","first-page":"257","article-title":"Septo-optic dysplasia - novel insights into the aetiology","volume":"69","author":"Kelberman","year":"2008","journal-title":"Horm. Res."},{"key":"10.1016\/j.devcel.2011.12.023_bib28","first-page":"2442","article-title":"Mutations within Sox2\/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans","volume":"116","author":"Kelberman","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2011.12.023_bib29","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1101\/gad.1462706","article-title":"Hedgehog-regulated localization of Vax2 controls eye development","volume":"20","author":"Kim","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2011.12.023_bib30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1242\/dev.124.3.603","article-title":"A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate","volume":"124","author":"Li","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ajmg.c.30239","article-title":"Genesis of teratogen-induced holoprosencephaly in mice","volume":"154C","author":"Lipinski","year":"2010","journal-title":"Am. J. Med. Genet. C. Semin. Med. Genet."},{"key":"10.1016\/j.devcel.2011.12.023_bib32","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1101\/gr.225502","article-title":"rVista for comparative sequence-based discovery of functional transcription factor binding sites","volume":"12","author":"Loots","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.devcel.2011.12.023_bib33","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.devcel.2006.09.021","article-title":"Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation","volume":"11","author":"Manning","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2011.12.023_bib34","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1242\/dev.129.13.3055","article-title":"Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development","volume":"129","author":"Mathieu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib35","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/dev.02493","article-title":"Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH","volume":"133","author":"Morcillo","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib36","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0012-1606(03)00159-3","article-title":"Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification","volume":"259","author":"Motoyama","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.12.023_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ydbio.2006.12.010","article-title":"Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb","volume":"304","author":"Nissim","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.12.023_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/dbio.1997.8794","article-title":"Pax2 expression and retinal morphogenesis in the normal and Krd mouse","volume":"193","author":"Otteson","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.12.023_bib39","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1242\/dev.124.20.4153","article-title":"Patterning of the chick forebrain anlage by the prechordal plate","volume":"124","author":"Pera","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.conb.2005.01.016","article-title":"SOX genes and neural progenitor identity","volume":"15","author":"Pevny","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.devcel.2011.12.023_bib41","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/dvdy.21511","article-title":"WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth","volume":"237","author":"Potok","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2011.12.023_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajmg.a.30642","article-title":"SOX2 anophthalmia syndrome","volume":"135","author":"Ragge","year":"2005","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.devcel.2011.12.023_bib43","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1242\/dev.007906","article-title":"SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis","volume":"134","author":"Rizzoti","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ng1309","article-title":"SOX3 is required during the formation of the hypothalamo-pituitary axis","volume":"36","author":"Rizzoti","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.12.023_bib45","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1196-357","article-title":"Mutations in the human Sonic Hedgehog gene cause holoprosencephaly","volume":"14","author":"Roessler","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2011.12.023_bib46","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1242\/dev.124.14.2709","article-title":"Inductive interactions direct early regionalization of the mouse forebrain","volume":"124","author":"Shimamura","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib47","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nn.2545","article-title":"A genomic atlas of mouse hypothalamic development","volume":"13","author":"Shimogori","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.devcel.2011.12.023_bib48","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1242\/dev.126.15.3359","article-title":"Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum","volume":"126","author":"Sussel","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib49","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1523\/JNEUROSCI.1089-09.2009","article-title":"Role of neuroepithelial Sonic hedgehog in hypothalamic patterning","volume":"29","author":"Szab\u00f3","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.devcel.2011.12.023_bib50","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1242\/dev.00305","article-title":"Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity","volume":"130","author":"Take-uchi","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib51","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1242\/dev.125.23.4835","article-title":"Formation of Rathke's pouch requires dual induction from the diencephalon","volume":"125","author":"Takuma","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib52","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1101\/gad.12.11.1691","article-title":"Multistep signaling requirements for pituitary organogenesis in\u00a0vivo","volume":"12","author":"Treier","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2011.12.023_bib53","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1242\/dev.128.3.377","article-title":"Hedgehog signaling is required for pituitary gland development","volume":"128","author":"Treier","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.devcel.2011.12.023_bib54","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ydbio.2010.09.024","article-title":"Direct and indirect requirements of Shh\/Gli signaling in early pituitary development","volume":"348","author":"Wang","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2011.12.023_bib55","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuron.2010.01.004","article-title":"Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates","volume":"65","author":"Xu","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.devcel.2011.12.023_bib56","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1152\/physrev.00006.2006","article-title":"Molecular physiology of pituitary development: signaling and transcriptional networks","volume":"87","author":"Zhu","year":"2007","journal-title":"Physiol. Rev."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580712000044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580712000044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:25:12Z","timestamp":1761521112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580712000044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S1534580712000044"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2011.12.023","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of SoxB1-Dependent Sonic hedgehog Expression in the Hypothalamus Causes Septo-optic Dysplasia","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2011.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}